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| Id: | 19497
| | Author: | Park, Eunkyue; Levis, Willian R; Quinn, Michael R; Park, Seung Yong; Schuller-Levis, Georgia B. | | Title: | Regulation of nitric oxide induced by mycobacterial lipoarabinomannan in murine macrophages: effects of interferon-B and taurine-chloramine.
| | Source: | Int. J. Lepr;68(4):444-451, Dec., 2000. graf.
| | Abstract: | We examined the effects of interferon beta (IFN-beta) on the production of liporabinomannan (LAM)-induced nitric oxide (NO) in peritoneal macrophages from low-responder and high-responder (C3H/HeJ and C3H/OuJ) mice. NO was produced in a dose response when induced by lipo-polysaccharide (LPS) or LAM plus interferon gamma (IFN-gamma) or IFN-beta in both high- and low-responder mice. In contrast to IFN-gamma, both high- and low-responder mice failed to induce nitrite production when IFN-beta was added, except at a high concentration of IFN-beta. Tau-Cl (0.5 mM) inhibited NO production about 50% in the high-responder strain when cells were activated with LPS or LAM in combination with either IFN-beta or IFN-gamma, and almost abolished NO production at 1.0 mM. In the low-responder strain, Tau-Cl (0.5 mM) significantly inhibited NO production when cells were activated with IFN-gamma or IFN-beta in addition to LPS or LAM, but did not completely inhibit NO production at 1.0 mM. Tau-Cl appears to play a potent role in regulating inflammatory reaction-induced bacterial or mycobacterial organisms. These data indicate a pivotal role for IFN-gamma and IFN-beta for the production of LPS and LAM initiated NO in peritoneal macrophages from low-responder (C3H/HeJ) mice. (AU)^ien.
| | Descriptors: | Macrófagos/imunol
Micobactérias Atípicas/imunol
Óxido Nítrico/imunol
Interferon beta/imunol
| | Limits: | Camundongos
| | Electronic Medium: | http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n4/v68n4a06.pdf / en
| | Location: | BR191.1 |
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