Database : HANSEN Search on : PELE/PATOL [Subject descriptor] References found : 94 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 17705 Author: Oda, Roseli Marega; Salotti, Selma Regina Axcar; Guimaraes, Heloisa Cristina Quatrini Carvalho Passos Title: Manual de normas, rotinas e tecnicas de curativos do ILSL Manual of norms and routines and techniques of dressings of the ILSL- Source: Bauru; Centro de Estudos Dr. Reynaldo Quagliato; 2004. 36 p. ilus. Descriptors: BANDAGENS/normas BANDAGENS/tend CURATIVOS BIOLOGICOS/normas CURATIVOS BIOLOGICOS/tend CURATIVOS BIOLOGICOS/util PELE/anat PELE/patol PELE/cirurg Limits: ESTUDO COMPARATIVO HUMANO Electronic Medium: http://hansen.bvs.ilsl.br/textoc/livros/ODA_ROSELI/PDF/manual_rotinas%20.pdf / pt Location: BR191.1; WO167, O1m

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Id: 17632 Author: Brakel, Wim H. Van. Title: Peripheral nerve function assessment. Source: In: Schwarz, Richard; Brandsma, Wim.Surgical reconstruction rehabilitation in leprosy and other neuropathies. Kathmandu, Ekta Books, 2004. p.11-24ilus, tab. Descriptors: DOENCAS DO SISTEMA NERVOSO PERIFERICO/diag DOENCAS DO SISTEMA NERVOSO PERIFERICO/reabil DOENCAS DO SISTEMA NERVOSO PERIFERICO/cirurg PELE/patol PELE/fisiopatol SENSIBILIDADE TERMICA/fisiol - ATAXIA/fisiopatol  DOENCA DOS NEURÔNIOS MOTORES/fisiopatol Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1, S96s

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Id: 17445 Author: Enna, C. E Title: Dermatological aspects of the skin its relationship to surgery in patients with leprosy ?- Source: Louisiana; s.n; 1967. 10p p. . Abstract: Definitive surgery for leprosy includes plastic, orthopedic, and general procedures. They are performed to improve or correct cosmetic and functional deformities that primarily affect the face and extremities, also for other problems due to leprosy, as gynecomastia and orchitis, and for problems that are unrelated to leprosy. Details of surgical technique would hardly be of interest to dermatologists. More important are the problems that contribute in the selection of surgical candidates. Knowledge of the pathogenesis, pathology and the morbidity of the indications and the appropriate surgical procedures. Factors concerning these problems are included in today's subject: the dermatological aspects and the relationship of the skin to surgery. Descriptors: HANSENIASE/microbiol HANSENIASE/cirurg PELE/les PELE/microbiol PELE/patol PELE/cirurg MEMBRANA MUCOSA/patol Limits: RELATO DE CASO Location: BR191.1; 01097/d.a

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Id: 13715 Author: Franco-Paredes, Carlos; Guarner, Jeannette; Mehrabi, Don; McCall, Calvin; Rio, Carlos del Title: Clinical and pathological recognition of leprosy ..- Source: s.l; s.n; 2003. 2 p. ilus. Descriptors: BIOPSIA/métodos HANSENOSTATICOS/uso terap HANSENIASE/quimioter HANSENIASE/patol PELE/patol COLORACAO E ROTULAGEM/métodos Limits: RELATO DE CASO HUMANO MASCULINO MEIA-IDADE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09136/s

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Id: 13704 Author: Antoni-Bach, N; Cribier, B; Piémont, Y; Heid, E; Lipsker, D Title: Lèpre: un diagnostic devenu difficile par sa rareté en France métropolitaine Leprosy: difficult to diagnose today because of its rarity in France- Source: s.l; s.n; 2002. 2 p. . Descriptors: BIOPSIA DIAGNOSTICO DIFERENCIAL FRANCA HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/patol PELE/patol Limits: RELATO DE CASO HUMANO FEMININO MEIA-IDADE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09001/s

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Id: 13578 Author: Kramarsky, Bernard; Edmondson, Hugh A; Peters, Robert L; Reynolds, Telfer B Title: Lepromatous leprosy in reaction ..- Source: s.l; s.n; May 1968. 16 p. ilus. Abstract: Biopsies of the skin and liver were obtained from a patient with Lucio's type of leprosy and from one with erythema nodosum leprosum. Vasculitis, a dense inflammatory exudate, and necrosis of the skin characterized the Lucio type of leprosy; in erythema nosodum leprosum the vasculitis was not so severe and necrosis did not occur. Large numbers of organisms in the endothelial cells of the vessels in the skin could have given rise to bacteremia and development of the disease in the liver. The liver in the patient with Lucio's phrnomenon contained tuberculoid lesions, whereas necrosis of sinusoidal walls and many Virchow's cells were noted in the other patient. Lperosy bacilli in Kupffer cells were easily demonstrated with electron microscopy. The presence of the bacteria within membrane-bound phagocytic vacuoles and the fusion of lysosomes with the vacuoles were seen.(AU). Descriptors: GRANULOMA/etiol GRANULOMA/patol HANSENIASE/compl HANSENIASE/patol NECROSE PELE/microbiol PELE/patol MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/isol - MICROSCOPIA ELETRÔNICA  MITOCÔNDRIA  NEUTROFILOS  FAGOCITOSE Limits: HUMANO MASCULINO FEMININO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00765/s

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Id: 13563 Author: Shepard, Charles C Title: Immunology and animal experimentation in leprosy ..- Source: s.l; s.n; jul. 1976. 17 p. ilus, tab, graf. Abstract: The immunological status of leprosy patients is reflected in the clinical picture. Figure 1 and 2 illustrate the lepromatous variety.(AU). Descriptors: VACINA BCG ANTIGENO DE MITSUDA/admin HANSENIASE/clas HANSENIASE/imunol HANSENIASE/patol TESTES CUTÂNEOS PELE/imunol PELE/patol MYCOBACTERIUM LEPRAE/imunol Limits: HUMANO ANIMAL MASCULINO ADULTO MEIA-IDADE CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00573/s

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Id: 13549 Author: Binford, Chapman H; Meyers, Wayne M; Walsh, Gerald P; Storrs, Eleanor E; Brown, Harriet L Title: Naturally acquired leprosy-like disease in the nine-banded armadillo (Dasypus Novemcinctus): histopathologic and microbiogic studies of tissues ..- Source: s.l; s.n; oct. 1977. 12 p. ilus, tab. Abstract: Histopathologic studies were conducted on tissues from necropsies on 41 nine-banded armadillos from Louisiana with a natural disease resembling lepromatous leprosy, hereafter often referred to as the "natural disease". The lesions were composed of macrophages (histiocytes) containing numerous acid-fast bacilli and were similar those seen in armadillos experimentally inoculated with Mycobacterium leprae. Invasion of small and large nerves by phagocytes containing acid-fast bacilli was a characteristic feature of the natural disease. The Mycobacterium presumed to cause the disease was not cultivable on standard mycobacterial media; however, mycobacteria belonging to the M. avium-intracellulare group were cultivated from lymph nodes of 8 and the spleen of 1 of 32 of the diseased armadillos but not from other organs. Cultures of lymph node specimens and other organs from each of the remaining 24 diseased armadillos were negative. Acid-fastness of the bacilli in all tissues was abolished on exposure to pyridine. The bacilli were DOPA oxidase positive, but interpretation of this finding is difficult because some tissues from normal armadillos also gave positive reactions in the spot test employed. Histopathologic studies of tissue from autopsies on the 41 armadillos and microbiologic studies on tissues from 32 of the animals provided evidence indicating that the cause of the natural disease in armadillos may be M. leprae.(AU). Descriptors: TATUS/microbiol HANSENIASE/microbiol HANSENIASE/patol HANSENIASE/vet LINFONODOS/microbiol MACROFAGOS/microbiol MYCOBACTERIUM/isol PELE/microbiol PELE/patol Limits: ESTUDO COMPARATIVO ANIMAL SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 00571/s

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Id: 13545 Author: Convit, Jacinto; Avila, J. L; Goihman, M; Pinardi, M. E Title: A test for the determination of competency in clearing bacilli in leprosy patients ..- Source: s.l; s.n; 1972. 6 p. ilus. Abstract: A skin test has been developed to determine the degree of competency in clearing bacilli from the tissues of patients suffering from various forms of leprosy. The test involves the intradermal ijection of a suspension of killed Mycobacterium leprae. The response of leprosy patients to the injection of other mycobacterial antigens, one prepared from M. lepraemurium and another from an atypical mycobacterium from a hamster, was also investigated in roder to study the isopathic phenomenon. Since lepromatous patients react negatively in tests with standard Mitsuda antigen, a concentration of 640 x 10(6) M. leprae per ml was used to producce macroscopic responses. The results of the test can be applied to determine the duration of consolidation treatment for lepromatous and indeterminate bacteriologically negative patients after regular treatment has ended. The test can also be used to indicate which Mitsuda-negative contacts should be given preventive treatment, and might be used to identify a given mycobacterium as M. leprae.(AU). Descriptors: ANTIGENOS DE BACTERIAS BIOPSIA HANSENIASE/imunol HANSENIASE/patol MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAEMURIUM PELE/patol TESTES CUTÂNEOS - MACROFAGOS  METODOS  FAGOCITOSE Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00581/s

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Id: 13519 Author: Kramarsky, Bernard; Edmondson, Hugh A; Peters, Robert L; Reynolds, Telfer B Title: Lepromatous leprosy in reaction ..- Source: s.l; s.n; may 1968. 16 p. ilus. Abstract: Biopsies of the skin and liver were obtained from a patient with Lucio´s type of leprosy and from one with erythema nodosum leprosum. Vasculitis, a dense inflammatory exudate, and necrosis of the skin characyerized the Lucio type of leprosy; in erythema nodosum leprosum the vasculitis was not so severe and necrosis didi not occur. Large numbers of organisms in the endothelial cells of the vessels in the skin could have given rise to bacteremia and development of the disease in the liver. The liver in the patient with Lucio´s phenomenon contained tuberculoid lesions, whereas necrosis of sinusoidal walls and many Virchow´s cells were noted in the other patient. Leprosy becilli in Kupffer cells were easily demonstrated with electron microscopy. The presence of the bacteria within membrane-bound phagocytic vacuoles and the fusion of lysosomes with the vacuoles were seen...(AU). Descriptors: PELE/microbiol PELE/patol GRANULOMA/etiol GRANULOMA/patol HANSENIASE/compl HANSENIASE/patol MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/isol Limits: HUMANO MASCULINO FEMININO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00606/s

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Id: 13489 Author: Gómez-Estrada, Hector; Morales-Ortiz, Roberto; González-Mendoza, Amado; Barba-Rubio, Jose; Ceja-Mendoza, Sagrario Title: Peroxidase deficiency in histiocytes of patients with nodular lepromatous leprosy ..- Source: s.l; s.n; Apr.-Jun. 1983. 11 p. ilus, tab. Abstract: The purpose of this study was to investigate the presence of peroxidase (PO) in the histiocytes which are found in the lepromatous lesions of patients with nodular lepromatous leprosy (NLL). We studied dermoepidermal biopsy specimens from lepromstous lesions and blood smears of 10 patients with NLL, eight males and twoo females 28 to 63 years age (average 45 + or - 6.2), of which nine coursed with the stable form of the disease and one was in lepromatous reaction. Six had received treatment with diaminodiphenylsulphone for more than six months, and the other four, none. As controls we studied the blood smears of 10 healthy controls and 10 rat liver sections. PO was investigated in histiocytes, Kupffer cells and polymorphonuclears by dichlorhydrate oxydation, according to the technique of Kaplow. By means of Fite-Faraco´s stain, all ten cases proved to have abundant phagocytized M. leprae. PO was not found in histiocytes of lepromatous lesions in nine cases of stable NLL in lepromatous reaction. PO was present in Kupffer cells, in polymorphonuclears of patients with NLL and in controls. No difference was found either in the PO or M. leprae contents between treated and untreated patients. The PO deficiency in histiocytes of patients with NLL may be related to an incapacity of these cells to destroy M. leprae.(AU). Descriptors: PELE/enzimol PELE/patol FAGOCITOSE PEROXIDASES/defic HANSENIASE/enzimol HANSENIASE/patol HISTIOCITOS/enzimol Limits: HUMANO ANIMAL MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO RATOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 01309/s

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Id: 13483 Author: Jacobson, Robert R; Trautman, John R Title: The diagnosis and treatment of leprosy ..- Source: s.l; s.n; aug. 1976. 7 p. ilus. Abstract: Leprosy is a complex disease, but recent research and the Ridley-Jopling classification which emphasize its immunologic aspects have greatly aided our understanding of and approach to the problem. The diagnosis should be considered whenever skin lesions and sensory loss occur. Dapsone remains the treatment of choice, but several newer drugs show great promise, especially in those cases whose bacilli have become sulfone resistant. Immunotherapy may play an increasingly prominent role in the future. Reactive episodes continue to be a serious complication, but the availability of thalidomide to control erythema nodosum leprosum has markedly improved the prognosis. Physicians of the US Public Health Service Hospital at Carville, Louisiana, are available at all times for consultation on these and other matters related to leprosy.(AU). Descriptors: ERITEMA NODOSO/quimioter DAPSONA/uso terap TALIDOMIDA/uso terap ESTADOS UNIDOS RIFAMPINA/uso terap PELE/patol HANSENIASE/diag HANSENIASE/imunol HANSENIASE/terap Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00234/s

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Id: 13467 Author: Stevens, Michael H; Nielsen, David R Title: Otolaryngologic manifestations of Hansen's disease ..- Source: s.l; s.n; Sep-Oct. 1982. 4 p. ilus, tab. Abstract: A Mexican migrant farm worker whose condition was previously undiagnosed was examined at the University of Utah Medical Center. He had an unusual peripheral neuropathy, ulcerative and nodular skin lesions, and multiple head and neck complaints. Results of the history, physical examination, and multiple biopsies led to the diagnosis of lepromatous leprosy. Although an uncommon disease in the United States, leprosy remains a common cause of head and neck pathologic conditions in many parts of the world and must be considered in the appropriate clinical setting.(AU). Descriptors: PELE/patol OTORRINOLARINGOPATIAS/patol UTAH HANSENIASE/patol MEXICO/etnol Limits: RELATO DE CASO HUMANO MASCULINO ADULTO BIOPSIA Electronic Medium: http://www.ilsl.br Location: BR191.1; 01457/s

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Id: 13428 Author: Modlin, R. L; Gebhard, J. F; Taylor, C. R; Rea, T. H Title: In situ characterization of T lymphocyte subsets in the reactional states of leprosy ..- Source: s.l; s.n; jul. 1983. 8 p. ilus, tab. Abstract: Using monoclonal antibodies and the immunoperoxidase technique, the numbers and distribution of T lymphocyte subsets in the tissues of reactional states of leprosy (six reversal reaction, nine erythema nodosum leprosum (ENL) and two Lucio's reaction) were determined and compared with those found in stable, non-reactional patients (six tuberculoid, two borderline lepromatous and seven lepromatous). The pattern of segregation of the suppressor/cytotoxic phenotype at the periphery of the granuloma was found in both non-reactional tuberculoid lesions and reversal reactions, but was better developed in the former. In ENL and Lucio's reaction, as well as in non-reactional lepromatous tissue, the helper/inducer and suppressor/cytotoxic phenotypes were both admixed with the aggregated histiocytes. However, the helper/suppressor ratio in ENL (2.1 +/- 0.4) was significantly larger than that in non-reactional lepromatous tissue (0.7 +/- 0.4, P less than 0.001). The immature thymocyte antigen OKT6 was found on scattered large non-lymphoid cells, most commonly in tuberculoid and reversal reaction tissues, less commonly in ENL, but only irregularly in non-reactional lepromatous tissue. The peripheral pattern of the suppressor/cytotoxic phenotype may be an immunohistological reflection of a cell-mediated immune response common to both non-reactional tuberculoid and reversal reaction patients. The reversal of the helper/suppressor ratio in ENL as compared to non-reactional lepromatous disease suggests some role for cell-mediated immunity in the pathogenesis of ENL. The OKT6 positive cell is of unknown origin and function.(AU). Descriptors: PELE/patol CONTAGEM DE LEUCOCITOS HANSENIASE/imunol HANSENIASE/patol TECNICAS IMUNOENZIMATICAS LINFOCITOS T/imunol ERITEMA NODOSO/patol LINFOCITOS T AUXILIADORES-INDUTORES/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol ANTICORPOS MONOCLONAIS/imunol Limits: ESTUDO COMPARATIVO HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01386/s

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Id: 13425 Author: Narayanan, R. B; Bhutani, L. K; Sharma, A. K; Nath, I Title: T cell subsets in leprosy lesions: in situ characterization using monoclonal antibodies ..- Source: s.l; s.n; mar. 1983. 9 p. ilus, tab. Abstract: Cryostat sections of dermal lesions from 30 untreated leprosy patients were studied by indirect immunofluorescence using monoclonal antibodies defining T cell subsets and Ia like antigens. Most lymphocytes in leprosy lesions were positive for OKT3 and Ia like antigens indicating thereby the presence of activated T cells. Maximal numbers of these cells were seen in localized paucibacillary tuberculoid leprosy lesions in close association with epithelioid cells. A decline in their numbers was observed over the leprosy spectrum with a marked reduction in disseminated, multi-bacillary, lepromatous leprosy where only scattered OKT3+ cells were visualized. OKT4 and OKT8 positive cells defining T cell subsets, were frequently found within the OKT3+ lymphocytes throughout the leprosy spectrum. The ratio of OKT4+/OKT8+ cells ranged from 1.2 to 5.0 in tuberculoid and from 0.2 to 1.0 in lepromatous lesions. Macrophages in the granulomas stained intensely with anti-Ia antisera. Ia like antigens were expressed to the same degree on macrophages with or without intracellular acid fast bacilli.(AU). Descriptors: GRANULOMA/imunol GRANULOMA/patol CONTAGEM DE LEUCOCITOS PELE/imunol PELE/patol HANSENIASE/imunol HANSENIASE/patol LINFOCITOS T/clas LINFOCITOS T/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01382/s

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Id: 13419 Author: Binford, Chapman H; Meyers, Wayne M; Walsh, Gerald P; Storrs, Eleanor E; Brown, Harriet L Title: Naturally acquired leprosy-like disease in the nine-banded armadillo (Dasypus novemcinctus): histopathologic and microbiologic studies of tissues ..- Source: s.l; s.n; oct. 1977. 12 p. ilus, tab. Abstract: Histopathologic studies were conducted on tissues from necropsies on 41 nine-banded armadillos from Louisiana with a natural disease resembling lepromatous leprosy, hereafter often referred to as the natural disease. The lesions were composed of macrophages (histiocytes) containing numerous acid-fast bacilli and were similar to those seen in armadillos experimentally inoculated with Mycobacterium leprae. Invasion of small and large nerves by phagocytes containing acid-fast bacilli was characteristic feature of the standard mycobacterial media; however, mycobacteria belonging to the M. avium-intracellulare group were cultivated from lymph nodes of 8 and the spleen of 1 of 32 of the diseased armadillos but not from other organs. Cultures of lymph node specimens and other organs from each of the remaining 24 diseased armadillos were negative. Acid-fastness of the bacilli in all tissues was abolished on exposure to pyridine. The bacilli were DOPA oxidase positive, but interpretation of this finding is difficult because some tissues from normal armadillos also gave positive reactions in the spot test employed. Histopathologic studies from 32 of the animals provided evidence indicating that the cause of the natural disease in armadillos may be M. leprae.(AU). Descriptors: MYCOBACTERIUM/isol PELE/microbiol PELE/patol XENARTROS/microbiol LINFONODOS/microbiol SISTEMA NERVOSO/microbiol HANSENIASE/microbiol HANSENIASE/patol HANSENIASE/vet Limits: ESTUDO COMPARATIVO ANIMAL SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 00571/s

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Id: 13412 Author: Ridley, D. S Title: The pathogenesis of the early skin lesion in leprosy ..- Source: s.l; s.n; nov. 1973. 16 p. ilus, tab. Abstract: A study of early skin lesions of leprosy patients, many the with a history known to be of less than 1 years duration, showed that by the use of serial sections the great majority could be classified on an immunological basis.(AU). Descriptors: CELULAS DE SCHWANN HANSENIASE/clas HANSENIASE/imunol HANSENIASE/microbiol HANSENIASE/patol NEURÔNIOS/microbiol PELE/irrig PELE/inerv PELE/microbiol PELE/patol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00029/s

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Id: 13337 Author: Convit, J; Pinardi, M. E; Rodríguez Ochoa, G; Ulrich, M; Avila, J. L; Goihman M Title: Elimination of Mycobacterium leprae subsequent to local in vivo activation of macrophages in lepromatous leprosy by other mycobacteria ..- Source: s.l; s.n; jun. 1974. 5 p. ilus. Abstract: This investigation studied the possibility og activating lepromatous macrophages by a local `in vivo` test...(AU). Descriptors: VACINA BCG HANSENIASE/imunol HANSENIASE/patol LINFOCITOS/imunol ANTIGENOS DE BACTERIAS MACROFAGOS/imunol MYCOBACTERIUM BOVIS/imunol MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAEMURIUM/imunol DERMATOPATIAS/etiol - GRANULOMA/etnol  IMUNIDADE CELULAR  PELE/patol Limits: HUMANO Electronic Medium: http:/www.ilsl.br Location: BR191.1; 01063/s

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Id: 13303 Author: Cantwell, Alan R Title: Variably acid-fast bacteria in a case of systemic sarcoidosis and hypodermitis sclerodermiformis ..- Source: s.l; s.n; 1981. 10 p. ilus. Abstract: The histologic finding of variably acid-fast coccoid forms in all the available biopsy material (skin, lymph nodes, and lung) from a case of coexisting scleroderma-like cutaneous disease (hypodermitis sclerodermiformis) and systemic sarcoidosis is reported. The morphologic size, shape, and staining characteristics of these microbes, along with the presence of the lung of 'large bodies', suggest that these microbes are cell wall deficient L forms of mycobacteria. Culture of the skin of the scleroderma-like lesion yielded Staphylococcus epidermidis, and the relationship of this isolate to the histologic findings of bacteria is discussed, as well as the possible pathogenic role played by L forms of mycobacteria in collagen disease and systemic sarcoidosis.(AU). Descriptors: BIOPSIA FASCIITE/microbiol FASCIITE/patol MYCOBACTERIUM/isol SARCOIDOSE/microbiol SARCOIDOSE/patol STAPHYLOCOCCUS/isol PELE/microbiol PELE/patol - PULMAO/microbiol  PULMAO/patol  FORMAS L Limits: RELATO DE CASO HUMANO FEMININO MEIA-IDADE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00914/s

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Id: 13285 Author: Leininger, J. R; Donham, K. J; Rubino, M. J Title: Leprosy in a chimpanzee ..- Source: s.l; s.n; may 1978. 8 p. ilus, tab. Abstract: Microscopic features of lepromatoid lesions in a chimpanzee inoculated with bovine leukemia virus consisted of diffuse dermal infiltrations of foamy histiocytes, except for a subepidermal clear zone devoid of infiltrating cells. Acid-fast organisms were in histiocytes, dermal nerves and a branch of the left radial nerve. The organisms were more intensely acid-fast with the Fite-Faraco than with the Ziehl-Neelsen stain. The oganisms did not oxidize 3,4dihydroxyphenylalanine (dopa) to indole but their acid-fast staining quality was removed by pretreatment with pyridine. Human leprosy patients, inoculated simultaneously with chimpanzee and human lepromin, reacted similarly to both lepromins. Organisms, whwn inoculated into mouse footpads, multiplied in 6 months to a quantity that was compatible with their identification as Mycobacterium leprae.(AU). Descriptors: HANSENIASE/microbiol HANSENIASE/patol HANSENIASE/vet MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/isol PAN TROGLODYTES PELE/patol Limits: ANIMAL CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00537/s

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