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Id:19530
Author:Truman, Richard W; Gillis, Thomas P.
Title:The effect of ultraviolet light radiation on mycobacterium leprae.
Source:Int. J. Lepr;68(1):11-17, Mar., 2000. graf.
Abstract:Ultraviolet (UV) light is recognized as a potent sterilizing aid, but its relative effectiveness against Mycobacterium leprae has not been shown. We examined the influence of UV on the growth and metabolic activity of M. leprae harvested fresh from foot pads of nude mice. Temporary static suspensions were exposed to timed intervals of UV radiation generated from a fixed source to constitute dosages ranging from 0-12.64 x 10(4) erg/cm2. The metabolic activity of the bacilli was indexed by the oxidation of 14C-palmitate in BACTEC 12-B vials. The long-term effects of irradiation on cell division and growth were assessed by inoculation of BALB/c mouse foot pads. The metabolic activity in BACTEC showed an immediate dose-response-related decline to a maximum of 50% of the control activity after exposure to 6.3 x 10(4) erg/cm2. Mouse foot pad studies showed a similar dose-response pattern. Effective-dose determinations based on metabolic or foot pad data were similar. UV doses of 3.52 x 10(4) erg/cm2 resulted in an average 50% killing, and 7.73 x 10(4) erg/cm2 killed 84% of the M. leprae exposed. This UV sensitivity is similar to that reported for M. tuberculosis. UV sterilization and disinfection practices suitable for M. tuberculosis are likely to be equally effective for M. leprae. (AU)^ien.
Descriptors:Mycobacterium leprae/imunol
Mycobacterium leprae/isol
Raios Ultravioleta/uso diag
Electronic Medium:http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n1/v68n1a02.pdf / en
Location:BR191.1


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Id:17964
Author:Gloster HM; Neal K
Title:Skin cancer in skin of color Skin cancer in skin of color-v.55
Source:s.l; s.n; 2006. 19 p. ilus, tab.
Abstract:Skin cancer is less common in persons with skin of color than in light-skinned Caucasians but is often associated with greater morbidity and mortality. Thus, it is crucial that physicians become familiar with skin cancer in persons of color so as to maximize the likelihood of early detection of these tumors. In dark-skinned ethnic groups, squamous cell carcinoma is most common; squamous cell carcinoma and melanoma usually occur on nonsun-exposed sites; and ultraviolet radiation is not an important etiologic factor for skin cancer with the exception of basal cell carcinoma. Races of intermediate pigmentation, such as Hispanics and Asians, share epidemiologic and clinical features of dark-skinned ethnic groups and Caucasians. Skin cancers pose a significant risk in skin of color and clinicians should focus on preventive measures in these groups such as regular skin exams, self-examination, public education, and screening programs. LEARNING OBJECTIVE: At the completion of this learning activity, participants should be familiar with the epidemiology and unique clinical features of skin cancer in skin of color and be aware of strategies to prevent skin cancer in skin of color.(AU).
Descriptors:NEOPLASIAS CUTÂNEAS/quim
NEOPLASIAS CUTÂNEAS/compl
NEOPLASIAS CUTÂNEAS/diag
NEOPLASIAS CUTÂNEAS/genet
NEOPLASIAS CUTÂNEAS/imunol
NEOPLASIAS CUTÂNEAS/prev
NEOPLASIAS CUTÂNEAS/fisiopatol
NEOPLASIAS CUTÂNEAS/reabil
NEOPLASIAS CUTÂNEAS/radioter
NEOPLASIAS CUTÂNEAS/cirurg
NEOPLASIAS CUTÂNEAS/terap
SARCOMA DE KAPOSI/compl
SARCOMA DE KAPOSI/diag
SARCOMA DE KAPOSI/fisiopatol
RAIOS ULTRAVIOLETA/uso diag
 TERAPIA ULTRAVIOLETA/instrum
 TERAPIA ULTRAVIOLETA/métodos
Limits:ESTUDO COMPARATIVO
HUMANO
Location:BR191.1; 00326/cme



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