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| Id: | 13219
| | Author: | Wall, J. R; Wright, D. J
| | Title: | Antibodies against testicular germinal cells in lepromatous leprosy
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| | Source: | s.l; s.n; May 1974. 9 p. ilus, tab.
| | Abstract: | Testicular germinal cell antibodies were found in forty-four out of the fifty-nine patients with lepromatous leprosy and in four out of ten patients with tuberculoid disease. A similar pattern was found in twelve out of 262 control patients and normal subjects.The antibody was found to be of the IgC class and forty out of forty-nine of these antibodies were shown to be complement fixing. Spermatozoal antibodies were detected in twelve patients, but no ovarian antibodies were found in any specimen. There was no close correlation between erythema nodosum leprosum (ENL) and testicular antibodies. It was found that the characteristic of the testicular antibody in leprosy was its ability to be absorberd by Mycobacterium BCG suspension suggesting that this is another antibody induced by infection. A similar fluorescent pattern was seen in some patients who did not have leprosy, but in these cases it could not be abolished with BCG. It is concluded that autoimmunity may be one of the factors involved in the pathogenesis of orchitis in leprosy.(AU).
| | Descriptors: | VACINA BCG
REACOES CRUZADAS
IMUNOGLOBULINA G
HANSENIASE/imunol
MYCOBACTERIUM BOVIS/imunol
ESPERMATOCITOS/imunol
ESPERMATOGÔNIAS/imunol
TESTICULO/citol
TESTICULO/imunol
| | Limits: | HUMANO
MASCULINO
FEMININO
ADULTO
MEIA-IDADE
IDOSO
ADOLESCENTE
| | Electronic Medium: | http://www.ilsl.br
| | Location: | BR191.1; 01581/s |
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