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| Id: | 18224
| | Autor: | Russell, D. A; Worth, R. M; Jano, B; Fasal, P; Shepard, C. C
| | Título: | Acedapsone in the prevention of leprosy: field trial in three high prevalence villages in Micronesia
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| | Fonte: | s.l; s.n; May 1979. 5 p. tab.
| | Resumo: | The 1,659 non-leprous people in a Micronesian population experiencing an annual leprosy incidence rate of about 7/1,000 were offered 15 acedapsone (DADDS) injections during 1967--1970 for leprosy prevention purposes. Subsequent annual surveillance showed an initial cessation of new cases during the 3-year DADDS campaign, followed by a resumption of cases thereafter at a yearly level of about 2/1,000 with a longer pause and slower rise among those who received the full regimen. A secondary wave of cases that has occurred since 1973 among children born after 1968 shows that post-campaign transmission occurred, probably principally from relapsing multibacillary cases with onset before the campaign. Recommendations are made for a balanced, long-term control program with DADDS preventive treatment limited to contacts of multibacillary cases.(AU).
| | Descritores: | RECIDIVA
RESISTÊNCIA MICROBIANA A DROGAS
DAPSONA/analog
HANSENIASE/epidemiol
HANSENIASE/prev
HANSENIASE/transm
ACEDAPSONA/uso terap
| | Limites: | HUMANO
CRIANÇA
ADULTO
SUPPORT, U.S. GOV'T, P.H.S.
| | Meio Eletrônico: | - .
| | Localização: | BR191.1; 00464/s |
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