Database : HANSEN
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Id:18270
Author:Coock, J. V
Title:Complement fixation in leprosy ..-
Source:s.l; s.n; s.d. 19 p. tab.
Abstract:Leper serums contain complement-binding substances that react with antigens of acid-fast bacilli and give an acid-fast fixation similar to taht obtained with serums of rabbits immunized with acid-fast organisms. Some serums contain these antibodies in rather high concentration, notably those from cases with the nodular type of the disease; other serums show a relatively low antibody content. The serums of high titer may give a nonspecific fixation also with non-acid-fast antigens and with lipoidal (Wassermann) antigen, but only in comparatively low dilutions. It is suggested that this attribute of such high titer leper serums may explain a certain percentage of positive Wassermann reactions described in leprosy. Among the acid-fast antigens studied, certain organisms have superior antigenic properties in complement-fixation tests with leper serums. The acid-fast reaction given by leper serums with acid-fast bacterial antigens prevents the use of the complement-fixation reaction in obtaining evidence of the etiologic importance of any acid-fast organism isolated from leprosy. (AU).
Descriptors:HANSENIASE/genet
HANSENIASE/microbiol
HANSENIASE/patol
ANTIGENOS/genet
ANTIGENOS/fisiol
Limits:ESTUDO COMPARATIVO
Location:BR191.1; 03835/s


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