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Id:18146
Author:Irvin H Blank and Robert J Sheuplein
Title:Transport into and within the skin ver-
Source:Boston; s.n; 1969. 07 p. tab.
Abstract:Developments in recent years permit us to state the following principles which relate to percutaneous obsorption. The entire stratum corneum functions as the rate limiting barrier in the skin. For penetration from weak solutions flux is directly proportionbal to the concentration of the penetrat in the solution which is presented to the cutaneos surface. Flux increases as the mobility of the penetrat in the stratum corneum (diffusion constant) increases. Flux decreases as the thickness of the membrane increases. When concentrations in the presenting solution reach higt values flux is not proportional to concentratio. Flux through dermal tissue is much more rapid than flux through the stratum corneum. For substances which penetrate relatively rapidiy the major pathway throug the skin for steady state conditions is directy thorough the cells of the stratum corneum. For very slowly penetratingsubstances shunts, e.g., the appendages may be the major pathway. Strongly polar and strongly non polar molecules probably travel via different molecular pathways. (AU).
Descriptors:PELE/anat
PELE/ef drogas
PELE/fisiopatol
- FISIOLOGIA DA PELE/ef drogas
Limits:HUMANO
Location:BR191.1; 01118/s


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