Database : HANSEN Search on : INDIA [Subject descriptor] References found : 90 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19590 Author: Lord, Rosanne; Naish, Caroline; Taylor, Clare; Stanford, Cynthia; Stanford, John L; Chacko, Chinoy JG; Debandu, Vivanathan; Samson, Prabhakar D; Berchmans, John; Surendran, Deeradaylu; Ramu, Gopal; Rees, Richard JW. Title: Skin test studies on close contacts of leprosy patients in India. Source: Int. J. Lep;57(4):801-809, dec. 1989. ^btab, ^bgraf. Abstract: Skin-test studies with a series of tuberculins have been carried out in close contacts of multibacillary (MB) leprosy patients around three leprosy centers in India, and casual contacts of the disease around two centers. The results show that the rate of acquisition of leprosin A positivity is associated with age and the closeness of contact with MB leprosy. At the age of 15 years, the differences between the two types of contact were highly significant (p less than 0.00001). Many responses to leprosin A are directed toward the group iv species-specific, antigens of the leprosy bacillus, and the significance of positivity is discussed in relation to protective immunity from leprosy. The differences from Iran show that positivity to leprosin A is not solely the effect of the degree of contact with the disease, but must also have a genetic or environmental element, the latter being favored. The results from Miraj show that the high levels of tuberculin, scrofulin, and vaccin positivity seen in Fathimanagar, and to a lesser extent in Karigiri, are not a consequence of contact with leprosy. BCG vaccination made little difference to the leprosin A positivity of close contacts of leprosy patients, although it significantly enhanced positivity among casual contacts around Miraj (p less than 0.002). BCG vaccination significantly increased tuberculin positivity in Miraj and Karigri, and in those under 11 years of age in Fathimanagar. It made no difference to the already high level of positivity found in older persons around Fathimanagar. Descriptors: Antígenos de Bactérias/imunol Vacina BCG/imunol Hanseníase/epidemiol Hanseníase/transm Índia/epidemiol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a08.pdf / en Location: Br191.1

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Id: 19384 Author: Kumar, Anil; Girdhar, Anita; Yadav, V. S; Girdhar, B. K. Title: Some epidemiological observations on leprosy in India. Source: Int. J. Lepr;69(3):234-240, Sept., 2001. tab. Abstract: This population sample survey conducted in rural and urban areas of the Agra District in India showed an active leprosy caseload of 60.1/10,000 in the rural and 39.1/10,000 in the urban areas against a targeted prevalence of < 1/10,000. The disease appeared to be widespread since almost 65% of the villages or urban pockets surveyed had at least one prevalent case of leprosy. Significantly larger numbers of leprosy patients were found among males, agricultural/manual workers, persons with no formal schooling, individuals living in unkept households with dirty surroundings, and among those living in dark and poorly ventilated houses. The epidemiological significance of this study reveals the endemic nature of leprosy in Agra and suggests the need to intensify and widen case-detection activities to achieve leprosy control.(AU)^ien. Descriptors: Hanseníase/etnol Hanseníase/epidemiol Hanseníase/prev Índia/etnol Índia/epidemiol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2001/pdf/v69n3/v69n3a08.pdf / en Location: BR191.1

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Id: 18225 Author: Ebenezer, G. J; Norman, G; Joseph, G. A; Daniel, S; Job, C. K Title: Drug resistant-Mycobacterium leprae--results of mouse footpad studies from a laboratory in south India ..- Source: s.l; s.n; 2002. 12 p. tab. Abstract: Out of 265 biopsies of leprosy patients received at the Experimental Pathology Laboratory of Schieffelin Leprosy Research and Training Centre from 1987 to 1997 for evaluating resistant strains of M. leprae, using the mouse footpad technique, 49 showed resistant strains of M leprae to varying concentrations of dapsone, rifampicin and clofazimine. 23 (47%) of these were from a control area. With 369 skin-smear positive multibacillary (MB) patients as the risk group (denominator), 23 (6.23%) were resistant to one or more drugs. 18 (4.88%) had dapsone resistance, 5 (1.36%) were resistant to rifampicin and 9 (2.44%) had resistance to low concentrations of clofazimine (0.0001%). Out of the 23 biopsies with drug resistance from the control area, primary dapsone resistance was seen in 7 (30%) biopsies and secondary dapsone resistance in 11 (48%). Primary rifampicin resistance was seen in 4 (17.4%) patients, secondary rifampicin resistance in 1 (4.35%) and primary clofazimine resistance in 7 (30%). 3 (13%) of the strains showed secondary clofazimine resistance. One biopsy had resistant strains to all the three drugs. In a control area where properly supervised effective multidrug therapy (MDT) was regularly administered over the years, the emergence of drug resistance is negligible. It may not be the case if the content, duration and regularity of the drug regimen were not satisfactory. Aware of the possible shortcomings in mass administration of MDT, it is emphasized that mouse footpad studies on drug resistance should be made available at least in endemic areas where the incidence of the disease has not changed despite good MDT coverage in order to monitor the emergence of drug resistance. Research into molecular biological identification of drug resistant-M.leprae should be intensified. These steps would help to institute timely measures to check the spread of any drug-resistant organisms in the community. (AU). Descriptors: Clofazimina/PD Dapsona/PD Farmacorresistência Bacteriana Farmacorresistência Bacteriana Múltipla Índia Hansenostáticos/*PD Hanseníase/*DT/MI Camundongos Camundongos Endogâmicos CBA Testes de Sensibilidade Microbiana Mycobacterium leprae/*DE Rifampina/PD Limits: HUMANO ANIMAL MASCULINO FEMININO Location: BR191.1; 09179/S

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Id: 18118 Author: Collier, D. R Title: Inoculation of monkeys with leprosy, following a diet of puak (colocasia) ?- Source: s.l; s.n; 1940. 6p p. . Abstract: A number of monkeys have been fed on a diet of colocasia, and then inoculated with material from lepers. All four female monkeys, so treated six or more months ago, have developed symptoms similar to those seen in leprosy in humans. There have been positive bacteriological findings in nodules and changes in pigmentation of the skin. One animal developed thickening of the ulnar nerves. One male monkey has developed abcesses containing acid-fast bacilli as well as other sympstoms after being injected with a solution of sapotoxin in addition to the diet of colocasia. Descriptors: MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/patogen HANSENIASE/microbiol HANSENIASE/patol HANSENIASE/transm HANSENIASE/vet ANIMAIS DE LABORATORIO/imunol ANIMAIS DE LABORATORIO/microbiol - MODELOS ANIMAIS  MESOCRICETUS  MACACO  cachorro  coelho  porquinho da índia  porco Limits: ANIMAL Location: BR191.1; 00536/s

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Id: 17659 Author: Organizacao Mundial da Saude*. Title: Eliminating leprosy ..- Source: s.l; OMS; 1998. 30 p. ilus, mapas, graf. (WHO/LEP/98.4).   (WHO/LEP/98.4). Descriptors: HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/fisiopatol HANSENIASE/compl HANSENIASE/hist HANSENIASE/reabil - UGANDA/epidemiol  INDIA/epidemiol  TAILÂNDIA/epidemiol Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1; WC335.300, O14e

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Id: 17556 Author: Gill, A. L; Bell, D. R; Gill, G. V; Wyatt, G. B; Beeching, N. J Title: Leprosy in Britain: 50 years experience in Liverpool ..- Source: s.l; s.n; Jun. 2005. 7 p. tab, graf. Abstract: BACKGROUND: Leprosy is a chronic infection that presents with varying dermal and neurological symptoms, and which can lead to extensive disability and morbidity, often with accompanying social stigma. AIM: To review the patients presenting to the Liverpool School of Tropical Medicine (LSTM) between 1946 and 2003, looking specifically at country of birth and of infection, details of clinical presentation, diagnosis, management and reactions. DESIGN: Retrospective record review. METHODS: We retrieved all available clinical records for patients seen between 1946 and 2003 (n = 50), consisting of letters, hospital and LSTM casenotes, and some radiographs and photographs. Any history of tuberculosis or diabetes was recorded. RESULTS: Most patients (64%) were born in the Indian subcontinent, and most were thought to have contracted the disease there (62%). Features at presentation included anaesthetic skin lesions in 19 (36%), hypopigmentation in 15 (30%), and peripheral nerve enlargement in 25 (50%). Diagnoses were made by a combination of clinical data and biopsy (60%), and slit skin smears were positive for acid-fast bacilli in 61% of multibacillary patients. Initial presentation was with a leprosy reaction in five cases (10%), and reactions were documented in 42% of all patients. Treatments were varied, progressing from traditional Eastern medicine to the WHO-approved multidrug therapy in use today, with prophylaxis for children and close contacts. DISCUSSION: Leprosy remains an important diagnosis to consider in patients with a history of work or travel in the tropics, and is a diagnosis with far-reaching medical, social and emotional consequences. (AU). Descriptors: Inglaterra/EP Índia/EH Hansenostáticos/TU Hanseníase/DI/DT/*EP Estudos Retrospectivos Dermatopatias Bacterianas/DI/EP/PA Limits: Adolescente Adulto Idoso Criança Feminino Humanos Masculino Meia-Idade Location: BR191.1; 09335/s

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Id: 17549 Author: Boggild, Andrea K; Correia, Jason D; Keystone, Jay S; Kain, Keven C Title: Leprosy in Toronto: an analysis of 184 imported cases ..- Source: s.l; s.n; Jan. 2004. 5 p. tab. Abstract: BACKGROUND: Leprosy is a rare but serious mycobacterial infection. Immigration from areas where the disease is endemic has resulted in the importation of leprosy into countries where it is not endemic and where physicians and health care workers have little or no experience in diagnosis and therapy. In this study we characterized leprosy patients seen in a tropical disease unit that manages most of the reported leprosy cases in Canada. METHODS: We reviewed the clinical records of all 184 leprosy patients who were referred to the Tropical Disease Unit at Toronto General Hospital between 1979 and 2002 and abstracted demographic and clinical information. RESULTS: Patients were more likely to be male (122 or 66.3%) and of Indian (44 or 23.9%), Filipino (49 or 26.6%) or Vietnamese (37 or 20.1%) origin. Patients experienced symptoms for a mean of 4.8 years before referral to the Tropical Disease Unit. Most had no family history of leprosy (152/172 or 88.4%). Most patients presented with either borderline tuberculoid (80 or 43.5%) or borderline lepromatous (37 or 20.1%) disease. On average, patients presented with 5.8 skin lesions. Upper- and lower-extremity nerve dysfunction was common at presentation, with up to one-third of patients demonstrating either sensory or motor loss. A significantly greater lag time to presentation was observed in patients who emigrated from low-prevalence regions (p < 0.001). INTERPRETATION: Leprosy is a chronic infectious disease that is associated with serious morbidity if left untreated. Leprosy is uncommon in developed countries, but it is important for physicians to have a high index of suspicion when a foreign-born patient presents with chronic dermatitis and peripheral nerve involvement. (AU). Descriptors: Análise de Variância Distribuição de Qui-Quadrado Migração Internacional Índia/EH Hanseníase/*EP Ontario/EP Filipinas/EH População Urbana Vietnã/EH Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE Location: BR191.1; 09327/s

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Id: 15632 Author: Shelleh, Hamdi H; Al-Shayeb, Abdul M; Khan, Sarosh A; Khan, Latif A; Al-Hateeti, Hussni S Title: Cold cellulitis: an unusual presentation of leprosy ..- Source: s.l; s.n; 2001. 2 p. ilus. Abstract: The presentation of leprosy plays an important role in it´s identification. The features of the disease determine how it is clinically approached and diagnosed. Leprosy has diverse types of presentations. They are commonly calm and insidious.(AU). Descriptors: DOENCA AGUDA BIOPSIA CELULITE/diag CELULITE/etiol DIAGNOSTICO DIFERENCIAL DERMATOSES FACIAIS/diag DERMATOSES FACIAIS/etiol INDIA/etnol HANSENIASE DIMORFA/compl HANSENIASE DIMORFA/diag HANSENIASE DIMORFA/quimioter HANSENIASE DIMORFA/etnol DISTRIBUICAO ESPACIAL Limits: RELATO DE CASO HUMANO MASCULINO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09105/s

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Id: 13946 Author: De Sarkar, Bishakha Title: Leprosy elimination in India inches closer ..- Source: s.l; s.n; 2003. 2 p. ilus. Abstract: India has recently been oscillating between good and bad news in its bid to defeat leprosy. The Indian government has effectively curbed the disease in many parts of the country, but health experts believe that it may not be able to "eliminate" it from India within the next three years as planned......(AU). Descriptors: PREVALÊNCIA HANSENIASE/quimioter HANSENIASE/epidemiol HANSENIASE/prev HANSENOSTATICOS/provis HANSENOSTATICOS/uso terap EDUCACAO EM SAUDE/org INDIA/epidemiol CONSCIENTIZACAO Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09087/s

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Id: 13873 Author: Zafarullah, M; Bano, Hasina; Vohora, S. B Title: Juzam (leprosy) and its treatment in Unani medicine ..- Source: s.l; s.n; 1980. 15 p. tab. Abstract: Juzam (leprosy) is attributed to excessive accumulation, infiltration and dispersal of sauda (burnt humours) throughout the body disturbing the normal temperament of the organs. A variety of causative factors responsible for excessive production or retention of sauda are enumerated. Unani simple plants, animals and minerals and formulations used for the treatment of leprosy are tabulated with recipes, methods of preparation, does and modes of administration.(AU). Descriptors: HANSENIASE/quimioter HANSENIASE/etiol INDIA MEDICINA ARABICA PLANTAS MEDICINAIS Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 0714/s

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Id: 13862 Author: Terencio de las Aguas, José. Title: La lepra en la India - História (Editorial). Source: Fontilles - Revista de Leprología;18(1):7-17, Ene.-Abr. 1991. mapas, tab. Descriptors: HANSENIASE/etnol HANSENIASE/hist INDIA/etnol Location: BR191.1

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Id: 13733 Author: Mattoo, S. K; Handa, S; Kaur, I; Gupta, N; Malhotrat, R Title: Psychiatry morbidity in vitiligo: prevalence and correlates in India ..- Source: s.l; s.n; 2002. 6 p. tab. Abstract: BACKGROUND: Vitiligo, a common pigmentary disorder, is recognized to be associated with a high psychiatric morbidity, yet compared to other dermatological disorders like leprosy, psoriasis, etc., it has not been subjected to detailed evaluation of its psychological consequences. The data from the developing countries on this aspect in particular is meager. METHODS: One hundred and thirteen cases with vitiligo were evaluated along with 55 healthy controls comparable for sociodemographic profile and matched on attitude to appearance scale. Clinical details, impact of illness, associated dysfunction and psychological morbidity were additionally assessed. RESULTS: Twenty-eight patients with vitiligo were found to have psychiatric morbidity, a clinic prevalence rate of 25 per cent (95 per cent confidence interval 20.3-29.3per cent). The majority of the cases had a diagnosis of adjustment disorder. Psychiatric morbidity was significantly correlated with dysfunction arising out of illness. CONCLUSIONS: Vitiligo is associated with high psychiatric morbidity. There is a need to develop cross-cultural database on psychosocial aspects and psychiatric morbidity associated with vitiligo. (AU). Descriptors: TRANSTORNOS DE ADAPTACAO/epidemiol COMPARACAO TRANSCULTURAL INDIA/epidemiol MORBIDADE VITILIGO/epidemiol VITILIGO/psicol PREVALÊNCIA Limits: HUMANO MASCULINO FEMININO ADULTO SUPPORT, NON-U.S. GOV'T ESTUDOS DE CASOS E CONTROLES Electronic Medium: http://www.ilsl.br Location: BR191.1; 09027/s

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Id: 13729 Author: Pai, Sanjay A Title: V.R. Khanolkar: father of patology and medical research in India ..- Source: s.l; s.n; 2002. 4 p. ilus. Abstract: Vasant Ramji Khanolkar was the first pathologist in India. He made major contributions to the epidemiology and understanding of cancer, blood groups, and leprosy. He was the first to show the existence of dhoti cancers, and was among the earliest to demonstrate the carcinogenicity of tobacco and the use of needle aspiration cytology for the diagnosis of neoplasms. He was an acclaimed teacher and was on the boards of numerous international organizations. He was a bibliophile and his writings are Oslerian in style. He serves as a role model to the few in India who are aware of him. He deserves to be called the "Father of pathology and medical research in India." (AU). Descriptors: INDIA HANSENIASE/hist NEOPLASIAS/hist PATOLOGIA/hist RETRATOS DISTINCOES E PRÊMIOS Limits: HUMANO HISTORIA DA MEDICINA DO SÉCULO 20 Electronic Medium: http://www.ilsl.br Location: BR191.1; 09019/s

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Id: 13708 Author: Daniel, E; Koshy, S; Rao, G. Sundar; Rao, P. S. S. S Title: Ocular complications in newly diagnosed borderline lepromatous and lepromatous leprosy patients: baseline profile of the Indian cohort ..- Source: s.l; s.n; 2002. 5 p. tab. Abstract: Aim: To describe ocular manifestations in newly diagnosed borderline lepromatous (BL) and lepromatous leprosy (LL) patients in India. METHODS: Ocular complications, at enrolment, occurring in all new borderline lepromatous and lepromatous leprosy patients detected by active case finding within the geographically defined leprosy endemic area of the Gudiyattam Taluk in India from 1991 to 1997 who consented to ocular examinations every 6 months, during and 5 years after treatment with multidrug therapy (MDT), were studied. RESULTS: Orbicularis oculi weakness (4.62 per cent), lagophthalmos (4.20 per cent), ectropion (0.42 per cent), trichiasis (0.84 per cent), blocked nasolacrimal ducts (1.68 per cent), pterygium (11.34 per cent), impaired corneal sensation (53 per cent), corneal opacity (10.5 per cent), corneal nerve beading (1.68 per cent), punctate keratitis (1.26 per cent), keratic precipitates (4.62 per cent), iris atrophy (1.68 per cent), and cataract (12.6 per cent) were ocular complications seen in the 301 lepromatous patients at enrolment. 4.6 per cent had blind eyes. Increasing age was associated with ocular complications. 80 per cent of patients were skin smear acid fast bacilli (AFB) positive. The LL/BL ratio was 1:6.4. 71 per cent had some limb deformity. 44 per cent had only leprosy related ocular complications (LROC), 28 per cent had only general ocular complications (GOC) while 14 per cent had both LROC and GOC. Ocular complications were significantly related to leg deformities. Corneal nerve beading was seen most in LL patients (100 per cent) having high bacterial content. Lagophthalmos and muscle weakness were associated with reversal reactions. CONCLUSIONS: Corneal nerve beading occurs in LL patients with high bacillary count. Patients with reversal reaction are more likely to present with orbicularis oculi weakness and lagophthalmos. Leprosy related ocular complications and general ocular complications are significant problems in newly diagnosed lepromatous patients. Elderly, deformed, skin smear positive, lepromatous patients are associated with increased ocular morbidity and form a group that require acceptable and accessible eye care. (AU). Descriptors: ESTUDOS DE COORTES OFTALMOPATIAS/EP/*ET INDIA/EP HANSENIASE DIMORFA/*CO/EP HANSENIASE VIRCHOWIANA/*CO/EP ESTUDOS LONGITUDINAIS TRANSTORNOS DA VISAO/EP/*ET ACUIDADE VISUAL/PH Limits: ADOLESCENTE FATORES ETARIOS IDOSO CRIANCA FEMININO HUMANO MASCULINO MEIA-IDADE SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09069/s

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Id: 13651 Author: Lanjewar, D. N; Bhosale, Ashish; Iyer, Anita Title: Spectrum of dermatopathologic lesions associated with HIV/AIDS in India ..- Source: s.l; s.n; July 2002. 6 p. ilus, tab. Abstract: Histopatholgoical analysis of cutaneous lesions in 195 patients with HIV/AIDS was carried out between 1989 to 1997 at tertiary level public hospital in Mumbai. 104/195 (53 per cent) cases showed infectious diseases which comprised of molluscum contagiosum (28), condyloma accuminata (18), verruca vulgaris (7), varicella zoster (5), syphilis (14), tuberculosis (13), donovanosis (4), leprosy (2), chancroid (2), bacillary angiomatosis (2), lymphogranuloma venercum (1), Norwegian scabies (3), leishmaniasis (2), demodicidosis (1), crytococcosis (1), tinea versicolor (1). In 12 (6 per cent) cases neoplasms were observed which included squamous cell carcinoma (9), basal cell carcinoma (2) and kaposi's sarcoma (1) case. The miscellaneous conditions were observed in 66(33.5 per cent) cases which comprised of psoriasis (21), papular urticaria (13), Reiter's disease (7) and eosinophilic folliculitis (6). The prevalence of cutaneous tuberculosis observed in this study is high as compared with western literature while the prevalence of kaposis's sarcoma is quite low as compared with reports from Africa, USA and United Kingdom. (AU). Descriptors: SINDROME DE IMUNODEFICIÊNCIA ADQUIRIDA/compl INFECCOES POR HIV/compl INDIA/epidemiol PREVALÊNCIA DERMATOPATIAS/compl DERMATOPATIAS/epidemiol XERODERMA PIGMENTOSO/epidemiol XERODERMA PIGMENTOSO/etiol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09127/s

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Id: 13645 Author: Thomas, Ravi; Thomas, Saju; Muliyil, Jayaprakash Title: Prevalence of glaucoma in treated multibacillary Hansen disease ..- Source: s.l; s.n; Fev. 2003. 7 p. tab. Abstract: PURPOSE: To determine the prevalence of glaucoma in a population of patients with multibacillary Hansen disease who had completed treatment. PATIENTS AND METHODS: The authors examined 386 of 446 patients with treated multibacillary Hansen disease residing in a geographically limited area. A complete ophthalmic examination including slit-lamp, applanation tonometry, gonioscopy, ophthalmoscopy, and stereobiomicroscopic examination of the optic disc was performed in all subjects. Glaucoma suspects were invited to the base hospital for further examination including automated perimetry. RESULTS: The overall prevalence of glaucoma was 3.6 per cent (CI 1.9-5.3); 1.3 per cent had primary open-angle glaucoma, 7 per cent were primary angle-closure suspects (occludable angles), 1.8 per cent had primary angle-closure glaucoma, and 0.5 per cent had secondary glaucoma. CONCLUSION: The prevalence of primary glaucoma in patients with treated multibacillary Hansen disease was similar to that in the general population, and secondary glaucoma was rare. (AU). Descriptors: CLOROQUINA/uso terap GLAUCOMA DE ÂNGULO FECHADO/epidemiol GLAUCOMA DE ÂNGULO ABERTO/epidemiol GLUCOCORTICOIDES SINTETICOS/uso terap GONIOSCOPIA INDIA/epidemiol HANSENIASE/quimioter HANSENIASE/epidemiol OFTALMOSCOPIA DISCO OPTICO/patol TONOMETRIA - PREVALÊNCIA Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE IDOSO ADOLESCENTE IDOSO DE 80 ANOS OU MAIS Electronic Medium: http://www.ilsl.br Location: BR191.1; 09133/s

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Id: 13640 Author: Daniel, Ebenezer; Koshy, Sheena; Joseph, Geetha A; Rao, P. S. S Title: Ocular complications in incident relapsed borderline lepromatous and lepromatous leprosy patients in South India ..- Source: s.l; s.n; 2003. 5 p. tab. Abstract: PURPOSE: To determine the magnitude of ocular complications that present in incident cases of relapsed borderline lepromatous (BL) and lepromatous leprosy (LL) patients. METHOD: From 1991 to 1997, all new BL and LL patients who had relapsed from an earlier disease, detected by active case finding in the geographically defined area of Gudiyattam taluk, were invited for ocular examination after their leprosy status was confirmed clinically and histopathologically. RESULTS: Sixty relapsed lepromatous patients, 45 male and 15 females, were examined. Fifty-two patients had relapsed after receiving only dapsone mono-therapy, 4 after receiving paucibacillary multi-drug therapy (PB-MDT) preceded by dapsone mono-therapy and 4 after only PB-MDT. Three (5 per cent) patients had lagophthalmos, 1 (1.6 per cent) patients each had ectropion and trichiasis, 32 (53 per cent) patients had impaired corneal sensation in both eyes, 2 (3.3 per cent) patients each had corneal opacity (associated with reduced vision), corneal nerve beading, punctate keratitis, keratic precipitates, and iris atrophy, 4 (6.6 per cent) patients had cataract associated with decreased vision, 1 (1.6 per cent) patient had blocked naso-lacrimal duct and 13 (21.7 per cent) patients had pterygium. Seven (12 per cent) patients had a visual acuity of 6/18 or less, 4 (6.7 per cent) patients had 6/60 or less and one patients had vision below 3/60. General ocular complications rather than leprosy-related ocular complications were responsible for reduced vision. Lagophthalmos was associated with increased duration of the disease (P = 0.009), Grade II deformity (P = 0.001), punctate keratitis (P < 0.001) and cataract (P < 0.001). Beaded corneal nerves were associated with lepromatous leprosy (P < 0.001) and high mycobacterial infection (P = 0.05). Patients whose initial disease was categorised as BL and LL had greater impairment of vision (P = 0.037), more iris atrophy (P = 0.013), increased keratic precipitates (P = 0.013) and more corneal nerve beading (P = 0.013), when compared with the group comprising Tuberculoid-tuberculoid (TT), Borderline-tuberculoid (BT) and Intermediate (IND). CONCLUSION: This first report on ocular complications in relapsed lepromatous patients demonstrates that general and leprosy-related ocular complications occur in these patients. However, they are not in excess of those reported in other leprosy groups... (AU). Descriptors: OFTALMOPATIAS/microbiol OFTALMOPATIAS/fisiopatol INDIA HANSENIASE VIRCHOWIANA/compl VISAO Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09049/s

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Id: 13627 Author: Tosh, Kerrie; Meisner, Sarah; Siddiqui, M. Ruby; Balakrishnan, Karuppiah; Ghei, Satish; Golding, Marina; Sengupta, Utpal; Pitchappan, Ramasamy M; Hill, Adrian V. S Title: A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population ..- Source: s.l; s.n; 2002. 4 p. tab, graf. Abstract: A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker. (AU). Descriptors: MAPEAMENTO CROMOSSÔMICO CROMOSSOMOS HUMANOS PAR 20/genet MARCADORES GENETICOS/genet PREDISPOSICAO GENETICA PARA DOENÇA/genet GENETICA POPULACIONAL HANSENIASE/genet REPETICOES DE MICROSSATELITES/genet MYCOBACTERIUM LEPRAE INDIA Limits: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 08997/s

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Id: 13555 Author: Kushwah, S. S; Govila, A. K; Kushwah, J Title: An epidemiological study of disabilities among leprosy patients attending leprosy clinic in Gwalior ..- Source: s.l; s.n; apr. 1981. 8 p. tab. Abstract: Leprosy is known to be a dreadful disease because of the disabilities and deformities caused by it. The second report of the WHO expert committee on leprosy (WHO, 1960) estimated that about 25% of leprosy patients have some degree of disabilities.(AU). Descriptors: FATORES ETARIOS PESSOAS PORTADORAS DE DEFICIÊNCIA INDIA HANSENIASE/compl ESTUDOS LONGITUDINAIS - FATORES SEXUAIS  FATORES SOCIOECONÔMICOS Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE IDOSO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00760/s

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Id: 13511 Author: Mathur, N. K; Kanwar, A. J; Kalla, G; Ujwal, J. S Title: Leprosy in Jodhpur (Rajasthan) ..- Source: s.l; s.n; apr. 1978. 5 p. ilus, mapas, tab. Abstract: A clinical and epidemiological study of leprosy revealed 232 cases in Jodhpur (Rajasthan); a non-endemic area. Males were three times more affected than females. Lepromatous leprosy was the most common type (70.70%). Maximum number of cases were observed in the age group 20-49 years. The probable causes for an increase in incidence are discussed.(AU). Descriptors: INDIA HANSENIASE/diag HANSENIASE/epidemiol Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE IDOSO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00328/s

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