Database : HANSEN Search on : DOENCA [Subject descriptor] References found : 179 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19947 Author: Pavithran, K; Satish, T. C. Title: Dapsone-induced motor polyneuropathy in a patient with leprosy. Source: Int. J. Lepr;65(2):262-263, Jun. 1997. . Descriptors: Hanseníase Dimorfa/quimioter Dapsona/ef adv Dapsona/uso terap Doença dos Neurônios Motores/ind quim Doença dos Neurônios Motores/diag Limits: Humanos Masculino Feminino Location: BR191.1

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Id: 19620 Author: Thomas, Mathew M; Jacob, Mary; Chandi, Sushil M; George, Soshamma; Pulimood, Susanne; Jeyaseelan, L; Job, Charles K. Title: Role of S-100 staining in differentiating leprosy from other granulomatous diseases of the skin. Source: Int. J. Lepr;67(1):1-5, Mar., 1999. ilus, tab, graf. Abstract: Since Mycobacterium leprae are rarely demonstrable in the tuberculoid spectrum of leprosy, a confirmatory diagnosis of leprosy can be made on the basis of finding active destruction of cutaneous nerves by granulomatous inflammation in a skin biopsy. Immunoperoxidase staining for S-100 protein, which is a marker for Schwann cells, was used to delineate nerves in lesional skin biopsies of 25 patients with tuberculoid and borderline tuberculoid leprosy as well as 15 controls with nonleprous granulomatous inflammation. Four different patterns of nerve damage were observed: infiltrated, fragmented, absent, and intact. All of the nonleprous granulomatous dermatoses showed only intact nerves, either inside or outside the granuloma, and so S-100 staining can be used to rule out leprosy. (AU)^ien. Descriptors: Proteínas S100/imunol Hanseníase/imunol Hanseníase/fisiopatol Doença Granulomatosa Crônica/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n1/v67n1a01.pdf / en Location: BR191.1

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Id: 19091 Author: Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância Epidemiológica. Title: Caderno 10 - Doença de Chagas - Esquistossomose - Malária - Peste - Tracoma / Book 10 - Chagas disease - Schistosomiasis - Malaria - Death - Trachoma Source: In: Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância Epidemiológica.Guia de Vigilância Epidemiológica^ipt. Brasília, Ministério da Saúde, 2009. p.1-75ilus, tab, graf, mapas. Descriptors: Doença de Chagas/fisiopatol Esquistossomose/fisiopatol Malária/fisiopatol Peste/fisiopatol Tracoma/fisiopatol Location: BR191.1, B736g, pt.3

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Id: 19057 Author: Almeida, Jos‚ Oliveira de; Carvalho, Renato P. de Souza. Title: Estudos sôbre a sorologia da lepra / Studies on the serology of leprosy Source: Rev. bras. Leprol;20(1):30-31, mar. 1952. . Descriptors: Doença de Chagas/imunol Sífilis/imunol Hanseníase/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/1952/PDF/v20n1/v20n1a05.pdf / pt Location: BR191.1

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Id: 18388 Author: Jamieson, S. E; Miller, E. N; Black, G. F; Peacock, C. S; Cordel, H. J; Howson, J. M. M; Shaw, M. A; Burgner, D; Xu, W; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Title: Evidence for cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians ..- Source: s.l; s.n; 2004. 12 p. ilus, tab. Abstract: The region of conserved synteny on mouse chromosome 11/human 17q11-q21 is known to carry a susceptibility gene(s) for intramacrophage pathogens. The region is rich in candidates including NOS2A, CCL2/MCP-1, CCL3/MIP-1x, CCL4/mip-1b, CCL5/RANTES, CCR7, STAT3 and STAT5A/5B. To examine the region in man, we studied 92 multicase tuberculosis (627 individuals) and 72 multicase leprosy (372 individuals) families from Brazil. Multipoint nonparametric analysis (ALLEGRO) using 16 microsatallites shows two peaks of linkage for leprosy at D17S250 (Z score 2.34; P=0.01) and D17S1795 (Z 2.67; P=0.004) and a single peak for tuberculosis at D17S250 (Z 2.04; P=0.02). Combined analysis shows significant linkage genes contribute, 49 informative single nucleotide polymorphisms were typed in candidate genes. Family-based allelic associationtesting that was robust to family clustering demonstrated siginificant associations with tuberculosis susceptibility at four loci separated by intervals (NOS2A-8.4Mb-CCL18-32.3kb-CCL4-6.04 Mb-STAT5B) up to several Mb. Stepwise conditional logistic regression analysis using a case/pseudo-control data set showed that the four genes contributed separate main effects, consistent with a cluster of susceptibility genes across 17q11.2 (AU). Descriptors: CROMOSSOMOS HUMANOS PAR 17/genet CROMOSSOMOS HUMANOS PAR 17/imunol PREDISPOSICAO GENETICA PARA DOENÇA MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol MYCOBACTERIUM TUBERCULOSIS/metab - HANSENIASE/genet  TUBERCULOSE/genet  BRASIL/etnol  BRASIL/epidemiol Limits: HUMANO ANIMAL Location: BR191.1; 09314/s

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Id: 18387 Author: Miller, E. N; Jamieson, S. E; Jobert, C; Fakiola, M; Peacock, C. S; Cordell, H. J; Shaw, M. A; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Title: Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians ..- Source: s.l; s.n; 2004. 5 p. tab, graf. Abstract: Genome-wide scans were conducted for tuberculosis and leprosy per se in Brazil. At stage 1,405 markers (10 cM map) were typed in 16 (178 individuals) tuberculosis and 21 (173 individuals) leprosy families. Nonparametric multipoint analysis detected 8 and 9 chromosomal regions respectively with provisional evidence (P<0.05) for linkage. A stage 2, 58 markers from positive regions were typed in a second set of 22 (176 individuals) tuberculosis families, with 22 additional markers types in all families; 42 positive markers in 50 (192 individuals) new leprosy families, and 30 additional markers in all families. Three regions (10q26.13, 11q12.3, 20p12.1) retained suggestive evidence (peak LOD scores 1.31, 1.78, 1.78; P=0.007, 0.0018, 0.0021) for linkage to tuberculosis, 3 regions (6p21.32, 17q22, 20p13) to leprosy (HLA-DQA, 3.23, P=5.8 x 10-5; D17S1868.2.38, P=0.0005; D20S889, 1.51, P=0.004). The peak at D20S889 for leprosy is 3.5 Mb distal to that reported at D20S115 for leprosy in India (AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS HANSENIASE/genet TUBERCULOSE/genet - MYCOBACTERIUM LEPRAE/imunol  MYCOBACTERIUM LEPRAE/metab  MYCOBACTERIUM TUBERCULOSIS/imunol  MYCOBACTERIUM TUBERCULOSIS/metab Location: BR191.1; 09313/s

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Id: 18386 Author: Malhotra, Dheeraj; Relhan, Vineet; Reddy, B. S. N; Bamezai, Ramesh Title: TLR2 Arg677rp polymorphism in leprosy: revisited ..- Source: s.l; s.n; 2005. 3 p. ilus. Abstract: We investigated the Toll-like receptor 2 (TLR2) Arg677Trp polymorphism, associated with lepromatous leprosy in the Korean population and shown to abrogaet TLR2-mediated signalling in response to mycobacterial ligands, in 286 Indian leprosy patients and 183 ethnically matched controls. The case-control comparison also involved investigation of possible variation(s) in the promoter region of the TLR2 gene. Genotyping results after direct PCR sequencing showed that the TLR2 Arg677Trp polymorphism associated with lepromatous leprosy in the Korean population is not a true polymorphism of the TLR2 gene and has resulted from the variation present in the 93% homologous duplicated region of TLR2 exon 3 present approximately 23 kb upstream (AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol PREDISPOSICAO GENETICA PARA DOENÇA/epidemiol PREDISPOSICAO GENETICA PARA DOENÇA/etiol PREDISPOSICAO GENETICA PARA DOENÇA/genet HANSENIASE/genet HANSENIASE/imunol HANSENIASE/microbiol - COREIA (GEOGRAFICO)/etnol  COREIA (GEOGRAFICO)/epidemiol Limits: HUMANO Location: BR191.1; 09312/s

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Id: 18380 Author: Frist, Thomas F Title: Community factors influencing the Hansen´s disease patient and his treatment ..- Source: s.l; s.n; 1980. 7 p. . Descriptors: HANSENIASE/compl HANSENIASE/psicol EFEITOS PSICO-SOCIAIS DA DOENCA PARTICIPACAO COMUNITARIA/psicol PARTICIPACAO COMUNITARIA/tend - PAISES EM DESENVOLVIMENTO  MOTIVACAO  EDUCACAO EM SAUDE/tend  SERVICOS DE SAUDE COMUNITARIA/tend  SERVICOS DE SAUDE COMUNITARIA/util Limits: HUMANO Location: BR191.1; 00363/s

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Id: 18359 Author: Gordon, Robert A Title: Skin infiltration in hodgkins disease ..- Source: s.l; s.n; 1980. 3 p. ilus. Descriptors: PELE/anat PELE/irrig PELE/les PELE/fisiopatol DOENCA DE HODGKIN/diag DOENCA DE HODGKIN/fisiopatol Limits: ESTUDO COMPARATIVO Location: BR191.1; 02251/s

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Id: 18282 Author: Varkevisser, Corlien M Title: Methodology of research into social aspects of leprosy control ..- Source: s.l; s.n; 1980. 7 p. . Descriptors: HANSENIASE/prev PESQUISA/clas PESQUISA/tend - EFEITOS PSICO-SOCIAIS DA DOENCA  METODOS Limits: HUMANO Location: BR191.1; 00472/s

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Id: 18206 Author: Douglas, J. T; Cellona, R. V; Fajardo, T. T; Abalos, R. M; Balagon, M. V. F; Klatser, P. R Title: Prospective study of serological conversion as a risk factor for development of leprosy among household contacts ..- Source: s.l; s.n; 2004. 4 p. tab. Abstract: Although the prevalence of leprosy has decline over the years, there is no evidence that incidence rates are falling. A method of early detection of those people prone to develop the mosth infectious form of leprosy would contribute to breaking the chain of transmission. Prophylactic treatment of serologically idenfified high-risk contacts of incidend patients should be an operationally feasible approach for routine control programs. In addition, classification of high-risk household contacts will allow control program resources to be more focused. Is this prospective study, we examined the ability of serology used for the detection of antibodies to phenolic glycolipid I of Mycobacterium leprae to identify those household contacts of multibacillary leprosy patients who had the highest risk of developing leprosy. After the start of multidrug therapy for the index case, a new case of leprosy developed in one in seven of the 178 households studied. In households where new cases appeared, the seropositivity rates were significantly higher (P<0.001) than those in households without new cases. Seropositive household contacts had a significantly higher risk of developing leprosy (relative hazard adjusted for age and sex [aRH], 7.2), notably multibacillary leprosy (aRH=24), than seronegative contacts (AU). Descriptors: ANTICORPOS/anal ANTICORPOS/sangue ANTICORPOS/clas HANSENIASE/epidemiol HANSENIASE/prev HANSENIASE/transm - TRANSMISSAO DE DOENCA/prev  BUSCA DE COMUNICANTE Limits: HUMANO Location: BR191.1; 09189/s

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Id: 17973 Author: World Health Organization*. Title: Fourth Annual Report ..- Source: s.l; WHO; 1980. 346 p. tab. Conference: Present in: Fourth Annual Report, s.l, 1980. Descriptors: DOENCAS TRANSMISSIVEIS/clas DOENCAS TRANSMISSIVEIS/epidemiol DOENCAS TRANSMISSIVEIS/etiol MALARIA/clas MALARIA/epidemiol MALARIA/etiol DOENCA DE CHAGAS/clas DOENCA DE CHAGAS/epidemiol DOENCA DE CHAGAS/etiol Limits: RELATO DE CASO ESTUDO COMPARATIVO HUMANO Location: BR191.1; WC680, U3f

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Id: 17713 Author: Dariush, Akhavan Title: Análise de custo-efetividade do programa de controle da Doença de Chagas no Brasil Analysis of cost-effectiveness of the program of control of the Illness of Chagas in Brazil- Source: Brasília; s.n; 2000. 271 p. ilus, tab, graf. Descriptors: DOENCA DE CHAGAS/diag DOENCA DE CHAGAS/prev Limits: RELATO DE CASO ESTUDO COMPARATIVO HUMANO Location: BR191.1; , D251p

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Id: 17691 Author: Scollard, D. M; Adams, L. B; Gillis, T. P; Krahenbuhl, J. L; Truman, R. W; Williams, D. L Title: The continuing challenges of leprosy ..- Source: s.l; s.n; 2006. 44 p. ilus, tab. Abstract: Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans. The second is a peripheral neuropathy that is initiated by the infection and the accompanying immunological events. The infection is curable but not preventable, and leprosy remains a major global health problem, especially in the developing world, publicity to the contrary notwithstanding. Mycobacterium leprae remains noncultivable, and for over a century leprosy has presented major challenges in the fields of microbiology, pathology, immunology, and genetics; it continues to do so today. This review focuses on recent advances in our understanding of M. leprae and the host response to it, especially concerning molecular identification of M. leprae, knowledge of its genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Advances in experimental models include studies in gene knockout mice and the development of molecular techniques to explore the armadillo model. In clinical studies, notable progress has been made concerning the immunology and immunopathology of leprosy, the genetics of human resistance, mechanisms of nerve injury, and chemotherapy. In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases. (AU). Descriptors: Antiinfecciosos/TU Proteínas de Bactérias/ME Vacinas Bacterianas Modelos Animais de Doenças Suscetibilidade à Doença/IM Resistência Bacteriana a Drogas Genes Bacterianos/GE Predisposição Genética para Doença Genoma Bacteriano Imunidade Celular Imunidade Natural/GE Hansenostáticos/PD/TU Hanseníase/*/DI/MI/TH Mycobacterium leprae/*/CH/DE/IP/PH Nervos Periféricos/MI Doenças do Sistema Nervoso Periférico/MI/PA Reação em Cadeia da Polimerase Research Support, N.I.H., Extramural Células de Schwann/IM/MI Limits: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09365/S

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Id: 17665 Author: Brasil. Ministerio da Saude. Secretaria de Vigilancia em Saude*. Title: A vigilancia, o controle e a preveçao das doenças cronicas nao-transmissiveis: DCNT no contexto do sistema unico de saude brasileiro The monitoring, the control and the prevention of not transmissible the chronic illnesses- Source: Brasilia; OPAS/OMS; 2005. 79 p. mapas, tab, graf. Descriptors: SUS (BR)/hist SUS (BR)/org DOENCA CRÔNICA/epidemiol DOENCA CRÔNICA/reabil DOENCA CRÔNICA/terap POLITICA DE SAUDE/tend - HIPERTENSAO/diag  HIPERTENSAO/reabil  HIPERTENSAO/terap  SAUDE PÚBLICA/métodos  SAUDE PÚBLICA/tend Limits: RELATO DE CASO ESTUDO COMPARATIVO HUMANO Location: BR191.1; WT500, B736v

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Id: 17632 Author: Brakel, Wim H. Van. Title: Peripheral nerve function assessment. Source: In: Schwarz, Richard; Brandsma, Wim.Surgical reconstruction rehabilitation in leprosy and other neuropathies. Kathmandu, Ekta Books, 2004. p.11-24ilus, tab. Descriptors: DOENCAS DO SISTEMA NERVOSO PERIFERICO/diag DOENCAS DO SISTEMA NERVOSO PERIFERICO/reabil DOENCAS DO SISTEMA NERVOSO PERIFERICO/cirurg PELE/patol PELE/fisiopatol SENSIBILIDADE TERMICA/fisiol - ATAXIA/fisiopatol  DOENCA DOS NEURÔNIOS MOTORES/fisiopatol Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1, S96s

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Id: 17559 Author: Save, M. P; Shetty, V. P; Shetty, K. T; Antia, N. H Title: Alterations in neurofilament protein(s) in human leprous nerves: morphology, immunohistochemistry and Western immunoblot correlative study ..- Source: s.l; s.n; 2004. 16 p. ilus, tab. Abstract: Using a specific antibody (SMI 31), the state of phosphorylation of high and medium molecular weight neurofilaments (NF-H and NF-M) was studied in 22 leprous and four nonleprous human peripheral nerves by means of immunohistochemistry, sodium dodecyl sulfate-poly acrylamide gel electrophoresis (SDS-PAGE) and Western immunoblot (WB). The results thus obtained were compared with morphological changes in the respective nerves studied through light and electron microscopy. Many of the leprous nerves showing minimal pathology revealed lack of or weak staining with SMI 31, denoting dephosphorylation. Remyelinated fibres stained intensely with SMI 31 antibody. The WB analysis of Triton X-100 insoluble cytoskeletal preparation showed absence of regular SMI 31 reactive bands corresponding to 200 and 150 kDa molecular weight (NF-H and NF-M, respectively) in 10 nerves. Three of the 10 nerves revealed presence of NF protein bands in SDS-PAGE but not in WB. Presence of additional protein band (following NF-M) was seen in four nerves. Two nerves revealed NF-H band but not NF-M band and one nerve showed trace positivity. In the remaining five nerves presence of all the three NF bands was seen. Thus, 77.3% (17/22) of human leprous nerves studied showed abnormal phosphorylation of NF protein(s). The ultrastructural study showed abnormal compaction and arraying of NF at the periphery of the axons in the fibres with altered axon to myelin thickness ratio (atrophied fibres) as well as at the Schmidt-Lantermann (S-L) cleft region. Such NF changes were more pronounced in the severely atrophied axons suggesting a direct correlation. The observed well-spaced NF in the remyelinated fibres under ultrastructural study was in keeping with both intense SMI 31 staining and presence of NF triplet bands seen in WBs in four of leprous nerves that showed a large number of regenerating fibres suggesting reversal of changes with regeneration. Findings in the present study suggest that atrophy, that is, the reduction in axonal calibre and paranodal demyelination, seen in leprous nerves may result from dephosphorylation of NF-H and NF-M proteins. (AU). Descriptors: Doença de Alzheimer/PA Esclerose Amiotrófica Lateral/PA Atrofia Axônios/PA Western Blotting Citoesqueleto/ME/PA Doenças Desmielinizantes/PA Eletroforese em Gel de Poliacrilamida Imunohistoquímica Hanseníase/*ME Fibras Nervosas/PA Proteínas de Neurofilamentos/*ME Neurônios/*ME/*PA/UL Inclusão em Parafina Fosforilação Limits: Research Support, Non-U.S. Gov't Humanos Location: BR191.1; 09338/s

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Id: 17368 Author: Brasil. Ministério da Saúde. Secretaria de Políticas de Saúde*. Title: O que é doença de Alzheimer ?- Source: Brasília; s.n; 2001. 24p p. . Descriptors: DOENCA CRÔNICA/epidemiol DOENCA CRÔNICA Limits: RELATO DE CASO Location: BR191.1; W500, B736q

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Id: 17287 Author: Engers, H; Morel, C. M Title: Leprosy ..- Source: s.l; s.n; 2003. 2 p. mapas. Descriptors: Antituberculosos/TU Predisposição Genética para Doença Hanseníase/*/DI/DT/EP/GE Mycobacterium leprae/GE Organização Mundial da Saúde Limits: Humano Location: BR191.1; 00252/s

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Id: 17277 Author: Mohammad, Hatta Title: Epidemiology of leprosy: molecular, biological, and immunological approach ..- Source: s.l; s.n; 2003. 10 p. tab. Abstract: Leprosy is an infectious disease for which humans are considered the only source of infection. The major hindrance in leprosy control and thus in reaching the elimination goal is that numerous leprosy cases remain undetected for a long time. Many of these patients are a continuous source of infection and, and hence perpetuate transmission. The goal of the World Health Organization (WHO) is to eliminate leprosy as a public problem by the year 2000; that is, to reach as a global prevalence of <1 per 10,000 people. The epidemiological data generated routinely by health services are greatly influenced by their policies and activities. The data do not, however necessarily reflect the true situation in the field. Information on the magnitude of the leprosy problem in any one area is important for the health services with regard to their planning, monitoring and evaluation of leprosy control activities. Our studies have suggested that the high prevalence of antibodies in children may be indicative of the active transmission of M. leprae in their surroundings. The prevalence of these antibodies may also be important for leprosy control programs in order to detect new patients as early as possible and in an effective and sustainable manner. Based on PCR data, it seems that the environment also plays an important role in the transmission of leprosy in endemic areas. The results of our study show that contact with a leprosy patient is the major determinant in the incidence of leprosy and that this concept shows similarities with the "stone-in-the-pond" principle of tuberculosis transmission in concentric circle around patients. (AU). Descriptors: Anticorpos Análise por Conglomerados DNA Bacteriano Predisposição Genética para Doença/*GE Geografia Incidência Hanseníase/BL/*EP/TM Mycobacterium leprae/GE/*PY Prevalência Estudos Soroepidemiológicos Limits: Humano Location: BR191.1; 09176/s

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