Database : HANSEN
Search on : NEUTROFILOS [Subject descriptor]
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Texto Completo-pt
Id:18620
Author:Miranda, R. N..
Title:A propósito de um caso de manifestação aguda da lepra: encontro de bacilos de Hansen incluídos em polimorfonucleares. Esboço clínico e patogênico das manifestações agudas, em lepromatosos.
Source:Rev. bras. Leprol;29(1):3-12, mar. 1961. ilus.
Abstract:O autor descreve um caso de lepra lepromatosa, que apresentou fenomenos agudos constituidos por febre, adenopatias, hiperleucocitose, etc., e lesões cutaneas eritema-necroticas, em cujo exsudato foram encontrados bacilos de Hansen, sob a forma de globias, incluidos em polimorfonucleares. O surto agudo durou trinta dias, depois do qual o doente restabeleceu-se, continuando a sofrer sua lepra lepromatosa crônica, da variedade clinica difusa, vindo a manifestar, posteriormente, novos surtos. Aproveita a ocorrência desse caso para recordar um trabalho de sua autoria, publicado em 1942("Manifestações agudas da Lepra" Tese, Fac. Med., Curitiba, 1942), no qual: 1-estudou os chamados estado de reação, na lepra, como resultatntes de um processo patogênico comum, devidos a própria doença, em exarcebação aguda; 2- denominou esses estados, genericamente, de MANIFESTAÇÕES AGUDAS DA LEPRA, com diversas variedades clinicas; 3- fes referência, mais de uma vez, ao encontro de bacilos de Hansen, em lepromatosos, sob a forma de globias ou não, fagocitados pelos polimorfonucleares, em exsudato daquelas lesões agudas que supurararm ou ulceraram; 4- admitiu que as lesões agudas dessas manifestações, no tipo L, não se processam apenas no tegmento, mas tambem nos nervos, nos gânglios, nas visceras; 5- referiu-se ao fato de que, quando essas manifestações chegam a supuração de suas lesões cutâneas, pproporcionam grande eliminação de bacilos e, consequentemente, beneficio para o enfermo.(AU)^ipt.
Descriptors:Hanseníase/imunol
Hanseníase/microbiol
Hanseníase/fisiopatol
Mycobacterium leprae/citol
Mycobacterium leprae/fisiol
Mycobacterium leprae/patogen
Neutrófilos/microbiol
Neutrófilos/fisiol
Electronic Medium:http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1961/PDF/v29n1/v29n1a01.pdf / pt
Location:BR191.1


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Id:17616
Author:Lopez-Hurtado, Marcela; Flores-Medina, Saul; Díaz-García, Francisco J; Guerra-Infante, Fernando M
Title:Partial characterization of phagocytic activity in neutrophils of the nine-banded armadillo Dasypus novemcinctus ..-
Source:s.l; s.n; 2005. [7] p. tab.
Descriptors:Animais
Tatus/*IM
Atividade Bactericida do Sangue
Quimiotaxia de Leucócito/DE
Endocitose
Escherichia coli/IM
Humanos
In Vitro
Cinética
Hanseníase/IM
Monócitos/IM
N-Formilmetionina Leucil-Fenilalanina/PD
Neutrófilos/DE/*IM
Proteínas Opsonizantes/IM
Fagocitose/*
Location:BR191.1; 09349/S


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Id:13578
Author:Kramarsky, Bernard; Edmondson, Hugh A; Peters, Robert L; Reynolds, Telfer B
Title:Lepromatous leprosy in reaction ..-
Source:s.l; s.n; May 1968. 16 p. ilus.
Abstract:Biopsies of the skin and liver were obtained from a patient with Lucio's type of leprosy and from one with erythema nodosum leprosum. Vasculitis, a dense inflammatory exudate, and necrosis of the skin characterized the Lucio type of leprosy; in erythema nosodum leprosum the vasculitis was not so severe and necrosis did not occur. Large numbers of organisms in the endothelial cells of the vessels in the skin could have given rise to bacteremia and development of the disease in the liver. The liver in the patient with Lucio's phrnomenon contained tuberculoid lesions, whereas necrosis of sinusoidal walls and many Virchow's cells were noted in the other patient. Lperosy bacilli in Kupffer cells were easily demonstrated with electron microscopy. The presence of the bacteria within membrane-bound phagocytic vacuoles and the fusion of lysosomes with the vacuoles were seen.(AU).
Descriptors:GRANULOMA/etiol
GRANULOMA/patol
HANSENIASE/compl
HANSENIASE/patol
NECROSE
PELE/microbiol
PELE/patol
MYCOBACTERIUM LEPRAE/citol
MYCOBACTERIUM LEPRAE/isol
MICROSCOPIA ELETRÔNICA
 MITOCÔNDRIA
 NEUTROFILOS
 FAGOCITOSE
Limits:HUMANO
MASCULINO
FEMININO
ADULTO
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 00765/s


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Id:13559
Author:Srivastava, D. C; Shekhawat, R. S; Saksena, H. C; Gupta, L. N
Title:Granulocyte adherence in leprosy ..-
Source:s.l; s.n; apr. 1984. 4 p. tab.
Abstract:Granulocyte adherence was assessed in 45 patients suffering from three different of leprosy (20 lepromatous, 10 borderline and 15 tuberculoid). A significant (P<0.001) impairment of granulocyte adherence was found in all types of leprosy studied in comparison with equal number of matched controls. Impairment was more in the lepromatous leprosy group followed by borderline and tuberculoid groups.(AU).
Descriptors:ADESIVIDADE
GRANULOCITOS/fisiol
HANSENIASE/sangue
NEUTROFILOS/fisiol
Limits:ESTUDO COMPARATIVO
HUMANO
MASCULINO
FEMININO
ADULTO
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 01770/s


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Id:13537
Author:Wahba, Asher; Cohen, Haim; Sheskin, Jacob
Title:Neutrophil chemotactic response in lepromatous leprosy: an in vitro study of 52 patients ..-
Source:s.l; s.n; 1980. 6 p. ilus, tab, graf.
Abstract:The chemotactic responses of neutrophils derived from 52 patients with lepromatous leprosy and 24 healthy controls were assessed in vitro by a modification of the Boyden chamber method using lipopolysaccharide-activated serum as a chemotactic factor. Highly bacilliferous patients with active disease of long-standing duration had significantly reduced chemotactic responses, while patients with burnt-out lepromatous leprosy as well as those with recently acquired disease showed normal chemotactic responses. Preincubation of normal human blood group O leukocytes in plasma from patients with active disease of long-standing duration markedly reduced their chemotactic responses whereas preincubation in plasma derived from patients belonging to the other two subgroups of patients did not affect much leokotaxis. These findings suggest that the diminished chemotactic capacities among certain plasma factors sucha as immunoglobulins or antigen - antibody complexes that may-by attachment to the cell membrane-block the receptors required for interaction with the chemotactic factor. (AU).
Descriptors:NEUTROFILOS
FATORES DE TEMPO
HANSENIASE/imunol
QUIMIOTAXIA DE LEUCOCITO
Limits:HUMANO
MASCULINO
FEMININO
ADULTO
MEIA-IDADE
IDOSO
SUPPORT, NON-U.S. GOV'T
Location:BR191.1; 08987/s


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Id:13420
Author:Purtilo, David T; Walsh, Gerald P; Storrs, Eleanor E; Gannon, Carman
Title:The immune system of the nine-banded armadillo (Dasypus novemcinctus, Linn) ..-
Source:s.l; s.n; apr. 1975. 9 p. ilus, tab.
Abstract:The armadillo is rapidly emerging as an animal for biomedical research. A morphological study of the immune system of the armadillo was undertaken to try to demonstrate a possible defect in the morphogenesis of the lymphoid organs that could account for their susceptibility to leprosy. Blood from 20 domesticated adult armadillos revealed lymphocytes predominated among circulating leukocytes in the majority of animals, whereas in wild animals neutrophils predominated. Necropsies revealed well-developed thymus glands and the thymus-dependent areas in lymph nodes and spleens contained abundant lymphoid cells. Hence, we conclude that the susceptibility of the armadillo to leprosy cannot be explained on a morphological basis.(AU).
Descriptors:HANSENIASE/imunol
LINFOCITOS/citol
LEUCOCITOS/citol
MYCOBACTERIUM LEPRAE/patogen
HISTIOCITOS/citol
NEUTROFILOS/citol
TECIDO LINFOIDE/anat
LINFONODOS/anat
XENARTROS/anat
XENARTROS/imunol
Limits:ANIMAL
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 00495/s


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Id:13260
Author:Anderson, R; Gatner, E. M. S; van Rensburg, C. E; Grabow, G; Imkamp, F. M. G. H; Kok, S. K; van Rensburg, A. J
Title:In vitro and in vivo effects of dapsone on neutrophil and lymphocyte functions in normal individuals and patients with lepromatous leprosy ..-
Source:s.l; s.n; apr. 1981. 9 p. tab, graf.
Abstract:The effects of dapsone on polymorphonuclear leukocyte functions and lymphocyte mitogen-induced transformation were assessed in vitro and in vivo in normal individuals and in newly diagnosed untreated patients with lepromatous leprosy. The effects of dapsone on the cell-free generation of superoxide by the xanthine: xanthine oxidase system and iodination of bovine serum albumin by horseradish peroxidase were also investigated. In normal individuals dapsone mediated stimulation of polymorphonuclear leukocyte migration in vitro and vivo. Dapsone had no effect on postphagocytic hexose monophosphate shunt activity in vivo. Similar effects were found in patients with lepromatous leprosy. Dapsone also decreased the inhibitory activity of serum from patients with lepromatous leprosy on normal polymorphonuclear leukocyte migration in vitro. Progressive loss of serum-mediated inhibition of migration was observed after ingestion of dapsone by the patients. Further experiments showed that stimulation of polymorphonuclear leukocyte motility was related to inhibition of lymphocyte transformation at high concentrations in vitro, but had slight stimulatory activity on phytohemagglutinin-induced transformation in controls and patients in vivo.(AU).
Descriptors:PEROXIDASE/metab
SUPEROXIDOS/metab
HANSENIASE/sangue
PEROXIDO DE HIDROGÊNIO/metab
TRANSFORMACAO LINFOCITICA/ef drogas
LINFOCITOS/ef drogas
NEUTROFILOS/ef drogas
FAGOCITOSE/ef drogas
MOVIMENTO CELULAR/ef drogas
DAPSONA/farmacol
Limits:HUMANO
IN VITRO
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 00756/s


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Id:12225
Author:Cemerski, Saso; cantagrel, Alain; Van Meerwijk, Joost P. M; Romagnoli, Paola
Title:Reactive oxygen species differentially affect T cell receptor-signaling pathways ..-
Source:s.l; s.n; May 2002. 9 p. iluis, tab, graf.
Descriptors:ANTICORPOS MONOCLONAIS
ANTIGENOS CD3
DIVISAO CELULAR
COCULTURA
RELAÇAO DOSE-RESPOSTA A DROGA
CITOMETRIA DE FLUXO
IMMUNOBLOTTING
PROTEINAS DA MEMBRANA
PROTEINAS DA MEMBRANA
NEUTROFILOS
ESTRESSE OXIDATIVO
FOSFORILAÇAO
ESPÉCIES DE OXIGENIO REATIVAS
RECEPTORES DE ANTIGENO DA CÉLULA-T
RECEPTORES DE ANTIGENO DA CÉLULA-T
TRANSDUÇAO DE SINAL
FATORES DE TEMPO
Location:BR191.1; 08708/s


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Id:12224
Author:Anshu,; Gangane, Nitin; Vagha, Sunita; Samal, N
Title:Cytodiagnosis of erythema nodosum leprosum: a case report ..-
Source:s.l; s.n; Mar.-Apr. 2002. 3 p. ilus.
Descriptors:BIOPSIA POR AGULHA
ERITEMA NODOSO
ERITEMA NODOSO
HANSENIASE LEPROMATOSA
HANSENIASE LEPROMATOSA
NEUTROFILOS
Limits:RELATO DE CASO
Location:BR191.1; 08707/s


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Id:11760
Author:Oliveira, Rosane Barbosa de
Title:Atividade de neutrófilos polimorfonucleares ?-
Source:Rio de Janeiro; s.n; 1998. xiv,126 p. ilus, graf.
Thesis:Present for Fundação Oswaldo Cruz presented for the degree Mestre.
Abstract:No presente estudo ficou demonstrado que neutrófilos polimorfonucleares (PMN) participam da resposta inflamatória aguda como células efetoras. Pacientes lepromatosos com episódio reacional (50 por cento) apresentam intenso infiltrado de neutrófilos, e justamente com pacientes não reacionais e doadores sadios tiveram suas células de sangue periférico purificadas e analisadas. Na primeira fase do trabalho, foi confirmado o tempo de vida limitado destas células em cultura, assim como sua progressão para apoptose de forma crescente. Consequentemente, o número de células em cultura diminui, mas as células remanescentes mantêm integridade de membrana. Apoptose foi marcadamente acelerada nos pacientes com ENL quando avaliada por eletroforese em gel de agarose e análise quantitativa através da reação de difenilamina. Numa segunda fase do trabalho, observamos que neutrófilos estimulados com LPS e M. leprae sintetizam e secretam TNF-a e IL-8 em quantidade significativas. Foi também demonstrado que neutrófilos estimulados com LAM-ML secretam IL-8. A talidomida, droga conhecida por inibir a produção de TNF-a por monócitos, também foi capaz de inibir a produção de TNF-a induzido por LPS em neutrófilos "in vitro". A expressão do gene de TNF-a foi avaliada por hibridização por Northen blot. A capacidade de neutrófilos de sintetizar e secretar citocinas após estímulo por produtos micobacterianos sugere a participação destas células na regulação da resposta imune. A citocina inflamatória TNF-a que é secretada em altos níveis nos estados reacionais, é também produzida por neutrófilos, o que pode estar relacionado a amplificação da produção de TNF-a no local da lesão. (AU).
Descriptors:HANSENIASE
NEUTROFILOS
MYCOBACTERIUM LEPRAE
Location:BR191.1; WC335.400, O4a


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Id:11747
Author:Anshu,; Gangane, Nitin; Vagha, Sunita; Samal, N
Title:Cytodiagnosis of erythema nodosum leprosum. A case Report ..-
Source:s.l; s.n; 2002. 3 p. ilus.
Descriptors:HANSENIASE LEPROMATOSA
HANSENIASE LEPROMATOSA
BIOPSIA POR AGULHA
ERITEMA NODOSO
ERITEMA NODOSO
NEUTROFILOS
Limits:RELATO DE CASO
HUMANO
MASCULINO
MEIA-IDADE
Location:BR191.1; 08452/s


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Id:11026
Author:Chogle, A. R
Title:Rheumatic manifestations of leprosy ..-
Source:s.l; s.n; jun. 1999. 3 p. .
Descriptors:RELAÇAO CD4-CD8
DIAGNOSTICO DIFERENCIAL
HANSENIASE
HANSENIASE
DOENÇAS REUMATICAS
DOENÇAS REUMATICAS
Anticorpos Anticitoplasma de Neutrófilos/BL
Location:BR191.1; 07470/s


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Id:10282
Author:Oliveira, R. B; Moraes, M. O; Oliveira, E. B; Sarno, E. N; Nery, J. A. C; Sampaio, E. P
Title:Neurotrophils isolated from leprosy patients release TNF-a and accelerated apoptosis in vitro ..-
Source:s.l; s.n; 1999. 8 p. ilus, tab, graf.
Descriptors:HANSENIASE
HANSENIASE
HANSENIASE
MYCOBACTERIUM LEPRAE
APOPTOSE
LIPOPOLISSACARIDIOS
LIPOPOLISSACARIDIOS
NEUTROFILOS
NEUTROFILOS
FATOR DE NECROSE DE TUMOR
Location:BR191.1; 07421/s


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Id:9870
Author:Ochoa, Maria Teresa; Valderrama, Lilliana; Ochoa, Augusto; Zea, Arnold; Escobar, Carlos E; Moreno, Luis H; Falabella, Rafael
Title:Lepromatous and tuberculoid leprosy: clinical presentation and cytokine response ..-
Source:s.l; s.n; 1996. 5 p. ilus, tab.
Descriptors:CITOCINAS
TÉCNICAS IMUNOENZIMATICAS
INTERFERON TIPO II
INTERLEUCINA-1
INTERLEUCINA-10
INTERLEUCINA-2
INTERLEUCINA-4
INTERLEUCINA-6
HANSENIASE LEPROMATOSA
HANSENIASE LEPROMATOSA
HANSENIASE TUBERCULOIDE
HANSENIASE TUBERCULOIDE
TRANSFORMAÇAO LINFOCITICA
MUROMONAB-CD3
NEUTROFILOS
Location:BR191.1; 06807/s


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Id:9767
Author:Singh, Navjeevan; Arora, Vinod Kumar; Ramam, M
Title:Nodular lepromatous leprosy: report of a case diagnosed by FNA ..-
Source:s.l; s.n; 1994. 3 p. ilus.
Descriptors:HANSENIASE LEPROMATOSA
HANSENIASE LEPROMATOSA
HANSENIASE LEPROMATOSA
AXILA
BIOPSIA POR AGULHA
NUCLEO CELULAR
CITOPLASMA
LINFOCITOS
GANGLIOS LINFATICOS
MACROFAGOS
MYCOBACTERIUM LEPRAE
NEUTROFILOS
COLORAÇAO
Location:BR191.1; 06682/s


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Id:8362
Author:Cree, I. A; Swanson Beck, J
Title:The influence of killed Mycobacterium leprae and other mycobacteria on opsonized yeast phagocytosis ..-
Source:s.l; s.n; 1986. 6 p. ilus, graf.
Descriptors:MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
HANSENIASE
AGREGAÇAO CELULAR
LUMINESCENCIA
MICROSCOPIA ELETRONICA
MONOCITOS
NEUTROFILOS
OPSONINAS
ZIMOSAN
Location:BR191.1; 02421/s


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Id:7641
Author:Clark, Richard A. F
Title:Cutaneous tissue repair: basic biology considerations. I ..-
Source:s.l; s.n; 1985. 25 p. ilus, tab.
Abstract:Wound repair of the integument is reviewed in the context of new developments in cell biology and biochemistry. Injury of the skin and concomitant blood vessel disruption lead to extravasation of blood constituents, followed by platelet aggregation and blood clotting. These events initiate inflammation and set the stage for repair processes. The macrophage plays a pivotal role in the transition between wound inflammation and repair (granulation tissue formation), since this cell both scavenges tissue debris and releases a plethora of biologically active substances that include growth factors. Although concrete evidence is lacking, growth factors are probably at least partially responsible for the angiogenesis and fibroplasia (granulation tissue) that gradually fill the wound void. If the epidermal barrier is disrupted during injury, reepithelialization begins within 24 hours and proceeds first over the margin of residual dermis and subsequently over granulation tissue. The signals for angiogenesis, fibroplasia, neomatrix formation, and reepithelialization in wound repair are not known, but a number of possibilities are discussed. Matrix remodeling is the last stage of wound repair and gradually increases the scar tensile strength to 70% to 80% of normal skin. (AU).
Descriptors:COAGULACAO SANGUINEA
COLAGENO/AN
EPITELIO/PH
MATRIZ EXTRACELULAR/PH
FIBROBLASTOS/PA
FIBRONECTINAS/AN
TECIDO DE GRANULACAO/PH
ACIDO HIALURONICO/AN
INFLAMACAO/PA
NEOVASCULARIZACAO PATOLOGICA
NEUTROFILOS/PA
PROTEOGLICANOS/AN
PELE/IN
FISIOLOGIA DA PELE
CICATRIZACAO DE FERIDAS
Limits:ANIMAL
HUMANO
SUPPORT, NON-U.S. GOV'T
Location:BR191.1; 0075/cme


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Texto Completo-En
Id:7006
Author:Fliess, Enrique; Franceschini, Gabriela; Ortiz, Maria C.
Title:In vitro effect of Mycobacterium leprae suspensios on the polymorphonueclear neutrophiles funcion on the hanseniasis patients to Candida and Candida pseudotropicalis.
Source:Hansen. Int;9(1/2):3-9, jun.-dez 1984. tab.
Abstract:The in vitro effect of Mycobacterium leprae suspensions on the PMN hability to phagocyting and killing Candida albicans and Candida pseudotropicalis was studied in forty-five patients of Hansen's disease and in fifteen healthy controls. Our results show no significative differences between the diferent studied groups, both for the phagocytosis and for the lysis of yeasts. There was no significant changes in the mean values of these functions after previous or simultaneously incubation with Mycobacterium leprae suspensions. Those observations confirmed that there are not alterations in the enzimatic battery of PMN in Hansen's disease patients and that the Mycobacterium leprae presence does not exert stimulating effect on this in vitro model. (AU). .
Descriptors:HANSENIASE
MYCOBACTERIUM LEPRAE
 MYCOBACTERIUM LEPRAE
 MYCOBACTERIUM LEPRAE
 NEUTROFILOS
 NEUTROFILOS
 CANDIDA ALBICANS
Electronic Medium:http://hansen.bvs.ilsl.br/textoc/hansenint/v01aov20/1984/PDF/v9n1-2a01.pdf / En
Location:BR191.1



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