Database : HANSEN Search on : APOPTOSE [Subject descriptor] References found : 11 [refine] Displaying: 1 .. 11   in format [Detailed]

page 1 de 1

1 / 11

HANSEN

select to print Texto Completo-en

Id: 19719 Author: Niang, Mbayane Ndiaye; Balde, Aissatou Toure; Perraut, Ronald; Mane, Ibrahima; Cartel, Jean Louis. Title: Apoptosis in leprosy patients. Source: Int. J. Lepr;67(4):473-474, Dec., 1999. tab. Descriptors: Apoptose/fisiol Hanseníase/compl Hanseníase/diag Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n4/v67n4cor02.pdf / en Location: BR191.1

2 / 11

HANSEN

select to print

Id: 18585 Author: Marani, Angela Messias Title: Análise da apoptose induzida pelo Mycobacterium Leprae em células mononucleares de pacientes com formas polares de Hanseníase^ipt Analysis of apoptosis induced by Mycobacterium leprae in mononuclear cells of patients with polar forms of leprosy- Source: Bauru; s.n; 2008. 49 p. ^bilus, ^bgraf. Descriptors: Hanseníase Virchowiana/microbiol Hanseníase Virchowiana/virol Hanseníase Tuberculóide/microbiol Hanseníase Tuberculóide/virol Mycobacterium leprae/citol Mycobacterium leprae/genet Mycobacterium leprae/patogen Apoptose/fisiol Limits: Humanos Masculino Feminino Location: BR191.1; WC335.400, M825a

3 / 11

HANSEN

select to print

Id: 18202 Author: Walsh, Douglas S; Lane, Joshua E; Abalos, Rodolfo M; Myint, Khin Saw Aye Title: Tunel and limited immunophenotypic analysis of apoptosis in paucibacillary leprosy lesions ..- Source: s.l; s.n; 2004. 5 p. ilus. Abstract: Some mycobacterial infections, such as tuberculosis, are characterized by apoptosis in infected or by-stander mononuclear immune cells. For localized (paucibacillary, PB) and diseminated (multibacillary, MB) leprosy, characterized by polarized Thl-like vs, Th2-like immune responses, respectivelly little is known about lesional apoptosis. We analyzed sections of paraffin-embedded, untreated leprosy lesions from 21 patients by an indirect immunofluorescent terminal deoxynucleotide-transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) assay. Some TUNEL (+) PB sections were then reacted with phycoerythein-conjugated (red)antibodies against T cells, monocytes, or antigen-presenting (Langerhans) cells. TUNEL (+) bodies were detected in 9 of 16 PB lesions (56%) and in 1 of 5 MB lesions (20%). Some TUNELL (+) bodies in PB disease were CD3+ (T cell), as well as CD4+ (T-helper) or cd8+ (T-cytotoxic) Apoptosis characterizes PB and MB leprosy lesions and may be more freqeunt in PB disease. In PB disease, some TUNEL (+) bodies may derive from T cells (AU). Descriptors: HANSENIASE DIMORFA/imunol HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/imunol HANSENIASE/imunol IMUNOHISTOQUIMICA/util MYCOBACTERIUM LEPRAE/patogen HANSENIASE/patol HANSENIASE DIMORFA/patol HANSENIASE VIRCHOWIANA/patol HANSENIASE TUBERCULOIDE/patol - APOPTOSE/imunol  APOPTOSE/fisiol  IMUNOHISTOQUIMICA/normas  BIOPSIA/util Limits: HUMANO Location: BR191.1; 09200/s

4 / 11

HANSEN

select to print

Id: 13928 Author: Vescovo, Giorgio; Ravara, Barbara; Angelini, Annalisa; Sandri, Marco; Carraro, Ugo; Ceconi, Claudio; Dalla Libera, Luciano Title: Effect of thalidomide on the skeletal muscle in experimental heart failure ..- Source: s.l; s.n; 2002. 6 p. ilus, tab. Abstract: BACKGROUND: Tumour Necrosis Factor alpha (TNFalpha) has been shown to contribute to heart failure (CHF) progression. AIMS: We have tried to antagonise the detrimental effects of TNFalpha on skeletal muscle apoptosis, by using thalidomide, a drug that inhibits its biosynthesis. METHODS: CHF was induced in 20 rats by injecting monocrotaline, which determines right ventricle (RV) failure. After 2 weeks, when CHF developed, 12 rats were treated with thalidomide 3.5.mg/kg per day for 2 weeks. Eight had saline and served as CHF controls. RESULTS: Thalidomide failed to decrease TNFalpha and its second messenger sphingosine (SPH), but was able to prevent the shift toward the fast myosin heavy chains. In the Tibialis Anterior muscle of the thalidomide group, the degree of atrophy, the number of apoptotic nuclei and the levels of caspases, were similar to those of the CHF controls. CONCLUSIONS: Thalidomide, at the doses used in this study, which are the same employed for the treatment of tubercolosis, leprosy, AIDS and cancer in humans, did not lower either TNFalpha or SPH and only marginally influenced the apoptosis-induced muscle atrophy. Since other TNFalpha blockers are under investigation for improving the clinical status of patients with CHF, the present data could be relevant in the design of randomised clinical trials in humans. (AU). Descriptors: APOPTOSE/ef drogas INSUFICIÊNCIA CARDIACA CONGESTIVA/ind quim INSUFICIÊNCIA CARDIACA CONGESTIVA/patol MONOCROTALINA/tox MUSCULO ESQUELETICO/ef drogas MUSCULO ESQUELETICO/patol ATROFIA MUSCULAR/ind quim ATROFIA MUSCULAR/patol CADEIAS PESADAS DE MIOSINA/metab RATOS SPRAGUE-DAWLEY ESFINGOSINA/antag ESFINGOSINA/metab TALIDOMIDA/farmacol FATOR DE NECROSE TUMORAL/antag FATOR DE NECROSE TUMORAL/metab DISFUNCAO VENTRICULAR DIREITA/ind quim DISFUNCAO VENTRICULAR DIREITA/patol Limits: ANIMAL RATOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 09104/s

5 / 11

HANSEN

select to print

Id: 13732 Author: Oliveira, Rosane B; Ochoa, Maria T; Sieling, Peter A; Rea, Thomas H; Rambukkana, Anura; Sarno, Euzenir N; Modlin, Robert L Title: Expression of toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy ..- Source: s.l; s.n; 2003. 7 p. ilus, graf. Abstract: Nerve damage is a clinical hallmark of leprosy and a major source of patient morbidity. We investigated the possibility that human Schwann cells are susceptible to cell death through the activation of Toll-like receptor 2 (TLR2), a pattern recognition receptor of the innate immune system. TLR2 was detected on the surface of human Schwann cell line ST88-14 and on cultured primary human Schwann cells. Activation of the human Schwann cell line and primary human Schwann cell cultures with a TLR2 agonist, a synthetic lipopeptide comprising the N-terminal portion of the putative Mycobacterium leprae 19-kDa lipoprotein, triggered an increase in the number of apoptotic cells. The lipopeptide-induced apoptosis of Schwann cells could be blocked by an anti-TLR2 monoclonal antibody. Schwann cells in skin lesions from leprosy patients were found to express TLR2. It was possible to identify in the lesions Schwann cells that had undergone apoptosis in vivo. The ability of M. leprae ligands to induce the apoptosis of Schwann cells through TLR2 provides a mechanism by which activation of the innate immune response contributes to nerve injury in leprosy. (AU). Descriptors: APOPTOSE CELULAS CULTIVADAS DANO DO DNA IMUNIDADE NATURAL HANSENIASE/imunol HANSENIASE/patol LIPOPROTEINAS/fisiol CELULAS DE SCHWANN/patol GLICOPROTEINAS DE MEMBRANA/anal GLICOPROTEINAS DE MEMBRANA/fisiol RECEPTORES DA SUPERFICIE CELULAR/anal RECEPTORES DA SUPERFICIE CELULAR/fisiol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S Electronic Medium: http://www.ilsl.br Location: BR191.1; 09028/s

6 / 11

HANSEN

select to print

Id: 13650 Author: Hernandez, M. O; Neves Junior, I; Sales, J. S; Carvalho, D. S; Sarno, E. N; Sampaio, E. P Title: Induction of apoptosis in monocytes by Mycobacterium leprae in vitro: a possible role for tumour necrosis factor-alpha ..- Source: s.l; s.n; 2003. 9 p. graf. Abstract: A diverse range of infectious organisms, including mycobacteria, have been reported to induce cell death in vivo and in vitro. Although morphological features of apoptosis have been identified in leprosy lesions, it has not yet been determined whether Mycobacterium leprae modulates programmed cell death. For that purpose, peripheral blood mononuclear cells obtained from leprosy patients were stimulated with different concentrations of this pathogen. Following analysis by flow cytometry on 7AAD/CD14+ cells, it was observed that M. leprae induced apoptosis of monocyte-derived macrophages in a dose-dependent manner in both leprosy patients and healthy individuals, but still with lower efficiency as compared to M. tuberculosis. Expression of tumour necrosis factor-alpha (TNF-alpha), Bax-alpha, Bak mRNA and TNF-alpha protein was also detected in these cultures; in addition, an enhancement in the rate of apoptotic cells (and of TNF-alpha release) was noted when interferon-gamma was added to the wells. On the other hand, incubation of the cells with pentoxifylline impaired mycobacterium-induced cell death, the secretion of TNF-alpha, and gene expression in vitro. In addition, diminished bacterial entry decreased both TNF-alpha levels and the death of CD14+ cells, albeit to a different extent. When investigating leprosy reactions, an enhanced rate of spontaneous apoptosis was detected as compared to the unreactive lepromatous patients. The results demonstrated that M. leprae can lead to apoptosis of macrophages through a mechanism that could be at least partially related to the expression of pro-apoptotic members of the Bcl-2 protein family and of TNF-alpha. Moreover, while phagocytosis may be necessary, it seems not to be crucial to the induction of cell death by the mycobacteria. (AU). Descriptors: APOPTOSE/ef drogas APOPTOSE/imunol CELULAS CULTIVADAS REGULACAO DA EXPRESSÃO GÊNICA INTERFERON TIPO II/farmacol HANSENIASE/imunol PROTEINAS DE MEMBRANA/genet MONOCITOS/imunol MONOCITOS/patol MYCOBACTERIUM LEPRAE/imunol PENTOXIFILINA/farmacol FAGOCITOSE/imunol PROTEINAS PROTO-ONCOGÊNICAS/genet FATOR DE NECROSE TUMORAL/imunol Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09128/s

7 / 11

HANSEN

select to print

Id: 12244 Author: Rambukkana, Anura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; May 2002. 5 p. ilus, graf. Descriptors: APOPTOSE AXONIOS AXONIOS LINFOCITOS B ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL CAMUNDONGOS KNOCKOUT MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL FIBRAS NERVOSAS MIELINIZADAS NEURONIOS CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN NERVO CIATICO NERVO CIATICO LINFOCITOS T CULTURA DE TECIDO Limits: ANIMAL Location: BR191.1; 08647/s

8 / 11

HANSEN

select to print

Id: 12228 Author: Mustafa, T; Bjune, G; Jonsson, R; Pando, R. H.; Nilsen, R Title: Increased expression of fas ligand in human tuberculosis and leprosy lesions: a potential novel mechanism of immune evasion in mycobacterial infection ..- Source: s.l; s.n; 2001. 10 p. ilus, tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS ANTIGENOS CD ANTIGENOS CD95 ANTIGENOS DE DIFERENCIAÇAO MIELOMONOCITICA APOPTOSE GRANULOMA DE CORPO ESTRANHO GRANULOMA DE CORPO ESTRANHO IMUNOHISTOQUIMICA LEISHMANIOSE CUTANEA LEISHMANIOSE CUTANEA HANSENIASE HANSENIASE HANSENIASE GLICOPROTEINAS DE MEMBRANAS MODELOS IMUNOLOGICOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS TUBERCULOSE TUBERCULOSE TUBERCULOSE Location: BR191.1; 08711/s

9 / 11

HANSEN

select to print

Id: 12226 Author: Sampaio, E. P; Hernandez, M. O; Carvalho, D. S; Sarno, E. N Title: Management of erythema nodosum leprosum by thalidomide: thalidomide analogues inhibit M. leprae-induced TNFalpha production in vitro ..- Source: s.l; s.n; 2002. 7 p. ilus, graf. Descriptors: APOPTOSE CITOCINAS CITOCINAS ERITEMA NODOSO IMUNOSSUPRESSORES IMUNOSSUPRESSORES INTERLEUCINA-12 MONOCITOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE RNA MENSAGEIRO RNA MENSAGEIRO RNA MENSAGEIRO TALIDOMIDA TALIDOMIDA TALIDOMIDA FATOR DE NECROSE TUMORAL/AI/GE Location: BR191.1; 08709/s

10 / 11

HANSEN

select to print

Id: 10373 Author: Gupta, Anu; Sharma, V. K; Vohra, Harpreet; Ganguly, N. K Title: Spontaneous apoptosis in peripheral blood mononuclear cells of leprosy patients: role of cytokines ..- Source: s.l; s.n; 1999. 7 p. tab, graf. Descriptors: ANTICORPOS ESPECIFICIDADE DE ANTICORPOS ANTIGENOS CD28 APOPTOSE CITOCINAS CITOCINAS INTERLEUCINA-1 INTERLEUCINA-6 INTERLEUCINA-6 IONOMICINA HANSENIASE HANSENIASE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES ZINCO CELULAS CULTIVADAS FATOR DE NECROSE TUMORAL/AI/PH Location: BR191.1; 07501/s

11 / 11

HANSEN

select to print

Id: 10282 Author: Oliveira, R. B; Moraes, M. O; Oliveira, E. B; Sarno, E. N; Nery, J. A. C; Sampaio, E. P Title: Neurotrophils isolated from leprosy patients release TNF-a and accelerated apoptosis in vitro ..- Source: s.l; s.n; 1999. 8 p. ilus, tab, graf. Descriptors: HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE APOPTOSE LIPOPOLISSACARIDIOS LIPOPOLISSACARIDIOS NEUTROFILOS NEUTROFILOS FATOR DE NECROSE DE TUMOR Location: BR191.1; 07421/s

---

page 1 de 1

Refine the search

Database : HANSEN

Advanced form

Search for : Free form

		Search	in field
1			WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
2	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
3	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type

Search engine: iAH powered by WWWISIS

IAH - © BIREME/PAHO/WHO Latin American and Caribbean Center on Health Sciences Information