Database : HANSEN Search on : HANSENIASE/IMUNOL [Subject descriptor] References found : 1342 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19877 Author: Porichha, D; Ramesh, V. Title: The primary lesion in leprosy. Source: Int. J. Lepr;66(3):388-390, Sept. 1998. . Descriptors: Hanseníase/imunol Hanseníase/patol Granuloma/patol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3cor02.pdf / en Location: BR191.1

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Id: 19872 Author: Stefani, Mariane M. A; Martelli, Celina M. T; Morais-Neto, Otaliba L; Martelli, Pierpaolo; Costa, Mauricio B; Andrade, Ana Lucia S. S de. Title: Assessment of anti-PGL-I as a prognostic marker of leprosy reaction. Source: Int. J. Lepr;66(3):356-364, Sept. 1998. tab, graf. Abstract: The anti-phenolic glycolipid-I (PGL-I) assay as currently applied for leprosy is conceived as an early marker of asymptomatic infection, early disease diagnosis and cure monitoring. Its use as a prognostic marker of reaction is still a matter of controversy. We conducted a case-control study to investigate whether IgM and IgG anti-PGL-I antibodies could discriminate patients at increased risk of developing reactions. Eligible cases were untreated leprosy patients at the onset of type 1 and type 2 reactions recruited from among 600 concurrent, newly detected, untreated leprosy patients attending an outpatient clinic in central Brazil. For the patients with reaction, approximately the same number of leprosy cases without reaction matched as to bacterial index (BI), age and gender were randomly selected. Individuals without clinical leprosy were evaluated as healthy controls. Sera from type 1 reaction (N = 43) and type 2 reaction (N = 26) patients were tested by an ELISA using PGL-I synthetic disaccharide-BSA antigen and 1:300 sera dilution (cut-off point > or = 0.2 OD). Antibody profiles were evaluated by exploratory data analysis and reverse cumulative distribution curves. The IgG anti-PGL-I response did not have a defined pattern, being detected only at low levels. Our results indicate that leprosy patients, independently of their reactional status, produce high levels of IgM anti-PGL-I, demonstrating a strong correlation between the magnitude of antibody response and the BI. Patients with a higher BI were at least 3.4 times more prone to produce an antibody response compared to healthy controls. (AU)^ien. Descriptors: Hanseníase/quimioter Hanseníase/imunol ELISA/instrum Imunoglobulina G/sangue Imunoglobulina M/sangue Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3a06.pdf / en Location: BR191.1

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Id: 19869 Author: Fokkens, Wytske J; Trenite, Gijs J. Nolst; Virmond, Marcus; KleinJan, Alex; Andrade, Vera L. G; Baar, Nino G. van; Naafs, Ben. Title: The nose in leprosy: Immunohistology of the nasal mucosa. Source: Int. J. Lepr;66(3):328-339, Sept. 1998. ilus, tab. Abstract: A detailed study of the nose was undertaken in 40 leprosy patients with different classifications of leprosy and different durations of disease at two hospitals in Brazil. This manuscript describes the immunohistochemical data on cellular infiltrates in the nasal biopsies of those patients. It was surprising that the damage to the whole depth of the nasal mucosa, epithelium and lamina propria was considerable, as was the case in the nasal mucosa which looked relatively normal during clinical inspection. The epithelium showed large holes which looked like very extended goblet cells. Very obvious was the lack of vasoconstriction after cocaine application, and the vessels also showed a lack of staining with factor VIII, possibly indicating a disruption of the endothelium. The number of neurofilaments was extensively reduced in all leprosy groups compared to normal controls. As in the skin, an increased number of CD68+ cells was found in the lamina propria of the nasal mucosa of the lepromatous patients. Contrary to findings in the skin, in the nasal mucosa of the borderline/lepromatous patients the number of CD4+ cells was increased and the number of CD8+ cells was decreased compared to normal controls. The number of CD8+ cells tended to be more reduced when the history of leprosy was longer. It is not clear as yet whether the reduced numbers of CD8+ cells are acquired during infection or whether persons with a low number of CD8+ cells in the nose might have a higher risk of acquiring leprosy. (AU)^ien. Descriptors: Hanseníase/imunol Hanseníase/patol Mucosa Nasal/imunol Mucosa Nasal/patol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3a03.pdf / en Location: BR191.1

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Id: 19860 Author: Anon. Title: Immunology. Source: Int. J. Lepr;66(4):94A-111A, Dec. 1998. . Conference: Present in: International Leprosy Congress, 15, Beijing, 07-12 Sept. 1998. Descriptors: Hanseníase/quimioter Hanseníase/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4abs08.pdf / en Location: BR191.1

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Id: 19854 Author: Anon. Title: Chemotherapy. Source: Int. J. Lepr;66(4):2A-18A, Dec. 1998. . Conference: Present in: International Leprosy Congress, 15, Beijing, 07-12 Sept. 1998. Descriptors: Hanseníase/quimioter Hanseníase/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4abs02.pdf / en Location: BR191.1

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Id: 19851 Author: Lockwood, Diana; Scollard, David M. Title: Report of workshop on nerve damage and reactions. Source: Int. J. Lepr;66(4):598-599, Dec. 1998. . Conference: Present in: International Leprosy Congress, 15, Beijing, 07-12 Sept. 1998. Descriptors: Hanseníase/compl Hanseníase/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4repcur03.pdf / en Location: BR191.1

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Id: 19848 Author: Grosset, J. H; Franzblau, Scott. Title: Report of workshop on chemotherapy. Source: Int. J. Lepr;66(4):595-596, Dec. 1998. . Conference: Present in: International Leprosy Congress, 15, Beijing, 07-12 Sept. 1998. Descriptors: Hanseníase/quimioter Hanseníase/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4repcur03.pdf / en Location: BR191.1

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Id: 19845 Author: Gillis, Thomas P. Title: Potential application of molecular biology to leprosy research. Source: Int. J. Lepr;66(4):591-592, Dec. 1998. . Conference: Present in: International Leprosy Congress, 15, Beijing, 07-12 Sept. 1998. Descriptors: Hanseníase/imunol Hanseníase/prev Hanseníase/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4repcur03.pdf / en Location: BR191.1

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Id: 19843 Author: Gupte, M. D. Title: Vaccine trials against leprosy. Source: Int. J. Lepr;66(4):587-589, Dec. 1998. tab. Conference: Present in: International Leprosy Congress, 15, Beijing, 07-12 Sept. 1998. Descriptors: Hanseníase/imunol Hanseníase/prev Mycobacterium leprae/imunol Limits: Humanos Masculino Feminino Criança Adolescente Adulto Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4repcur03.pdf / en Location: BR191.1

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Id: 19802 Author: Yogi, Yasuko; Endoh, Masumi; Banba, Tomoko; Okamura, Haruki; Nomaguchi, Hiroko. Title: Susceptibility to Mycobacterium leprae of ALY (Alymphoplasia) mice and IFN-gamma induction in the culture supernatant of spleen cells. Source: Int. J. Lepr;66(4):464-474, Dec. 1998. ilus, graf. Abstract: The aly/aly (alymphoplasia) mice from a mutation of a colony of the C57BL/6J mouse strain, which has a systemic absence of lymph nodes and Peyer's patches, are deficient in both T- and B-cell-mediated immune functions. We have undertaken a comparison of susceptibility to Mycobacterium leprae of ALY (aly/aly, aly/+) mice with C57BL/6J mice. The aly/aly mouse was found to have an excellent high susceptibility to M. leprae with no distinction between female and male. The aly/+ mouse also was more susceptible to M. leprae at an earlier stage than the C57BL/6J mouse. Therefore, we examined and compared the cytokine gene expression and gamma interferon (IFN-gamma) induction in the splenocytes of ALY mice. The expression of interleukin 4 (IL-4), IL-10 and IL-12 mRNA was weakly stimulated with ML-lysate in inoculated aly/aly mice but IL-2, IL-6, IGIF/IL-18 and IFN-gamma mRNA were not observed. None of the cytokine genes used appeared, except the mRNA for IL-1-alpha, when uninfected cultured spleen cells were stimulated with ML-lysate. Also, IFN-gamma production was not induced. However, the appearance of these cytokine genes was observed when stimulated with concanavalin A (ConA), and IFN-gamma production was also induced in the culture supernatant by aly/+ and even aly/aly mice stimulated with ConA. To examine the reason why IFN-gamma cannot be produced by splenocytes of ALY mice inoculated with M. leprae, we detected cytokine gene expression and IFN-gamma induction in the presence of recombinant murine IL-12 or IGIF/IL-18. IL-2 mRNA expression was detected in all of the mice tested in the presence of IL-12 but not in aly/aly mice under IGIF/IL-18, and iNOS mRNA expression was not observed in aly/aly mice under IL-12 or IGIF/IL-18. IL-4 and IL-10 mRNA were detected by aly/aly mice only by exposure to IGIF/IL-18. In culture, the supernatant with ML antigens of the aly/aly mice did not produce IFN-gamma in spite of the presence of IL-12 and IGIF/IL-18, while IFN-gamma was weakly induced in aly/+ mice stimulated with ML-lysate and in the presence of IGIF/IL-18. Nevertheless, IFN-gamma production was observed in splenocytes of the aly/aly mice stimulated with ConA and also with IGIF/IL-18 plus anti-CD3 antibody. Our results suggest that ALY mice might be showing a high susceptibility to M. leprae because of deficient priming for activation of T cells with the leprosy bacilli infection. Moreover, it is possible that the phagocytic activities of the macrophages of ALY mice are also impaired. (AU)^ien. Descriptors: Hanseníase/genet Hanseníase/imunol Mycobacterium leprae/genet Mycobacterium leprae/imunol Limits: Animais Camundongos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4a04.pdf / en Location: BR191.1

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Id: 19788 Author: Antia, Noshir H. Title: A critique on the interpretation of the lepromin reaction using heat kiled M. leprae vaccine. Source: Int J Lep;57(1):110-111, Mar. 1989. . Descriptors: Mycobacterium leprae/imunol Hanseníase/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1cor01.pdf / en Location: Br191.1

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Id: 19787 Author: Pfaltzgraff, Roy E. Title: The management of reaction in leprosy. Source: Int J Lep;57(1):103-109, Mar. 1989. . Abstract: Reaction and the subsequent development of neuritis is the basis for the majority of the disabilities and deformities that occur in leprosy. All possible means to prevent, to treat, and to reverse every reaction should be employed in all-out effort to ultimately effect as ideal a functional status for the patient as can be attained^ien. Descriptors: Hanseníase/quimioter Hanseníase/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1edt03.pdf / en Location: Br191.1

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Id: 19785 Author: Ramos, Teresa; Zalcberg-Quintana, Ilana; Appelberg, Rui; Sarno, Euzenir N; Silva, Manuel T. Title: T-helper cell subpopulations and the immune spectrum of leprosy. Source: Int J Lep;57(1):73-81, Mar. 1989. . Descriptors: Hanseníase/genet Hanseníase/imunol Linfócitos T Auxiliares-Indutores/clas Linfócitos T Auxiliares-Indutores/imunol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1edt01.pdf / en Location: Br191.1

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Id: 19782 Author: Saidi, Kiumars Ghazi; Stanford, John L; Stanford, Cynthia A; Rook, Graham AW; Dowlati, Yahya; Rees, Richard JW. Title: Vaccination and skin test studies on children living in villages with differing endemicity for leprosy and tuberculosis. Source: Int J Lep;57(1):45-53, Mar. 1989. ^btab. Abstract: The purpose of this study carried out in Iranian Azerbaijan was to determine the pattern of skin-test positivity to mycobacterial antigens in children living in the valley, and to assess the effect on this of a series of vaccines against mycobacterial disease. Set up in 1978, 1707 tuberculin-negative children without scars of previous BCG vaccination were vaccinated with BCG Glaxo alone (vaccine A) or with the addition of a suspension of killed Mycobacterium vaccae (vaccine B). One hundred children were vaccinated with BCG Glaxo plus a suspension of M. leprae (vaccine C). Eight to 10 years later about half of the children were found for follow up. At this time further children were skin tested, and the results obtained were related to whether or not they had scars of vaccination with BCG Pasteur (Teheran) given by the local health authorities. Between setting up the study and the first follow up, cases of leprosy or tuberculosis had occurred in some of the villages, although not among those we had vaccinated. Differences between the effects of the vaccines were only found in villages with cases of leprosy. In these villages positivity to leprosin A was significantly greater after vaccine B (49%) than after vaccine A (36%; p less than 0.04). The results for scrofulin and vaccine were the same after both vaccines, and significantly lower than in the villages without cases of leprosy. The general reduction in skin-test positivity in the villages with leprosy cases was mainly due to a loss of category 1 responders to group i, common mycobacterial, antigens. It was concluded that where casual contact with cases of leprosy occurs the combination of BCG with killed M. vaccae is likely to be a better vaccine for leprosy than is BCG alone. Although few children received the combination with M. leprae, the results obtained were not particularly promising^ien. Descriptors: Hanseníase/epidemiol Hanseníase/imunol Tuberculose/epidemiol Tuberculose/imunol Limits: Humanos Masculino Feminino Criança Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1a07.pdf / en

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Id: 19781 Author: Stanford, John L; Stanford, Cynthia A; Saidi, Kiumars Ghazi; Dowlati, Yahya; Weiss, Sister Fabiola; Farshchi, Yusef; Madlener, Frits; Rees, Richard JW. Title: Vaccination and skin test studies on the children of leprosy patients. Source: Int J Lep;57(1):38-44, Mar. 1989. ^bgraf, ^btab. Abstract: The purpose of this study carried out in Iranian Azerbaijan was to determine the pattern of skin-test positivity to mycobacterial antigens in children living in the valley, and to assess the effect on this of a series of vaccines against mycobacterial disease. Set up in 1978, 1707 tuberculin-negative children without scars of previous BCG vaccination were vaccinated with BCG Glaxo alone (vaccine A) or with the addition of a suspension of killed Mycobacterium vaccae (vaccine B). One hundred children were vaccinated with BCG Glaxo plus a suspension of M. leprae (vaccine C). Eight to 10 years later about half of the children were found for follow up. At this time further children were skin tested, and the results obtained were related to whether or not they had scars of vaccination with BCG Pasteur (Teheran) given by the local health authorities. Between setting up the study and the first follow up, cases of leprosy or tuberculosis had occurred in some of the villages, although not among those we had vaccinated. Differences between the effects of the vaccines were only found in villages with cases of leprosy. In these villages positivity to leprosin A was significantly greater after vaccine B (49%) than after vaccine A (36%; p less than 0.04). The results for scrofulin and vaccine were the same after both vaccines, and significantly lower than in the villages without cases of leprosy. The general reduction in skin-test positivity in the villages with leprosy cases was mainly due to a loss of category 1 responders to group i, common mycobacterial, antigens. It was concluded that where casual contact with cases of leprosy occurs the combination of BCG with killed M. vaccae is likely to be a better vaccine for leprosy than is BCG alone. Although few children received the combination with M. leprae, the results obtained were not particularly promising^ien. Descriptors: Hanseníase/imunol Hanseníase/prev Mycobacterium leprae/imunol Tuberculose/imunol Tuberculose/prev Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1a06.pdf / en Location: Br191.1

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Id: 19776 Author: Mustafa, Abu Salim; Qvigstad, Erik. Title: HLA-DR-restricted antigen induced proliferation and cytotoxicity mediated by CD4+ T-cell clones from subjects vaccinated with killed M. leprae. Source: Int J Lep;57(1):1-11, Mar. 1989. ^btab. Abstract: Thirteen CD4+ T-cell clones raised against Mycobacterium leprae from three M. leprae-vaccinated subjects were studied for major histocompatibility complex (MHC) restriction in proliferative and cytotoxicity assays. These T-cell clones recognized at least nine different epitopes, ranging from M. leprae-specific to broadly crossreactive. Restriction studies with a panel of antigen-presenting cells (APCs) suggest that all of the T-cell clones recognized antigens in the context of the DR locus. Three T-cell clones with three different reactivities from a DR1, 2-positive subject responded to M. leprae in proliferation and cytotoxicity when the antigen was presented in the context of DR1-positive APCs. Four T-cell clones responding to M. leprae-specific or crossreactive epitopes from the second donor, who was DR4,DW4; DR4,Dw14-positive, and a single M. leprae-specific T-cell clone from the third subject, who was DR3,4:Dw4, recognized the antigens in the presence of Dw4 APCs. Four crossreactive T-cell clones from the second subject responded in the presence of Dw14-positive APCs, and one limited crossreactive clone recognized the antigen in the context of DR4 and DR7-positive cells, suggesting that its response was restricted by a common determinant. The T-cell clones that recognize the 65-kDa, 18-kDa, and 13B3 recombinant M. leprae antigens in proliferative assays were cytotoxic for autologous adherent cells pulsed with the respective antigens^ien. Descriptors: Hanseníase/imunol Mycobacterium leprae/imunol Linfócitos/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1a01.pdf / en Location: Br191.1

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Id: 19765 Author: Grosset, Jacques H; Baohong, Ji. Title: Controled clinical trial for evaluation of antimicrobial drug activity against M leprae. Source: Int J Lepr;57(2):529-531, June 1989. . Descriptors: Mycobacterium leprae/ef drogas Hanseníase/imunol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2clinot02.pdf / en Location: Br191.1

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Id: 19764 Author: Pannikar, Vijayakumar; Jesudasan, Kumar; Christinan, Melville. Title: Relapse or later reversal reaction. Source: Int J Lepr;57(2):526-528, June 1989. ^btab. Descriptors: Mycobacterium leprae/ef drogas Mycobacterium leprae/imunol Hanseníase/imunol Hanseníase/patol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2clinot01.pdf / en Location: Br191

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Id: 19763 Author: Antia, Noshir H; Birdi, TJ. Title: The macrophage in leprosy: a review on the current status. Source: Int J Lepr;57(2):511-525, June 1989. . Descriptors: Mycobacterium leprae/isol Mycobacterium leprae/patogen Hanseníase/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2edt.pdf / en Location: Br191.1

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Id: 19746 Author: Kato, Laszlo. Title: Comments in leprosy vaccination. Source: Int J Lep;57(3):693-694, sept. 1989. . Descriptors: Hanseníase/imunol Hanseníase/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n3/v57n3cor03.pdf / en Location: Br191.1

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