Database : HANSEN Search on : CROMOSSOMOS HUMANOS PAR 6/GENET [Subject descriptor] References found : 2 [refine] Displaying: 1 .. 2   in format [Detailed]

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Id: 13725 Author: Mira, Marcelo T; Alcais, Alexandre; Van Thuc, Nguyen; Thai, Vu Hong; Huong, Nguyen Thu; Ba, Nguyen Ngoc; Verner, Andrei; Hudson, Thomas J; Abel, Laurent; Schurr, Erwin Title: Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population ..- Source: s.l; s.n; 2003. 4 p. tab, graf. Abstract: Leprosy, a chronic infectious disease caused by Mycobacterium leprae, affects an estimated 700,000 persons each year. Clinically, leprosy can be categorized as paucibacillary or multibacillary disease. These clinical forms develop in persons that are intrinsically susceptible to leprosy per se, that is, leprosy independent of its specific clinical manifestation. We report here on a genome-wide search for loci controlling susceptibility to leprosy per se in a panel of 86 families including 205 siblings affected with leprosy from Southern Vietnam. Using model-free linkage analysis, we found significant evidence for a susceptibility gene on chromosome region 6q25 (maximum likelihood binomial (MLB) lod score 4.31; P = 5 x 10(-6)). We confirmed this by family-based association analysis in an independent panel of 208 Vietnamese leprosy simplex families. Of seven microsatellite markers underlying the linkage peak, alleles of two markers (D6S1035 and D6S305) showed strong evidence for association with leprosy (P = 6.7 x 10(-4) and P = 5.9 x 10(-5), respectively). (AU). Descriptors: ALELOS CROMOSSOMOS HUMANOS PAR 10/genet CROMOSSOMOS HUMANOS PAR 6/genet REPETICOES DE MICROSSATELITES VIETNA HANSENIASE/genet LIGACAO (GENETICA) ESCORE LOD Limits: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 08992/s

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Id: 13659 Author: Mira, M. T; Alcais, A; Pietrantonio, T. di; Thuc, N. V; Phuong, M. C; Abel, L; Schurr, E Title: Segregation of HLA/TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypes ..- Source: s.l; s.n; 2003. 7 p. ilus, tab, graf. Abstract: Each year an estimated 600000 new leprosy cases are diagnosed worldwide. The spectrum of the disease varies widely from limited tuberculoid forms to extensive lepromatous forms. A measure of the risk to develop lepromatous forms of leprosy is provided by the extent of skin reactivity to lepromin (Mitsuda reaction). To address a postulated oligogenic control of leprosy pathogenesis, we investigated in the present study linkage of leprosy susceptibility, leprosy clinical subtypes, and extent of the Mitsuda reaction to six chromosomal regions carrying known or suspected leprosy susceptibility loci. The only significant result obtained was linkage of leprosy clinical subtype to the HLA/TNF region on human chromosome 6p21 (P(corrected)=0.00126). In addition, we established that within the same family different HLA/TNF haplotypes segregate into patients with different leprosy subtypes directly demonstrating the importance of this genome region for the control of clinical leprosy presentation. (AU). Descriptors: CROMOSSOMOS HUMANOS PAR 6/genet PREDISPOSICAO GENETICA PARA DOENÇA GENOTIPO HANSENIASE/clas HANSENIASE/genet ANTIGENOS HLA/genet LIGACAO (GENETICA)/genet FATOR DE NECROSE TUMORAL/genet - FENOTIPO  LINHAGEM Limits: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09137/s

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