Database : HANSEN Search on : HANSENIASE/COMPL [Subject descriptor] References found : 1163 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19937 Author: Saunderson, Paul R; Haile-Mariam, Negussie. Title: Monitoring steroid use in a field program; possible process indicators. Source: Int. J. Lepr;65(2):217-223, Jun. 1997. tab. Abstract: Two new indicators are proposed in order to make the task of monitoring certain prevention of disability (POD) activities more straightforward. The indicators are very similar to the case detection rates and the cohort analyses already used in both leprosy and tuberculosis (TB) control; this makes them very simple to put into practice. Despite their simplicity, it is argued that these indicators can give important information about the implementation of POD activities in a routine field program and could, therefore, help in improving the quality of those services to patients. The indicators are the steroid start rate (SSR) and the steroid completion rate (SCR). A number of possible confounding factors have been looked at and they are not negligible. However, the case detection rates for new cases of leprosy and treatment completion rates for multidrug therapy (MDT) are subject to similar biases, which are well recognized and which have not detracted from the usefulness of these indicators in evaluating leprosy control activities. The POD indicators, if used with an awareness of the possible biases involved, can help to improve the quality of certain POD activities. (AU)^ien. Descriptors: Hanseníase/compl Hanseníase/quimioter Hanseníase/prev Quimioterapia Combinada Limits: Humanos Masculino Feminino Location: BR191.1

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Id: 19935 Author: Broek, Jacques van den; Chum, Hamza J; Swai, Ronald; O´Brien, Richard J. Title: Association between leprosy and HIV infection Tanzania. Source: Int. J. Lepr;65(2):203-210, Jun. 1997. tab, graf. Abstract: SETTING: An epidemiological study of the interaction of leprosy and HIV infection in Tanzania. OBJECTIVE: To establish the prevalence of HIV infection among leprosy patients, and to measure the association of HIV and leprosy by comparing the HIV prevalence in leprosy patients and blood donors. DESIGN: Testing for HIV infection in consecutively diagnosed leprosy patients (new and relapsed after MDT) in all regions in Tanzania successively for a period of 3 to 6 months during 1991, 1992 and 1993. RESULTS: Out of the total estimated eligible leprosy patients, 697 patients (69%) entered the final analysis. The HIV prevalence among these leprosy patients was 12% (83/697) as compared to 6% (8960/ 158,971) in blood donors examined in Tanzania during the same period. There were no significant differences in HIV seroprevalence by age, sex, residence or type of disease. However, the adjusted odds ratio (OR) of the presence of a BCG scar was 1.9 [95% confidence interval (CI) 1.1-3.3] among HIV-positive leprosy cases compared to HIV-negative leprosy cases. Comparing leprosy cases with blood donors as controls, the logistic regression model, controlling for sex, age group and residence, showed the OR for HIV seropositivity among leprosy patients to be 2.5 (95% CI 2.0-3.2). This association existed in all strata, but was strongest in the 15-34-year age group. No difference of HIV status between multibacillary and paucibacillary leprosy could be shown to exist. The point estimate of the population attributable risk of HIV infection for leprosy was 7%. CONCLUSION: HIV infection is associated with leprosy and might reverse the epidemiological trend of the slow decline in case notification in Tanzania if HIV infection is increasing greatly. Previous BCG vaccination loses its protection against leprosy in the presence of HIV infection. A repeated study is recommended in order to validate these findings, whereby recording of the disability grading of the cases is necessary to adjust for delay in diagnosis. (AU)^ien. Descriptors: Hanseníase/compl Hanseníase/epidemiol Anticorpos Anti-HIV/anal Infecções por HIV/compl Infecções por HIV/epidemiol Limits: Humanos Masculino Feminino Adolescente Adulto Location: BR191.1

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Id: 19918 Author: Jayalakshmi, Pailoor; Tong, M; Sing, Santokh; Ganesapillai, T. Title: Leprosy in Children. Source: Int. J. Lepr;65(1):95-97, Mar., 1997. tab. Descriptors: Hanseníase/compl Hanseníase/diag Hanseníase/prev Hanseníase/fisiopatol - Malásia/etnol  Malásia/epidemiol Limits: Humanos Masculino Feminino Criança Location: BR191.1

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Id: 19871 Author: Premkumar, Ramaswamy; Daniel, Ebenezer; Suneetha, Sujai; Yovan, Paramanandam. Title: Quantitative assessment of facial sensation in leprosy. Source: Int. J. Lepr;66(3):348-355, Sept. 1998. ilus, tab. Abstract: The trigeminal and great auricular nerves which supply sensation to the face are affected in leprosy. No objective sensory testing methods have been devised for testing sensation in the face. Testing for corneal sensation to ascertain trigeminal nerve or visualization and palpation of the great auricular nerve alone may not be enough to establish the involvement of these nerves. In a sample of leprosy patients, face sensation threshold measurements were done using a set of three Semmes-Weinstein (SW) monofilaments that gave a force of 0.05-0.07, 0.2 and 2 g. Sensation was tested by three examiners and intra- and inter-observer testing was used as a means to validate the findings. Within the limitations of this study, the results indicate that use of SW monofilaments is a fairly reliable and repeatable method for sensory testing in the face. During follow up, a single filament with a force of 0.5-0.7 g (2.83 marking number in SW filament or any other filament with a corresponding gram force) could be used to assess sensation. A simple procedure of quantifying sensation in these nerves is suggested. A method to incorporate trigeminal or great auricular nerve sensory testing into the existing sensory assessment charts is also discussed. (AU)^ien. Descriptors: Hanseníase/compl Hanseníase/fisiopatol Nervo Trigêmeo/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3a05.pdf / en Location: BR191.1

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Id: 19851 Author: Lockwood, Diana; Scollard, David M. Title: Report of workshop on nerve damage and reactions. Source: Int. J. Lepr;66(4):598-599, Dec. 1998. . Conference: Present in: International Leprosy Congress, 15, Beijing, 07-12 Sept. 1998. Descriptors: Hanseníase/compl Hanseníase/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4repcur03.pdf / en Location: BR191.1

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Id: 19836 Author: Richardus, J. H; Virmond, M. Title: Report of workshop on prevention of disability. Source: Int. J. Lepr;66(4):576-576, Dec. 1998. . Conference: Present in: International Leprosy Congress, 15, Beijing, 07-12 Sept. 1998. Descriptors: Hanseníase/compl Hanseníase/terap Pessoas com Deficiência/reabil Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4repcur01.pdf / en Location: BR191.1

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Id: 19766 Author: Job, Charles K; Path, FRC. Title: Nerve damage in leprosy. Source: Int J Lepr;57(2):532-539, June 1989. . Descriptors: Hanseníase Dimorfa/compl Hanseníase Dimorfa/patol Hanseníase Virchowiana/compl Hanseníase Virchowiana/patol Hanseníase Tuberculóide/compl Hanseníase Tuberculóide/patol Hanseníase/compl Hanseníase/patol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2soalec01.pdf / en Location: Br191.1

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Id: 19758 Author: Max, Emmanuel; Shepard, Donald S. Title: Productivity loss due to deformity from leprosy in India. Source: Int J Lepr;57(2):476-482, June 1989. ^btab. Descriptors: Hanseníase/compl Hanseníase/reabil Limits: Humanos Masculino Feminino Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2a05.pdf / en Location: Br191.1

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Id: 19747 Author: Thomas, Jayakar; Wilson, NC; Parimalam, S; Augustine, SM. Title: Multiple neurofibromatosis with histoid leprosy. Source: Int J Lep;57(3):695-695, sept. 1989. ^bilus. Descriptors: Neurofibromatoses/compl Neurofibromatoses/diag Neurofibromatoses/fisiopatol Hanseníase/compl Hanseníase/diag Hanseníase/fisiopatol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n3/v57n3cor04.pdf / en Location: Br191.1

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Id: 19740 Author: Rao, PSS Sundar; Jesudasan, Kumar; Mani, Kandaswamy; Christian, Melville. Title: Impact of MDT on incidence rates of leprosy among household contacts part 1. Baseline data. Source: Int J Lep;57(3):647-651, sept. 1989. ^btab, ^bgraf. Abstract: This preliminary study from Gudiyatham Taluk, the leprosy control area of the Schieffelin Leprosy Research & Training Centre, investigated the incidence rates of leprosy among household contacts during the period 1970-1985. The incidence rates of leprosy among the household contacts prior to and during the initiation of multi-drug therapy are presented here. The overall incidence rate among the household contacts was 4 per 1000 person-years at risk. Contacts of multibacillary and paucibacillary cases had a relative risk of 3-6 times and 2-4 times the risk of leprosy in the general population, respectively. The incidence rates among children were higher than adults; the peak age-specific incidence rate was between 5-9 years, and nearly one third of the primary cases were children. These findings are presented and the methodological issues^ien. Descriptors: Hanseníase/compl Hanseníase/diag Hanseníase/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n3/v57n3a08.pdf / en Location: Br191.1

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Id: 19719 Author: Niang, Mbayane Ndiaye; Balde, Aissatou Toure; Perraut, Ronald; Mane, Ibrahima; Cartel, Jean Louis. Title: Apoptosis in leprosy patients. Source: Int. J. Lepr;67(4):473-474, Dec., 1999. tab. Descriptors: Apoptose/fisiol Hanseníase/compl Hanseníase/diag Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n4/v67n4cor02.pdf / en Location: BR191.1

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Id: 19714 Author: Yogi, Yasuko; Banba, Tomoko; Kobayashi, Masanori; Katoh, Hideki; Jahan, Nilufar; Endoh, Masumi; Nomaguchi, Hiroko. Title: Leprosy in hypertensive nude rats (SHR/NCrj-rnu). Source: Int. J. Lepr;67(4):435-445, Dec., 1999. ilus, tab, graf. Abstract: Since more than a decade ago, we have attempted to develop spontaneously hypertensive rats carrying the nude gene that permits high multiplication of Mycobacterium leprae. A congenic strain carrying nude (rnu) and hypertensive genes was produced using SHR/NCrj females and F344/NJcl-rnu males. Cross-intercross was carried out 12 times to establish the hypertensive nude rat congenic strain. As a result of the genetic monitoring test with NE12F2 generation rats, the genetic profile of the SHR/NCrj-rnu rats was the same as that of the SHR/NCrj rats except for the rnu gene. We have successfully developed a hypertensive congenic nude rat strain (SHR.F344Hfh11; SHR/NCrj-rnu). An increase in the blood pressure in nude rats was found to begin at a slightly delayed age when compared with their hairy litter mates. Both female and male rats showed the highest blood pressure at approximately 20 weeks of age--166 +/- 1.4 and 197 +/- 11 mm Hg in nude rats and 175 +/- 11 and 193 +/- 3.2 mm Hg in their hairy litter mates in female and male rats, respectively. In the present study, comparisons were made on the susceptibility to M. leprae in hypertensive SHR/NCrj-rnu and normotensive F344/NJcl-rnu rats. We have reconfirmed that hypertensive SHR/NCrj-rnu rats of the NE12F3 generation were highly susceptible to M. leprae. In the SHR/NCrj-rnu rats of both sexes excellent massive swelling due to multiplication of M. leprae was observed and, also, nodular lesions were produced in uninoculated fore feet and lips while those sites in the F344/NJcl-rnu rats showed only a slight swelling of the inoculated feet with mild nodular lesions. Although mild lymphocyte proliferation was seen only in the M. leprae-inoculated site with numerous bacilli and partial necrosis in the SHR/NCrj-rnu rats, at noninoculated sites, multiplication of M. leprae was only observed in the cells of the mononuclear phagocyte system. However, in F344/NJcl-rnu rats, lymphocyte proliferation with a few neutrophils was seen at the site of inoculated hind foot pads and everywhere at the site of multiplication of M. leprae. There was a wide difference in the susceptibility to M. leprae between the SHR/NCrj-rnu and the F344/NJcl-rnu rats. (AU)^ien. Descriptors: Hanseníase/compl Hanseníase/diag - Ratos/microbiol Limits: Ratos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n4/v67n4a10.pdf / en Location: BR191.1

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Id: 19707 Author: Daniel, Ebenezer; Premkumar, Ramaswamy; Koshy, Sheena; Yowan, Paramanandam; Kurian, Nisha; Ffytche, Timothy J. Title: Hypopigmented face patches; their distribution and relevance to ocular complications in leprosy. Source: Int. J. Lepr;67(4):388-391, Dec., 1999. tab. Abstract: Eighty-two leprosy patients with hypopigmented patches over the face (cases) and an equal number of age-, sex-, and classification-matched leprosy patients without any hypopigmented patches over the face (controls) were examined for the distribution of hypopigmented facial patches, areas of anesthesia over the face, and eye complications. The hypopigmented patches did not follow any pattern and overlapped in the areas of sensation supplied by the three branches of the trigeminal nerve. Anesthesia over the face, evaluated by a Semmes-Weinstein monofilament which exerted a force of 0.05 grams, was present in 19.5% of the cases and 15.9% of the controls. Patients with hypopigmented facial patches were found to have more corneal hypoesthesia than patients who did not have hypopigmented facial patches. The risk of having impaired corneal sensation was three to four times higher in patients with hypopigmented facial patches. This feature can be used to identify decreased corneal sensation among leprosy patients under field conditions where direct estimation of corneal sensation is not advocated. (AU)^ien. Descriptors: Hanseníase/compl Hanseníase/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n4/v67n4a03.pdf / en Location: BR191.1

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Id: 19698 Author: Daniel, Ebenezer; Alexander, Rebecca; Chacko, Shirley. Title: Correspondence: Ocular Leprosy: Do Steroids Complicate Matters?. Source: Int. J. Lepr;63(1):115-117, 1995. ^bilus. Descriptors: Hanseníase/compl Hanseníase/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1995/pdf/v63n1/v63n1cor11.pdf / en Location: BR191.1

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Id: 19680 Author: Misra, Namita; Ramesh, Venkatesh; Misra, Radhey S; Narayan, N. P. S; Colston, Michael Joseph; Nath, Indira. Title: Clinical Utility of LSR/A 15 Gene for Micobacterium leprae Detection in Leprosy Tissues Using the Polymerase Chain Reaction. Source: Int. J. Lepr;63(1):35-41, 1995. ^bilus, ^btab. Abstract: Resumo: Skin biopsy and slit-skin smears from 46 leprosy patients and 4 nonleprosy patients were tested for the presence of Mycobacterium leprae by the polymerase chain reaction (PCR) using primers based on the sequence of the LSR/15 kD gene. The PCR was found to be specific and sensitive, with a detection level of 10 and 100 bacilli. PCR using skin biopsies gave a higher detection rate than did slit-skin smears, probably due to the higher density of bacilli in a 4-mm punch biopsy. Dot blot hybridization with radioactive probes was 10-fold more sensitive than the ethidium bromide staining. Eight patients who did not show acid-fast bacilli in tissues by the conventional methods were shown to have PCR-amplified M. leprae DNA. False-negative results were obtained in 3 cases even though formal evidence for tissue inhibitors was absent. Descriptors: Mycobacterium leprae/genet Hanseníase/compl Hanseníase/diag Hanseníase/fisiopatol Reação em Cadeia da Polimerase/métodos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1995/pdf/v63n1/v63n1a06.pdf / en

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Id: 19664 Author: Daniel, Ebenezer; Thompson, Kirsteen. Title: Corneal sensation in leprosy. Source: Int. J. Lepr;67(3):298-301, Sept., 1999. . Descriptors: Hanseníase/compl Hanseníase/fisiopatol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n3/v67n3edt.pdf / en Location: BR191.1

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Id: 19650 Author: Krishna, Kshiteendra Kewal. Title: Histoid leprosy; report of three cases. Source: Int. J. Lepr;67(2):174-176, Jun., 1999. ilus. Descriptors: Hanseníase/compl Hanseníase/fisiopatol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n2/v67n2cor07.pdf / en Location: BR191.1

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Id: 19648 Author: Pavithran, K; Bindu, V. Title: Dapsone syndrome: hepatitis-B infection a risk factor for its development?. Source: Int. J. Lepr;67(2):171-172, Jun., 1999. tab. Descriptors: Dapsona/anal Dapsona/imunol Hepatite B/compl Hepatite B/fisiopatol Hanseníase/compl Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n2/v67n2cor05.pdf / en Location: BR191.1

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Id: 19575 Author: Barbosa, Jaqueline Caracas; Ramos Junior, Alberto Novaes; Mota, Maria Vaudelice; Hinders, Duane; Mello, Márcia Gomide da Silva. Title: Olhares sobre as ações do Programa de Controle da Hanseníase: a perspectiva dos profissionais de saúde no Brasil / Different views over Hansen´s Disease Control Program actions: the health care professionals' perspective in Brazil Source: In: Universidade Federal do Rio de Janeiro.Instituto de Estudos em Saúde Coletiva.Investigações em sistema de saúde e controle da hanseníase^ipt. Rio de Janeiro, s.n, abr.-jun., 2008. p.273-292. Abstract: Baseado na percepção dos profissionais de saúde envolvidos nas ações de gerência e assistência do Programa de Controle da Hanseníase desenvolveu-se estudo qualitativo para construção do contexto real dessas ações. Foram incluídos profissionais de estados da região Norte e Nordeste que participaram de Oficinas de Pesquisas Operacionais realizadas em 2006. No total, 16 profissionais participaram do estudo, tendo como atuação principal: gestão em Secretarias Municipais e Estaduais de Saúde, centros de referência (CR) e equipes de Saúde da Família. Os aspectos abordados sobre CR foram: importância; atendimento de maior e menor complexidade; atendimento a intercorrências; realização de pesquisas; diversidade de CR e necessidade de melhoria da estrutura. Quanto às unidades básicas de saúde: atendimento de menor complexidade; deficiência na assistência; variação nos modelos de assitência; necessidade de sensibilização de profissionais e gestores; descentralização da assitência e formação de profissionais. Quanto às unidades secundárias: ligação entre atenção básica e referência estadual; desconhecimento do funcionamento; existência ou inexistência de atenção secundária. Percebe-se a deficiência e não padronização da assistência na rede básica, com parte de suas ações realizada pelos centros de referência. A rede de assistência secundária é pouco percebida. Revelou-se a fragilidade da rede assistencial em hanseníase, apesar dos avanços nos últimos dez anos. (AU)^ipt. Descriptors: Hanseníase/compl Hanseníase/diag Hanseníase/prev Location: BR191.1; 01224/D.A

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Id: 19550 Author: Antunes, Sergio Luis Gomes; Motta, Ester; Almeida, Sonia Maria Rocha de; Gallo, Maria Eugenia; Nery, Jose Augusto da Costa; Lenzi, Henrique Leonel. Title: Distinct patterns of microvasculature in the cutaneous lesions of leprosy. Source: Int. J. Lepr;68(2):143-151, Jun., 2000. ilus. Abstract: This work is an investigation on the microvasculature of the cutaneous infiltrates of leprosy with the immunohistochemical staining of endothelial cells in cutaneous biopsies. Anti-Factor VIII-related antigen antibody (anti-FVIII-ra) and Ulex Europaeus-1 lectin (UEA-1) binding were utilized as endothelial cell markers. Thirty-nine patients grouped according to the Ridley-Jopling classification (14 borderline tuberculoid, 18 borderline lepromatous, 6 lepromatous, and 1 indeterminate leprosy) were selected for this study. Two microvascular architectural patterns could be clearly distinguished: lepromatous lesions presented a dense and tortuous mesh of microvessels among the Mycobacterium leprae-glutted macrophages; whereas the microvessels in the tuberculoid lesions were restricted to the periphery of the granulomas and were not seen among the central epithelioid cells. We were able to distinguish three basic morphological kinds of infiltrate distribution related to the microvessels: micronodules, cords and macronodules. Intensifications of the FVIII-ra immunoreactivity and UEA-1 binding capacity were observed in the endothelial cells of microvessels involved by the inflammatory infiltrate. A distinct cytokine expression profile at the leprosy poles and the role of mast cells in angiogenesis were speculated as factors contributing to these distinct patterns. Growth of the lesion and systemic dissemination of M. leprae in the bipolar spectrum of leprosy may hypothetically be influenced by the vascular-infiltrate relationship. The detection of angiogenesis in the cutaneous lesions of leprosy may bring about alternate and/or additional strategies for leprosy treatment. (AU)^ien. Descriptors: Hanseníase/compl Hanseníase/diag Hanseníase/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n2/v68n2a04.pdf / en Location: BR191.1

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