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| Id: | 18103
| | Author: | Desforges, J. F; Thayer, W. W; Dawson, J. P
| | Title: | Hemolytic anemia induced by sulfoxone therapy, with investigations into the mechanisms of its production
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| | Source: | Boston; s.n; 1960. 5p p. ilus.
| | Abstract: | A case report is presented of a patient in whom clinical evidence of hemolytic anemia with methemoglobinemia developed upon increasing the dosage of sulfoxone which he was receiving for Hansen's disease. Administration of the drug was withdrawn for six weeks, after which studies were made with the use of radioactive iron to demosntrate the hemolytic effect of sulfoxone. By means of tagging cells of a single age group, it was shown that the suceptibility to hemolysis was related to cell age, and it was only after the red cells had been in the circulation for approximately fifty days that they were subject to the hemolytic effects of this drug. No significant biochemical defect could be demonstrated in the erythrocytes of this patient. However, the decline in activity of glucose-6-phosphate dehydrogenase and glutathione reductase in the aging red cell and the reported sensitivity to this drug of patients with red cell deficiency of glucose-6-phosphate dehydrogenase suggest that the hemolytic mechanism is related to this enzyme system. The case demonstrates that drug-induced hemolytic anemia of this type may occur without demonstrable enzymatic defect of the erythrocytes. The observation that patients appear to compensate for the hemolytic anemia and methemoglobinemia if maintained on this drug may be explained by the fact that the older cells containing less adequate enzyme systems are removed from the circulation and an equilibrium is maintained by increased production of red cells with a shorter age span.
| | Descriptors: | HANSENOSTATICOS/admin
HANSENOSTATICOS/ef adv
HANSENOSTATICOS/sangue
HANSENOSTATICOS/uso terap
ANEMIA HEMOLITICA/ind quim
ANEMIA HEMOLITICA/diag
ANEMIA HEMOLITICA/etiol
- HANSENIASE/clas
HANSENIASE/compl
HANSENIASE/diag
HANSENIASE/terap
| | Limits: | RELATO DE CASO
| | Location: | BR191.1; 00720/s |
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