Database : HANSEN Search on : BIOPSIA [Subject descriptor] References found : 117 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 18419 Author: Patrocinio, Lucas Gomes; Goulart, Isabela Maria Bernardes; Goulart, Luiz Ricardo; Patrocinio, Jose Antonio; Ferreira, Frederico Regerio; Fleury, Raul Negrao Title: Detection of Mycobacterium leprae in nasal mucosa biopsies by the polymerase chain reaction ..- Source: s.l; s.n; 2005. 6 p. ilus, tab. Abstract: Several discoveries about leprosy indicate that Mycobacterium leprae transmission mainly accurs by inhalation, and the nose is major port of entry and exit. The present study evaluated the clinical application of PCR for detection of M. leprae DNA in nasal mucosa biopsies in untreated leprosy patients (52) and their contacts (99) from the State Reference Center in Sanitary Dermatology and Leprosy, Uberlandia, MG, Brazil. PCR detection of a 372-base pair DNA fragment from M. leprae was accomplished in 36 (69.2%) patients, from which 34 (91.9%) of them were multibacillaries. Furhermore, PCR was positive in 3 (16.7%) of 18 slit-skin smear negative, 4 (25.0%) of 16 skin lesion BI negative, 8 (33.3%) of 24 nasal mucosa BI negative patients, and 10 of 99 contacts (10.1%). The presence of bacilli in 10.1% of the contats may potentially reflect an occult leprosy, and reflect an occult leprosy, and these patients must be accompanied, followed by a chemoprophylaxy treatment. Considering all PCR results against clinical and BI classification of patients and controls, we have found a sensitivity of 69.2%, a specificity of 89.9% and an accuracy of 82.8%. It has been demonstrated here through PCR of nasal biopsies that the bacillus invades the mucosa, passing through the nasal inferior turbinate to reach peripheral blood. Therefore, the molecular investigation of invasive nasal biopsies by PCR tests has proven to be useful in defining patients of higher risk of transmission and risk-group contacts, which is an important step ti reach the World Health Organization objective towards the elimination of leprosy as a public health problem (AU). Descriptors: MUCOSA NASAL/imunol MUCOSA NASAL/les MUCOSA NASAL/microbiol MUCOSA NASAL/patol MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/ultraest REACAO EM CADEIA DA POLIMERASE/estatíst REACAO EM CADEIA DA POLIMERASE/tend REACAO EM CADEIA DA POLIMERASE/util - BIOPSIA/estatíst  BIOPSIA/tend  BIOPSIA/util  HANSENIASE/clas  HANSENIASE/diag  HANSENIASE/microbiol  HANSENIASE/patol Limits: HUMANO Location: BR191.a; 09307/s

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Id: 18329 Author: Fasal, P Title: Leprosy occurs everywhere ?- Source: San Francisco; s.n; 1965. 7p p. ilus. Abstract: Leprosy can occur at all ages, in both sexes and in every race. It can be found in any geographic area and can simulate many diseases, especially those affecting the skin. The lepromatous type indicates less host resistance than the tuberculoid type. Histopathologic examination of a properly stained specimen obtained by skin biopsy is the most important diagnostic procedure. Treatment consist of long-term chemotherapy with sulfone drugs. Descriptors: HANSENIASE/clas HANSENIASE/compl HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/imunol HANSENIASE/terap HANSENIASE/transm HANSENIASE DIMORFA/diag HANSENIASE TUBERCULOIDE/diag HANSENIASE VIRCHOWIANA/diag HANSENIASE/patol DAPSONA/admin DAPSONA/uso terap - DISTRIBUICAO ESPACIAL  ANTIGENO DE MITSUDA/admin  ANTIGENO DE MITSUDA/anal  BIOPSIA/util Limits: HUMANO Location: BR191.1; 00198/s

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Id: 18202 Author: Walsh, Douglas S; Lane, Joshua E; Abalos, Rodolfo M; Myint, Khin Saw Aye Title: Tunel and limited immunophenotypic analysis of apoptosis in paucibacillary leprosy lesions ..- Source: s.l; s.n; 2004. 5 p. ilus. Abstract: Some mycobacterial infections, such as tuberculosis, are characterized by apoptosis in infected or by-stander mononuclear immune cells. For localized (paucibacillary, PB) and diseminated (multibacillary, MB) leprosy, characterized by polarized Thl-like vs, Th2-like immune responses, respectivelly little is known about lesional apoptosis. We analyzed sections of paraffin-embedded, untreated leprosy lesions from 21 patients by an indirect immunofluorescent terminal deoxynucleotide-transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) assay. Some TUNEL (+) PB sections were then reacted with phycoerythein-conjugated (red)antibodies against T cells, monocytes, or antigen-presenting (Langerhans) cells. TUNEL (+) bodies were detected in 9 of 16 PB lesions (56%) and in 1 of 5 MB lesions (20%). Some TUNELL (+) bodies in PB disease were CD3+ (T cell), as well as CD4+ (T-helper) or cd8+ (T-cytotoxic) Apoptosis characterizes PB and MB leprosy lesions and may be more freqeunt in PB disease. In PB disease, some TUNEL (+) bodies may derive from T cells (AU). Descriptors: HANSENIASE DIMORFA/imunol HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/imunol HANSENIASE/imunol IMUNOHISTOQUIMICA/util MYCOBACTERIUM LEPRAE/patogen HANSENIASE/patol HANSENIASE DIMORFA/patol HANSENIASE VIRCHOWIANA/patol HANSENIASE TUBERCULOIDE/patol - APOPTOSE/imunol  APOPTOSE/fisiol  IMUNOHISTOQUIMICA/normas  BIOPSIA/util Limits: HUMANO Location: BR191.1; 09200/s

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Id: 18121 Author: Boddingius, Janny; Rees, R. J. W; Weddeli, A. G. M Title: Leprosy neuropathy in mice and men: an electron microscopical study ..- Source: s.l; s.n; 1973. 1 p. . Descriptors: NERVOS PERIFERICOS/anat NERVOS PERIFERICOS/les NERVOS PERIFERICOS/microbiol NERVOS PERIFERICOS/ultraest HANSENIASE DIMORFA/compl HANSENIASE DIMORFA/patol HANSENIASE DIMORFA/fisiopatol HANSENIASE VIRCHOWIANA/compl HANSENIASE VIRCHOWIANA/patol HANSENIASE VIRCHOWIANA/fisiopatol - BIOPSIA/métodos  MYCOBACTERIUM LEPRAE/isol  MYCOBACTERIUM LEPRAE/patogen Limits: ESTUDO COMPARATIVO Location: BR191.1; 00877/s

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Id: 17593 Author: Gomes, Maria Katia Title: Pacientes com hanseniase paucibacilar lesao unica tratados com terapia de dose unica ROM: avaliacao de progressao da doenca em coorte multicentrica (1997 - 2001) ?- Source: Rio de Janeiro; s.n; 2004. 49 p. ilus, tab. Thesis: Present for Univerasidade Federal do Rio de Janeiro. Faculdade de Medicina presented for the degree Doutor. Abstract: Este projeto de investigacao teve por objetivo definir o perfil clinico, epidemiologico, histopatologico e imunologico ao diagnostico e tambem avaliar os fatores prognosticos associados com a evolucao clinica dos pacientes de hanseniase PB/lesao unica tratados com ROM/dose unica em condicoes do campo. Trata-se de estudo de coorte multicentrica com seguimento de tres anos, conduzido em diferentes regioes do Brasil: Norte, Centro-Oeste e Sudeste. Os casos recem-detectados de hanseniase PB/lesao unica (n=259) foram recrutados e tratados de outubro de 1997 a dezembro de 1998. Na linha de base, a media de idade foi 32,4 (dp=16,0). 61,8% dos pacientes eram mulheres e 33,6% dos pacientes apresentaram histomorfologia BT, 29,7% I e33,6% TT. 74,4% tiveram Mitsuda positivo e 17,7% anti-PGL1 positivo. A avaliação clinica dos pacientes recrutados foi mensal no primeiro semestre e de 6 em 6 meses de outubro de 1997 a dezembro de 2001. O completo desaparecimento ou reducao do tamanho da lesao foi categorizado como evolucao favoravel. Evolucao desfavoravel foi definida como aumento no numero das lesoes, episodios de reacao reversa e/ou neurites perifericas isoladas, alem de mudanca de forma clinica para MB. A densidade de incidencia (DI) de eventos desfavoraveis foi calculada por pessoas-mes. Para calcular a probalidade cumulativa de intervalos livres de eventos foi usado de Metodo de Kaplan-Meier. Em 03 anos de seguimento, 88,1% dos pacientes tratados apresentaram completo desaparecimento da lesao. A incidencia de evolucao desfavoravel foi 17,8% (DI= 6,9/1000 pessoas-mes). A reacao reversa (RR) foi o evento desfavoravel predominante, principalmente entre pacientes BT. Houve baixa taxa de incidencia de progressao de PB para MB (7/10 000 pessoas-mes). Para a coorte como um todo, a probabilidade de permanecer livre de eventos a partir do diagnostico foi 92% (+/- 1,7%) no primeiro ano e 80,6% (+/- 2,55) no terceiro ano, estimado pelo metodo de Kaplan-Meier. A probalidade de permanecer livre de eventos foi mais alta entre pacientes com menos de 40 anos (92,4% no primeiro ano e 85,7% no terceiro ano de acompanhamento). Os pacientes BT tiveram mais probabilidade cumulativa de apresentar evolucao desfavoravel durante os intervalos seguimento, quanto comparados com os pacientes I e TT (p=0,03). Em conclusao, nossos resultados evidenriaram a predominancia de evolucao favoravel e baixa densidade de incidencia de progressao para formas MB nos (AU). Descriptors: HANSENIASE/clas HANSENIASE/diag DOSE UNICA QUIMIOTERAPIA COMBINADA BIOPSIA/métodos - ANALISE ESTATISTICA Limits: HUMANO MASCULINO FEMININO MEIA-IDADE Location: BR191.1; WC335.900, G585p

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Id: 17565 Author: Patrocinio, Lucas Gomes; Goulart, Isabela Maria Bernardes; Goulart, Luiz Ricardo; Patrocinio, Jose Aantonio; Ferreira, Frederico Rogerio; Fleury, Raul Negrao Title: Detection of Mycobacterium leprae in nasal mucosa biopsies by the polymerase chain reaction ..- Source: s.l; s.n; 2005. 6 p. ilus, tab. Abstract: Several discoveries about leprosy indicate that Mycobacterium leprae transmission mainly occurs by inhalation, and the nose is major port of entry and exit. The present study evaluated the clinical application of PCR for detection of M. leprae DNA in nasal mucosa biopsies in untreated leprosy patients (52) and their contacts (99) from the State Reference Center in Sanitary Dermatology and Leprosy, Uberlandia, MG, Brazil. PCR detection of a 372-base pair DNA fragment from M. leprae was accomplished in 36 (69.2%) patients, from which 34 (91.9%) of them were multibacillaries. Furthermore, PCR was positive in 3 (16.7%) of 18 slit-skin smear negative, 4 (25.0%) of 16 skin lesion BI negative, 8 (33.3%) of 24 nasal mucosa BI negative patients, and 10 of 99 contacts (10.1%). The presence of bacilli in 10.1% of the contacts may potentially reflect an occult leprosy, and these patients must be accompanied, followed by a chemoprophylaxy treatment. Considering all PCR results against clinical and BI classification of patients and controls, we have found a sensitivity of 69.2%, a specificity of 89.9%, and an accuracy of 82.8%. It has been demonstrated here through PCR of nasal biopsies that the bacillus invades the mucosa, passing through the nasal inferior turbinate to reach peripheral blood. Therefore, the molecular investigation of invasive nasal biopsies by PCR tests has proven to be useful in defining patients of higher risk of transmission and risk-group contacts, which is an important step to reach the World Health Organization objective towards the elimination of leprosy as a public health problem. (AU). Descriptors: Biópsia Brasil/EP DNA Bacteriano/AN Hanseníase/*DI/EP/MI Mycobacterium leprae/GE/*IP Mucosa Nasal/*MI/PA Reação em Cadeia da Polimerase/* Fatores de Risco Sensibilidade e Especificidade Limits: Estudo Comparativo Humanos Location: BR191.1; 09345/s

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Id: 17564 Author: Kramme, Stefanie; Bretzel, Gisela; Panning, Marcus; Kawuma, Joseph; Drosten, Christian Title: Detection and quantification of Mycobacterium leprae in tissue samples by real-time PCR ..- Source: s.l; s.n; 2004. 5 p. tab, graf. Abstract: Real-time PCR technology has improved molecular diagnostics of many pathogens, but no such test is available for Mycobacterium leprae. In this report we describe the establishment and the pre-clinical evaluation of such an assay. The test achieved a theoretical analytical sensitivity limit of 194 M. leprae cells per skin biopsy specimen and facilitated quantification of mycobacteria in tissue over a range of 54-54,000,000 cells per sample. In punch skin biopsies from 39 untreated Ugandan patients with newly diagnosed leprosy, the clinical diagnosis could be confirmed in 88.9% of multibacillary and 33.3% of paucibacillary (microscopically negative) patients. Real-time detection thus did not increase the clinical sensitivity of PCR as compared to conventional protocols, in spite of its evidently high analytical sensitivity. On the other hand, as still no culture system exists for M. leprae, the assay appears to be a robust tool for detection of the bacterium in selected clinical situations, as well as for quantitation in experimental settings. (AU). Descriptors: Antígenos de Bactérias/GE Proteínas de Bactérias/GE Biópsia DNA Bacteriano/CH/IP Hanseníase/*DI/MI Dados de Sequência Molecular Mycobacterium leprae/GE/*IP Reação em Cadeia da Polimerase/*MT Sensibilidade e Especificidade Alinhamento de Sequência Análise de Sequência de DNA Pele/MI Uganda Limits: Research Support, Non-U.S. Gov't Humanos Location: BR191.1; 09344/s

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Id: 17320 Author: Gupta, Akash; Seiden, Allen M Title: Nasal leprosy: case study ..- Source: s.l; s.n; 2003. 3 p. ilus. Descriptors: Biópsia Hanseníase/*PA Cavidade Nasal/*PA Limits: Adulto Masculino Humano Location: BR191.1; 00223/s

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Id: 17319 Author: Stefani, Mariane M. A; Martelli, Celina M. T; Gillis, Thomas P; Krahenbuhl, James L Title: In situ type 1 cytokine gene expression and mechanism associated with early leprosy progression ..- Source: s.l; s.n; 2003. 8 p. ilus. Abstract: We explored the prognostic value of in situ cytokine patterns in 39 patients with single-skin-lesion paucibacillary leprosy before single-dose therapy, with 3 years of follow-up. Interferon (IFN)-gamma, interleukin (IL)-12, IL-10, IL-4, tumor necrosis factor (TNF)-alpha, and macrophage inflammatory protein (MIP)-1alpha mRNA was quantified in skin biopsy samples at diagnosis, and Mycobacterium leprae DNA was detected in 51.4% of cases. Type 1 immunity predominance with measurable IFN-gamma and undetectable IL-4, which is indicative of effective cell-mediated immunity, is compatible with both the reversal reactions (33.3%) and the resolution of lesions (64.1%) observed. A positive correlation between IL-12 and IFN-gamma indicated type 1 polarization via IL-12. The TNF-alpha/MIP-1alpha correlation implied the TNF-alpha induction of chemokines, which is important for granuloma formation. Positive correlations between key regulatory cytokines-IL-10 and IFN-gamma, IL-10 and IL-12, and IL-10 and TNF-alpha-suggests that there may be some level of an intralesional pro- or anti-inflammatory mechanism essential in avoiding immunopathology. (AU). Descriptors: Anticorpos Antibacterianos/BL Biópsia Estudos de Coortes Citocinas/BI/*GE/IM Regulação Bacteriana da Expressão Gênica/*IM Hanseníase/DT/*GE/IM Minociclina/TU Mycobacterium leprae/*GE/IM Ofloxacino/TU Prognóstico RNA Mensageiro/BI/GE RNA Viral/BI/GE Reação em Cadeia da Polimerase Via Transcriptase Reversa Rifampina/TU Limits: Adolescente Adulto Criança Feminino Humano Masculino Células Th1/IM Location: BR191.1; 01884/s

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Id: 17314 Author: Williams, Diana L; Oby-Robinson, Sandra; Pittman, TAna L; Scollard, David M Title: Purification of Mycobacterium leprae RNA for gene expression analysis from leprosy biopsy specimens ..- Source: s.l; s.n; 2003. 3 p. ilus, tab. Abstract: Gene expression analysis in Mycobacterium leprae, an obligate intracellular pathogen and the etiologic agent of leprosy, has been hampered by the lack of an efficient method to purify RNA from leprosy lesions. Therefore to date, transcripts for only a few genes have been identified. We report the use of a single-tube homogenization/RNA extraction method that produces enough RNA to study the expression of 30 genes from a single skin biopsy specimen of a multibacillary leprosy patient and demonstrate that RNA can be purified after fixation of biopsies in 70% ethanol for up to a year. This represents a major advancement in the ability to study M. leprae gene expression directly from biopsy material and should help to define genes that are associated with intracellular survival of this human pathogen. (AU). Descriptors: Biópsia/*MT Perfilação da Expressão Gênica/*MT Triagem Genética/MT Hanseníase/*MI/*PA Mycobacterium leprae/GE/*IP/*ME RNA Bacteriano/*GE/*IP Análise de Sequência de RNA/MT Pele/MI/PA Limits: Humano Location: BR191.1; 01850/s

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Id: 17310 Author: Grimald, J; Vallat, J. M Title: Manifestations neurologiques de la lepre Neurological manifestations of leprosy- Source: s.l; s.n; 2003. 19 p. . Abstract: Leprosy, also known as Hansen's disease, is a chronic, infectious disease caused by Mycobacterium leprae. Bacilli localize preferentially in the skin and peripheral nerves and have a propensity to cause nerve damage. The resulting disability has caused great suffering for victims in many countries. Despite recent advances in the immunopathogenesis, epidemiology and prognostic factors of leprosy nerve damage, many aspects of the disease have remained enigmatic. The spectrum of clinical and pathological manifestations of the disease ranges from lepromatous to tuberculoid, depending on the host's T-cell-mediated immune response. Diagnosis is based on three criteria: characteristic skin lesions in association with thickened nerves, demonstration of acid fast bacilli in slit skin smears, and histopathology of skin biopsies. Nerve biopsy is necessary to establish the diagnosis of pure "neural leprosy". In developed countries, the diagnosis is suspected when a patient who has stayed in an endemic area suffers from a peripheral neuropathy of unknown etiology. To facilitate determination of the appropriate antibiotic regimen, patients are classified as either paucibacillary or multibacillary. Some patients may have multibacillary leprosy in nerves and paucibacillary leprosy in skin, which emphasizes the usefulness of nerve biopsy. The course of the disease is often complicated by immune mediated "reactions", which can rapidly lead to further nerve damage, namely reversal reaction and erythema nodosum leprosy. However, nerves are often functionally impaired before developing obvious symptoms such as skin reactions or nevralgia (silent neuropathy). Early recognition and prompt treatment with corticosteroids of leprous reactions and "silent neuropathies" is very important to prevent disability with all its attendant problems. Research progress from clinical trials may improve current methods of prevention and treatment of nerve damage in leprosy.(AU). Descriptors: Antiinfecciosos/TU Biópsia Diagnóstico Diferencial Hanseníase/DT/*PA/VI Mycobacterium leprae/IP Nervos Periféricos/*PA/VI Pele/VI Limits: Humano Location: BR191.1; 00254/s

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Id: 17207 Author: Khanolkar, V. R. Title: Studies in the histology of early lesions in leprosy. Source: Lepr Ind;24(2):62-77, apr., 1952. ilus, tab. Abstract: The studies which have been presented here bring out five essential features of leprosy which have been abscure hitherto. 1. It is unnecessary to the likelihood of portals of entry for leprosy bacilli to the human body other than healthy or slightly altered skin from the point or points of entry in the skin the bacilli their way anywhere under the epidermis, through the inter-communicating superficial lymphatic network. 2. All leprosy is neural in its inception, inasmuch as the spread of micro-organisms is or along nerve fibres in initial stages. The bacilli are attracted towards the degenerating and regenerating nerve fibres in cutaneous nerve plexuses. 3. The proneness of children to acquire the disease is explained on the basis of a continuous growth and change in the skin in childhood and the special liability of the cutaneous nerve plexuses to damage. 4. It is evident that as a therapeutic measure designed to control the course of the didease, the therapeutic agent or its products must reach the axonal substance so as to be able to exert their influence on the bacilli (AU). Descriptors: HANSENIASE/patol BIOPSIA/métodos MYCOBACTERIUM LEPRAE/isol Limits: HUMANO Location: BR191.1

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Id: 17206 Author: Khanolkar, V. R; Rajalaksmi, K. Title: A method for concentration of acid-fast bacilli in skin biopsies from leprosy patients. Source: Lepr Ind;24(2):47-62, apr., 1952. tab. Descriptors: HANSENIASE/diag HANSENIASE/microbiol HANSENIASE/patol BIOPSIA/métodos MYCOBACTERIUM LEPRAE/isol Location: BR191.1

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Id: 15632 Author: Shelleh, Hamdi H; Al-Shayeb, Abdul M; Khan, Sarosh A; Khan, Latif A; Al-Hateeti, Hussni S Title: Cold cellulitis: an unusual presentation of leprosy ..- Source: s.l; s.n; 2001. 2 p. ilus. Abstract: The presentation of leprosy plays an important role in it´s identification. The features of the disease determine how it is clinically approached and diagnosed. Leprosy has diverse types of presentations. They are commonly calm and insidious.(AU). Descriptors: DOENCA AGUDA BIOPSIA CELULITE/diag CELULITE/etiol DIAGNOSTICO DIFERENCIAL DERMATOSES FACIAIS/diag DERMATOSES FACIAIS/etiol INDIA/etnol HANSENIASE DIMORFA/compl HANSENIASE DIMORFA/diag HANSENIASE DIMORFA/quimioter HANSENIASE DIMORFA/etnol DISTRIBUICAO ESPACIAL Limits: RELATO DE CASO HUMANO MASCULINO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09105/s

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Id: 13952 Author: Mehdi, Ghazala; Maheshwari, Veena; Gaur, Sonal; Sharma, Rajeev Title: Histoid leprosy: diagnosis by fine needle aspiration cytology ..- Source: s.l; s.n; 2003. 3 p. ilus. Abstract: Histoid leprosy is a distinct and rare form of multibacillary leprosy that presents clinically as well-demarcated cutaneous and subcutaneous nodules similar to dermatofibroma.....(AU). Descriptors: HANSENIASE/patol HISTIOCITOMA FIBROSO/patol MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/isol CELULAS ESPUMOSAS/patol DIAGNOSTICO DIFERENCIAL NEOPLASIAS CUTÂNEAS/patol DERMATOPATIAS BACTERIANAS/patol BIOPSIA POR AGULHA - Hisd Limits: RELATO DE CASO HUMANO MASCULINO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09095/s

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Id: 13951 Author: Kiszewski, C. A; Becerril, E; Baquera, J; Aguilar, L. D; Hernández-Pando, R Title: Expression of transforming growth factor-beta isoforms and their receptors in lepromatous and tuberculoid leprosy ..- Source: s.l; s.n; 2003. 7 p. ilus, tab, graf. Abstract: Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TT) and lepromatous leprosy (LL), that are characterized by strong cell-mediated immunity (CMI) and CMI anergy, respectively. Transforming growth factor-beta (TGF-beta) belongs to a family of pleiotropic cytokines (TGF-beta1, TGF-beta2 and TGF-beta3) that participate in the control of cell differentiation and proliferation, as well as tissue repair. This cytokine family is unique because it suppresses CMI. In this study, we compared the expression of the three TGF-beta isoforms and their receptors in skin biopsies from LL and TT patients (LL = 20; TT = 20) using immunohistochemistry and automated morphometry. The percentage of cells immunostained for the three TGF-beta isoforms and cells positive for the three TGF-beta receptors in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexal tissue were significantly higher in LL than that in TT, with macrophages being the most common and strongest immunoreactive cells. Some lymphocytes, fibroblasts, keratinocytes and epithelial cells from sweat glands and hair roots were also positive. In situ reverse-transcription polymerase chain reaction corroborated the capacity of these cells to synthesize TGF-beta1 and TGF-beta receptor 2. This high expression of TGF-beta isoforms and their receptors could contribute to CMI anergy and other clinical characteristic features of leprosy, like skin atrophy. (AU). Descriptors: HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/metab HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/metab MYCOBACTERIUM LEPRAE ISOFORMAS DE PROTEINAS HIBRIDIZACAO IN SITU RNA MENSAGEIRO/quim RNA MENSAGEIRO/genet RECEPTORES DO FATOR DE CRESCIMENTO TRANSFORMADOR BETA/bios RECEPTORES DO FATOR DE CRESCIMENTO TRANSFORMADOR BETA/imunol PELE/citol PELE/imunol REACAO EM CADEIA POR POLIMERASE VIA TRANSCRIPTASE REVERSA IMUNOHISTOQUIMICA BIOPSIA FATOR DE CRESCIMENTO TRANSFORMADOR BETA/bios FATOR DE CRESCIMENTO TRANSFORMADOR BETA/genet FATOR DE CRESCIMENTO TRANSFORMADOR BETA/imunol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09092/s

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Id: 13932 Author: Boonpucknavig, Vijitr; Soontornniyomkij, Virawudh Title: Pathology of renal diseases in the tropics ..- Source: s.l; s.n; Jan. 2003. 19 p. ilus. Abstract: Renal diseases unique to the tropics are those that occur in association with infectious diseases including dengue hemorrhagic fever, typhoid fever, shigellosis, leptospirosis, lepromatous leprosy, malaria, opisthorchiasis, and schistosomiasis. These renal complications can be classified on the basis of their clinical and pathologic characteristics into acute transient reversible glomerulonephritis, chronic progressive irreversible glomerulonephritis, amyloidosis, and acute renal failure (ARF) resulting from acute tubular necrosis, acute tubulointerstitial nephritis, and thrombotic microangiopathy. Certain primary glomerular diseases including immunoglobulin (Ig) M nephropathy and focal segmental and global glomerulosclerosis are prevalent in some tropical countries. Renal complications of venomous snakebites also are common in the tropics. This article discusses and summarizes important works in the literature in respect to the clinical syndromes, pathologic features, and pathogenesis of tropical renal diseases both in humans and experimental animal models. (AU). Descriptors: DOENCAS TRANSMISSIVEIS/compl DOENCAS TRANSMISSIVEIS/diag GLOMERULOSCLEROSE FOCAL/etiol GLOMERULOSCLEROSE FOCAL/patol IMUNOHISTOQUIMICA NEFROPATIAS/epidemiol NEFROPATIAS/etiol NEFROPATIAS/patol NECROSE TUBULAR AGUDA/etiol NECROSE TUBULAR AGUDA/patol BIOPSIA POR AGULHA NEFRITE INTERSTICIAL/etiol NEFRITE INTERSTICIAL/patol PREVALÊNCIA PROGNOSTICO INDICE DE GRAVIDADE DE DOENCA TAXA DE SOBREVIVÊNCIA FATORES DE RISCO CLIMA TROPICAL/ef adv Limits: HUMANO MASCULINO FEMININO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09109/s

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Id: 13715 Author: Franco-Paredes, Carlos; Guarner, Jeannette; Mehrabi, Don; McCall, Calvin; Rio, Carlos del Title: Clinical and pathological recognition of leprosy ..- Source: s.l; s.n; 2003. 2 p. ilus. Descriptors: BIOPSIA/métodos HANSENOSTATICOS/uso terap HANSENIASE/quimioter HANSENIASE/patol PELE/patol COLORACAO E ROTULAGEM/métodos Limits: RELATO DE CASO HUMANO MASCULINO MEIA-IDADE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09136/s

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Id: 13704 Author: Antoni-Bach, N; Cribier, B; Piémont, Y; Heid, E; Lipsker, D Title: Lèpre: un diagnostic devenu difficile par sa rareté en France métropolitaine Leprosy: difficult to diagnose today because of its rarity in France- Source: s.l; s.n; 2002. 2 p. . Descriptors: BIOPSIA DIAGNOSTICO DIFERENCIAL FRANCA HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/patol PELE/patol Limits: RELATO DE CASO HUMANO FEMININO MEIA-IDADE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09001/s

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Id: 13701 Author: Singh, Navjeevan; Arora, V. K; Jain, Annu; Bhattacharya, S. N; Bhatia, Arati Title: Cytology of testicular changes in leprosy ..- Source: s.l; s.n; 2002. 5 p. ilus, tab. Abstract: OBJECTIVE: To study the changes in testicular aspirates and semen of patients with leprosy. STUDY DESIGN: A prospective study of 56 patients in the reproductive-age group, with no record of treatment for leprosy. Both Ridley-Jopling and WHO classification systems were used. Skin and/or nerve biopsies were performed for documentation of the diagnosis. Semen analysis and fine needle aspirates of the testes were performed. Smears from the testicular aspirates were stained with May-Grünwald-Giemsa and Ziehl-Neelsen stain. RESULTS: Five patients were unable to produce an ejaculate. Abnormal semen analysis and/or testicular aspirates were seen in 24 (42.8 per cent) patients. Eleven had oligospermia and eight azoospermia. Abnormalities in testicular aspirates ranged from hypospermatogenesis (4) through maturation arrest (1) and atrophy (11). Two patients had hydrocoele, and two had associated microfilariae. Three patients with multibacillary leprosy had type 2 reaction. Mycobacterium lepre was demonstrable in testicular aspirates from all patients with multibacillary and in three with paucibacillary leprosy. CONCLUSION: Abnormal semen analysis and/or testicular aspirates occur in a very high percentage of patients with leprosy. While this is expected for multibacillary disease, the high incidence in the paucibacillary form was surprising. With the rapid elimination of leprosy, fertility-related disability might emerge as a major problem in these people. (AU). Descriptors: BIOPSIA POR AGULHA HANSENIASE/microbiol HANSENIASE/patol SÊMEN/citol ESPERMATOGÊNESE TESTICULO/patol Limits: HUMANO MASCULINO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09008/s

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