| Id: | 13193
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| Author: | Shetty, V. P; Mehta, L. N; Irani, P. F; Antia, N. H
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| Title: | Study of the evolution of nerve damage in leprosy. Part I--Lesions of the index branch of the radial cutaneous nerve in early leprosyStudy of evolution of nerve damage in leprosy. Part II--Observations on the index branch of the radial cutaneous nerve in contacts of leprosy
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| Source: | s.l; s.n; jan. 1980. 14 p. tab, graf, ilus.
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| Abstract: | A total of six index finger branch of the radial cutaneous (IRC) nerves from three BL, two BB and one BT cases of leprosy, with less than 6 months history of disease were subjected for nerve conduction velocity (NCV) studies followed by biopsy. The biopsy was divided into three parts and subjected for light microscopy quantitative histology, electron-microscopy and fibre tease studies. The nerves revealed a slight reduction in NCV and a varying degree of segmental demyelination ranging from 10% to 35%. The earliest changes observed were the thickening and proliferation of Schwann cell processes of the unmyelinated fibres and degeneration of their axons regardless of the type of leprosy.(AU) A total of 35 contacts from 20 families of lepromatous index cases were screened clinically. All of them were subjected for nerve conduction velocity (NCV) studies of both left and right index branch of the radial cutaneous (IRC) nerve. Fifteen of these nerves were biopsied. Out of 15 IRC nerves biopsied 10 had slightly reduced average NCV values and 5 were normal. Four nerves out of 10 where average NCV was reduced and 1 nerve out of 5 where NCV was normal showed significant ultrastructural changes and higher percentage of segmental demyelination (10%--13%). There was a striking similarity between the changes seen in the IRC nerves of early cases of leprosy and of contacts.(AU).
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| Descriptors: | PELE/irrig
FATORES DE TEMPO
HANSENIASE/patol
DEGENERACAO NEURAL
FIBRAS NERVOSAS/ultraest
CONDUCAO NERVOSA
NERVO RADIAL/patol
NERVO RADIAL/ultraest
DEDOS/irrig
HANSENIASE/diag
HANSENIASE/genet
CELULAS DE SCHWANN/ultraest
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| Limits: | MASCULINO
FEMININO
ADOLESCENTE
ADULTO
CRIANCA
HUMANO
MEIA-IDADE
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| Electronic Medium: | http://www.ilsl.br
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| Location: | BR191.1; 01984/s |
