Database : HANSEN Search on : IMUNOHISTOQUIMICA [Subject descriptor] References found : 47 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 18202 Author: Walsh, Douglas S; Lane, Joshua E; Abalos, Rodolfo M; Myint, Khin Saw Aye Title: Tunel and limited immunophenotypic analysis of apoptosis in paucibacillary leprosy lesions ..- Source: s.l; s.n; 2004. 5 p. ilus. Abstract: Some mycobacterial infections, such as tuberculosis, are characterized by apoptosis in infected or by-stander mononuclear immune cells. For localized (paucibacillary, PB) and diseminated (multibacillary, MB) leprosy, characterized by polarized Thl-like vs, Th2-like immune responses, respectivelly little is known about lesional apoptosis. We analyzed sections of paraffin-embedded, untreated leprosy lesions from 21 patients by an indirect immunofluorescent terminal deoxynucleotide-transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) assay. Some TUNEL (+) PB sections were then reacted with phycoerythein-conjugated (red)antibodies against T cells, monocytes, or antigen-presenting (Langerhans) cells. TUNEL (+) bodies were detected in 9 of 16 PB lesions (56%) and in 1 of 5 MB lesions (20%). Some TUNELL (+) bodies in PB disease were CD3+ (T cell), as well as CD4+ (T-helper) or cd8+ (T-cytotoxic) Apoptosis characterizes PB and MB leprosy lesions and may be more freqeunt in PB disease. In PB disease, some TUNEL (+) bodies may derive from T cells (AU). Descriptors: HANSENIASE DIMORFA/imunol HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/imunol HANSENIASE/imunol IMUNOHISTOQUIMICA/util MYCOBACTERIUM LEPRAE/patogen HANSENIASE/patol HANSENIASE DIMORFA/patol HANSENIASE VIRCHOWIANA/patol HANSENIASE TUBERCULOIDE/patol - APOPTOSE/imunol  APOPTOSE/fisiol  IMUNOHISTOQUIMICA/normas  BIOPSIA/util Limits: HUMANO Location: BR191.1; 09200/s

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Id: 17559 Author: Save, M. P; Shetty, V. P; Shetty, K. T; Antia, N. H Title: Alterations in neurofilament protein(s) in human leprous nerves: morphology, immunohistochemistry and Western immunoblot correlative study ..- Source: s.l; s.n; 2004. 16 p. ilus, tab. Abstract: Using a specific antibody (SMI 31), the state of phosphorylation of high and medium molecular weight neurofilaments (NF-H and NF-M) was studied in 22 leprous and four nonleprous human peripheral nerves by means of immunohistochemistry, sodium dodecyl sulfate-poly acrylamide gel electrophoresis (SDS-PAGE) and Western immunoblot (WB). The results thus obtained were compared with morphological changes in the respective nerves studied through light and electron microscopy. Many of the leprous nerves showing minimal pathology revealed lack of or weak staining with SMI 31, denoting dephosphorylation. Remyelinated fibres stained intensely with SMI 31 antibody. The WB analysis of Triton X-100 insoluble cytoskeletal preparation showed absence of regular SMI 31 reactive bands corresponding to 200 and 150 kDa molecular weight (NF-H and NF-M, respectively) in 10 nerves. Three of the 10 nerves revealed presence of NF protein bands in SDS-PAGE but not in WB. Presence of additional protein band (following NF-M) was seen in four nerves. Two nerves revealed NF-H band but not NF-M band and one nerve showed trace positivity. In the remaining five nerves presence of all the three NF bands was seen. Thus, 77.3% (17/22) of human leprous nerves studied showed abnormal phosphorylation of NF protein(s). The ultrastructural study showed abnormal compaction and arraying of NF at the periphery of the axons in the fibres with altered axon to myelin thickness ratio (atrophied fibres) as well as at the Schmidt-Lantermann (S-L) cleft region. Such NF changes were more pronounced in the severely atrophied axons suggesting a direct correlation. The observed well-spaced NF in the remyelinated fibres under ultrastructural study was in keeping with both intense SMI 31 staining and presence of NF triplet bands seen in WBs in four of leprous nerves that showed a large number of regenerating fibres suggesting reversal of changes with regeneration. Findings in the present study suggest that atrophy, that is, the reduction in axonal calibre and paranodal demyelination, seen in leprous nerves may result from dephosphorylation of NF-H and NF-M proteins. (AU). Descriptors: Doença de Alzheimer/PA Esclerose Amiotrófica Lateral/PA Atrofia Axônios/PA Western Blotting Citoesqueleto/ME/PA Doenças Desmielinizantes/PA Eletroforese em Gel de Poliacrilamida Imunohistoquímica Hanseníase/*ME Fibras Nervosas/PA Proteínas de Neurofilamentos/*ME Neurônios/*ME/*PA/UL Inclusão em Parafina Fosforilação Limits: Research Support, Non-U.S. Gov't Humanos Location: BR191.1; 09338/s

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Id: 17339 Author: Jjoo, David; Hu, Ricardo V. P; Tank, Bhupendra; Kolk, Arend, H. J; Koyy, Angela; Kant, Rene; Naafs, Bernard. Title: Detection of shared antigenic determinants between Mycobacterium leprae heat shock protein 65 and human heat shock protein 60. Source: Hansen. Int;28(1):31-43, jan.-jun. 2003. tab. Abstract: In these studies, it was investigated whether M. leprae and man share antigenic determinants which may be located on Heat Shock Proteins (HSPs), and which may be responsible for tissue destruction. Using immunoperoxidase single-staining technique on cryostat sections it was observed that three antibodies which are directed against HSP 60 (polyclonal antibodies SPA 804 and SPA 805 and monoclonal antibody SPA 807) probably reacted specifically with macrophages and epitheloid cells in leprosy skin sections. On Western Blotting, it was observed that the antibodies againts human HSP 60 nomoclonal antibodies (MoAbs) against M. leprae HSP 65 (F 47-10, F 67-18, F 88-1) all reacted strongly with sonicated M. leprae proteins with a molecular mass of 65 kDa undicating similarity of some antigenic determinants between human HSP 60 and M. leprae HSP 65. Subsequently, a comparative immunohistochemical study of the staining patterns of antibodies against human HSP 60 and antibodies against M. leprae HSP 65 using cryostat skin section of paucibacillary (PB) leprosy multibacillary (MB) leprosy and other granulomatous skin disorders revealed that the MoAbs F 47-10 and F 67-18 reacted only weakly with the granulomas in PB leprosy and in other granulomatous skin diseases, but stained MB leprosy granuloma strongly. The MoAb F 88-1 and the polyclonal antibodies SPA 804, SPA 805 and the MoAb SPA 807 stained granulomas of PB patients and of other granulomatous skin disorders with the same intensity as that MB patients. Using a double-staining technique, it was observed that the antigenic determinants recognized by the MoAb against human HSP 60 (SPA 807) and the MoAbs against M. leprae HSP 65 (F 67-18, F 47-10, F 88-1) were mostly located in the macrophages. These findings do not contradict our suggestion, Heath Shock Proteins of M. leprae and the human host may be at least in part responsible for the induction of an autoimmune reaction causing granuloma formation with subsequent tissue damage in leprosy. The results of this study also indicated that some of these determinats are probably located on HSP 60. A similar explanation possibly applies to the findings in the other granulomatous disease e.g. sarcoidosis probably micobacterial induced and necrobiosis lipoidica related to diabetis, in which antigenic similarities between bacterial HSP 65 and human HSP 60 are considered to play a part. (AU). Descriptors: HANSENIASE/imunol HANSENIASE/microbiol HANSENIASE/fisiopatol MYCOBACTERIUM LEPRAE/imunol IMUNOHISTOQUIMICA/métodos IMUNOHISTOQUIMICA/util - IMUNOELETROFORESE/métodos  IMUNOELETROFORESE/util  RESPOSTA A CHOQUE TERMICO/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v21aov29/2003/PDF/v28n1/v28n1a02eng.pdf / en Location: BR191.1

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Id: 17338 Author: Njoo, David; Hu, Ricardo, V. P; Tank, Bhupendra; Kolk, Arend H. J; Kooy, Angela; Kant, René; Naafs, Bernard. Title: Deteccao de determinantes antigenicos compartilhados entre a proteina de choque termico 65 do Mycobacterium leprae e proteina de choque termico 60 humana / Detection of shared antigenic determinantes between Mycobacterium leprae heat shock protein 65 and human heat shock protein 60 Source: Hansen. Int;28(1):19-30, jan.-jun. 2003. tab, graf. Abstract: Nestes estudos foram investigados se o Mycobacterium leprae (M. leprae) e o homem compartilham determinantes antigenicos que podem estar localizados nas Proteinas de Choque Termico (HSPs) e que podem ser responsaveis pela destruicao tecidual. Usando-se tecnica de coloracao unica pela imunoperoxidase em cortes feitos com criostato, observaram-se tres anticorpos que eram dirigidos contra HSP-60 (anticorpos policlonais SPA-804, SP-805 e o anticorpo monoclonal SPA-807, que provavelmente reagiram especificamente com macrofagos e celular epitelioides em biopsia cutaneas de pacientes com hanseniase. No Western Blot foi observado que todos os anticorpos contra HSP-60 humana a anticorpos monoclonais (MoAbs) contra HSP-65 do M. leprae (F47-10, F67-18, F88-1) reagiram intensamente com as proteinas do M. leprae sonicado com peso molecular de 65 kDa, indicando semelhanca de alguns determinantes antigenicos entre HSP-60 humana e HSP-65 do M. leprae. Subsequentemente, um estudo imunohistoquimico comparativo dos padroes de coloracao de anticorpos contra HSP-60 humana e anticorpos contra HSP-65 do M. leprae, usando cortes cutaneos feito em criostato de hanseniase paucibacilar (PB), multibacilar (MB) e outras doencas granulomatosas, revelaram que os MoAbs F47-10 e F67-18 reagiram somente fracamente com os granulomas em hanseniase PB e em outras doencas granulomatosas cutaneas, mas coravam o granuloma da hanseniase MB intensamente. O MoAb F88-1 e os anticorpos policlonais SPA-804, SPA-805 e o MoAb SPA 807 coraram os granulomas dos pacientes PB e de outros doencas cutaneas granulomatosas com a mesma intensidade daquela nos pacientes MB. Utilizando-se uma tecnica de dupla coloracao, observou-se que os determinantes antigenicos reconhecidos pelo MoAb contra HSP-60 humana (SPA-807) e os MoBbs contra a HSP-65 do M. leprae (F67-18, F47-10, F88-1) estavam, na maioria das vezes, localizados nos macrofagos. Esses achados nao contradizem nossa hipotese de que semelhancas entre determinantes antigenicos nas HSPs no M. leprae e no hospedeiro humano podem ser, no minimo em parte, responsaveis pela inducao de uma reacao autoimune na hanseniase causando formacao de granuloma com subsequente dano tecidual. Os resultados deste estudo tambem indicaram que alguns destes determinantes estao provavelmente localizados na HSP-60. Uma explicacao similar possivelmente se aplique aos achados em...(AU). Descriptors: HANSENIASE/imunol HANSENIASE/microbiol HANSENIASE/fisiopatol MYCOBACTERIUM LEPRAE/imunol IMUNOHISTOQUIMICA/métodos IMUNOHISTOQUIMICA/util - IMUNOELETROFORESE/métodos  IMUNOELETROFORESE/util  RESPOSTA A CHOQUE TERMICO/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v21aov29/2003/PDF/v28n1/v28n1a02.pdf / pt Location: BR191.1

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Id: 17315 Author: Kirkaldy, A. A; Musonda, A. C; Khanolkhar-Young, S; Suneetha, S; Lockwood, D. N. J Title: Expression of CC and CXC chemokines and chemokine receptors in human in human leprosy skin lesions ..- Source: s.l; s.n; 2003. 7 p. ilus, tab, graf. Abstract: We have investigated the expression of chemokines and their receptors in leprosy skin lesions using immunohistochemistry. Skin biopsies from 25 leprosy patients across the leprosy spectrum, 11 patients undergoing type I reversal reactions and four normal donors were immunostained by ABC peroxidase method using antibodies against CC and CXC chemokines and their receptors. Using an in situ hybridization technique we have also studied the expression of monocyte chemoattractant protein 1 (MCP-1), RANTES and interleukin (IL)-8 chemokines mRNA in leprosy skin lesions. Chemokines and receptor expression was detected in all leprosy skin biopsies. Expression of CC chemokines MCP-1 (P < 0.01) and RANTES (P < 0.01) were elevated significantly in borderline tuberculoid leprosy in reversal reaction compared to non-reactional borderline tuberculoid leprosy, but there was no difference in the expression of IL-8 chemokine. Surprisingly, there was no significant difference in the expression of CC (CCR2 and CCR5) and CXC (CXCR2) chemokine receptors across the leprosy spectrum. Similarly, there was no significant difference in the expression of mRNA for MCP-1, regulated upon activation normal T cell expressed and secreted (RANTES) and IL-8 chemokines. Here, the presence of a neutrophil chemoattractant IL-8 in leprosy lesions, which do not contain neutrophils, suggests strongly a role of IL-8 as a monocyte and lymphocyte recruiter in leprosy lesions. These results suggest that the chemokines and their receptors, which are known to chemoattract T lymphocytes and macrophages, are involved in assembling the cellular infiltrate found in lesions across the leprosy spectrum. (AU). Descriptors: Linfócitos T CD4-Positivos/IM Linfócitos T CD8-Positivos/IM Quimiocinas/*AN/GE Imunohistoquímica/MT Hibridização In Situ/MT Interleucina-8/GE Hanseníase/*IM Macrófagos/IM Proteína-1 Quimioatraente de Monócito/GE RANTES/GE RNA Mensageiro/AN Receptores CCR5/AN Receptores de Quimiocinas/*AN/GE Receptores de Interleucina-8B/AN Limits: Humano Pele/*IM Estatísticas não Paramétricas Location: BR191.1; 00253/s

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Id: 13951 Author: Kiszewski, C. A; Becerril, E; Baquera, J; Aguilar, L. D; Hernández-Pando, R Title: Expression of transforming growth factor-beta isoforms and their receptors in lepromatous and tuberculoid leprosy ..- Source: s.l; s.n; 2003. 7 p. ilus, tab, graf. Abstract: Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TT) and lepromatous leprosy (LL), that are characterized by strong cell-mediated immunity (CMI) and CMI anergy, respectively. Transforming growth factor-beta (TGF-beta) belongs to a family of pleiotropic cytokines (TGF-beta1, TGF-beta2 and TGF-beta3) that participate in the control of cell differentiation and proliferation, as well as tissue repair. This cytokine family is unique because it suppresses CMI. In this study, we compared the expression of the three TGF-beta isoforms and their receptors in skin biopsies from LL and TT patients (LL = 20; TT = 20) using immunohistochemistry and automated morphometry. The percentage of cells immunostained for the three TGF-beta isoforms and cells positive for the three TGF-beta receptors in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexal tissue were significantly higher in LL than that in TT, with macrophages being the most common and strongest immunoreactive cells. Some lymphocytes, fibroblasts, keratinocytes and epithelial cells from sweat glands and hair roots were also positive. In situ reverse-transcription polymerase chain reaction corroborated the capacity of these cells to synthesize TGF-beta1 and TGF-beta receptor 2. This high expression of TGF-beta isoforms and their receptors could contribute to CMI anergy and other clinical characteristic features of leprosy, like skin atrophy. (AU). Descriptors: HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/metab HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/metab MYCOBACTERIUM LEPRAE ISOFORMAS DE PROTEINAS HIBRIDIZACAO IN SITU RNA MENSAGEIRO/quim RNA MENSAGEIRO/genet RECEPTORES DO FATOR DE CRESCIMENTO TRANSFORMADOR BETA/bios RECEPTORES DO FATOR DE CRESCIMENTO TRANSFORMADOR BETA/imunol PELE/citol PELE/imunol REACAO EM CADEIA POR POLIMERASE VIA TRANSCRIPTASE REVERSA IMUNOHISTOQUIMICA BIOPSIA FATOR DE CRESCIMENTO TRANSFORMADOR BETA/bios FATOR DE CRESCIMENTO TRANSFORMADOR BETA/genet FATOR DE CRESCIMENTO TRANSFORMADOR BETA/imunol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09092/s

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Id: 13932 Author: Boonpucknavig, Vijitr; Soontornniyomkij, Virawudh Title: Pathology of renal diseases in the tropics ..- Source: s.l; s.n; Jan. 2003. 19 p. ilus. Abstract: Renal diseases unique to the tropics are those that occur in association with infectious diseases including dengue hemorrhagic fever, typhoid fever, shigellosis, leptospirosis, lepromatous leprosy, malaria, opisthorchiasis, and schistosomiasis. These renal complications can be classified on the basis of their clinical and pathologic characteristics into acute transient reversible glomerulonephritis, chronic progressive irreversible glomerulonephritis, amyloidosis, and acute renal failure (ARF) resulting from acute tubular necrosis, acute tubulointerstitial nephritis, and thrombotic microangiopathy. Certain primary glomerular diseases including immunoglobulin (Ig) M nephropathy and focal segmental and global glomerulosclerosis are prevalent in some tropical countries. Renal complications of venomous snakebites also are common in the tropics. This article discusses and summarizes important works in the literature in respect to the clinical syndromes, pathologic features, and pathogenesis of tropical renal diseases both in humans and experimental animal models. (AU). Descriptors: DOENCAS TRANSMISSIVEIS/compl DOENCAS TRANSMISSIVEIS/diag GLOMERULOSCLEROSE FOCAL/etiol GLOMERULOSCLEROSE FOCAL/patol IMUNOHISTOQUIMICA NEFROPATIAS/epidemiol NEFROPATIAS/etiol NEFROPATIAS/patol NECROSE TUBULAR AGUDA/etiol NECROSE TUBULAR AGUDA/patol BIOPSIA POR AGULHA NEFRITE INTERSTICIAL/etiol NEFRITE INTERSTICIAL/patol PREVALÊNCIA PROGNOSTICO INDICE DE GRAVIDADE DE DOENCA TAXA DE SOBREVIVÊNCIA FATORES DE RISCO CLIMA TROPICAL/ef adv Limits: HUMANO MASCULINO FEMININO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09109/s

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Id: 13741 Author: Fiallo, Paolo; Clapasson, Andrea; Favre, Anna; Pesce, Carlo Title: Overexpression of vascular endothelial growth factor and its endothelial cell receptor KDR in type I leprosy reaction ..- Source: s.l; s.n; Feb. 2002. 6 p. ilus, tab. Abstract: The sites of expression of vascular endothelial growth factor (VEGF) and of KDR, its endothelial cell receptor, were investigated in leprosy reaction Type 1, or reversal reaction (RR), by immunohistochemistry and in situ hybridization. In comparison with nonreactional leprosy, overexpression of both VEGF and KDR was seen in granuloma cells, especially epithelioid and foreign body-type giant cells, the epithelium and the vascular endothelium of RR specimens. In granuloma cells, hybridization for VEGF was stronger than immunostaining, a finding that may reflect the rapid turnover of VEGF in an immunologically dynamic situation such as RR. In the epidermis, double immunohistochemistry revealed VEGF overexpression in CDla-positive dendritic cells. The VEGF may not only be relevant for hyperpermeability and mononuclear cell differentiation (the key morphologic features in the acute, clinically evident phase of RR), but it could also be implicated in RR onset, when dendritic cells are activated in response to antigen stimulation. (AU). Descriptors: PRIMERS DO DNA FATORES DE CRESCIMENTO ENDOTELIAL/metab HANSENIASE DIMORFA/metab HANSENIASE DIMORFA/patol RECEPTORES DOS FATORES DE CRESCIMENTO/metab RECEPTORES MITOGÊNICOS/metab LINFOCINAS/metab RECEPTORES PROTEINA TIROSINA QUINASES/metab IMUNOHISTOQUIMICA HIBRIDIZACAO IN SITU - INCLUSAO EM PARAFINA Limits: HUMANO SUPPORT, NON-U.S. GOV'T RECEPTORES DE FATOR DE CRESCIMENTO DO ENDOTELIO VASCULAR Electronic Medium: http://www.ilsl.br Location: BR191.1; 09033/s

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Id: 12291 Author: Little, David; Khanolkar-Young, Saroj; Coulthart, Anne; Suneetha, Sujai; Lockwood, Diana N. J Title: Immunohistochemical analysis of cellular infiltrate and gamma interferon, interleukin-12, and inducible nitric oxide synthase expression in leprosy type 1 (reversal) reactions before and during prednisolone treatment ..- Source: s.l; s.n; May 2001. 5 p. ilus, tab, graf. Descriptors: IMUNOHISTOQUIMICA INTERFERON TIPO II INTERLEUCINA-12 HANSENIASE HANSENIASE HANSENIASE SINTASE DE OXIDO NITRICO PREDNISOLONA Location: BR191.1; 08686/s

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Id: 12288 Author: Adams, Linda B; Scollard, David M; Ray, Nashome A; Cooper, Andrea M; Frank, Anthony A; Orme, Ian M; Krahenbuhl, James L Title: The study of mycobacterium leprae infection in interferon-gamma gene - disrupted mice as a model to explore the immunopathologic spectrum of leprosy ..- Source: s.l; s.n; 2002. 8 p. ilus, graf. Descriptors: LINFOCITOS T CD4-POSITIVOS LINFOCITOS T CD8-POSITIVOS CITOCINAS MODELOS ANIMAIS DE DOENÇAS CITOMETRIA DE FLUXO PELE PELE DELEÇAO DE GENES IMUNOHISTOQUIMICA INTERFERON TIPO II HANSENIASE HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA MACROFAGOS PERITONEAIS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE Limits: ANIMAL Location: BR191.1; 08655/s

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Id: 12264 Author: Gerosa, P. L; Spinelli, M; Giussani, G; Vai, C; Fontana, A; Canepari, C Title: Neurofibromatosi(NF1) e neurolabbra: immunoreazione verso cellule di Schwann patologiche Neurofibromatosis (NF1) and neuroleprosy: immunoreaction against pathologic Schwann-cells physiopathogenetic observations- Source: s.l; s.n; 2001. 9 p. ilus, tab. Descriptors: IMUNOHISTOQUIMICA HANSENIASE HANSENIASE DIMORFA DOENÇAS DO SISTEMA NERVOSO NEUROFIBROMATOSE CÉLULAS DE SCHWANN Location: BR191.1; 08695/s

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Id: 12228 Author: Mustafa, T; Bjune, G; Jonsson, R; Pando, R. H.; Nilsen, R Title: Increased expression of fas ligand in human tuberculosis and leprosy lesions: a potential novel mechanism of immune evasion in mycobacterial infection ..- Source: s.l; s.n; 2001. 10 p. ilus, tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS ANTIGENOS CD ANTIGENOS CD95 ANTIGENOS DE DIFERENCIAÇAO MIELOMONOCITICA APOPTOSE GRANULOMA DE CORPO ESTRANHO GRANULOMA DE CORPO ESTRANHO IMUNOHISTOQUIMICA LEISHMANIOSE CUTANEA LEISHMANIOSE CUTANEA HANSENIASE HANSENIASE HANSENIASE GLICOPROTEINAS DE MEMBRANAS MODELOS IMUNOLOGICOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS TUBERCULOSE TUBERCULOSE TUBERCULOSE Location: BR191.1; 08711/s

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Id: 11947 Author: Fiallo, Paolo; Clapassom, Andrea; Favre, Anna; Pesce, Carlo Title: Overexpression of vascular endothelial growth factor and its endothelial cell receptor KDR in type 1 leprosy reaction ..- Source: s.l; s.n; 2002. 6 p. ilus, tab. Descriptors: HANSENIASE DIMORFA HANSENIASE DIMORFA PRIMERS DO DNA FATORES DE CRESCIMENTO ENDOTELIAL IMUNOHISTOQUIMICA HIBRIDIZAÇAO IN SITU LINFOCINAS INCLUSAO EM PARAFINA RECEPTORES DOS FATORES DE CRESCIMENTO RECEPTORES MITOGENICOS Location: BR191.1; 08598/s

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Id: 11945 Author: Lockwood, Diana N. J; Colston, M. J; Khanolkar-Young, S. R Title: The detection of Mycobacterium leprae protein and carbohydrate antigens in skin and nerve from leprosy patients with type 1 (reversal) reactions ..- Source: s.l; s.n; 2002. 7 p. ilus, tab. Descriptors: HANSENIASE DIMORFA HANSENIASE DIMORFA MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ANTICORPOS ANTIBACTÉRIAS ANTICORPOS MONOCLONAIS ANTIGENOS DE BACTÉRIAS BIOPSIA CHAPERONINAS CHAPERONINAS HIPERSENSIBILIDADE TARDIA IMUNOHISTOQUIMICA LIPOPOLISSACARIDIOS LIPOPOLISSACARIDIOS MACROFAGOS NERVOS PERIFÉRICOS NERVOS PERIFÉRICOS CÉLULAS DE SCHWANN PELE PELE Location: BR191.1; 08600/s

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Id: 11888 Author: Siddiqui, M. Ruby; Moreira, Andre L; Negesse, Yohannes; Taye, Genet A; Hanekom, Willem A; Haslett, Patrick A; Britton, Swen; Kaplan, Gilla Title: Local nerve damage in leprosy does not lead to an impaired cellular immune response or decreased wound healing in the skin ..- Source: s.l; s.n; 2002. 6 p. ilus, tab. Descriptors: HANSENIASE HANSENIASE HANSENIASE ANTIGENOS CD1 ANTIGENOS CD13 ANTIGENOS CD18 BIOPSIA HIPERSENSIBILIDADE TARDIA IMUNOHISTOQUIMICA MYCOBACTERIUM LEPRAE NEURITE NEURITE NEURITE TESTE TUBERCULINICO CICATRIZAÇAO DE FERIDAS Location: BR191.1; 08577/s

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Id: 11755 Author: Adams, Linda B; Scollard, David M; Ray, Nashone A; Cooper, Andrea M; Frank, Anthony A; Orne, Ian M; Krahenbuhl, James L Title: The study of Mycobacterium leprae infection in interferon-y gene-disrupted mice as a model to explore the immunopathologic spectrum of leprosy ..- Source: s.l; s.n; 2002. 8 p. ilus, graf. Descriptors: LINFOCITOS T CD4-POSITIVOS LINFOCITOS T CD8-POSITIVOS CITOCINAS MODELOS ANIMAIS DE DOENÇAS CITOMETRIA DE FLUXO PÉ PÉ DELEÇAO DE GENES IMUNOHISTOQUIMICA INTERFERON TIPO II HANSENIASE HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA MACROFAGOS PERITONEAIS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ANIMAL LINFONODOS/IM Limits: ANIMAL Location: BR191.1; 08511/s

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Id: 11752 Author: Mempel, Martin; Flageut, Beatrice; Suarez, Felipe; Ronet, Catherine; Dubertret, Louis; Korisky, Philippe; Gachelin, Gabriel; Musette, Philippe Title: Comparasion of the T cell patterns in leprous and cutaneous sarcoid granulomas. Presence of Valpha24-invariant natural killer T cells in T-cell-reactive leprosy together with a highly biased t cell receptor Valpha repertoire ..- Source: s.l; s.n; 2000. 16 p. ilus, tab, graf. Descriptors: HANSENIASE DERMATOPATIAS DERMATOPATIAS DERMATOPATIAS PELE PELE PELE SEQUENCIA DE AMINOACIDOS BIOPSIA DNA DNA GRANULOMA GRANULOMA GRANULOMA IMUNOHISTOQUIMICA CÉLULAS KILLER NATURAIS CÉLULAS KILLER NATURAIS DADOS DE SEQUENCIA MOLECULAR RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA SARCOIDOSE SARCOIDOSE SARCOIDOSE ANALISE DE SEQUENCIA DE DNA LINFOCITOS T Location: BR191.1; 08522/s

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Id: 11751 Author: Oliver, Stephen J; Kikuch, Toyoko; Krueger, James G; Kaplan, Gilla Title: Thalidomide induces granuloma differentiation in sarcoid skin lesions associated with disease improvement ..- Source: s.l; s.n; 2002. 11 p. ilus, tab, graf. Descriptors: ANTIGENOS CD CÉLULAS DENDRITICAS AGENTES DERMATOLOGICOS AGENTES DERMATOLOGICOS CITOMETRIA DE FLUXO ANTIGENOS HLA-DR IMUNOHISTOQUIMICA IMUNOSSUPRESSORES INTERLEUCINA-12 INTERLEUCINA-2 CÉLULAS DE LANGERHANS SARCOIDOSE SARCOIDOSE SARCOIDOSE DERMATOPATIAS DERMATOPATIAS DERMATOPATIAS LINFOCITOS T TALIDOMIDA TALIDOMIDA RESULTADO DE TRATAMENTO FATOR DE NECROSE DE TUMOR Location: BR191.1; 08523/s

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Id: 11454 Author: Little, David; Khanolkar-Young, Saroj; Coulthart, Anne; Sunnetha, SujaiLockwood, Diana N. J Title: Immunohistochemical analysis of cellular infiltrate and gamma interferon, interleukin-12, and inducible nitric oxide synthase expression in leprosy type 1 (reversal) reaction before and during prednisolone treatment ..- Source: s.l; s.n; 2001. 5 p. ilus, tab, graf. Descriptors: IMUNOHISTOQUIMICA INTERFERON TIPO II INTERLEUCINA-12 HANSENIASE HANSENIASE HANSENIASE SINTASE DE OXIDO NITRICO PREDNISOLONA Location: BR191.1; 08337/s

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Id: 11328 Author: de Blaquiere, G. E; Santamaria, L; Curtis, J; Terenghi, G; Polak, J. M; Turk, J. L Title: A morphological and functional assessment of mycobacterium leprae-induced nerve damage in a aguinea-pig model of leprous neuritis ..- Source: s.l; s.n; 1994. 11 p. ilus, tab, graf. Descriptors: AXONIOS ESTIMULAÇAO ELÉTRICA ELETROFISIOLOGIA GRANULOMA COBAIAS IMUNOHISTOQUIMICA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA MYCOBACTERIUM LEPRAE FIBRAS NERVOSAS NEUROPEPTIDIOS PESO DOS ORGAOS DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO NERVO CIATICO NERVO TIBIAL NERVO TIBIAL Limits: ANIMAL Location: BR191.1; 07267/s

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