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| Id: | 17021
| | Author: | Faget, G. H; Pogge, R. C. | | Title: | Pooled blood plasma transfusions in the treatment of leprosy.
| | Source: | Int. J. Lepr;11(n.esp):32-35, Dec. 1943. tab.
| | Abstract: | Of the twelve cases there was possible improvement in two (1406 and 1441). Definite unfavorable progress in leprosy was noted in five cases (971, 1289, 1521, and 1550). No demonstrable effect was noted in the leprosy of the remaining six cases (979, 1037, 1117, 1160, 1209, and 1566). Disappointingly, two of the three cases in which the prognosis seemed most favorable reacted unsatisfactorily and the third was not definitely benefited by pooled plasma therapy. In three cases a variation in the non-protein nitrogen of the blood was observed, showing in two cases (117 and 1160) a decrease in nitrogen retention and in one (971) a rise. Of three cases with hypoproteinemia (971, 1117, and 1037), there occurred an increase in total serum protein in two without any appreciable change in the albumin-globin ratio, and the third patient died before the blood chemistry could be repeated. Red blood cell counts dropped sharply in seven cases (971, 979, 1160, 1209, 1441, 1550, and 1566) out of ten observed carefully, while in the other three (1117, 1289, and 1406) there was an increase. The writers therefore believe that at present there is no evidence to indicate that non-specific liquid blood plasma has any value in the treatment of leprosy. Whether frozen blood plasma with its higher content of antibodies in a specially selected group of early cases would be more effective therapeutically is problematic. (AU).
| | Descriptors: | HANSENIASE/sangue
HANSENIASE/clas
HANSENIASE/terap
ATIVIDADE BACTERICIDA DO SANGUE
| | Location: | BR191.1 |
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