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| Id: | 17319
| | Author: | Stefani, Mariane M. A; Martelli, Celina M. T; Gillis, Thomas P; Krahenbuhl, James L
| | Title: | In situ type 1 cytokine gene expression and mechanism associated with early leprosy progression
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| | Source: | s.l; s.n; 2003. 8 p. ilus.
| | Abstract: | We explored the prognostic value of in situ cytokine patterns in 39 patients with single-skin-lesion paucibacillary leprosy before single-dose therapy, with 3 years of follow-up. Interferon (IFN)-gamma, interleukin (IL)-12, IL-10, IL-4, tumor necrosis factor (TNF)-alpha, and macrophage inflammatory protein (MIP)-1alpha mRNA was quantified in skin biopsy samples at diagnosis, and Mycobacterium leprae DNA was detected in 51.4% of cases. Type 1 immunity predominance with measurable IFN-gamma and undetectable IL-4, which is indicative of effective cell-mediated immunity, is compatible with both the reversal reactions (33.3%) and the resolution of lesions (64.1%) observed. A positive correlation between IL-12 and IFN-gamma indicated type 1 polarization via IL-12. The TNF-alpha/MIP-1alpha correlation implied the TNF-alpha induction of chemokines, which is important for granuloma formation. Positive correlations between key regulatory cytokines-IL-10 and IFN-gamma, IL-10 and IL-12, and IL-10 and TNF-alpha-suggests that there may be some level of an intralesional pro- or anti-inflammatory mechanism essential in avoiding immunopathology. (AU).
| | Descriptors: | Anticorpos Antibacterianos/BL
Biópsia
Estudos de Coortes
Citocinas/BI/*GE/IM
Regulação Bacteriana da Expressão Gênica/*IM
Hanseníase/DT/*GE/IM
Minociclina/TU
Mycobacterium leprae/*GE/IM
Ofloxacino/TU
Prognóstico
RNA Mensageiro/BI/GE
RNA Viral/BI/GE
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Rifampina/TU
| | Limits: | Adolescente
Adulto
Criança
Feminino
Humano
Masculino
Células Th1/IM
| | Location: | BR191.1; 01884/s |
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