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| Id: | 15191
| | Author: | Read, Bernard E. | | Title: | The toxicity of sodium hydnocarpate.
| | Source: | Int. J. Lepr;1(3):293-307, July 1933. tab.
| | Abstract: | 1-High concentrations and large doses of commercial preparations of sodium hydnocarpate administered to rabbits and dogs intravenously and subcutaneouly produce albuminuria, hematuria, and emaciation. 2- There is loss os weight when either the sodium salts or the ethyl esters are given subcutaneously in amounts more than 50 milligrams per kilogram of body weight. A certain degree of tolerance can be developed with suitable dosage. 3-Pronounced albuminuria is observed in rabbits after subcutaneous injection of 12.5 milligrams of the salts. With larger or smaller doses it is not so pronunced. In dogs, a 4 per cent solution of esters in olive oil is apparently most rapidly absorbed and gives the earliest traces of albumen. $- The less readily absorbed and less reactive concentrations also produce albuminuria, but only after an interval of several days...(AU).
| | Descriptors: | CHAULMOOGRA/admin
CHAULMOOGRA/tox
CHAULMOOGRA/farmacocin
HANSENOSTATICOS/admin
HANSENOSTATICOS/ef adv
HANSENOSTATICOS/farmacocin
HANSENOSTATICOS/tox
| | Limits: | ANIMAL
| | Location: | BR191.1 |
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