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| Id: | 17561
| | Author: | Geluk, A; van Meijgaarden, K. E; Franken, K. L. M. C; Wieles, B; Arend, S. M; Faber, W. R; Naafs, B; Ottenhoff, T. H. M
| | Title: | Immunological crossreactivity of the Mycobacterium leprae CFP-10 with its homologue in Mycobacterium tuberculosis
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| | Source: | s.l; s.n; 2004. 5 p. tab, graf.
| | Abstract: | Mycobacterium tuberculosis culture filtrate protein-10 (CFP-10) (Rv3874) is considered a promising antigen for the immunodiagnosis of tuberculosis (TB) together with early secreted antigens of M. tuberculosis (ESAT-6). Both ESAT-6 and CFP-10 are encoded by the RD1 region that is deleted from all tested M. bovis bacille Calmette-Guérin (BCG) strains but present in M. leprae, M. tuberculosis, M. bovis, M. kansasii, M. africanum and M. marinum. In this study, the homologue of CFP-10 in M. leprae (ML0050) is identified and characterized. Interferon-gamma production in response to this homologue by T cells from leprosy patients, TB patients and unexposed controls shows that CFP-10 of M. leprae is a potent antigen that crossreacts with CFP-10 of M. tuberculosis at the T-cell level. This crossreactivity has implications for the use of CFP-10 of these mycobacterial species as diagnostic tool in areas endemic for both the diseases. (AU).
| | Descriptors: | Sequência de Aminoácidos
Antígenos de Bactérias/IM
Proteínas de Bactérias/*IM
Reações Cruzadas/IM
Interferon Tipo II/IM/SE
Hanseníase/*IM
Ativação Linfocítica/IM
Dados de Sequência Molecular
Mycobacterium leprae/*IM
Mycobacterium tuberculosis/*IM
Homologia de Sequência
Linfócitos T/IM/ME
Tuberculose/*IM
| | Limits: | Research Support, Non-U.S. Gov't
Humanos
Estudo Comparativo
Animais
| | Location: | BR191.1; 09340/s |
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