HANSEN - Results of the search <page 1>

Database :	HANSEN
Search on :	HANSENOSTATICOS/FARMACOCIN [Subject descriptor]
References found :	9 [refine]
Displaying:	1 .. 9 in format [Detailed]

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Id:	18385
Author:	Consigny, Sophie; Bentoucha, Abdelhalim; Bonnafous, Pascale; Grosset, Jacques; Ji, Baohong
Title:	Bactericidal activities of HMR 3647, moxifloxacin, and rifapentine against Mycobacterium leprae in mice ..-
Source:	s.l; s.n; 2000. 3 p. tab.
Abstract:	Bactericidal activities of HMR 3647 (HMR), moxifloxacin (MXFX), and rifapentine (RPT) against Mycobacterium leprae, measured by the proportional bactericidal technique in the mouse footpad system, were compared with those of the established antileprosy drugs clarithromycin (CLARI), ofloxacin (OFLO), and rifampin (RMP. Administered in five daily doses of 100 mg/kg of body weight, HMR appeared slightly more bactericidal than CLARI. In a single dose, MXFX at 150 mg/kg was more active than the same dose of OFLO and displayed exactly the same level of activity as RMP at 10 mg/kg; the combination MXFX-minocycline (MINO) (MM) was more bactericidal than the combination OFLO-MINO (OM); RPT at 10mg/kg was more bactericidal than the same dose of RMP and even more active than the combination RMP-OFLO-MINO (ROM); the combination RPT-MXFX-MINO (PMM) killed 99.9% of viable M. leprae and was slighthy more bactericidal than RPT alone, indicating that the combination PMM showed an additive effect against M. leprae (AU).
Descriptors:	HANSENIASE/quimioter HANSENOSTATICOS/admin HANSENOSTATICOS/farmacol HANSENOSTATICOS/farmacocin HANSENOSTATICOS/uso terap MYCOBACTERIUM LEPRAE TESTES DE SENSIBILIDADE MICROBIANA/métodos DROGAS EM INVESTIGACAO/admin DROGAS EM INVESTIGACAO/anal DROGAS EM INVESTIGACAO/uso terap - BACTERICIDAS QUIMIOTERAPIA COMBINADA MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM LEPRAE/fisiol DAPSONA/uso terap RIFAMPINA/uso terap CLOFAZIMINA/uso terap OFLOXACINO/uso terap MINOCICLINA/uso terap CLARITROMICINA/uso terap
Limits:	ESTUDO COMPARATIVO
Location:	BR191.1; 09311/s

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Id:	17456
Author:	Shepard, C. C
Title:	Experimental chemotherapy in leprosy ?-
Source:	s.l; s.n; 1976. 9p p. .
Abstract:	The Memorandum reviews the considerable progress that has been made in research on the chemotherapy of leprosy during the last 10-15 years, as a result of which it is now possible to study the same topics in leprosy as are studied in other bacterial diseases. Thus drugs have been screened in mice for their activity against Mycobacteerium leprae. Those that have been found to have the greatest activity against M. leprae at acceptable dosages-dapsone, rifampicin, and clofazimine-have been characterized in terms of the minimal effective dosage and rate of bacterial kill. Similarly, their pharmacokinetics in man and in certain animals have been defined. The theoretical basis for drug trials in leprosy patients is discussed in terms of the number of viable and the number of dead M.leprae that remain of various stages of therapy.
Descriptors:	HANSENIASE/clas HANSENIASE/quimioter HANSENOSTATICOS/admin HANSENOSTATICOS/clas HANSENOSTATICOS/metab HANSENOSTATICOS/farmacol HANSENOSTATICOS/farmacocin QUIMIOTERAPIA COMBINADA
Limits:	RELATO DE CASO
Location:	BR191.1; 00945/s

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Id:	17440
Author:	Browne, S. G
Title:	The chemotherapy of leprosy ?-
Source:	s.l; s.n; s.d. 5p p. .
Descriptors:	HANSENIASE/dietoter HANSENIASE/quimioter HANSENOSTATICOS/farmacocin HANSENOSTATICOS/uso terap SULFONAS/ef adv SULFONAS/farmacol SULFONAS/farmacocin SULFONAS/tox SULFONAS/uso terap
Limits:	RELATO DE CASO
Location:	BR191.1; 01105/d.a

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Id:	15665
Author:	Muir, E; Chatterji, S. P.
Title:	The uses of Mercurochrome soluble-220 in leprosy.
Source:	Lepr Ind;4(3):4-12, july. 1932. ilus.
Descriptors:	HANSENIASE/quimioter HANSENIASE/hist HANSENOSTATICOS/admin HANSENOSTATICOS/farmacocin HANSENOSTATICOS/uso terap - MERCURIO/admin MERCURIO/uso terap
Limits:	HUMANO
Location:	BR191.1

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Id:	15292
Author:	Maxwell, James L; Grant, Alan M. B; Rodriguez, José; Lara, C. B; Cochrane, Robert G.
Title:	Correspondence (Staining by iodized drugs).
Source:	Int. J. Lepr;2(2):223-226, Apr.-July 1934. tab.
Descriptors:	HANSENIASE/quimioter HANSENIASE/hist HANSENOSTATICOS/admin HANSENOSTATICOS/hist HANSENOSTATICOS/farmacocin
Limits:	HUMANO
Location:	BR191.1

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Id:	15218
Author:	Muir, Ernest.
Title:	Treatment of leprosy: a review.
Source:	Int. J. Lepr;1(4):407-458, Oct. 1933. ilus.
Descriptors:	HANSENOSTATICOS/hist HANSENOSTATICOS/admin HANSENOSTATICOS/ef adv HANSENOSTATICOS/isol HANSENOSTATICOS/farmacol HANSENOSTATICOS/farmacocin HANSENOSTATICOS/tox HANSENOSTATICOS/uso terap - HANSENIASE/quimioter HANSENIASE/terap
Limits:	HUMANO
Location:	BR191.1

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Id:	15209
Author:	Muir, E.
Title:	The iodide-antimony treatment of leprosy.
Source:	In: Muir, E.The iodide-antimony treatment of leprosy. São Paulo, s.n, jun. 1941. p.8.
Abstract:	It has long been known that the iodides, especially the potassium salt, have a special action in leprosy. Most workers have regarded the apparent exacerbation produced by this drug as dangerous and a thing to be avoided. A few workers have considered it useful, especially in diagnosis because they found that nasal catarrh produced facilitated the search for lepra bacilli in the nasal secretion. (AU).
Descriptors:	HANSENOSTATICOS/ef adv HANSENOSTATICOS/farmacocin HANSENOSTATICOS/uso terap
Location:	BR191.1; 864/d.a

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Id:	15208
Author:	Muir, E
Title:	The iodide-antimony treatment of leprosy ..-
Source:	São Paulo; s.n; jun. 1941. 8 p. .
Abstract:	It has long been known that the iodides, especially the potassium salt, have a special action in leprosy. Most workers have regarded the apparent exacerbation produced by this drug as dangerous and a thing to be avoided. A few workers have considered it useful, especially in diagnosis because they found that nasal catarrh produced facilitated the search for lepra bacilli in the nasal secretion. (AU).
Descriptors:	HANSENOSTATICOS/ef adv HANSENOSTATICOS/farmacocin HANSENOSTATICOS/uso terap
Location:	BR191.1; 0864/d.a

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Id:	15191
Author:	Read, Bernard E.
Title:	The toxicity of sodium hydnocarpate.
Source:	Int. J. Lepr;1(3):293-307, July 1933. tab.
Abstract:	1-High concentrations and large doses of commercial preparations of sodium hydnocarpate administered to rabbits and dogs intravenously and subcutaneouly produce albuminuria, hematuria, and emaciation. 2- There is loss os weight when either the sodium salts or the ethyl esters are given subcutaneously in amounts more than 50 milligrams per kilogram of body weight. A certain degree of tolerance can be developed with suitable dosage. 3-Pronounced albuminuria is observed in rabbits after subcutaneous injection of 12.5 milligrams of the salts. With larger or smaller doses it is not so pronunced. In dogs, a 4 per cent solution of esters in olive oil is apparently most rapidly absorbed and gives the earliest traces of albumen. $- The less readily absorbed and less reactive concentrations also produce albuminuria, but only after an interval of several days...(AU).
Descriptors:	CHAULMOOGRA/admin CHAULMOOGRA/tox CHAULMOOGRA/farmacocin HANSENOSTATICOS/admin HANSENOSTATICOS/ef adv HANSENOSTATICOS/farmacocin HANSENOSTATICOS/tox
Limits:	ANIMAL
Location:	BR191.1

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