Database : HANSEN Search on : OLIGONUCLEOTIDIOS [Subject descriptor] References found : 2 [refine] Displaying: 1 .. 2   in format [Detailed]

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Id: 13656 Author: Bleharski, Joshua R; Li, Huiying; Meinken, Christoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Title: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Source: s.l; s.n; Sep. 2003. 4 p. graf. Abstract: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descriptors: HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/fisiopatol HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/genet HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/fisiopatol CITOCINAS/genet CITOCINAS/metab PERFILACAO DA EXPRESSÃO GÊNICA ANALISE POR CONGLOMERADOS CONTAGEM DE COLÔNIA MICROBIANA REGULACAO DA EXPRESSÃO GÊNICA IMUNIDADE CELULAR IMUNIDADE NATURAL MACROFAGOS ALVEOLARES/microbiol GLICOPROTEINAS DE MEMBRANA/imunol MYCOBACTERIUM TUBERCULOSIS/cresc MYCOBACTERIUM TUBERCULOSIS/imunol REACAO EM CADEIA DA POLIMERASE RECEPTORES IMUNOLOGICOS/genet RECEPTORES IMUNOLOGICOS/metab RECEPTORES DA SUPERFICIE CELULAR/imunol - REGULACAO PARA CIMA  Análise de Componente Principal  ALGORITMOS  GENES DE IMUNOGLOBULINAS  ANALISE DE SEQUÊNCIA COM SERIES DE OLIGONUCLEOTIDIOS Limits: SUPPORT, NON-U.S. GOV'T HUMANO SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09142/s; BR191.1; 09145/s

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Id: 9731 Author: Sela, S; Thole, J. E. R; Ottenhoff, Tom H. M; Clark-Curtiss, J. E Title: Identification of mycobacterium leprae antigens from a cosmid library: characterization of a 15-kilodalton antigen that is recognized by both the humoral and cellular immune systems in leprosy patients ..- Source: s.l; s.n; 1991. 8 p. ilus, tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTICORPOS ANTIBACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS SEQUENCIA DE BASES WESTERN BLOTTING DNA BACTERIANO BIBLIOTECA GENOMICA HANSENIASE HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE HIBRIDIZAÇAO DE ACIDO NUCLÉICO OLIGONUCLEOTIDIOS HOMOLOGIA DE SEQUENCIA DO ACIDO NUCLÉICO FASES DE LEITURA REAÇAO EM CADEIA POR POLIMERASE MAPEAMENTO POR RESTRIÇAO Location: BR191.1; 06530/s

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