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| Id: | 13243
| | Author: | Kenner, D. J; Holt, K; Agnello, R; Chester, G. H
| | Title: | Permanent retinal damage following massive dapsone overdose
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| | Source: | s.l; s.n; oct. 1980. 4 p. ilus, graf.
| | Abstract: | A massive dose of 7.5 g of 4,4'-diamino, diphenyl sulphone (dapsone) taken as a suicide attempt in a patient on long-term therapy for tuberculoid leprosy resulted in permanent bilateral retinal necrosis, previously unreported side effect of this drug. The patient developed a severe haemolytic anaemia, methaemoglobinaemia, and acute renal failure requiring peritoneal dialysis. It is proposed that the retinal damage was due to a combination of severe hypoxaemia and the physical effects of red cell fragmentation producing vascular occlusion in the macular and perimacular region, with consequent ischaemic necrosis...(AU).
| | Descriptors: | ANEMIA HEMOLITICA/ind quim
ANGIOFLUORESCEINOGRAFIA
INSUFICIÊNCIA RENAL AGUDA/ind quim
MACULA LUTEA
METEMOGLOBINEMIA/ind quim
DAPSONA/env
NECROSE
DOENCAS RETINIANAS/ind quim
TENTATIVA DE SUICIDIO
| | Limits: | RELATO DE CASO
HUMANO
MASCULINO
ADULTO
| | Electronic Medium: | http://www.ilsl.br
| | Location: | BR191.1; 00677/s |
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