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Id: 17275 Author: Bleharski, Joshua R; Li, Huiying; Meinken, Cristoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Title: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Source: s.l; s.n; 2003. 4 p. . Abstract: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descriptors: Algoritmos Análise por Conglomerados Contagem de Colônia Microbiana Citocinas/GE/ME Perfilação da Expressão Gênica/* Regulação da Expressão Gênica/* Genes de Imunoglobulinas Imunidade Celular Imunidade Natural Hanseníase Virchowiana/*CL/*GE/IM/PP Hanseníase Tuberculóide/*CL/*GE/IM/PP Macrófagos Alveolares/MI Glicoproteínas de Membrana/IM Mycobacterium tuberculosis/GD/IM Análise de Sequência com Séries de Oligonucleotídeos Reação em Cadeia da Polimerase Análise de Componente Principal Receptores da Superfície Celular/IM Receptores Imunológicos/GE/ME Limits: Humano Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Regulação para Cima Location: BR191.1; 09174/s

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