Database : HANSEN Search on : MOLECULA 1 DE ADESAO INTERCELULAR/METAB [Subject descriptor] References found : 5 [refine] Displaying: 1 .. 5   in format [Detailed]

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Id: 13937 Author: Teles, Rosane M. B; Moraes, Milton O; Geraldo, Natasha T. R; Salles, Ana M; Sarno, Euzenir N; Sampaio, Elizabeth P Title: Differential TNFalpha mRNA regulation detected in the epidermis of leprosy patients ..- Source: s.l; s.n; 2002. 8 p. ilus, tab, graf. Abstract: The epidermis is an important site of the immunoinflammatory response in the skin. In the present study, the expression of cytokine and ICAM-1 (intercellular adhesion molecule-1) genes was evaluated by RT-PCR in the epidermis isolated from biopsies from 25 reactional leprosy patients. TNFalpha and IL-6 mRNAs were detected in all individuals during the reactional state (reversal reaction or erythema nodosum leprosum), IL-8 message was detected in 66.6 per cent and 62.5 per cent of the patients, IL-12 mRNA was present in 91.6 per cent and 62.5 per cent and ICAM-1 in 100 per cent and 71.4 per cent, respectively. In addition, when skin biopsies were obtained from the same patients before and during the reactional episode, an enhancement in cytokine mRNA, but not in ICAM-1 mRNA, was observed. Seven patients were also evaluated at the onset of reaction and during antiinflammatory treatment. In contrast to a preferential decrease in the TNFalpha gene detected in the dermis, during the treatment phase, persistent/enhanced TNFalpha mRNA expression was detected in the epidermis in six out of the seven patients assessed. This peculiar pattern of expression might reflect a differential impact that in vivo antiinflammatory therapy has on the epidermis. The present findings indicate that the epidermis plays an important role in the local inflammatory response in leprosy and that the profile of response detected in the epidermis during the reactions may be regulated differently from that in the dermis. (AU). Descriptors: CITOCINAS/genet CITOCINAS/metab ANTIINFLAMATORIOS ESTERÓIDES/uso terap DERME/metab HANSENOSTATICOS/uso terap EPIDERME/metab MOLECULA 1 DE ADESAO INTERCELULAR/genet MOLECULA 1 DE ADESAO INTERCELULAR/metab HANSENIASE/quimioter HANSENIASE/metab PENTOXIFILINA/uso terap ANTIINFLAMATORIOS/uso terap RNA MENSAGEIRO/metab TALIDOMIDA/uso terap PREDNISONA/uso terap FATOR DE NECROSE TUMORAL/genet FATOR DE NECROSE TUMORAL/metab Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09157/s

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Id: 13727 Author: Cheadle, Eleanor J; Selby, Peter J; Jackson, Andrew M Title: Mycobacterium bovis bacillus Calmette-Guérin-infected dendritic cells potently activate autologous T cells via a B7 and interleukin-12-dependent mechanism ..- Source: s.l; s.n; 2003. 10 p. graf. Abstract: Mycobacteria are potent adjuvants, can survive intracellularly and have been safely used for many years as vaccines against tuberculosis and leprosy. They are thus important potential vectors for recombinant vaccines. Many of their adjuvant properties are mediated following phagocytosis by dendritic cells (DC), which are in turn critical for priming naïve T cells. Although the maturation of DC in response to mycobacteria, such as Mycobacterium bovis bacillus Calmette-Guérin (BCG), is well described the subsequent responses of autologous T cells to mycobacterium-infected DC remains uncharacterized. In our experiments DC infected with BCG expressed more co-stimulatory molecules than tumour-necrosis factor-alpha (TNF-alpha) -treated DC and stimulated more potent mixed leucocyte reactions. When autologous T cells were co-cultured with BCG-exposed DC they became highly activated, as determined by display of CD25, CD54 and CD71 on both CD4+ and CD8+ cells. In contrast, the response of T cells to TNF-alpha-matured DC was significantly less. Cytokine production from T cells cultured with BCG-exposed DC was enhanced with elevated secretion of interleukin-2 (IL-2), IL-10 and interferon-gamma (IFN-gamma) and was produced by both CD4+ and CD8+ lymphocytes as determined by intracellular staining. In particular, IFN-gamma secretion was increased from 50 pg/ml to 25 000 pg/ml and IL-10 secretion increased from 20 pg/ml to 300 pg/ml in BCG-exposed DC co-cultures. Blocking antibodies to B7.1 and B7.2 or IL-12 significantly reduced the secretion of IFN-gamma and reductions were also seen in the expression of CD25 and CD71 by CD4+ cells. These data demonstrate that mycobacterially infected DC are particularly potent activators of autologous T cells compared to TNF-alpha-exposed DC and that the resultant T cells are functionally superior. (AU). Descriptors: ANTIGENOS CD/metab ANTIGENOS CD80/imunol ANTIGENOS DE DIFERENCIACAO DE LINFOCITOS B/metab LINFOCITOS T CD4-POSITIVOS/imunol LINFOCITOS T CD8-POSITIVOS/imunol CITOCINAS/bios CELULAS DENDRITICAS/imunol CELULAS DENDRITICAS/microbiol MOLECULA 1 DE ADESAO INTERCELULAR IMUNOFENOTIPAGEM INTERLEUCINA-12/imunol TRANSFORMACAO LINFOCITICA/imunol MYCOBACTERIUM BOVIS/imunol RECEPTORES DA INTERLEUCINA-2/metab LINFOCITOS T/imunol FATOR DE NECROSE TUMORAL/imunol REGULACAO PARA CIMA/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 08996/s

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Id: 10037 Author: Agrewala, J. N; Kumar, B; Vohra, H Title: Potential role of B7-1 and CD28 molecules in immunosuppression in leprosy ..- Source: s.l; s.n; 1998. 8 p. graf. Descriptors: HANSENIASE ANTIGENOS DE BACTÉRIAS ANTIGENOS CD28 ANTIGENOS CD80 IMUNOSSUPRESSAO MOLÉCULA 1 DE ADESAO INTERCELULAR ANTIGENO-1 LINFOCITARIO ASSOCIADO A FUNÇAO MYCOBACTERIUM LEPRAE Location: BR191.1; 07002/s

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Id: 9865 Author: Rieckmann, P; Scholze, G; Weichselbraun, I; Ganapati, R; Prange, H. W Title: Soluble adhesion molecules in sera of patients with leprosy: levels of soluble intracellular adhesion molecule-1 (sICAM-1) rapidly decrease during multi-drug therapy ..- Source: s.l; s.n; 1996. 4 p. tab, graf. Descriptors: HANSENIASE HANSENIASE HANSENIASE QUIMIOTERAPIA COMBINADA SELECTINA E MOLÉCULA 1 DE ADESAO INTERCELULAR MOLÉCULA 1 DE ADESAO INTERCELULAR SELECTINA L Location: BR191.1; 06812/s

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Id: 9308 Author: Sullivan, Laura; Sano, Shigetoshi; Pirmez, Claude; Salgame, Padmini; Mueller, Christoph; Hofaman, Florence; Uyemura, Koichi; Rea, Thomas H; Bloom, Barry R; Modlin, Robert L Title: Expression of adhesion molecules in leprosy lesions ..- Source: s.l; s.n; 1991. 7 p. ilus, tab, graf. Descriptors: ANTIGENOS CD2 ANTIGENOS CD58 ANTIGENOS DE DIFERENCIAÇAO DE LINFOCITOS T ANTIGENOS DE SUPERFICIE MOLÉCULAS DE ADESAO CELULAR EPIDERME EPIDERME EXPRESSAO GENICA MOLÉCULA 1 DE ADESAO INTERCELULAR INTERFERON TIPO II HANSENIASE HANSENIASE HANSENIASE ANTIGENO-1 LINFOCITARIO ASSOCIADO A FUNÇAO HIBRIDIZAÇAO DE ACIDO NUCLÉICO RECEPTORES IMUNOLOGICOS LINFOCITOS T LINFOTOXINA Location: BR191.1; 06211/s

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