Database : HANSEN
Search on : LEVAMISOL/ADMIN [Subject descriptor]
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Id:13871
Author:Shepard, C. C; Van Landingham, R; Walker, L. L
Title:Effect of levamisole on Mycobacterium leprae in mice ..-
Source:s.l; s.n; may 1977. 4 p. graf.
Descriptors:ADMINISTRACAO ORAL
VACINA BCG
INJECOES SUBCUTÂNEAS
HANSENIASE/imunol
LEVAMISOL/admin
LEVAMISOL/farmacol
MYCOBACTERIUM LEPRAE/ef drogas
MYCOBACTERIUM LEPRAE/cresc
Limits:ANIMAL
CAMUNDONGOS
SUPPORT, U.S. GOV'T, P.H.S.
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 00596/s


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Id:13520
Author:Meyers, Wayne M; Kvernes, Staffan; Staple, Edna M
Title:Failure of levamisole to alter the lepromin reaction ..-
Source:s.l; s.n; sep. 1975. 3 p. tab.
Abstract:In a study of 37 leprosy patients, the oral administration of levamisole failed to provoke an increase in both the Fernandez and Mitsuda reactions to lepromins of human and armadillo origin. We interpret this as evidence against an effective specific immunostimulatory capability of levamisole in leprosy patients under the conditions of the study. Current knowledge of the mechanism of levamisole action supports the concept that the fundamental immunologic defect in lepromatosus leprosy may reside in the lymphocyte and not the macrophage, or the respective related functions of these two cell forms.(AU).
Descriptors:LINFOCITOS/imunol
MYCOBACTERIUM LEPRAE/isol
LEVAMISOL/admin
LEVAMISOL/farmacol
HANSENIASE/imunol
ANTIGENO DE MITSUDA/imunol
IMUNIDADE CELULAR/ef drogas
TATUS
Limits:HUMANO
ANIMAL
ADULTO
MEIA-IDADE
IDOSO
CAMUNDONGOS
SUPPORT, U.S. GOV'T, NON-P.H.S.
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 01921/s


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Id:13191
Author:Shepard, C. C; Van Landingham, R; Walker, L. L
Title:Effect of levamisole on Mycobacterium leprae in mice ..-
Source:s.l; s.n; may 1977. 14 p. tab, graf.
Abstract:Levamisole, an antihelminthic drug that is capable of enhancing immune responses in mice and in humans, was tested in experimental Mycobacterium leprae infections in mice by a number of schedules. Intermittent schedules were used, and administration of the drug was started (i) around the time of inoculation with M. leprae, (ii) when the M. leprae population was approaching the plateau level, (iii) after the onset of the plateau phase, or (iv) after BCG vaccination 28 days following the inoculation with M. leprae. No effect of drug could be discerned with any of the schedules.(AU).
Descriptors:MYCOBACTERIUM LEPRAE/ef drogas
MYCOBACTERIUM LEPRAE/cresc
LEVAMISOL/admin
LEVAMISOL/farmacol
HANSENIASE/imunol
INJECOES SUBCUTÂNEAS
VACINA BCG
ADMINISTRACAO ORAL
Limits:ANIMAL
CAMUNDONGOS
SUPPORT, U.S. GOV'T, P.H.S.
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 00596/s



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