Base de dados : HANSEN Pesquisa : BRASIL/EP [Descritor de assunto] Referências encontradas : 2 [refinar] Mostrando: 1 .. 2   no formato [Detalhado]

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Id: 23739 Autor: Moraes Braga, Anna Carolina de; Reason, Iara J. Messias; Maluf, Eliane Cesario Pereira; Vieira, Elizabete Regina Título: Leprosy and confinement due to leprosy show high association with hepatitis C in Southern Brazil ..- Fonte: s.l; s.n; 2006. 6 p. . Resumo: Leprosy is a disease, which is accompanied by cellular immunity defects, which may increase the susceptibility of patients in developing co-infections. The association of leprosy with hepatitis C virus (HCV) infection, human immunodeficiency virus types 1 and 2 (HIV 1+2) infection and human T-lymphotropic virus types I and II (HTLV I+II) infection have previously been described in different populations. In this study, the prevalence of these infections was determined in 199 Southern Brazilian leprosy patients and in 681 matched controls. Antibodies to HCV were positive in 3.52% of the patients (7/199) and in 0.15% of the controls (1/681; odds ratio (OR)=24.79; 95% CI=3.03-202.74; p=0.0002). An increased risk of HCV infection was observed in institutionalized patients (OR=14.95; 95% CI=1.76-127.03; p=0.004) and in the lepromatous form of the disease (OR=7.67; 95% CI=0.43-136.62; p=ns). Anti-HIV 1+2 antibodies were positive in only one out-patient (1/199; 0.50%) and in none of the controls (0/681; OR=3.43; 95% CI=0.21-55.16; p>0.05). No leprosy patient was positive for anti-HTLV I+II antibodies. These results demonstrate an increased prevalence of HCV infection in leprosy patients from South Brazil and that both institutionalization and lepromatous form of the disease confer higher risk to HCV infection. These data emphasizes the importance of monitoring hepatitis C and leprosy interactions and the need of special care to institutionalized and lepromatous patients in preventing HCV co-infection. (AU). Descritores: Brasil/EP Infecções por HIV/CO/EP Infecções por HTLV-I/CO/EP Infecções por HTLV-II/CO/EP Hepacivirus/IM Hepatite C/*CO/*EP Anticorpos Anti-Hepatite C/BL Hanseníase/*CO/*EP Isolamento de Pacientes/* Prevalência Limites: Masculino Meia-Idade Humanos Adolescente Adulto Idoso Idoso de 80 Anos ou mais Feminino Localização: BR191.1; 09359/S

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Id: 23201 Autor: Patrocinio, Lucas Gomes; Goulart, Isabela Maria Bernardes; Goulart, Luiz Ricardo; Patrocinio, Jose Aantonio; Ferreira, Frederico Rogerio; Fleury, Raul Negrao Título: Detection of Mycobacterium leprae in nasal mucosa biopsies by the polymerase chain reaction ..- Fonte: s.l; s.n; 2005. 6 p. ilus, tab. Resumo: Several discoveries about leprosy indicate that Mycobacterium leprae transmission mainly occurs by inhalation, and the nose is major port of entry and exit. The present study evaluated the clinical application of PCR for detection of M. leprae DNA in nasal mucosa biopsies in untreated leprosy patients (52) and their contacts (99) from the State Reference Center in Sanitary Dermatology and Leprosy, Uberlandia, MG, Brazil. PCR detection of a 372-base pair DNA fragment from M. leprae was accomplished in 36 (69.2%) patients, from which 34 (91.9%) of them were multibacillaries. Furthermore, PCR was positive in 3 (16.7%) of 18 slit-skin smear negative, 4 (25.0%) of 16 skin lesion BI negative, 8 (33.3%) of 24 nasal mucosa BI negative patients, and 10 of 99 contacts (10.1%). The presence of bacilli in 10.1% of the contacts may potentially reflect an occult leprosy, and these patients must be accompanied, followed by a chemoprophylaxy treatment. Considering all PCR results against clinical and BI classification of patients and controls, we have found a sensitivity of 69.2%, a specificity of 89.9%, and an accuracy of 82.8%. It has been demonstrated here through PCR of nasal biopsies that the bacillus invades the mucosa, passing through the nasal inferior turbinate to reach peripheral blood. Therefore, the molecular investigation of invasive nasal biopsies by PCR tests has proven to be useful in defining patients of higher risk of transmission and risk-group contacts, which is an important step to reach the World Health Organization objective towards the elimination of leprosy as a public health problem. (AU). Descritores: Biópsia Brasil/EP DNA Bacteriano/AN Hanseníase/*DI/EP/MI Mycobacterium leprae/GE/*IP Mucosa Nasal/*MI/PA Reação em Cadeia da Polimerase/* Fatores de Risco Sensibilidade e Especificidade Limites: Estudo Comparativo Humanos Localização: BR191.1; 09345/s

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