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| Id: | 13627
| | Author: | Tosh, Kerrie; Meisner, Sarah; Siddiqui, M. Ruby; Balakrishnan, Karuppiah; Ghei, Satish; Golding, Marina; Sengupta, Utpal; Pitchappan, Ramasamy M; Hill, Adrian V. S
| | Title: | A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population
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| | Source: | s.l; s.n; 2002. 4 p. tab, graf.
| | Abstract: | A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker. (AU).
| | Descriptors: | MAPEAMENTO CROMOSSÔMICO
CROMOSSOMOS HUMANOS PAR 20/genet
MARCADORES GENETICOS/genet
PREDISPOSICAO GENETICA PARA DOENÇA/genet
GENETICA POPULACIONAL
HANSENIASE/genet
REPETICOES DE MICROSSATELITES/genet
MYCOBACTERIUM LEPRAE
INDIA
| | Limits: | HUMANO
MASCULINO
FEMININO
SUPPORT, NON-U.S. GOV'T
| | Electronic Medium: | http://www.ilsl.br
| | Location: | BR191.1; 08997/s |
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