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| Id: | 18604
| | Author: | Hadler, W. A; Ziti, L. M. | | Title: | Algumas observações sôbre o modo de ação do 4- 4'-diaminodifenilsulfona na lepra murina / Some Observations on the mode of action of 4 - 4'-diaminodiphenyl in murine leprosy
| | Source: | Rev. bras. Leprol;24(1-2):56-68, jan-jun.- 1956. ^btab, ^bgraf.
| | Abstract: | Some aspects of the sulfone action on the murine leprosy were studied in rats, which were inoculated by the intraperitoneal route with 5, 5 mg of M. lepraemurium and then treated with 4- 4'-diamino-diphenylsulfone (DDS). The treatment was made by the oral route, 0,2 or 0,3 per cent of DDS being added to the food. The animals were divided into the following lots: Lot 1A - 20 rats treated with 0,2 per cent of DDS. Lote 1B - 20 untreated control rats. 2A - 20 rats inoculated with bacilli obtained from an animal of the lot 1A, preliminarily treated with DDS during 180 days; these animals then received 0,2 per cent of DDS mixed with the food. Lot 2B - 20 untreated control rats, which were inoculated with bacilli recovered from a rat of the lot 1B. Lot 3A - 20 rats inoculated with bacilli recovered from an animal of the lot 2A, which had previously been treated with DDS for 180 days; afterwards these animals received 0,2 per cent of DDS in the food. Lot 3B - 20 rats inoculated with the same material as the lot 3A, but afterwards treated with 0,3 per cent of DDS given with the food. Lot 3C - 20 rats inoculated with same material as the lot 3A, and kept as untreated controls. Lot 3D - 20 rats inoculated with bacilli obtained from an animal of the lot 2B; these rats were afterwards treated with DDS (0,3 per cent in the food). Lot 3E - 20 untreated control rats, inoculated with the same material as the lot 3D. The results of the treatment were based upon the survical time and the intensity of the lesions. The statistical analysis of the medium survical time in these lots of animals shows, that they constitute 3 groups. The lots which integrate these groups do not present significant difference when compared together. A first group comprises the control animals (lots 1B, 2B and 3E); a second group includes the animals inoculated with bacilli recovered from the control rats and then treated with DDS (lots 1A and 3D) and the animals inoculated with bacilli obtained from previo^ien.
| | Descriptors: | Hanseníase/quimioter
Hanseníase/imunol
Hanseníase/fisiopatol
Hanseníase/reabil
Hanseníase/terap
Dapsona/sint quim
Dapsona/farmacol
Dapsona/uso terap
| | Limits: | Humanos
| | Electronic Medium: | http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1956/PDF/v24n1-2/v24n1-2a06.pdf / pt
| | Location: | BR191.1 |
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