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| Id: | 13415
| | Author: | Nelson, D. S; Penrose, J. M; Waters, M. F; Pearson, J. M; Nelson, M
| | Title: | Depressive effect of serum from patients with leprosy on mixed lymphocyte reactions
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| | Source: | s.l; s.n; dec. 1975. 8 p. tab.
| | Abstract: | Mixed leucocyte cultures, from two normal donors, were set up in media containing human serum from one of the following sources: (a) a pool of normal group AB donors; (b) Chinese, Malay or Indian patients with untreated leprosy; (c) the same patients after effective anti-leprosy treatment; (d) control Chinese, Malay or Indian subjects. Transformation was estimated by measuring the incorporation of tritiated thymidine in the last 24 hr of a 7-day culture period. Transformation was impaired in sera from treated lepromatous patients, but was less impaired or not impaired at all in sera from treated lepromatous patients. The loss of depressive activity after treatment was more marked in Chinese and Indian than in Malay patients. Transformation was also impaired, though to a lesser extent, in sera from patients with untreated tuberculoid leprosy; it was still impaired in sera from treated tuberculoid patients. There was no evidence of specificity in impairment of mixed lymphocyte reactivity and lymphocytotoxic antibodies appeared to play no role. The incidences of hepatitis B antigen and antibody and of anti-nuclear factor were not notably high.(AU).
| | Descriptors: | ANTICORPOS ANTINUCLEARES
ESPECIFICIDADE DE ANTICORPOS
DAPSONA/uso terap
GRUPOS ETNICOS
ANTIGENOS DA HEPATITE B
HANSENIASE/quimioter
HANSENIASE/imunol
TESTE DE CULTURA MISTA DE LINFOCITOS
TRANSFORMACAO LINFOCITICA
| | Limits: | HUMANO
MASCULINO
FEMININO
CRIANÇA
ADULTO
MEIA-IDADE
IDOSO
ADOLESCENTE
| | Electronic Medium: | http://www.ilsl.br
| | Location: | BR191.1; 00021/s |
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