Database : HANSEN Search on : COCULTURA [Subject descriptor] References found : 8 [refine] Displaying: 1 .. 8   in format [Detailed]

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Id: 17687 Author: Tapinos, Nikos; Ohnishi, Makoto; Rambukkana, Anura Title: ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli ..- Source: s.l; s.n; 2006. 6 p. ilus, tab, graf. Abstract: Demyelination is a common pathologic feature in many neurodegenerative diseases including infection with leprosy-causing Mycobacterium leprae. Because of the long incubation time and highly complex disease pathogenesis, the management of nerve damage in leprosy, as in other demyelinating diseases, is extremely difficult. Therefore, an important challenge in therapeutic interventions is to identify the molecular events that occur in the early phase before the progression of the disease. Here we provide evidence that M. leprae-induced demyelination is a result of direct bacterial ligation to and activation of ErbB2 receptor tyrosine kinase (RTK) signaling without ErbB2-ErbB3 heterodimerization, a previously unknown mechanism that bypasses the neuregulin-ErbB3-mediated ErbB2 phosphorylation. MEK-dependent Erk1 and Erk2 (hereafter referred to as Erk1/2) signaling is identified as a downstream target of M. leprae-induced ErbB2 activation that mediates demyelination. Herceptin (trastuzumab), a therapeutic humanized ErbB2-specific antibody, inhibits M. leprae binding to and activation of ErbB2 and Erk1/2 in human primary Schwann cells, and the blockade of ErbB2 activity by the small molecule dual ErbB1-ErbB2 kinase inhibitor PKI-166 (ref. 11) effectively abrogates M. leprae-induced myelin damage in in vitro and in vivo models. These results may have implications for the design of ErbB2 RTK-based therapies for both leprosy nerve damage and other demyelinating neurodegenerative diseases. (AU). Descriptors: Anticorpos Monoclonais/PD Butadienos/PD Células COS Células Cultivadas Cercopithecus aethiops Técnicas de Cocultura Doenças Desmielinizantes/*ME/PA Ativação Enzimática/DE Inibidores Enzimáticos/PD Células Hela Hanseníase/*ME/MI Camundongos Knockout Proteína Quinase 1 Ativada por Mitógeno/ME Proteína Quinase 3 Ativada por Mitógeno/ME Mycobacterium leprae/GE/*ME Nitrilos/PD Pirimidinas/PD Pirróis/PD Receptor erbB-2/*ME Research Support, N.I.H., Extramural Células de Schwann/EN/ME Nervo Ciático/ME/MI/UL Transdução de Sinal Limits: Ratos Camundongos Nus Camundongos Humanos Estudo Comparativo Animais Location: BR191.1; 09361/s

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Id: 13720 Author: Brophy, Peter J Title: Subversion of schwann cells and the leper's bell ..- Source: s.l; s.n; May 3, 2002. 2 p. ilus. Descriptors: AXONIOS/PH MORTE CELULAR DIFERENCIACAO CELULAR MEMBRANA CELULAR/ME COCULTURA PROTEINAS CITOESQUELETO/ME DOENCAS DESMIELINIZANTES/*MI DISTROFINA/ME GLICOLIPIDEOS/ME LAMININA/ME HANSENIASE/*MI/PA/*PP GLICOPROTEINAS DE MEMBRANA/ME PROTEINAS DE MEMBRANA/ME MYCOBACTERIUM LEPRAE/GD/ME/*PY BAINHA DE MIELINA/*PH CELULAS DE SCHWANN/CY/*MI/*PH Limits: ANIMAL HUMANO CAMUNDONGOS Location: BR191.1; 09065/s

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Id: 12312 Author: Brophy, Peter J Title: Subversion of Schwann cells and the leper's bell ..- Source: s.l; s.n; May 2002. 2 p. ilus. Descriptors: AXONIOS MORTE CELULAR DIFERENCIAÇAO CELULAR MEMBRANA CELULAR COCULTURA PROTEINAS CITOESQUELETO DOENÇAS DESMIELINIZANTES DISTROFINA GLICOLIPIDIOS LAMININA HANSENIASE HANSENIASE HANSENIASE GLICOPROTEINAS DE MEMBRANAS PROTEINAS DA MEMBRANA CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN Limits: ANIMAL Location: BR191.1; 08621/s

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Id: 12244 Author: Rambukkana, Anura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; May 2002. 5 p. ilus, graf. Descriptors: APOPTOSE AXONIOS AXONIOS LINFOCITOS B ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL CAMUNDONGOS KNOCKOUT MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL FIBRAS NERVOSAS MIELINIZADAS NEURONIOS CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN NERVO CIATICO NERVO CIATICO LINFOCITOS T CULTURA DE TECIDO Limits: ANIMAL Location: BR191.1; 08647/s

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Id: 12225 Author: Cemerski, Saso; cantagrel, Alain; Van Meerwijk, Joost P. M; Romagnoli, Paola Title: Reactive oxygen species differentially affect T cell receptor-signaling pathways ..- Source: s.l; s.n; May 2002. 9 p. iluis, tab, graf. Descriptors: ANTICORPOS MONOCLONAIS ANTIGENOS CD3 DIVISAO CELULAR COCULTURA RELAÇAO DOSE-RESPOSTA A DROGA CITOMETRIA DE FLUXO IMMUNOBLOTTING PROTEINAS DA MEMBRANA PROTEINAS DA MEMBRANA NEUTROFILOS ESTRESSE OXIDATIVO FOSFORILAÇAO ESPÉCIES DE OXIGENIO REATIVAS RECEPTORES DE ANTIGENO DA CÉLULA-T RECEPTORES DE ANTIGENO DA CÉLULA-T TRANSDUÇAO DE SINAL FATORES DE TEMPO Location: BR191.1; 08708/s

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Id: 11749 Author: Rambukkana, Amura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; 2002. 5 p. ilus. Descriptors: HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE AXONIOS AXONIOS ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS MACROFAGOS MUTAÇAO BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL - FIBRAS NERVOSAS MIELINIZADAS  NEURONIOS  CÉLULAS DE SCHWANN  CÉLULAS DE SCHWANN  NERVO CIATICO  NERVO CIATICO  LINFOCITOS T  CULTURA DE TECIDO Location: BR191.1; 08525/s

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Id: 11744 Author: Brophy, Peter J Title: Subversion of Schwann cells and the leper's Bell ..- Source: s.l; s.n; 2002. 2 p. ilus. Descriptors: HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE AXONIOS DIFERENCIAÇAO CELULAR MEMBRANA CELULAR COCULTURA PROTEINAS CITOESQUELETO DOENÇAS DESMIELINIZANTES DISTROFINA GLICOLIPIDIOS LAMININA GLICOPROTEINAS DE MEMBRANAS BAINHA DE MIELINA CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN Location: BR191.1; 08527/s

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Id: 10270 Author: Singh, Neeta; Birdi, Tannaz J; Antia, Noshir H Title: Differential in vitro modulation of schwann cell proliferation by mycobacterium leprae and macrophages in the murine strains, Swiss white and C57BI/6 ..- Source: s.l; s.n; 1998. 10 p. tab, graf. Descriptors: DIVISAO CELULAR COCULTURA HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07165/s

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