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| Id: | 13554
| | Author: | Marchiondo Alan A; Smith, Jerome H; File, Sharon K
| | Title: | Naturally occurring leprosy-like disease of wild armadillos: ultrastructure of lepromatous lesions
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| | Source: | s.l; s.n; mar. 1980. 15 p. ilus.
| | Abstract: | An idependent survey of leprosy-like disease in wild armadillos was undertaken in the French Acadiana section of Louisiana in roder to arbitrate the controversy over the existence of this entity(21). As part of this study, material from lepromas was prepared for electron microscopy. Bacilli were concentrated in macrophages and were also found in capillary endothelial cells and fibroblasts, but tjey were not observed in lymphocytes or plasma cells. Bacilli consisted of electron-dense fibrillogranular material limited by a pentalaminar membrane (inner trilaminate plasma membrane and outer bilaminate cell wall). Bacillary division was common and was manifested as irregularly coiled nuclear strands and transverse septation by ingrowth of the plasma membrane. Degenerating bacilli were numerous in large multinucleate macrophages. The host inflammatory infiltrate was comprised of active plasma cells, untransformed lymphocytes, and macrophages originating from circulating monocytes. Monocytes recently emerging from capillaries were small and had a relative paucity of bacilli and lysosomes. These monocytes increased in size, plasma membrane complexity, bacillary burden, numbers and varieties of heterophagic and autophagic lysosomes, numbers of nuclei and nucleolar activity. Replicating, interphase and degenerating bacilli were found within macrophage phagolysosomes or free in the cytoplasmic matrix often aggreated in ranks forming "cigar bundles". Bacilli were variably surrounded by an eletronlucent substance comparable to the "gloae" or "schleim layer" described in human leprosy. Aggregates of bacilli in "gloae" formed "foamy bodies" and rarely observed opaqe droplets. thus, the ultrastructural features of this disease in wild armadillos are identical to those seen in human leprosy and armadillos experimentally infected with Mycobacterium leprae from human lesions. The findings suggest that B lymphocyte-macrophage interaction may be the predominant mechanism of leproma formation.(AU).
| | Descriptors: | TATUS/microbiol
FIBROBLASTOS/microbiol
HANSENIASE/microbiol
HANSENIASE/patol
HANSENIASE/vet
MACROFAGOS/microbiol
MACROFAGOS/ultraest
MYCOBACTERIUM LEPRAE/ultraest
XENARTROS/microbiol
| | Limits: | ANIMAL
| | Electronic Medium: | http://www.ilsl.br
| | Location: | BR191.1; 00937/s |
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