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Id: 19909 Author: Wilder-Smith, Annelies; Wilder-Smith, Einar. Title: Effect of steroid therapy on parameters of peripheral autonomic dysfunction in leprosy patients with acute neuritis. Source: Int. J. Lepr;65(1):20-27, Mar., 1997. tab, graf. Abstract: Recent electrophysiological studies on peripheral autonomic dysfunction in leprosy patients show a high prevalence of autonomic dysfunction as measured by abnormal vasomotor reflexes (VMR) and absent sympathetic skin response (SSR). Nothing is known about the reversibility of these autonomic parameters with treatment. Since there is evidence that small fiber function may be the most reversible component in neuropathies, we measured the effect of steroid treatment on autonomic parameters together with motor and sensory functions in leprosy patients with acute neuritis. Control subjects were investigated for repeatability testing of autonomic function. Due to a relatively high variability on repeat VMR testing in the controls, we defined a change in VMR testing as a change of > 30%. With this definition, the VMR of 14.8% of the patients improved, 75% remained unchanged, and 10.2% worsened. Absent SSR became positive in 16.6% and remained unchanged in 83.4%. Improvement in sensory motor functions was seen in 21.2% and 1.3% of the patients, respectively. (AU)^ien. Descriptors: Hanseníase/quimioter Neurite/quimioter Neurite/microbiol Limits: Humanos Location: BR191.1

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Id: 19461 Author: Anon. Title: Nerve Damage. Source: Int. J. Lepr;69(2,suppl):S224-S226, Jun., 2001. . Conference: Present in: Proceedings Asian Leprosy Congress, Agra, 9-13 Nov., 2000. Descriptors: Hanseníase/fisiopatol Neurite/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2001/pdf/v69n2sup/v69n2supabs20.pdf / en Location: BR191.1

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Id: 19437 Author: Job, C. K. Title: Pathology and pathogenesis of leprous neuritis: a preventable and treatable complication. Source: Int. J. Lepr;69(2,suppl):S19-S29, Jun., 2001. ilus. Conference: Present in: Proceedings Asian Leprosy Congress, Agra, 9-13 Nov., 2000. Abstract: In conclusion, it may be said that many advances have been made in the diagnosis, treatment and prevention of nerve damage. It is now a well accepted fact that the affinity of M. leprae for Schwann cells and the property of M. leprae to grow in cooler sites of the body have made certain segments of nerve trunks vulnerable. Trauma that supervenes the inflammation and swelling severely aggravates the nerve damage. The reactive phase in all forms of leprosy, the etiology of which is not clearly understood, produces intraneural caseous necrosis in tuberculoid disease and microabscesses in lepromatous disease, causing much irreversible damage to nerves. The steroid treatment that is administered during the reactive phase has helped greatly to stop further damage, although the damage already done to nerves is not always reversible. Preventive measures like detecting the disease before nerve trunks are infected and offering prompt and adequate antileprosy therapy as early as possible have helped to reduce the prevalence of deformities. It is hoped that administering steroids along with antileprosy therapy to prevent active inflammation and or fibrosis of the nerve will reduce the prevalence of nerve damage significantly. Measures which provide rest for the infected nerve to prevent trauma should be explored.(AU)^ien. Descriptors: Hanseníase/patol Hanseníase/fisiopatol Neurite/compl Neurite/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2001/pdf/v69n2sup/v69n2supsal04.pdf / en Location: BR191.1

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Id: 18750 Author: Jordy, Ceme Ferreira; Belda, Walter. Title: Considerações sôbre a condução nervosa periférica na hanseníase. Source: Rev. bras. Leprol;37(1/4):61-69, 1970. ^bilus, ^btab. Abstract: Em 16 pacientes de hanseníase, com sinais clínicos da neuropatia periférica, os autores estudaram o tempo de condução do impulso nervoso em 38 territórios, 22 correspondentes ao nervo ulnar e 16 ao nervo poplíteo lateral. Os valores encontrados se situam entre os valores classicamente admitidos como normais, ao contrário do que acontece em outras formas de neuropatias crônicas. A origem e o mecanismo destes achados são discutidos, supondo os autores que sua explicação se deve à ativação das fibras periféricas por um processo compressivo-isquêmico, determinado pela instalação da lesão leprótica do nervo. Recomendam a medida do tempo de condução do impulso nervoso como auxiliar do diagnóstico diferencial da neurite leprótica com outras neuropatias periféricas. (AU)^ipt. Descriptors: Neurite/diag Neurite/fisiopatol Hanseníase/compl Hanseníase/diag Hanseníase/fisiopatol Doenças do Sistema Nervoso Periférico/compl Doenças do Sistema Nervoso Periférico/fisiopatol Limits: Humanos Masculino Feminino Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1970/PDF/v37n1-4/v37n1-4a05.pdf / pt Location: BR191.1

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Id: 18729 Author: Reginato, L. E; Belda, W. Title: Correção das deformidades amiotróficas do dorso da mão pelo emprêgo de inclusões de silicone líquido e sólido. Source: Rev. bras. Leprol;35(1/4):31-40, jan.-dez. 1967. ^bilus. Abstract: Os autores, após analisar a importância das mãos na atividade diária, chamam a atenção para o problema da estética, nos pacientes de lepra, decorrente das amiotrofias do dorso da mão. Relatam a experiência do Serviço de Reabilitação do Departamento de Profilaxia da Lepra do Estado de São Paulo, na correção de tais deformidades com o emprêgo de enxertos dérmicos, enxertos dermo-gordurosos, fáscia lata e silicões.É exposta a técnica usada para estes últimos e feita a análise dos resultados obtidos em 7 casos. Concluem os AA. pela superioridade do emprêgo dos silicões sobre as outras técnicas, dados os bons resultados, ausência de reações colaterais, simplicidade de execução e baixo custo. (AU)^ipt. Descriptors: Neurite do Plexo Braquial/diag Neurite do Plexo Braquial/fisiopatol Neurite do Plexo Braquial/reabil Neurite do Plexo Braquial/cirurg Mão (anatomia)/cirurg Hanseníase/reabil Hanseníase/cirurg Limits: Humanos Masculino Feminino Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1967/PDF/v35n1-4/v35n1-4a04.pdf / pt Location: BR191.1

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Id: 18661 Author: Reginato, Lu¡s Eugênio; Melo, Paulo Homem de. Title: Ensaio de correção das deformidades amiotróficas do dorso da mão por um nôvo método: enxertos dérmicos. Source: Rev. bras. Leprol;30(3):125-130, jul.-set. 1962. ^bilus. Abstract: Os AA. fazem revisão histórica e cr¡tica dos métodos de restauração plástica do contôrno do dorso da mão, modificado pela amiotrofia leprosa dos interósseos. Concluindo que nenhum dos métodos propostos no passado resolveu o problema, relatam o ensaio de nôvo método: enxerto dérmico autógeno livre. Trataram paciente de forma tuberculóide, com alta definitiva há 15 anos, o qual apresentava como principal estigma profundas escavações dos espaços intermetacarpianos. As lojas intermetacarpianas, tunelizadas através de incisões disfarçadas nas pregas interdigitais, foram enchidas com enxertos dérmicos, de forma e espessura adequadas, fixados em posição com pontos transfixantes de nailon. A imobilização foi mantida durante 20 dias com simples talas de madeira. A área doadora, flanco direito do abdome, foi recoberta, após a retirada do transplante, com a própria pele. Decorrido um ano, os resultados cosméticos estabilizaram-se em nível bastante satisfatório. (AU)^ipt. Descriptors: Neurite do Plexo Braquial/compl Neurite do Plexo Braquial/diag Neurite do Plexo Braquial/fisiopatol Mão (anatomia)/anat Mão (anatomia)/cirurg Transplantes/util Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1962/PDF/v30n3/v30n3a05.pdf / pt Location: BR191.1

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Id: 18581 Author: Anon. Title: Resumo de revistas / Summary journals Source: Rev. Lepr. São Paulo;2(2):119-126, 1935. . Descriptors: Hanseníase/patol Hanseníase Tuberculóide/compl Hanseníase Tuberculóide/diag Hanseníase Tuberculóide/fisiopatol Hanseníase Tuberculóide/cirurg Neurite/compl Neurite/diag Neurite/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/leprolsp/1935/PDF/v2n2/v2n2rrevistas.pdf / pt Location: Br191.1

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Id: 18396 Author: Carayon, A Title: Bilan de recherches physiopathologiques sur la nevrite lepreuse: 1-role de la temperature, des microtraumatismes par elongation ou subluxation nerveuse et de la striction canalaire ?- Source: s.l; s.n; 1977. 18p p. ilus. Abstract: (Role of temperature, microtraumatisms by elongation or subluxation and canalar stricture.) Cold has a slight aggravating effect on leprosy which is observed in some countries as Iran, South Russia, North India and the Andean cordillera. The subluxation of the ulnar nerve has facilitating effect in the development of the neuritic damage in a limited number of patients. The elongation is important for the production of the ulnar neuritis. The canalar stricture is a major factor causing nerve damage in leprosy. It explains the segmentary localization of the principal damages of the leprous nerves in the proximal areas situated above the tunnels. Intraneural hypertension appears first and is responsible for the swelling of the nerve which gets entraped inside the tunnel. A circulus viciosus is, then, created which maintains and aggravates the intraneural hypertension. Descriptors: HANSENIASE DIMORFA/compl HANSENIASE DIMORFA/imunol HANSENIASE DIMORFA/microbiol HANSENIASE DIMORFA/patol HANSENIASE DIMORFA/fisiopatol HANSENIASE VIRCHOWIANA/compl HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/microbiol HANSENIASE VIRCHOWIANA/patol HANSENIASE VIRCHOWIANA/fisiopatol HANSENIASE TUBERCULOIDE/compl HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/microbiol HANSENIASE TUBERCULOIDE/patol HANSENIASE TUBERCULOIDE/fisiopatol NEURITE/etiol - SINDROMES DE COMPRESSAO NERVOSA/etiol  NERVOS PERIFERICOS/les  NERVOS PERIFERICOS/patol  NERVOS PERIFERICOS/fisiopatol Limits: HUMANO Location: BR191.1; 00508/s

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Id: 18364 Author: Santhanam, A Title: Silent neuropathy: detection and monitoring using Semmes-Weinstein monofilaments ..- Source: s.l; s.n; 2003. 3p p. . Descriptors: HANSENIASE/compl NEURITE/clas NEURITE/diag NEURITE/etiol - NERVOS PERIFERICOS/les  NERVOS PERIFERICOS/microbiol Limits: HUMANO Location: BR191.1; 01627/s

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Id: 18317 Author: Convit, J; Arvelo, J. J Title: Prevention and treatment of physical disabilities in leprosy ..- Source: s.l; s.n; s.d. 12 p. . Descriptors: HANSENIASE/diag HANSENIASE/prev HANSENIASE/reabil HANSENIASE/terap NEURITE/diag NEURITE/reabil NEURITE/terap - DEFORMIDADES DA MAO/reabil  DEFORMIDADES DO PE/reabil Limits: ESTUDO COMPARATIVO Location: BR191.1; 00658/s

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Id: 18228 Author: Carayon, A Title: Repercussions de la nevrite lepreuse sur la conduction et la douleur nerveuses Nervous conduction and pain in hansenian neuritis- Source: s.l; s.n; 1977. 9 p. ilus, tab. Abstract: A study of the nervous conduction with modern technics has lead to classify the nervous damage according to a new and hsitopathological way which seems more convenient than the Seddon's classification. It gives a better understanding of the hansenian neuritis and reasoned procedures for medical or surgical treatment are discussed (AU). Descriptors: NEURITE/compl NEURITE/etiol CONDUCAO NERVOSA COMPRESSAO NERVOSA/clas - HANSENIASE/compl Limits: HUMANO Location: BR191.1; 00301/s

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Id: 18218 Author: Britton, Warwick J; Lockwood, Diana N. J Title: Leprosy ..- Source: s.l; s.n; 2004. 11 p. ilus, tab, graf. Abstract: Leprosy remains an important health problem wordwide. The disease in caused by a chronic granulomatous infection of the skin and peripheral nerves with Mycobacterium leprae. The clinical range from tuberculoid to lepromatous leprosy is a result of variation in the cellular immune response to the mycobacterium. The resulting impairment of nerve fuinction causes be disabilities associated with leprosy. This review summarises recent advances in understanding of the biology of leprosy, clinical features of the disease, the current diagnostic criteria, and the new approaches to treatment of the infection and the immune-mediated complications. Supervesed multi-drug therapy (MDT) for fixed durations is highly effective for all forms of the disease. The widespread implemantation of MDT has been associated with a fall in the prevalence of the leprosy but as yet no reduction in the case-detection rate globally. Thus, leprosy control activities must be maintained for decades to interrupt transmission of infection (AU). Descriptors: HANSENIASE/compl HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/prev HANSENIASE/terap HANSENIASE/transm MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/patogen QUIMIOTERAPIA COMBINADA - NEURITE/etiol  NEURITE/imunol  NEURITE/microbiol  EDUCACAO EM SAUDE/tend  RELACOES HOSPEDEIRO-PARASITA/imunol Limits: HUMANO Location: BR191.1; 09193/s

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Id: 18214 Author: Gadoth, N; Bechar, M; Kushnir, M; Davidovitz, S; Sandbank, U Title: Somatosensory and autonomic neuropathy as the only manifestation of long standing leprosy ..- Source: s.l; s.n; 1979. 7 p. ilus. Abstract: The clinical and neuropathological findings an a patient with "neuritic" leprosy are described. In this rare form of leprosy, skin changes are only minimal or absent anf the diagnosis can be established only by nerve biopsy (AU). Descriptors: HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/compl HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/patol NEURITE/compl NEURITE/diag NEURITE/etiol NEURITE/patol - CORNEA/metab  CORNEA/microbiol  NERVO SURAL/anat  NERVO SURAL/les  NERVO SURAL/microbiol  NERVO SURAL/patol  NERVO SURAL/cirurg Limits: RELATO DE CASO Location: BR191.1; 09203/s

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Id: 18156 Author: Mitra, S K Title: Nerve damage in leprosy its complications prevention and management ver- Source: s.l; s.n; 1984. 7 p. . Descriptors: HANSENIASE TUBERCULOIDE/compl HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol NEURITE/etiol NEURITE/fisiopatol NEURITE/cirurg NEURITE/terap - NERVO FACIAL  NERVO MEDIANO  NERVO FIBULAR  NERVO RADIAL  NERVO TIBIAL  NERVO TRIGÊMEO  NERVO ULNAR Limits: HUMANO Location: BR191.1; 01621/s

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Id: 18155 Author: Bourrel, P Title: Concept epidemiologique de la prevention des mutilations lepreuses et chirurgie ver- Source: s.l; s.n; 1983. 6 p. . Descriptors: HANSENIASE/clas HANSENIASE/compl HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/reabil HANSENIASE/cirurg - NEURITE/compl  NEURITE/diag  NEURITE/etiol  NEURITE/cirurg Limits: HUMANO Location: BR191.1; 01624/s

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Id: 18142 Author: Martin M Fisher; William Mccann; Arthur Michele Title: Foot ulcers in hansens Disease ..- Source: New York; s.n; 1964. 5 p. ilus. Abstract: In this report we present the results of our observations of 2 patients in the New York City area with ulcers on the plantar surface. Our purpose in describing these cases is to emphasize the need to consiuder hansens diase in the diagnosis of ulcers of the foot. We have been able to heal theserefractory ulcers by the use of sodium sulfoxone (Diasone sodium), the specific for hansens disease. A critical evaluation of the newr technics for confirmation of this diagnosis is presented. The awareness of the existence of hansens disease helps to differentiate it from the more common causes of leg and foot ulcers in peripheral vascular diseases. Thus there is a need to evaluate all lower extremity ulcers with specifc diagnostic tests, such as blood sugar for diabetes cryoglobulins for cryoglobulinemia ulcer biopsy for epithelioma and a complete blood count bone marrow biopsy and coombs test for sickle cell anemia cooleys anemia and hemolytic anemia. A careful history and accurate physical examination can usually differentiate a thromboangiitis obliterans ulcer from that of peripheral arteriosclerosis obliterans. Similarly the ulcer of varicose veins is differentiated from that of diabetic neuritis by physival evaluation and the postphlebilitic ulcer is differenbtiated from that of choronic lymphedema by lymphangiography. The following are 2 typical cases of foot ulcers due to hansens disease found in the New York City area. (AU). Descriptors: HANSENIASE/compl HANSENIASE/terap ULCERA DO PE/compl ULCERA DO PE/diag ULCERA DO PE/etiol ULCERA DO PE/terap - HANSENOSTATICOS/uso terap  NEURITE/diag  NEURITE/terap Limits: HUMANO Location: BR191.1; 01142/s

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Id: 18131 Author: Wilkinson, FF Title: La hialuronidasa intraneural en las neuritis de la enfermedad de hansen Hialuronidasa intraneural in the neuritis of the leprosy- Source: Bueno Aires; s.n; 1959. 6 p. ilus. Descriptors: NEURITE/compl NEURITE/diag NEURITE/fisiopatol HANSENIASE/compl HANSENIASE/fisiopatol Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1; 01957/s

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Id: 18123 Author: Silveira, Linneu M Title: Tratamento cirurgico das neurites leprosas agudas Surgical treatment of the acute leprosy neurites- Source: s.l; s.n; s.d. 02 p. . Descriptors: NEURITE/diag NEURITE/reabil NEURITE/cirurg HANSENIASE/reabil HANSENIASE/cirurg Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1; 01085/s

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Id: 18111 Author: Ganapati, R; Pai, W; Kingsley, S Title: Disability prevention and management in leprosy: a field experience ..- Source: s.l; s.n; 2003. 6p p. . Abstract: Bombay leprosy project has conducted operational research into cost effective ways of using therapeutic management for prevention of disabilities (POD). The goal of achieving this are broadly divided as 1)prevention of impairments and disabilities(POID) and 2)prevention of worsening of disabilities (POWD). About 33-56% of newly registered leprosy patients already have clinically detectable nerve function impairment (NFI), often no longer amenable to MDT. An analysis of 892 leprosy cases treated with WHO-MD stresses the need to focus attention on leprosy patients...AU. Descriptors: HANSENIASE/compl HANSENIASE/epidemiol NEURITE/clas NEURITE/compl NEURITE/prev - EDUCACAO EM SAUDE/util  EDUCACAO DO PACIENTE/métodos  MEDICINA ESTATAL Limits: HUMANO Location: BR191.1; 01189/s

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Id: 18108 Author: Britton, W. J; Lockwood, D. N. J Title: Leprosy ..- Source: s.l; s.n; 2004. 10p p. . Abstract: Leprosy remains an important health problem wordlwide. The disease is caused by a chronic granulomatous infection of the skin and peripheral nerves with Mycobacterium leprae. The clinical range from tuberculoid to lepromatous leprosy is a result of variation in the cellular immune response to the mycobacterium. The resulting impaiment of nerve function causes the disabilities associated with leprosy. This review summarises recent advances in understanding of the biology of leprosy, clinical features of the disease, the current diagnostic criteria, and the new approaches to treatment of the infection and the immune-mediated complications. Supervised multi-drug therapy (MDT) for fixed durations is highly effective for all forms of the disease. The widespread implementation of MDT has been associated with a fall in the prevalence of the leprosy but as yet no reduction in the case-detection rate globally. Thus, leprosy control activities must be maintained for decades to interrupt transmission of infection. Descriptors: HANSENIASE/clas HANSENIASE/compl HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/etiol HANSENIASE/hist HANSENIASE/prev HANSENIASE/cirurg - HANSENOSTATICOS  NEURITE/patol  NEURITE/terap  INFECCOES OCULARES/patol  INFECCOES OCULARES/terap Location: BR191.1; 01016/s

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