Database : HANSEN
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Id:13275
Author:Prabhakaran, K; Harris, E. B; Kirchheimer, W. F
Title:A possible method for improving the efficacy of dapsone ..-
Source:s.l; s.n; December 15, 1980. 2 p. tab.
Abstract:The antileprosy drug dapsone is unable to penetrate intact Mycobacterium leprae in vitro, as determined by its effect on o-diphenoloxidase in the bacilli. When combined with the peptide polylysine, the sulfone drug passes through the bacterial cell membranes, and penetrates the enzyme protein, resulting in a 100% inhibition of its activity.
Descriptors:CATECOL OXIDASE/antag
PERMEABILIDADE DA MEMBRANA CELULAR/ef drogas
COMBINACAO DE MEDICAMENTOS
CONCENTRACAO DE IONS DE HIDROGÊNIO
MYCOBACTERIUM LEPRAE/enzimol
PEPTIDIOS/uso terap
DAPSONA/admin
DAPSONA/farmacol
POLILISINA/farmacol
POLILISINA/uso terap
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 00684/s


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