Database : HANSEN Search on : INTERLEUCINA-12 [Subject descriptor] References found : 21 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 18204 Author: Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae Title: Differential production of interleukin-10 and interleukin-12 mononuclear cells from leprosy patients with a Toll-like receptor 2 mutations ..- Source: s.l; s.n; 2004. 7 p. tab, graf. Abstract: Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infections with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Argo677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in Il-4 production between the mutant and wild-type during stimulation. Yhus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy pateints and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy (AU). Descriptors: HANSENIASE VIRCHOWIANA/sangue HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/diag HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/sangue HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol INTERLEUCINA-10/anal INTERLEUCINA-10/sangue INTERLEUCINA-10/imunol INTERLEUCINA-12/anal INTERLEUCINA-12/sangue INTERLEUCINA-12/imunol - LEUCOCITOS MONONUCLEARES/imunol  IMUNOCOMPETÊNCIA/imunol Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1; 09194/s

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Id: 13942 Author: Maeda, Yumi; Gidoh, Masaichi; Ishii, Norihisa; Mukai, Chifumi; Makino, Masahiko Title: Assessment of cell mediated immunogenicity of Mycobacterium leprae-derived antigens ..- Source: s.l; s.n; 2003. 9 p. tab, graf. Abstract: The antigenicity of Mycobacterium leprae (M. leprae)-derived cell membrane fraction was examined using human dendritic cells (DCs). Immature DCs internalized and processed the cell membrane components, and expressed M. leprae-derived antigens (Ags) on their surface. The expression of MHC class II, CD86, and CD83 Ags on DCs and CD40 ligand (L)-associated IL-12 p70 production from DCs were up-regulated by the membrane Ags. Moreover these stimulated DCs induced significantly higher level of interferon-gamma (IFN-gamma) production by autologous CD4(+) and CD8(+) T cells than those pulsed with equivalent doses of live M. leprae or its cytosol fraction. Both subsets of T cells from tuberculoid leprosy patients also produced several fold more IFN-gamma than those from normal individuals. Furthermore, the intracellular perforin production in CD8(+) T cells was up-regulated in an Ag-dose dependent manner. These results suggest that M. leprae membrane Ags might be useful as the vaccinating agents against leprosy. (AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE SUPERFÍCIE/imunol LINFOCITOS T CD4-POSITIVOS/imunol LIGANTE A CD40/fisiol LINFOCITOS T CD8-POSITIVOS/imunol CELULAS DENDRITICAS/imunol INTERFERON TIPO II/bios INTERLEUCINA-12/bios TRANSFORMACAO LINFOCITICA GLICOPROTEINAS DE MEMBRANA/bios MYCOBACTERIUM LEPRAE/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09083/s

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Id: 13727 Author: Cheadle, Eleanor J; Selby, Peter J; Jackson, Andrew M Title: Mycobacterium bovis bacillus Calmette-Guérin-infected dendritic cells potently activate autologous T cells via a B7 and interleukin-12-dependent mechanism ..- Source: s.l; s.n; 2003. 10 p. graf. Abstract: Mycobacteria are potent adjuvants, can survive intracellularly and have been safely used for many years as vaccines against tuberculosis and leprosy. They are thus important potential vectors for recombinant vaccines. Many of their adjuvant properties are mediated following phagocytosis by dendritic cells (DC), which are in turn critical for priming naïve T cells. Although the maturation of DC in response to mycobacteria, such as Mycobacterium bovis bacillus Calmette-Guérin (BCG), is well described the subsequent responses of autologous T cells to mycobacterium-infected DC remains uncharacterized. In our experiments DC infected with BCG expressed more co-stimulatory molecules than tumour-necrosis factor-alpha (TNF-alpha) -treated DC and stimulated more potent mixed leucocyte reactions. When autologous T cells were co-cultured with BCG-exposed DC they became highly activated, as determined by display of CD25, CD54 and CD71 on both CD4+ and CD8+ cells. In contrast, the response of T cells to TNF-alpha-matured DC was significantly less. Cytokine production from T cells cultured with BCG-exposed DC was enhanced with elevated secretion of interleukin-2 (IL-2), IL-10 and interferon-gamma (IFN-gamma) and was produced by both CD4+ and CD8+ lymphocytes as determined by intracellular staining. In particular, IFN-gamma secretion was increased from 50 pg/ml to 25 000 pg/ml and IL-10 secretion increased from 20 pg/ml to 300 pg/ml in BCG-exposed DC co-cultures. Blocking antibodies to B7.1 and B7.2 or IL-12 significantly reduced the secretion of IFN-gamma and reductions were also seen in the expression of CD25 and CD71 by CD4+ cells. These data demonstrate that mycobacterially infected DC are particularly potent activators of autologous T cells compared to TNF-alpha-exposed DC and that the resultant T cells are functionally superior. (AU). Descriptors: ANTIGENOS CD/metab ANTIGENOS CD80/imunol ANTIGENOS DE DIFERENCIACAO DE LINFOCITOS B/metab LINFOCITOS T CD4-POSITIVOS/imunol LINFOCITOS T CD8-POSITIVOS/imunol CITOCINAS/bios CELULAS DENDRITICAS/imunol CELULAS DENDRITICAS/microbiol MOLECULA 1 DE ADESAO INTERCELULAR IMUNOFENOTIPAGEM INTERLEUCINA-12/imunol TRANSFORMACAO LINFOCITICA/imunol MYCOBACTERIUM BOVIS/imunol RECEPTORES DA INTERLEUCINA-2/metab LINFOCITOS T/imunol FATOR DE NECROSE TUMORAL/imunol REGULACAO PARA CIMA/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 08996/s

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Id: 13619 Author: Kang, Tae Jin; Lee, Seong-Beom; Chae, Gue-Tae Title: A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy ..- Source: s.l; s.n; Oct. 2002. 7 p. graf. Abstract: Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections, and the mutations in the TLR2 have been shown to confer the susceptibility to infection with mycobacteria. We previously reported the detection of TLR2 Arg677Trp mutation in lepromatous leprosy. Here, the events triggered by TLR2 in response to cell lysate of Mycobacterium leprae(MLL), the causative agent of leprosy, were investigated. Upon stimulation with MLL, monocytes produced TNF-alpha and Interleukin-12 (IL-12), which play a role in the innate immune response to infection. Anti-TLR2 mAb blocked greater than 50 per cent of the MLL-induced production of IL-12. We also performed the functional study on TLR2 by measurement of IL-12 production in serum and monocytes from leprosy patients with TLR2 mutation (Arg677Trp). The monocytes obtained from patients with the TLR2 mutation, in comparison to the wild-type TLR2, is significantly less responsive to MLL. It was also confirmed that patients with TLR2 mutation showed significantly lower serum levels of IL-12, in comparing with TLR2 wild-type. Our results reveal that innate immune response of monocytes against M. lepraeis mediated by TLR2, and suggest that the mutation in the intracellular domain of TLR2 gene is associated with IL-12 production in lepromatous leprosy. (AU). Descriptors: SEQUÊNCIA DE AMINOACIDOS SEQUÊNCIA DE BASES ESTUDOS DE CASOS E CONTROLES DNA COMPLEMENTAR/genet IMUNIDADE NATURAL INTERLEUCINA-12/bios HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol GLICOPROTEINAS DE MEMBRANA/quim GLICOPROTEINAS DE MEMBRANA/genet MONOCITOS/imunol MYCOBACTERIUM LEPRAE/imunol MUTACAO PUNTUAL POLIMORFISMO (GENETICA) ESTRUTURA TERCIARIA DE PROTEINA RECEPTORES DA SUPERFICIE CELULAR/quim RECEPTORES DA SUPERFICIE CELULAR/genet FATOR DE NECROSE TUMORAL/bios Limits: HUMANO SUPPORT, NON-U.S. GOV'T HUMANO IN VITRO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09004/s

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Id: 12323 Author: Casanova, Jean-Laurent; Abel, Laurent Title: Genetic dissection of immunity to mycobacteria: the human model ..- Source: s.l; s.n; 2002. 40 p. ilus, tab. Descriptors: MICROBIOLOGIA AMBIENTAL IMUNIDADE SINDROMES DE DEFICIENCIA IMUNOLOGICA SINDROMES DE DEFICIENCIA IMUNOLOGICA SINDROMES DE DEFICIENCIA IMUNOLOGICA INTERFERON TIPO II INTERLEUCINA-12 MODELOS IMUNOLOGICOS MYCOBACTERIUM MYCOBACTERIUM MICOBACTERIOSE MICOBACTERIOSE MICOBACTERIOSE MYCOBACTERIUM BOVIS MYCOBACTERIUM BOVIS VIRULENCIA Location: BR191.1; 08717/s

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Id: 12291 Author: Little, David; Khanolkar-Young, Saroj; Coulthart, Anne; Suneetha, Sujai; Lockwood, Diana N. J Title: Immunohistochemical analysis of cellular infiltrate and gamma interferon, interleukin-12, and inducible nitric oxide synthase expression in leprosy type 1 (reversal) reactions before and during prednisolone treatment ..- Source: s.l; s.n; May 2001. 5 p. ilus, tab, graf. Descriptors: IMUNOHISTOQUIMICA INTERFERON TIPO II INTERLEUCINA-12 HANSENIASE HANSENIASE HANSENIASE SINTASE DE OXIDO NITRICO PREDNISOLONA Location: BR191.1; 08686/s

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Id: 12279 Author: Kim, Jenny; Uyemura, Koichi; Van Dyke, Melissa K; Legaspi, Annaliza J; Rea, Thomas H; Shuai, Ke; Modlin, Robert L Title: A role for IL-12 receptor expression and signal transduction in host defense in leprosy ..- Source: s.l; s.n; 2001. 8 p. graf. Descriptors: ANTIGENOS DE BACTÉRIAS PROTEINAS DE LIGAÇAO DE DNA TOLERANCIA IMUNOLOGICA IMUNIDADE CELULAR INTERFERON TIPO II INTERLEUCINA-12 INTERLEUCINA-12 HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE FOSFORILAÇAO RECEPTORES DA INTERLEUCINA RECEPTORES DA INTERLEUCINA TRANSDUÇAO DE SINAL LINFOCITOS T TRANSATIVADORES CELULAS CULTIVADAS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08631/s

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Id: 12226 Author: Sampaio, E. P; Hernandez, M. O; Carvalho, D. S; Sarno, E. N Title: Management of erythema nodosum leprosum by thalidomide: thalidomide analogues inhibit M. leprae-induced TNFalpha production in vitro ..- Source: s.l; s.n; 2002. 7 p. ilus, graf. Descriptors: APOPTOSE CITOCINAS CITOCINAS ERITEMA NODOSO IMUNOSSUPRESSORES IMUNOSSUPRESSORES INTERLEUCINA-12 MONOCITOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE RNA MENSAGEIRO RNA MENSAGEIRO RNA MENSAGEIRO TALIDOMIDA TALIDOMIDA TALIDOMIDA FATOR DE NECROSE TUMORAL/AI/GE Location: BR191.1; 08709/s

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Id: 11939 Author: Meada, Yumi; Makino, Masahiko; Crick, Dean C; Mahapatra, Sebabrata; Srisungnam, Sopa; Takii, Takemasa; Kashiwabara, Yoshiko; Brennan, Partrick J Title: Novel 33-kilodalton lipoprotein from Mycobacterium leprae ..- Source: s.l; s.n; 2002. 6 p. ilus, graf. Descriptors: MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MONOCITOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS CLONAGEM MOLECULAR ESCHERICHIA COLI EXPRESSAO GENICA GENES BACTERIANOS INTERLEUCINA-12 PESO MOLECULAR ANALISE SEQUENCIAL PRECURSORES DE PROTEINAS PRECURSORES DE PROTEINAS PRECURSORES DE PROTEINAS Location: BR191.1; 08605/s

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Id: 11751 Author: Oliver, Stephen J; Kikuch, Toyoko; Krueger, James G; Kaplan, Gilla Title: Thalidomide induces granuloma differentiation in sarcoid skin lesions associated with disease improvement ..- Source: s.l; s.n; 2002. 11 p. ilus, tab, graf. Descriptors: ANTIGENOS CD CÉLULAS DENDRITICAS AGENTES DERMATOLOGICOS AGENTES DERMATOLOGICOS CITOMETRIA DE FLUXO ANTIGENOS HLA-DR IMUNOHISTOQUIMICA IMUNOSSUPRESSORES INTERLEUCINA-12 INTERLEUCINA-2 CÉLULAS DE LANGERHANS SARCOIDOSE SARCOIDOSE SARCOIDOSE DERMATOPATIAS DERMATOPATIAS DERMATOPATIAS LINFOCITOS T TALIDOMIDA TALIDOMIDA RESULTADO DE TRATAMENTO FATOR DE NECROSE DE TUMOR Location: BR191.1; 08523/s

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Id: 11720 Author: Aleman, M; Barrera, S. de la; Fink, S; Finiasz, M; Arinna, M. H; Pizzariello, G; Sasiain, M. del C Title: Interleukin-12 amplifies the M. leprae hsp65-cytotoxic responses in the presence of tumor necrosis factor-alpha and interferon-gamma generating CD56+ effector cells: interleukin-4 downregulates this effect ..- Source: s.l; s.n; 2000. 9 p. tab, graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE ANTIGENOS CD56 CHAPERONINAS CITOTOXICIDADE IMUNOLOGICA SINERGISMO DE DROGAS SOROS IMUNES INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-4 INTERFASE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE LIGAÇAO PROTÉICA LINFOCITOS T CITOTOXICOS LINFOCITOS T CITOTOXICOS FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR Location: BR191.1; 07463/s

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Id: 11509 Author: García, Verónica E; Uyemura, Koichi; Sieling, Peter A; Ochoa, María T; Morita, Craig T; Okamura, Haruki; Kurimoto, Masashi; Rea, Thomas H; Modlin, Robert L Title: IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection ..- Source: s.l; s.n; 1999. 8 p. graf. Descriptors: HANSENIASE HANSENIASE CITOCINAS INTERFERON TIPO II INTERLEUCINA-12 CÉLULAS KILLER NATURAIS MONOCITOS LINFOCITOS T TUBERCULOSE PULMONAR Location: BR191.1; 08399/s

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Id: 11454 Author: Little, David; Khanolkar-Young, Saroj; Coulthart, Anne; Sunnetha, SujaiLockwood, Diana N. J Title: Immunohistochemical analysis of cellular infiltrate and gamma interferon, interleukin-12, and inducible nitric oxide synthase expression in leprosy type 1 (reversal) reaction before and during prednisolone treatment ..- Source: s.l; s.n; 2001. 5 p. ilus, tab, graf. Descriptors: IMUNOHISTOQUIMICA INTERFERON TIPO II INTERLEUCINA-12 HANSENIASE HANSENIASE HANSENIASE SINTASE DE OXIDO NITRICO PREDNISOLONA Location: BR191.1; 08337/s

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Id: 11299 Author: Moraes, M. O; Sarno, E. N; Almeida, A. S; Saraiva, B. C. C; Nery, J. A. C; Martins, R. C. L; Sampaio, E. P Title: Cytokine mRNA expression in leprosy: a possible role for interferon-gamma and interleukin-12 in reactions (RR and ENL) ..- Source: s.l; s.n; 1999. 9 p. ilus, tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS SEQUENCIA DE BASES ESTUDOS DE CASOS E CONTROLES CITOCINAS PRIMERS DO DNA EXPRESSAO GENICA FATOR ESTIMULADOR DE COLONIAS DE GRANULOCITOS-MACROFAGOS INTERFERON TIPO II INTERLEUCINA-12 HANSENIASE HANSENIASE GLICOPROTEINAS DE MEMBRANAS REAÇAO EM CADEIA POR POLIMERASE RNA MENSAGEIRO RNA MENSAGEIRO RNA MENSAGEIRO Location: BR191.1; 07238/s

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Id: 11075 Author: Kobayashi, Kazuo; Kai, Masanori; Gidoh, Masa-ichi; Nakata, Noboru; Endoh, Masumi; Singh, Ram Pyare; Kasama, Tsuyoshi; Saito, Hajime Title: The possible role of interleukin (IL)-12 and interferon -gamma-inducing factor/IL-18 in protection against experimental mycobacterium leprae infection in mice ..- Source: s.l; s.n; sep. 1998. 6 p. ilus, graf. Descriptors: HANSENIASE HANSENIASE HANSENIASE CITOCINAS CITOCINAS MYCOBACTERIUM LEPRAE INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-12 RNA MENSAGEIRO CÉLULAS TH1 CÉLULAS TH1 Location: BR191.1; 07371/s

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Id: 11067 Author: Santos, D. O; Santos, S. L; Esquenazi, D; Nery, J. A; Defruyt, M; Lorre, K; van Heuverswyn, H Title: Evaluation of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules and dendritic cells on the immune response in leprosy ..- Source: s.l; s.n; feb. 2001. 10 p. tab, graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE ANTIGENOS CD ANTIGENOS CD80 IMUNIZAÇAO INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-12 GLICOPROTEINAS DE MEMBRANAS MONOCITOS LINFOCITOS T Location: BR191.1; 07363/s

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Id: 11031 Author: Sieling, Peter A; Modlin, Robert L Title: Regulation of cytokine patterns in leprosy ..- Source: s.l; s.n; 1994. 11 p. . Descriptors: RELAÇAO CD4-CD8 CITOCINAS EXPRESSAO GENICA INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-7 INTERLEUCINAS HANSENIASE RNA MENSAGEIRO RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA RECEPTORES PARA ANTIGENOS DE CÉLULAS T GAMA-DELTA SUB-POPULAÇOES DE LINFOCITOS T LINFOCITOS T AUXILIADORES-INDUTORES LINFOCITOS T SUPRESSORES-EFETORES Location: BR191.1; 07209/s

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Id: 10278 Author: Yamauchi, Paul S; Bleharski, Joshua R; Uyemura, Koichi; Kim, Jenny; Sieling, Peter A; Miller, Ari; Brightbill, Hans; Schlienger, Katia; Rea, Thomas H; Moldin, Robert L Title: A role for CD40-CD40 ligand interactions in the generation of type 1 cytokine responses in human leprosy ..- Source: s.l; s.n; 2000. 7 p. ilus, graf. Descriptors: HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA MYCOBACTERIUM LEPRAE ANTIGENOS CD40 ANTIGENOS CD40 ANTIGENOS CD40 ANTIGENOS CD40 CITOCINAS IMUNIDADE CELULAR INTERLEUCINA-12 LIGANTES GLICOPROTEINAS DE MEMBRANAS GLICOPROTEINAS DE MEMBRANAS GLICOPROTEINAS DE MEMBRANAS GLICOPROTEINAS DE MEMBRANAS MONOCITOS MONOCITOS CÉLULAS TH1 CÉLULAS TH1 Location: BR191.1; 07418/s

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Id: 10245 Author: Sieling, Peter A; Wang, Xiao-Hong; Gately, Maurice K; Oliveros, Jennifer L; McHugh, Teresa; Barnes, Peter F; Wolf, Stanley F; Golkar, Linda; Yamamura, Masahiro; Yogi, Yasuko; Uyemura, Koichi; Rea, Thomas H; Modlin, Robert L Title: IL-12 regulates T helper type 1 cytokine responses in human infectious disease ..- Source: s.l; s.n; 1994. 9 p. ilus, graf. Descriptors: SEQUENCIA DE BASES LINFOCITOS T CD8-POSITIVOS PRIMERS DO DNA EXPRESSAO GENICA INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-4 INTERLEUCINA-4 HANSENIASE TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE RNA MENSAGEIRO SUB-POPULAÇOES DE LINFOCITOS T CÉLULAS TH1 Location: BR191.1; 06955/s

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Id: 10189 Author: De Jong, Rolien; Janson, Anneke A. M; Faber, William R; Naafs, Ben; Ottenhoff, Tom H. M Title: IL-2 and IL-12 act in synergy to overcome antigen-specific T cell unresponsiveness in mycobacterial disease ..- Source: s.l; s.n; 1997. 8 p. tab, graf. Descriptors: SINERGISMO DE DROGAS IMUNIDADE CELULAR INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-2 INTERLEUCINA-2 TRANSFORMAÇAO LINFOCITICA PROTEINAS RECOMBINANTES LINFOCITOS T Location: BR191.1; 07102/s

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