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| Id: | 19026
| | Author: | Hoxter, Gunter; Batista, Luiz; Vellini, L. L. | | Title: | Estudos eletrosféricos nas diversas formas clínicas da lepra / Studies eletrosféricos in different clinical forms of leprosy
| | Source: | Rev. bras. Leprol;19(1):27-40, mar. 1951. ^bgraf.
| | Abstract: | Many diseases cause modification of plasma protein fractions which amy be studied by electrophoretic analysis, The clinician receives valuable information enabling him to confirm diagnoses and guide treatment in cases of hemoconcentration, malnutrition and certain staets of disturbed protein equilibrium such as myeloma, nephosis, cirrhosis, kala azar and lymphogranuloma venereum. Hyperglobulinemias have been observed in various cases of leprosy by several authours 1,2,3,4, including Seibert and Nelson5, who were the first to analyse the serum of three leprosy patients by electrophoretic methods, findings increased gamma and alpha globulin fractions, without including clinical data or the classificationi of their cases. In order to make electrophoretic analyses available to the clinical leprologist, the authours undertook to study leprosy under its various clinical forms by combining clinical findings with electrophoretic data. The present paper brings the results of their first 24 cases. Leprosy patients who had not undergone previous antileprotic treatment were examined on arrival at the Departamento de Profilaxia da Lepra where they appeared for registration. Biopsies were performed for histopathological examination and venous blood was collected for electrophoretic analysis. The Mitsuda reaction could not be followed in most of the cases who bacame interned in distant leper colonies. The cases were divided into 3 groups, the first comprising the lepromatous and the other two the incharacteristics and tuberculoid forms respectively. Electrophoretic examinations revealed an increased gamma globulin fraction in the first group, with practically normal patterns in the other two groups. There was but one exception where a lepromatous case showed no gamma globulin increase. In the inchacateristic group there were 2 cases of slight gamma globulin increased and 2 others with a tendency towards a rising gamma fraction, all of which gave biopsy findings of lepromato...(AU)^ien.
| | Descriptors: | Eletrofisiologia/métodos
Hanseníase/metab
Hanseníase/prev
Hanseníase/fisiopatol
| | Electronic Medium: | http://hansen.bvs.ilsl.br/textoc/revistas/1951/PDF/v19n1a05.pdf / pt
| | Location: | BR191.1 |
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