Database : HANSEN Search on : GLICOLIPIDIOS [Subject descriptor] References found : 63 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 13935 Author: Jayapal, V; Selvibai, G; Mahalakshmi, K; Pushkala; Regunath, K; Subramanian, S Title: Comparative study of anti-PGL-1, anti-35 kDa and anti-lipoarabinomannan assays for serodiagnosis of leprosy ..- Source: s.l; s.n; 2001. 9 p. tab. Abstract: Three antibody assays (anti-PGL-1, anti-35 kDa and anti-LAM) were used to determine the levels of antibodies in the sera of untreated leprosy patients. All the three assays showed higher levels of antibodies in BL/LL patients as compared to I and TT/BT patients, as well as healthy controls. BL/LL patients showed positivity of 100 per cent, 84.2 per cent and 78.9 per cent by anti-PGL-1, anti-35 kDa and anti-LAM assays respectively. All the three assays were negative for leprosy in healthy controls. Anti-PGL-1 assay was positive in 20 per cent of TT/BT patients and 17.9 per cent of I patients. Anti-35 kDa assay was negative in all the TT/BT patients and positive in 7.14 per cent of I patients. Anti-LAM assay was positive in 13.3 per cent of TT/BT patients and in 10.7 per cent of I patients. Hence, while these assays are valuable in diagnosing BL/LL patients, their usefulness in diagnosing I, BT or TT leprosy is limited. (AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol TESTES SOROLOGICOS ANTICORPOS ANTIBACTERIAS/sangue ANTIGENOS DE BACTERIAS/imunol GLICOLIPIDIOS/imunol HANSENIASE/sangue HANSENIASE/clas HANSENIASE/diag HANSENIASE/imunol LIPOPOLISSACARIDIOS/imunol Limits: ESTUDO COMPARATIVO HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09162/s

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Id: 13896 Author: Mora, Nancy; Pérez, Milagros; Bendiche, María; González, Ángel B; González-Abreu, Elba; Gil, Reinaldo E. Title: Determinación de anticuerpos anti-glicolípido fenólico I en población general de un área endémica de lepra. Source: Fontilles - Revista de Leprología;18(6):587-597, Sep.-Dic. 1992. tab, graf. Abstract: Se estudiaron los niveles de anticuerpos anti-glicolípido fenólico I mediante ensayo inmunoenzimático por el Sistema Ultra Micro Analítico (SUMA), desarrolado en Cuba, en 26806 personas de la población general del municipio de Guantánamo, Cuba. En este municipio las tasas de prevalencia y de detección de casos de lepra fueron 5 y 4 veces mayores respectivamente que las del país en el año del estudio (1988). El 82'6 por ciento de los individuos mostraron valores por debajo del nivel de corte estabelecido, observándose entre los "seropositivos" una disminución de la frecuencia de acuerdo al aumento de la edad y una elevación en el sexo femenino. Se pudo precisar que 828 individuos "seropositivos" tenían contacto conocido con enfermos de lepra y que entre los que presentaron los valores más altos, la proporción de intradomiciliarios fue significativamente mayor que la de los extradomiciliares, lo que podría estar asociado con una exposición más intensa al M. leprae y con el reconocido mayor riego de enfermar que presentan los primeros. El examen de los "seropositivos" ha conducido, hasta el momento de la redación de este trabajo, al diagnóstico de 12 casos nuevos de lepra, de los cuales en 7 se comprobó la presencia de bacilos ácido-alcohol resistentes en la baciloscopía, por lo que constituían fuentes de infección en la comunidad. (AU). Descriptors: GLICOLIPIDIOS POPULACAO HANSENIASE/etnol Location: BR191.1

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Id: 13451 Author: Young, Douglas B; Khanolkar, Saroj R; Barg, Linda L; Buchanan, Thomas M Title: Generation and characterization of monoclonal antibodies to the phenolic glycolipid of Mycobacterium leprae ..- Source: s.l; s.n; jan. 1984. 6 p. ilus, tab, graf. Abstract: Nine cloned cell lines producing antibodies to the unique phenolic glycolipid of Mycobacterium leprae have been established as a result of fusions with spleens from mice immunized with the glycolipid complexed with methylated bovine serum albumin. One of the antibodies was relatively nonspecific, binding to a related glycolipid from Mycobacterium kansasii, but the remaining antibodies were specific for the M. leprae lipid. Some of the antibodies required the intact (trisaccharide) carbohydrate portion for recognition of the glycolipid antigen, whereas others recognized partially hydrolyzed forms lacking one or two sugar residues. Monoclonal antibodies directed at the terminal saccharide of the glycolipid showed the greatest specificity for M. leprae in enzyme-linked immunoassays. These antibodies brightly labeled whole mycobacteria in indirect immunofluorescence experiments, demonstrating the surface location of M. leprae-specific determinants of the glycolipid antigen. In addition to their use in providing information about the antigenic properties of the phenolic glycolipid, these antibodies have potential applications for elucidating the roles of glycolipid in the pathogenesis of leprosy.(AU). Descriptors: COMPLEXO ANTIGENO-ANTICORPO ELISA IMUNOFLUORESCÊNCIA GLICOLIPIDIOS/anal GLICOLIPIDIOS/imunol MYCOBACTERIUM LEPRAE CAMUNDONGOS ENDOGÂMICOS BALB C FENOIS PLASMOCITOMA/imunol ESPECIFICIDADE DE ESPECIES Limits: ESTUDO COMPARATIVO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01417/s

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Id: 13190 Author: Saad, M. H; Medeiros, M. A; Gallo, M. E; Gontijo, P. P; Fonseca, L. S Title: IgM immunoglobulins reacting with the phenolic glycolipid-1 antigen from Mycobacterium leprae in sera of leprosy patients and their contacts ..- Source: s.l; s.n; Apr.-Jun. 1990. 4 p. tab. Abstract: For the first time in Brazil it was investigated the occurrence of IgM anti-PGL-1 in the sera of household contacts of leprosy patients using the ELISA methodology. The sera of the multibacillary patients showed significantly more immuno-reactivity than from the paucibacillary patients. It was observed a high subclinical infection incidence among household contacts (19.4%). The percentage of leprosy development was 5% (1/21) among the seropositive contact group. This finding suggests that serology could be useful as prognostic test, but for better definition is necessary to test a population from endemic area for long period time.(AU). Descriptors: ELISA SEGUIMENTOS GLICOLIPIDIOS/anal HANSENIASE/diag HANSENIASE/imunol IMUNOGLOBULINA M/anal MYCOBACTERIUM LEPRAE/imunol PROGNOSTICO Limits: HUMANO ADOLESCENTE ADULTO IDOSO CRIANCA FEMININO MASCULINO MEIA-IDADE Electronic Medium: http://www.ilsl.br Location: BR191.1; 02104/s

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Id: 12312 Author: Brophy, Peter J Title: Subversion of Schwann cells and the leper's bell ..- Source: s.l; s.n; May 2002. 2 p. ilus. Descriptors: AXONIOS MORTE CELULAR DIFERENCIAÇAO CELULAR MEMBRANA CELULAR COCULTURA PROTEINAS CITOESQUELETO DOENÇAS DESMIELINIZANTES DISTROFINA GLICOLIPIDIOS LAMININA HANSENIASE HANSENIASE HANSENIASE GLICOPROTEINAS DE MEMBRANAS PROTEINAS DA MEMBRANA CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN Limits: ANIMAL Location: BR191.1; 08621/s

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Id: 12244 Author: Rambukkana, Anura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; May 2002. 5 p. ilus, graf. Descriptors: APOPTOSE AXONIOS AXONIOS LINFOCITOS B ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL CAMUNDONGOS KNOCKOUT MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL FIBRAS NERVOSAS MIELINIZADAS NEURONIOS CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN NERVO CIATICO NERVO CIATICO LINFOCITOS T CULTURA DE TECIDO Limits: ANIMAL Location: BR191.1; 08647/s

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Id: 12241 Author: Chae, Gue-Tae; Kim, Min-Joo; Kang, Tae-Jin; Lee, Seong-Beom; Shin, Hang-Kye; Kim, Jong-Pill; Ko, Young-Hoon; Kim, Sung-Hwa; Kim, Nan-Hee Title: DNA-PCR and RT-PCR for the 18-kDa gene of mycobacterium leprae to asses the efficacy of multi-drug therapy for leprosy ..- Source: s.l; s.n; 2002. 6 p. tab, graf. Descriptors: PROTEINAS DE BACTÉRIAS BIOPSIA DNA BACTERIANO DENSITOMETRIA QUIMIOTERAPIA COMBINADA ELETROFORESE EM GEL DE AGAR GLICOLIPIDIOS GLICOLIPIDIOS LEPROSTATICOS HANSENIASE HANSENIASE ESTUDOS LONGITUDINAIS CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE REAÇAO EM CADEIA POR POLIMERASE RNA MENSAGEIRO REPRODUTIBILIDADE DE RESULTADOS Location: BR191.1; 08644/s

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Id: 12197 Author: Young, Douglas B Title: Leprosy lipid provides the key to SChwann cell entry ..- Source: s.l; s.n; feb. 2001. 3 p. . Descriptors: GLICOLIPIDIOS HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN Limits: ANIMAL Location: BR191.1; 08704/s

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Id: 12126 Author: Rambukkana, Anura Title: Molecular basis for the peripheral nerve predilection of mycobacterium leprae ..- Source: s.l; s.n; 2001. 7 p. ilus. Descriptors: ANTIGENOS DE BACTÉRIAS PAREDE CELULAR GLICOLIPIDIOS LAMININA HANSENIASE HANSENIASE GLICOPROTEINAS DE MEMBRANAS MODELOS BIOLOGICOS MYCOBACTERIUM LEPRAE NERVOS PERIFÉRICOS LIGAÇAO PROTÉICA CÉLULAS DE SCHWANN TROPISMO Location: BR191.1; 08702/s

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Id: 11757 Author: Chae, Gue-Tae; Kim, Min-Joo; Kang, Tae-Jin; Lee, Seong-Beom; Shin, Hang-Kye; Kim, Jong-Pill; Ko, Young-Hoon; Kim, Sung-Hwa; Kim, Nan-Hee Title: DNA-PCR and RT-PCR for the 18-KDa gene of Mycobacterium leprae to asses the efficacy of multi-drug therapy for leprosy ..- Source: s.l; s.n; 2002. 6 p. tab. Descriptors: PROTEINAS DE BACTÉRIAS BIOPSIA DNA BACTERIANO DENSITOMETRIA QUIMIOTERAPIA COMBINADA ELETROFORESE EM GEL DE AGAR GLICOLIPIDIOS LEPROSTATICOS HANSENIASE HANSENIASE ESTUDOS LONGITUDINAIS CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE REAÇAO EM CADEIA POR POLIMERASE RNA MENSAGEIRO REPRODUTIBILIDADE DE RESULTADOS IMUNOGLOBULINA M/BL CAMUNDONGOS REACAO EM CADEIA POR POLIMERASE VIA TRANSCRIPTASE CAMUNDONGOS NUS REACAO EM CADEIA POR POLIMERASE VIA TRANSCRIPTASE REVERSA Limits: ANIMAL Location: BR191.1; 08517/s

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Id: 11749 Author: Rambukkana, Amura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; 2002. 5 p. ilus. Descriptors: HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE AXONIOS AXONIOS ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS MACROFAGOS MUTAÇAO BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL - FIBRAS NERVOSAS MIELINIZADAS  NEURONIOS  CÉLULAS DE SCHWANN  CÉLULAS DE SCHWANN  NERVO CIATICO  NERVO CIATICO  LINFOCITOS T  CULTURA DE TECIDO Location: BR191.1; 08525/s

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Id: 11744 Author: Brophy, Peter J Title: Subversion of Schwann cells and the leper's Bell ..- Source: s.l; s.n; 2002. 2 p. ilus. Descriptors: HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE AXONIOS DIFERENCIAÇAO CELULAR MEMBRANA CELULAR COCULTURA PROTEINAS CITOESQUELETO DOENÇAS DESMIELINIZANTES DISTROFINA GLICOLIPIDIOS LAMININA GLICOPROTEINAS DE MEMBRANAS BAINHA DE MIELINA CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN Location: BR191.1; 08527/s

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Id: 11622 Author: Padovesi, Evandro José Title: Avaliação do glicolipídio fenólico (PGL-I) no diagnóstico da hanseníase ?- Source: Londrina; s.n; 1996. xvi,98 p. ilus, tab, graf. Thesis: Present for Universidade Estadual de Londrina presented for the degree Mestre. Abstract: Foi realizada uma avaliação do teste de aglutinação de partículas de gelatina contendo o antígeno glicolipídio fenólico trissacarídico (PGL-I) no sorodiagnóstico da hanseníase (MLPA). Os pacientes foram separados de acôrdo com suas formas clínicas e tempo de tratamento, totalizando 1011 amostras. Nos pacientes paucibacilares (MHI e MHT), o teste MLPA não foi eficaz no diagnóstico sorológico e no acompanhamento dos pacientes em tratamento. Nos pacientes multibacilares (MHB e MHV) o teste MLPA demonstrou ser bastante sensível e específico e promissora a sua utilização no diagnóstico, no acompanhamento de pacientes multibacilares em tratamento, no diagnóstico de contatos hansenianos (suspeitos) e também no diagnóstico precoce de portadores sadios, sem sintomas aparentes (infecção subclínica). Para verificação da qualidade de um determinado teste sotológico, a Organização Mundial de Saúde (O.M.S.) recomenda que se determine o índice Kappa, utilizando como padrão o teste ELISA. O teste de aglutinação MLPA apresentou o índice Kappa de 0,852, classificado como quase perfeito (grau mais elevado do índice de Kappa). Os resultados do teste de MLPA foram também comparados com os resultados da bacterioscopia durante o tratamento dos hansenianos e se mostrou mais sensível apresentando um decréscimo mais lento dos títulos sorológicos do que a queda dos índice bacteriológicos. Devido à sua especificidade, sensibilidade, facilidade de execução e baixo custo, o teste sorológico MLPA associado à bacterioscopia e intradermoreação de Mitsuda constitui um teste bastante adequado no diagnóstico da hanseníase, principalmente da forma clínica mais grave da doença, a virchowiana. (AU). Descriptors: HANSENIASE GLICOLIPIDIOS ANTIGENO DE MITSUDA Location: BR191.1; WC335.102.20, P136a

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Id: 11605 Author: Young, Douglas B Title: Leprosy lipid provides the key to Schwann cell entry ..- Source: s.l; s.n; 2001. 3 p. . Descriptors: HANSENIASE GLICOLIPIDIOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN Location: BR191.1; 08428/s

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Id: 11466 Author: Cho, Sang-Nae; Cellona, Roland V; Villahermosa, Laarni G; Fajardo Junior, Tranquilino T; Balagon, M. Victoria F; Abalos, Rodolfo M; Tan, Esterlina V; Walsh, Gerald P; Kim, Joo-Deuk; Brennan, Patrick J Title: Detection of phenolic glycolipid I of mycobacterium leprae in sera fron leprosy patients before and after start of multidrug therapy ..- Source: s.l; s.n; 2001. 5 p. ilus, tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS ELISA GLICOLIPIDIOS LEPROSTATICOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE ESTUDOS RETROSPECTIVOS Location: BR191.1; 08345/s

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Id: 11307 Author: Chan, Gertrude P; Garcia-Ignacio, Bernadete Y; Chavez, Virginia E; Livelo, Jocelyn B; Jimenez, Claribel L; Parrilla, Manuela Luisa R; Franzblau, Scott G Title: Clinical trial of clarithromycin foor lepromatous leprosy ..- Source: s.l; s.n; mar. 1994. 3 p. tab. Descriptors: ADOLESCENCIA CLARITROMICINA CLARITROMICINA PÉ GLICOLIPIDIOS HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ESPIROMETRIA Limits: ANIMAL Location: BR191.1; 07246/s

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Id: 11304 Author: Kampirapap, Kowit Title: Mycobacterium leprae particle agglutination in diagnosis and monitoring of treatment of leprosy ..- Source: s.l; s.n; 1999. 5 p. tab, graf. Descriptors: ADOLESCENCIA TESTES DE AGLUTINAÇAO TESTES DE AGLUTINAÇAO ANALISE DE VARIANCIA ANTICORPOS ANTIBACTÉRIAS ANTIGENOS DE BACTÉRIAS CRIANÇA PRÉ-ESCOLAR MONITORAMENTO DE MEDICAMENTOS MONITORAMENTO DE MEDICAMENTOS GLICOLIPIDIOS LEPROSTATICOS HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE SENSIBILIDADE E ESPECIFICIDADE Location: BR191.1; 07243/s

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Id: 11296 Author: Rojas, R. E; Demichelis, S. O; Sarno, E. N; Segal-Eiras, A Title: IgM anti-phenolic glycolipid I and IgG anti 10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts ..- Source: s.l; s.n; 1997. 10 p. tab, graf. Descriptors: ADOLESCENCIA ANTICORPOS ANTIBACTÉRIAS ANTICORPOS ANTIBACTÉRIAS ANTICORPOS ANTIBACTÉRIAS ANTICORPOS MONOCLONAIS COMPLEXO ANTIGENO-ANTICORPO COMPLEXO ANTIGENO-ANTICORPO COMPLEXO ANTIGENO-ANTICORPO ANTIGENOS DE BACTÉRIAS CHAPERONINA 10 CHAPERONINA 10 ELISA ERITEMA NODOSO ERITEMA NODOSO GLICOLIPIDIOS IGG IGM HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA POLIETILENOGLICOIS PROTEINAS RECOMBINANTES Limits: ESTUDO COMPARATIVO Location: BR191.1; 07235/s

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Id: 11295 Author: Buhrer-Sekula, Samira; Cunha, Maria da Graca Souza; Ferreira, Willian Antunes; Klatser, Paul R Title: The use of whole blood in a dipstick assay for detection of antibodies to mycobacterium leprae: a field evaluation ..- Source: s.l; s.n; 1998. 5 p. tab, graf. Descriptors: ANTICORPOS ANTIBACTÉRIAS SANGUE ELISA ESTUDOS DE AVALIAÇAO GLICOLIPIDIOS HANSENIASE MYCOBACTERIUM LEPRAE SENSIBILIDADE E ESPECIFICIDADE TESTES SOROLOGICOS/*MT Limits: ESTUDO COMPARATIVO Location: BR191.1; 07234/s

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Id: 11155 Author: Rambukkana, Anura Title: Molecular basis for the peripheral nerve predilection of mycobacterium leprae ..- Source: s.l; s.n; 2001. 7 p. ilus, tab. Descriptors: HANSENIASE HANSENIASE PAREDE CELULAR LAMININA GLICOLIPIDIOS GLICOPROTEINAS DE MEMBRANAS MYCOBACTERIUM LEPRAE NERVOS PERIFÉRICOS TROPISMO Location: BR191.1; 07309/s

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