Database : HANSEN Search on : VIETNA [Subject descriptor] References found : 10 [refine] Displaying: 1 .. 10   in format [Detailed]

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Id: 17549 Author: Boggild, Andrea K; Correia, Jason D; Keystone, Jay S; Kain, Keven C Title: Leprosy in Toronto: an analysis of 184 imported cases ..- Source: s.l; s.n; Jan. 2004. 5 p. tab. Abstract: BACKGROUND: Leprosy is a rare but serious mycobacterial infection. Immigration from areas where the disease is endemic has resulted in the importation of leprosy into countries where it is not endemic and where physicians and health care workers have little or no experience in diagnosis and therapy. In this study we characterized leprosy patients seen in a tropical disease unit that manages most of the reported leprosy cases in Canada. METHODS: We reviewed the clinical records of all 184 leprosy patients who were referred to the Tropical Disease Unit at Toronto General Hospital between 1979 and 2002 and abstracted demographic and clinical information. RESULTS: Patients were more likely to be male (122 or 66.3%) and of Indian (44 or 23.9%), Filipino (49 or 26.6%) or Vietnamese (37 or 20.1%) origin. Patients experienced symptoms for a mean of 4.8 years before referral to the Tropical Disease Unit. Most had no family history of leprosy (152/172 or 88.4%). Most patients presented with either borderline tuberculoid (80 or 43.5%) or borderline lepromatous (37 or 20.1%) disease. On average, patients presented with 5.8 skin lesions. Upper- and lower-extremity nerve dysfunction was common at presentation, with up to one-third of patients demonstrating either sensory or motor loss. A significantly greater lag time to presentation was observed in patients who emigrated from low-prevalence regions (p < 0.001). INTERPRETATION: Leprosy is a chronic infectious disease that is associated with serious morbidity if left untreated. Leprosy is uncommon in developed countries, but it is important for physicians to have a high index of suspicion when a foreign-born patient presents with chronic dermatitis and peripheral nerve involvement. (AU). Descriptors: Análise de Variância Distribuição de Qui-Quadrado Migração Internacional Índia/EH Hanseníase/*EP Ontario/EP Filipinas/EH População Urbana Vietnã/EH Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE Location: BR191.1; 09327/s

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Id: 13725 Author: Mira, Marcelo T; Alcais, Alexandre; Van Thuc, Nguyen; Thai, Vu Hong; Huong, Nguyen Thu; Ba, Nguyen Ngoc; Verner, Andrei; Hudson, Thomas J; Abel, Laurent; Schurr, Erwin Title: Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population ..- Source: s.l; s.n; 2003. 4 p. tab, graf. Abstract: Leprosy, a chronic infectious disease caused by Mycobacterium leprae, affects an estimated 700,000 persons each year. Clinically, leprosy can be categorized as paucibacillary or multibacillary disease. These clinical forms develop in persons that are intrinsically susceptible to leprosy per se, that is, leprosy independent of its specific clinical manifestation. We report here on a genome-wide search for loci controlling susceptibility to leprosy per se in a panel of 86 families including 205 siblings affected with leprosy from Southern Vietnam. Using model-free linkage analysis, we found significant evidence for a susceptibility gene on chromosome region 6q25 (maximum likelihood binomial (MLB) lod score 4.31; P = 5 x 10(-6)). We confirmed this by family-based association analysis in an independent panel of 208 Vietnamese leprosy simplex families. Of seven microsatellite markers underlying the linkage peak, alleles of two markers (D6S1035 and D6S305) showed strong evidence for association with leprosy (P = 6.7 x 10(-4) and P = 5.9 x 10(-5), respectively). (AU). Descriptors: ALELOS CROMOSSOMOS HUMANOS PAR 10/genet CROMOSSOMOS HUMANOS PAR 6/genet REPETICOES DE MICROSSATELITES VIETNA HANSENIASE/genet LIGACAO (GENETICA) ESCORE LOD Limits: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 08992/s

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Id: 13604 Author: Ognibene, André J Title: Agranulocytosis due to dapsone ..- Source: s.l; s.n; apr. 1970. 4 p. ilus, tab. Abstract: Agranulocytosis developed in 16 U. S. soldiers in Vietnam who were receiving daily dapsone prophylaxis for falciparum malaria. The were eight deaths in the group. All patients had been on prophylaxis from 3 weeks to 3 months. recovery or death due to sepsis generally occurred within 9 days. The toxic effects of dapsone have resulted in a limitation in the use of dapsone for prophylaxis of falciparum malaria in U. S. troops in Vietnam.(AU). Descriptors: AGRANULOCITOSE/ind quim DAPSONA/ef adv MALARIA/prev MEDICINA MILITAR FATORES DE TEMPO MEDICINA TROPICAL ESTADOS UNIDOS VIETNA Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01870/s

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Id: 13534 Author: Alcaïs, A; Sanchez, F. O; Thuc, N. V; Lap, V. D; Oberti, J; Lagrange, P. H; Schurr, E; Abel, L Title: Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy ..- Source: s.l; s.n; 2000. 7 p. tab, graf. Abstract: The Mitsuda test, which measures the specific immune response against intradermally injected lepromin, has a high prognostic value for susceptibility or resistance to the lepromatous form of leprosy. A sib-pair linkage analysis between the Mitsuda response and the NRAMP1 gene was done among 20 nuclear families with leprosy (totaling 118 sibs) from Ho Chi Minh City, Vietnam. All family subjects were genotyped for several intragenic and flanking NRAMP1 markers, leading to the definition of a fully informative NRAMP1 haplotype. Significant linkage was observed between NRAMP1 and Mitsuda reaction when considered either as a quantitative (P<.002) or as a categorical (P=.001) trait. Separate analyses among healthy and affected sibs showed evidence for linkage in both subsamples, indicating that linkage between the Mitsuda reaction and NRAMP1 is independent of leprosy status. These results support the view that NRAMP1 plays a regulatory role for the development of acquired antimycobacterial immune responses as determined by in vivo Mitsuda test reaction. (AU). Descriptors: HANSENIASE/imunol ANTIGENO DE MITSUDA/imunol HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/imunol PELE/imunol VIETNA GRANULOMA CHINA/etnol - HAPLOTIPOS  IMUNIDADE NATURAL  INJECOES INTRADERMICAS  LINHAGEM  NUCLEO FAMILIAR  FENOTIPO  LINFOCITOS T AUXILIADORES-INDUTORES Limits: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Location: BR191.1; 08991/s

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Id: 13430 Author: Hornblass, Albert Title: Ocular leprosy in South Vietnam ..- Source: s.l; s.n; mar. 1973. 3 p. ilus, tab. Abstract: Fifty-one Montangards in South Vietnam with proven leprosy were studied ophthalmologically. Of these, 39 had ocular involvement. The cornea was involved in 31 of the 39 patients. About the same percentage of ocular complications were seen in cases of lepromatous leprosy as tuberculoid and the mixel type. Five patients were blind.(AU). Descriptors: ALOPECIA/etiol OFTALMOPATIAS/etiol PARALISIA FACIAL/etiol HANSENIASE/compl VIETNA Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00346/s

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Id: 13207 Author: Williams, Harry W Title: The peculiar problems of handicap due to leprosy ..- Source: s.l; s.n; mar. 1971. 4 p. ilus. Abstract: The author traces the development of a leprosy cure through modern drugs and reconstructive surgery, first in isolation then in general hospitals, to rehabilitation techniques and finally vocational training integrated for all forms of orthopedic handicap.(AU). Descriptors: CENTROS DE REABILITACAO HANSENIASE/reabil HANSENIASE/cirurg CIRURGIA PLASTICA SEGUIMENTOS INDIA SERVICOS CLINICOS HOSPITALARES EXTREMIDADES/cirurg INFECCAO/terap VIETNA - SAUDE PÚBLICA  QUARENTENA  SAUDE RURAL  MEDO Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 02022/s

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Id: 12310 Author: Truoc, Le Van; Ly, Ho Minh; Thuy, Nguyen Kim; Trach, Dang Duc; Stanford, C. A; Stanford, J. L Title: Vaccination against leprosy at Ben San Leprosy Center, Ho Chi Minh City, Vietnam ..- Source: s.l; s.n; 2001. 8 p. tab. Descriptors: ADOLESCENCIA VACINA BCG VACINAS BACTERIANAS PRÉ-ESCOLAR ESQUEMA DE IMUNIZAÇAO HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM TESTES CUTANEOS FATORES DE TEMPO VACINAS DE PRODUTOS INATIVADOS VIETNA Location: BR191.1; 08663/s

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Id: 11615 Author: Truoc, Le Van; Ly, Ho Minh; Thuy, Nguyen Kim; Trach, Dang Duc; Stanford, C. A; Stanford, J. L Title: Vaccination against leprosy at Ben San Leprosy Centre, Ho Chi Minh City, Vietnam ..- Source: s.l; s.n; 2001. 8 p. tab. Descriptors: MYCOBACTERIUM VACINA BCG VACINAS BACTERIANAS ESQUEMA DE IMUNIZAÇAO TESTES CUTANEOS FATORES DE TEMPO VACINAS DE PRODUTOS INATIVADOS VIETNA Location: BR191.1; 08438/s

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Id: 10371 Author: Winter, Cara A; Hsu, Sylvia Title: Ominous sign of a disfiguring disease ..- Source: s.l; s.n; 2000. 3 p. ilus. Descriptors: CLOFAZIMINA DAPSONA QUIMIOTERAPIA COMBINADA LEPROSTATICOS HANSENIASE HANSENIASE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE RIFAMPINA ESTADOS UNIDOS VIETNA Limits: RELATO DE CASO Location: BR191.1; 07442/s

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Id: 10180 Author: Abel, Laurent; Lap, Vu Dinh; Oberti, Jean; Thuc, Nguyen Van; Cua, Van Van; Guilloud-Bataille, Michel; Schurr, Erwin; Lagrange, Philippe H Title: Complex segregation analysis of leprosy in Southern Vietnam ..- Source: s.l; s.n; 1995. 20 p. tab, graf. Descriptors: ADOLESCENCIA CRIANÇA PRÉ-ESCOLAR CHINA SUSCETIBILIDADE A DOENÇA FREQUENCIA DOS GENES HETEROGENEIDADE GENÉTICA LACTENTE RECÉM-NASCIDO HANSENIASE HANSENIASE HANSENIASE MODELOS GENÉTICOS FENOTIPO AMOSTRAGEM VARIAÇAO (GENÉTICA) VIETNA VIETNA Location: BR191.1; 07093/s

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