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Id: 18844 Author: Menezes, Dardo. Title: Influência da calmetização na mutação da lepra indiferenciada para tuberculóide reacional. Source: Rev. Bras. Leprol;27(2):93-99, abr.-jun. 1959. . Abstract: O autor pesquisando a influência do BCG, em 16 leprosos do grupo indeterminado, no município de Uruguaiana, Rio Grande do sul, apresenta uma casuística de 7 doentes ou seja 43,7%, que sofreram brusca mutação para a forma tuberculóide reacional, ingàvelmente induzida ou precipitada pela calmetização empregada, cujas doses variaram de 400 a 1.200 miligramas. O outor baseia sua conclusão no alto percentual obtido, de 43,7% estatásticamente significativo. A correlação entre o uso da vacina e o aparecimento do surto, pela ausência de qualquer outra mutação nos demais casos, quer para L.D. ou T. minor, embora 10 indiferenciado do grupo estudado fossem de início lepromino-negativos. E finalmente, pela mutação análoga constatada em 1 paciente cujo surto foi precipitado pela tuberculose pulmonar, mostrando mais uma vez a relação existente entre o bacilo de Koch, de Hansen e o BCG. O autor, fazendo a separação de alergia e imunidade, que comumente se apresentam juntas, levanta a hipótese que a lepra tuberculóide reacional, na maioria das vêzes seja provocada por um excesso de antígeno, em determinado momento, em indivíduos sensibilizados ao bacilo de Hansen, já  doentes ou em fase de inoculação da lepra indiferenciada. O antígeno poderia ser: o próprio bacilo de Hansen (haja vista a frequente positividade deste bacilo no início do surto de T.R.); o BCG só ou associado ao bacilo de Hansen (7 casos aqui observados); ou bacilo de Koch (caso documentado de T.R. negativo para bacilo de Hansen e com tuberculose pulmonar positiva para o bacilo de Koch). Concluindo, afirma o autor, que advirão novas perspectivas profiláticas para o BCG, justamente na forma matriz do Morbus Hansen, se confirmada por outros autores a freqüência dessas mutações demonstradas em Uruguaiana. (AU)^ipt. Descriptors: Hanseníase Tuberculóide/imunol Hanseníase Tuberculóide/fisiopatol Mutação/imunol Mutação/fisiol Vacina BCG/imunol Limits: Humanos Masculino Feminino Adolescente Adulto Meia-Idade Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1959/PDF/v27n2/v27n2a04.pdf / pt Location: BR191.1

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Id: 17562 Author: Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae Title: Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation ..- Source: s.l; s.n; 2004. 7 p. ilus, tab, graf. Abstract: Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infection with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Arg677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in IL-4 production between the mutant and wild-type during stimulation. Thus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy patients and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy. (AU). Descriptors: Sequência de Bases Interleucina-10/*BI Interleucina-12/*BI Hanseníase/GE/*IM Leucócitos Mononucleares/IM Glicoproteínas de Membrana/*GE/ME Camundongos Nus Dados de Sequência Molecular Mutação Puntual/* Receptores da Superfície Celular/*GE/ME Receptor 2 Toll-Like Receptores Toll-Like Fator de Necrose Tumoral alfa/BI Limits: Adulto Idoso Animais Feminino Humanos Masculino Camundongos Research Support, Non-U.S. Gov't Meia-Idade Location: BR191.1; 09341/s

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Id: 13953 Author: Kim, Se -Kon; Lee, Seong- Beom; Kang, Tae -Jin; Chae, Gue -Tae Title: Detection of gene mutations related with drug resistance in Mycobacterium leprae from leprosy patients using Touch-Down (TD) PCR ..- Source: s.l; s.n; 2003. 6 p. ilus, tab. Abstract: The lack of methods to identify Mycobacterium leprae with the resistance against multi-drugs quickly and specifically has hindered effective chemotherapy against M. leprae infection. To screen M. leprae with resistance against multi-drugs, the Touch-Down (TD)-PCR has been used in this study. Sequences of the folP, rpoA, B, and gyrA, B genes were analyzed for isolates of M. leprae from leprosy patients in Korea. We amplified designated region of several genes in M. leprae involved in drug resistance and could obtain the PCR products of each gene. The mutations in the particular region of folP, rpoB, and gyrB gene were certified by TD-PCR single-stranded conformational polymorphism and DNA sequencing, respectively. (AU). Descriptors: DNA BACTERIANO/quim DNA BACTERIANO/genet Resistência Bacteriana a Múltiplas Drogas/genet COREIA (GEOGRAFICO) HANSENOSTATICOS/farmacol HANSENIASE/quimioter HANSENIASE/microbiol MYCOBACTERIUM LEPRAE/genet MUTACAO PUNTUAL REACAO EM CADEIA DA POLIMERASE/métodos POLIMORFISMO (GENETICA) POLIMORFISMO CONFORMACIONAL DE SIMPLES FITA ANALISE DE SEQUÊNCIA DE DNA Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09096/s

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Id: 13653 Author: Lee, Seong-Beom; Kim, Byoung Chul; Jin, Song Hou; Park, Yong-Gyu; Kim, Se-Kom; Kang, Tae-Jin; Chae, Gue-Tae Title: Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea ..- Source: s.l; s.n; 2003. 5 p. tab. Abstract: Interleukin-12 receptor beta 1 ( IL12RB1), interleukin-12 receptor beta 2 ( IL12RB2), and interferon gamma receptor 1 ( IFNGR1) perform important roles in the host defense against intracellular pathogens such as Mycobacteria. Several mutations within their genes have been confirmed as associated with increased susceptibility to mycobacterial infection. However, the association between mutations of the IL12RB1, IL12RB2, and IFNGR1 encoding genes and lepromatous leprosy has not been studied. This study screened for polymorphisms within IL12RB1, IL12RB2, and IFNGR1 encoding genes in the Korean populations using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP) DNA sequencing assay, and an association study was performed using the missense mutations of 705 A/G (Q214R), 1196 G/C (G378R), 1637 G/A (A525T), and 1664 C/T (P534S) of the IL12RB1, 83 G/A (V14M), and 1443 T/C (L467P) for the IFNGR1 encoding genes. There were no differences in the genotype and allele frequencies of IL12RB1 and IFNGR1 genes between 93 lepromatous leprosy patients and 94 control subjects. In conclusion, missense mutations of 705 A/G (Q214R), 1196 G/C (G378R), 1637 G/A (A525T), 1664 C/T (P534S) of the IL12RB1, 83 G/A (V14 M), and 1443 T/C (L467P) of the IFNGR1 encoding genes have no association with the susceptibility to lepromatous leprosy in the Korean population. (AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA COREIA (GEOGRAFICO) HANSENIASE VIRCHOWIANA/etiol HANSENIASE VIRCHOWIANA/genet MUTACAO DE SENTIDO INCORRETO RECEPTORES DE INTERFERON/genet RECEPTORES DA INTERLEUCINA/genet Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09125/s

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Id: 13619 Author: Kang, Tae Jin; Lee, Seong-Beom; Chae, Gue-Tae Title: A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy ..- Source: s.l; s.n; Oct. 2002. 7 p. graf. Abstract: Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections, and the mutations in the TLR2 have been shown to confer the susceptibility to infection with mycobacteria. We previously reported the detection of TLR2 Arg677Trp mutation in lepromatous leprosy. Here, the events triggered by TLR2 in response to cell lysate of Mycobacterium leprae(MLL), the causative agent of leprosy, were investigated. Upon stimulation with MLL, monocytes produced TNF-alpha and Interleukin-12 (IL-12), which play a role in the innate immune response to infection. Anti-TLR2 mAb blocked greater than 50 per cent of the MLL-induced production of IL-12. We also performed the functional study on TLR2 by measurement of IL-12 production in serum and monocytes from leprosy patients with TLR2 mutation (Arg677Trp). The monocytes obtained from patients with the TLR2 mutation, in comparison to the wild-type TLR2, is significantly less responsive to MLL. It was also confirmed that patients with TLR2 mutation showed significantly lower serum levels of IL-12, in comparing with TLR2 wild-type. Our results reveal that innate immune response of monocytes against M. lepraeis mediated by TLR2, and suggest that the mutation in the intracellular domain of TLR2 gene is associated with IL-12 production in lepromatous leprosy. (AU). Descriptors: SEQUÊNCIA DE AMINOACIDOS SEQUÊNCIA DE BASES ESTUDOS DE CASOS E CONTROLES DNA COMPLEMENTAR/genet IMUNIDADE NATURAL INTERLEUCINA-12/bios HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol GLICOPROTEINAS DE MEMBRANA/quim GLICOPROTEINAS DE MEMBRANA/genet MONOCITOS/imunol MYCOBACTERIUM LEPRAE/imunol MUTACAO PUNTUAL POLIMORFISMO (GENETICA) ESTRUTURA TERCIARIA DE PROTEINA RECEPTORES DA SUPERFICIE CELULAR/quim RECEPTORES DA SUPERFICIE CELULAR/genet FATOR DE NECROSE TUMORAL/bios Limits: HUMANO SUPPORT, NON-U.S. GOV'T HUMANO IN VITRO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09004/s

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Id: 12298 Author: Dequeker, Jan; Fabry, Guy; Vanopdenbosch, Ludo Title: Hieronymus Bosch (1450-1516): paleopathology of the medieval disabled and its relation to the Bone and Joint Decade 2000-2010 ..- Source: s.l; s.n; Nov. 2001. 8 p. ilus, tab. Descriptors: DAPSONA DIIDROPTEROATO SINTASE RESISTENCIA MICROBIANA A DROGAS LEPROSTATICOS HANSENIASE MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE REAÇAO EM CADEIA POR POLIMERASE POLIMORFISMO CONFORMACIONAL DE SIMPLES FITA ANALISE DE SEQUENCIA DE DNA Limits: ANIMAL Location: BR191.1; 08668/s

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Id: 12278 Author: Kang, Tae-Jin; Chae, Gue-Tae Title: Detection of toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients ..- Source: s.l; s.n; 2001. 6 p. ilus, tab. Descriptors: SEQUENCIA DE AMINOACIDOS HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES GLICOPROTEINAS DE MEMBRANAS GLICOPROTEINAS DE MEMBRANAS DADOS DE SEQUENCIA MOLECULAR MUTAÇAO MYCOBACTERIUM LEPRAE POLIMORFISMO CONFORMACIONAL DE SIMPLES FITA RECEPTORES DA SUPERFICIE CELULAR RECEPTORES DA SUPERFICIE CELULAR ALINHAMENTO DE SEQUENCIA TRANSDUÇAO DE SINAL Location: BR191.1; 08630/s

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Id: 12256 Author: Lee, S. B; Kim, S. K; Kang, T. J; Chae, G. T; Chun, J. H; Shin, H. K; Kim, J. P; Ko, Y. H; Kim, N. H Title: The prevalence of folP1 mutations associated with clinical resistance to dapsone, in mycobacterium leprae isolates from South Korea ..- Source: s.l; s.n; 2001. 4 p. ilus, tab. Descriptors: DAPSONA DIIDROPTEROATO SINTASE RESISTENCIA MICROBIANA A DROGAS LEPROSTATICOS HANSENIASE MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE REAÇAO EM CADEIA POR POLIMERASE POLIMORFISMO CONFORMACIONAL DE SIMPLES FITA ANALISE DE SEQUENCIA DE DNA Limits: ANIMAL Location: BR191.1; 08670/s

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Id: 12244 Author: Rambukkana, Anura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; May 2002. 5 p. ilus, graf. Descriptors: APOPTOSE AXONIOS AXONIOS LINFOCITOS B ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL CAMUNDONGOS KNOCKOUT MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL FIBRAS NERVOSAS MIELINIZADAS NEURONIOS CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN NERVO CIATICO NERVO CIATICO LINFOCITOS T CULTURA DE TECIDO Limits: ANIMAL Location: BR191.1; 08647/s

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Id: 11750 Author: Cambau, Emmanuelle; Bonnafous, Pascale; Perani, Evelyne; Sougkoff, Wladimir; Ji, Baohong; Jarlier, Vicent Title: Molecular detection of rifampin and ofloxacin resistance for patients Who experience relapse of multibacillary leprosy ..- Source: s.l; s.n; 2002. 7 p. tab. Descriptors: DNA BACTERIANO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE OFLOXACINA RECIDIVA RIFAMPINA ANTIBIOTICOS ANTITUBERCULOSE DNA TOPOISOMERASE (ATP-HIDROLISANTE) DNA TOPOISOMERASE (ATP-HIDROLISANTE) MODELOS ANIMAIS DE DOENÇAS TESTES DE SENSIBILIDADE MICROBIANA HANSENIASE MUTAÇAO PROTEINAS DE PLANTAS PROTEINAS DE PLANTAS Location: BR191.1; 08526/s; BR191.1; 08659/s

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Id: 11749 Author: Rambukkana, Amura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; 2002. 5 p. ilus. Descriptors: HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE AXONIOS AXONIOS ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS MACROFAGOS MUTAÇAO BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL - FIBRAS NERVOSAS MIELINIZADAS  NEURONIOS  CÉLULAS DE SCHWANN  CÉLULAS DE SCHWANN  NERVO CIATICO  NERVO CIATICO  LINFOCITOS T  CULTURA DE TECIDO Location: BR191.1; 08525/s

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Id: 11682 Author: Ramasoota, Pongrama; Wongwit, Waranya; Sampunachot, Prasert; Unnarat, Komes; Ngamying, Maeya; Svenson, Stefan B Title: Multiple mutations in the rpoB gene of Mycobacterium leprae strains from leprosy patients in Thailand ..- Source: s.l; s.n; 2000. 5 p. tab. Descriptors: HANSENIASE HANSENIASE LEPROSTATICOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE CODON DNA BACTERIANO MUTAÇAO PROTEINAS DE PLANTAS REAÇAO EM CADEIA POR POLIMERASE RIFAMPINA ANALISE DE SEQUENCIA DE DNA Location: BR191.1; 08474/s

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Id: 11564 Author: Lee, S. B; Kim, S. K; Kang, T. J; Chee, G. T; Chun, J. H; Shin, H. K; Kim, J.P; Ko, Y. H Title: The prevalence of folP1 mutations associated with clinical resistance to dapsone, in Mycobacterium leprae isolates from South Korea ..- Source: s.l; s.n; 2001. 4 p. ilus, tab. Descriptors: DAPSONA DIIDROPTEROATO SINTASE RESISTENCIA MICROBIANA A DROGAS LEPROSTATICOS HANSENIASE MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE REAÇAO EM CADEIA POR POLIMERASE POLIMORFISMO CONFORMACIONAL DE SIMPLES FITA ANALISE DE SEQUENCIA DE DNA Limits: ANIMAL Location: BR191.1; 08404/s

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Id: 11076 Author: Kang, Tae-Jin; Chae, Gue-Tae Title: Detection of toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients ..- Source: s.l; s.n; 2001. 6 p. tab, graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE GLICOPROTEINAS DE MEMBRANAS MUTAÇAO MYCOBACTERIUM LEPRAE Location: BR191.1; 07372/s

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Id: 10970 Author: Kai, Masanori; Matsuoka, Masanori; Nakata, Noboru; Maeda, Shinji; Gidoh, Masaichi; Maeda, Yumi; Hashimoto, Ken; Kobayashi, Kazuo; Kashiwabara, Yoshiko Title: Diaminodiphenylsulfone resistance of mycobacterium leprae due to mutations in the dihydropteroate synthase gene ..- Source: s.l; s.n; 1999. 5 p. tab. Descriptors: HANSENIASE LEPROSTATICOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE DAPSONA DIIDROPTEROATO SINTASE RESISTENCIA MICROBIANA A DROGAS GENES BACTERIANOS DADOS DE SEQUENCIA MOLECULAR MUTAÇAO Location: BR191.1; 07334/s

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Id: 9989 Author: Honore, Nadine; Cole, Stewart T Title: Molecular basis of ripampin resistance in mycobacterium leprae ..- Source: s.l; s.n; 1993. 5 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS SEQUENCIA DE BASES SEQUENCIA CONSERVADA RESISTENCIA MICROBIANA A DROGAS GENES ESTRUTURAIS BACTERIANOS HANSENIASE HANSENIASE HANSENIASE CAMUNDONGOS DADOS DE SEQUENCIA MOLECULAR MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE RIFAMPINA Location: BR191.1; 06633/s

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Id: 886 Author: Campos, Nelson de Souza; Lima, Lauro de Souza. Title: Das mutaçoes. Source: In: Campos, Nelson de Souza; Lima, Lauro de Souza.Lepra na infânçia. Rio de Janeiro, Nacional, 1950. p.119-36ilus, 23cm. Descriptors: HANSENIASE CRIANÇA MUTAÇAO Limits: RELATO DE CASO Location: BR191.1; WC335.102.40, C157L

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Id: 431 Author: Imaeda, T; Hawley, R. Title: The possible role pf prophages in mycobacterial mutation. Source: In: Annual Leprosy Research Conference, 7.Annual Leprosy Research Conference, 7/Abstracts. California, National Institute of Health, 1972. p.4-5. Conference: Present in: Annual Leprosy Research Conference, 7, California, 29 Feb.-01 Mar. 1972. Descriptors: MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM MUTAÇAO MUTAÇAO Location: BR191.1; WC335.3, 78a

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