Base de dados : HANSEN Pesquisa : GENES [Descritor de assunto] Referências encontradas : 52 [refinar] Mostrando: 1 .. 20   no formato [Detalhado]

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Id: 23973 Autor: Scollard, D. M; Adams, L. B; Gillis, T. P; Krahenbuhl, J. L; Truman, R. W; Williams, D. L Título: The continuing challenges of leprosy ..- Fonte: s.l; s.n; 2006. 44 p. ilus, tab. Resumo: Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans. The second is a peripheral neuropathy that is initiated by the infection and the accompanying immunological events. The infection is curable but not preventable, and leprosy remains a major global health problem, especially in the developing world, publicity to the contrary notwithstanding. Mycobacterium leprae remains noncultivable, and for over a century leprosy has presented major challenges in the fields of microbiology, pathology, immunology, and genetics; it continues to do so today. This review focuses on recent advances in our understanding of M. leprae and the host response to it, especially concerning molecular identification of M. leprae, knowledge of its genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Advances in experimental models include studies in gene knockout mice and the development of molecular techniques to explore the armadillo model. In clinical studies, notable progress has been made concerning the immunology and immunopathology of leprosy, the genetics of human resistance, mechanisms of nerve injury, and chemotherapy. In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases. (AU). Descritores: Antiinfecciosos/TU Proteínas de Bactérias/ME Vacinas Bacterianas Modelos Animais de Doenças Suscetibilidade à Doença/IM Resistência Bacteriana a Drogas Genes Bacterianos/GE Predisposição Genética para Doença Genoma Bacteriano Imunidade Celular Imunidade Natural/GE Hansenostáticos/PD/TU Hanseníase/*/DI/MI/TH Mycobacterium leprae/*/CH/DE/IP/PH Nervos Periféricos/MI Doenças do Sistema Nervoso Periférico/MI/PA Reação em Cadeia da Polimerase Research Support, N.I.H., Extramural Células de Schwann/IM/MI Limites: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Localização: BR191.1; 09365/S

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Id: 23970 Autor: Geluk, Annemieke; Ottenhoff, Tom H. M Título: HLA and leprosy in the pre and postgenomic eras ..- Fonte: s.l; s.n; 2006. 7 p. graf. Resumo: Leprosy has intrigued immunologists for many decades. Despite minimal genetic variation between Mycobacterium leprae isolates worldwide, two completely different forms of the disease can develop in the susceptible human host: localized, tuberculoid, or paucibacillary leprosy, which can heal spontaneously, and disseminating, lepromatous, or multibacillary leprosy, which is progressive if untreated. The questions which host factors regulate these very different outcomes of infection, by what mechanisms, and whether these can be used to combat disease remain unanswered. Leprosy has been one of the very first human diseases in which human leukocyte antigen (HLA) genes were demonstrated to codetermine disease outcome. Jon van Rood was among the earliest researchers to recognize the potential of this ancient disease as a human model to dissect the role of HLA in disease. Decades later, it is now clear that HLA molecules display highly allele-specific peptide binding capacity. This restricts antigen presentation to M. leprae-reactive T cells and controls the magnitude of the ensuing immune response. Furthermore, specific peptide/HLA class II complexes can also determine the quality of the immune response by selectively activating regulatory (suppressor) T cells. All these factors are believed to contribute to leprosy disease susceptibility. Despite the global reduction in leprosy disease prevalence, new case detection rates remain invariably high, demonstrating that treatment alone does not block transmission of leprosy. Better tools for early detection of preclinical M. leprae infection, likely the major source of unidentified transmission, therefore is a priority. Newly developed HLA-based bioinformatic tools now provide novel opportunities to help combat this disease. Here, we describe recent work using HLA-DR peptide binding algorithms in combination with recently elucidated genome sequences of several different mycobacteria. Using this postgenomic HLA-based approach, we were able to identify 12 candidate genes that were unique to M. leprae and were predicted to contain T cell epitopes restricted via several major HLA-DR alleles. Five of these antigens (ML0576, ML1989, ML1990, ML2283, ML2567) were indeed able to induce significant T cell responses in paucibacillary leprosy patients and M. leprae-exposed healthy controls but not in most multibacillary leprosy patients, tuberculosis patients, or endemic controls...(AU). Descritores: Motivos de Aminoácidos Anticorpos Antibacterianos/BL Antígenos de Bactérias/IM Sítios de Ligação Epitopos de Linfócito T Genes Classe II do Complexo de Histocompatibilidade (MHC) Genoma Bacteriano Glicolipídeos/IM Antígenos HLA-DR/*GE/IM Hanseníase/DI/*IM/MI Hanseníase Virchowiana/DI/IM/MI Hanseníase Tuberculóide/DI/IM/MI Mycobacterium leprae/GE/*IM Linfócitos T/IM/MI Limites: HUMANO Research Support, Non-U.S. Gov´t Localização: BR191.1; 09362/S

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Id: 23189 Autor: Young, Saroj K; Taylor, G. Michael; Jain, Suman; Suneetha, Lavanya M; Suneetha, Sujai; Lockwood, Diana N. J; Young, Douglas B Título: Microsatellite mapping of Mycobacterium leprae populations in infected humans ..- Fonte: s.l; s.n; Nov. 2004. 6 p. ilus, mapas, tab. Resumo: To investigate genetic diversity in a bacterial population, we measured the copy numbers of simple sequence repeats, or microsatellites, in Mycobacterium leprae from patients living in and around Hyderabad, India. Three microsatellite loci containing trinucleotide or dinucleotide repeats were amplified from infected tissues, and the copy numbers were established by sequence analysis. Extensive diversity was observed in a cross-sectional survey of 33 patients, but closely related profiles were found for members of a multicase family likely to share a common transmission source. Sampling of multiple tissues from single individuals demonstrated identical microsatellite profiles in the skin, nasal cavity, and bloodstream but revealed differences at one or more loci for M. leprae present in nerves. Microsatellite mapping of M. leprae represents a useful tool for tracking short transmission chains. Comparison of skin and nerve lesions suggests that the evolution of disease within an individual involves the expansion of multiple distinct subpopulations of M. leprae. (AU). Descritores: Técnica de Tipagem Bacteriana/* Estudos Transversais Família Dosagem de Genes Hanseníase/EP/*MI/*TM Repetições de Microssatélites/*GE Mycobacterium leprae/*CL/*GE Reação em Cadeia da Polimerase Especificidade de Espécies Variação (Genética)/* Limites: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Localização: BR191.1; 09333/s

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Id: 22674 Autor: Bleharski, Joshua R; Li, Huiying; Meinken, Cristoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Título: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Fonte: s.l; s.n; 2003. 4 p. . Resumo: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descritores: Algoritmos Análise por Conglomerados Contagem de Colônia Microbiana Citocinas/GE/ME Perfilação da Expressão Gênica/* Regulação da Expressão Gênica/* Genes de Imunoglobulinas Imunidade Celular Imunidade Natural Hanseníase Virchowiana/*CL/*GE/IM/PP Hanseníase Tuberculóide/*CL/*GE/IM/PP Macrófagos Alveolares/MI Glicoproteínas de Membrana/IM Mycobacterium tuberculosis/GD/IM Análise de Sequência com Séries de Oligonucleotídeos Reação em Cadeia da Polimerase Análise de Componente Principal Receptores da Superfície Celular/IM Receptores Imunológicos/GE/ME Limites: Humano Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Regulação para Cima Localização: BR191.1; 09174/s

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Id: 18570 Autor: Maeda, Yumi; Makino, Masahiko; Crick, Dean C; Mahapatra, Sebabrata; Srisungnam, Sopa; Takii, Takemasa; Kashiwabara, Yoshiko; Brennan, Patrick J Título: Novel 33-kilodalton lipoprotein from Mycobacterium leprae ..- Fonte: s.l; s.n; 2002. 6 p. tab, graf. Resumo: A novel Mycobacterium leprae lipoprotein LpK (accession no. ML0603) was identified from the genomic database. The 1,116-bp open reading frame encodes a 371-amino-acid precursor protein with an N-terminal signal sequence and a consensus motif for lipid conjugation. Expression of the protein, LpK, in Escherichia coli revealed a 33-kDa protein, and metabolic labeling experiments and globomycin treatment proved that the protein was lipidated. Fractionation of M. leprae demonstrated that this lipoprotein was a membrane protein of M. leprae. The purified lipoprotein was found to induce production of interleukin-12 in human peripheral blood monocytes. The studies imply that M. leprae LpK is involved in protective immunity against leprosy and may be a candidate for vaccine design. (AU). Descritores: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTERIAS/GE/*IM/IP PROTEINAS DE BACTERIAS/GE/*IM/IP CLONAGEM MOLECULAR ESCHERICHIA COLI EXPRESSAO GENICA GENES BACTERIANOS INTERLEUCINA-12/*BI LIPOPROTEINAS/GE/*IM/IP PROTEINAS DE MEMBRANA/GE/*IM/IP DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MONOCITOS/IM MYCOBACTERIUM LEPRAE/GE/*IM/IP PRECURSORES DE PROTEINAS/GE/*IM/IP ANALISE DE SEQUENCIA DE DNA Limites: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Localização: BR191.1; 09059/s

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Id: 18506 Autor: Sassetti, Christopher M; Boyd, Dana H; Rubin, Eric J Título: Genes required for mycobacterial growth defined by high density mutagenesis ..- Fonte: s.l; s.n; 2003. 8 p. tab, graf. Resumo: Despite over a century of research, tuberculosis remains a leading cause of infectious death worldwide. Faced with increasing rates of drug resistance, the identification of genes that are required for the growth of this organism should provide new targets for the design of antimycobacterial agents. Here, we describe the use of transposon site hybridization (TraSH) to comprehensively identify the genes required by the causative agent, Mycobacterium tuberculosis, for optimal growth. These genes include those that can be assigned to essential pathways as well as many of unknown function. The genes important for the growth of M. tuberculosis are largely conserved in the degenerate genome of the leprosy bacillus, Mycobacterium leprae, indicating that non-essential functions have been selectively lost since this bacterium diverged from other mycobacteria. In contrast, a surprisingly high proportion of these genes lack identifiable orthologues in other bacteria, suggesting that the minimal gene set required for survival varies greatly between organisms with different evolutionary histories. (AU). Descritores: ELEMENTOS DE DNA TRANSPONIVEIS GENES BACTERIANOS MUTAGÊNESE MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/genet MYCOBACTERIUM TUBERCULOSIS/cresc MYCOBACTERIUM TUBERCULOSIS/genet - EVOLUCAO MOLECULAR Limites: SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 09138/s

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Id: 18504 Autor: Bleharski, Joshua R; Li, Huiying; Meinken, Christoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Título: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Fonte: s.l; s.n; Sep. 2003. 4 p. graf. Resumo: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descritores: HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/fisiopatol HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/genet HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/fisiopatol CITOCINAS/genet CITOCINAS/metab PERFILACAO DA EXPRESSÃO GÊNICA ANALISE POR CONGLOMERADOS CONTAGEM DE COLÔNIA MICROBIANA REGULACAO DA EXPRESSÃO GÊNICA IMUNIDADE CELULAR IMUNIDADE NATURAL MACROFAGOS ALVEOLARES/microbiol GLICOPROTEINAS DE MEMBRANA/imunol MYCOBACTERIUM TUBERCULOSIS/cresc MYCOBACTERIUM TUBERCULOSIS/imunol REACAO EM CADEIA DA POLIMERASE RECEPTORES IMUNOLOGICOS/genet RECEPTORES IMUNOLOGICOS/metab RECEPTORES DA SUPERFICIE CELULAR/imunol - REGULACAO PARA CIMA  Análise de Componente Principal  ALGORITMOS  GENES DE IMUNOGLOBULINAS  ANALISE DE SEQUÊNCIA COM SERIES DE OLIGONUCLEOTIDIOS Limites: SUPPORT, NON-U.S. GOV'T HUMANO SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 09142/s; BR191.1; 09145/s

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Id: 17847 Autor: Hackel, C; Houard, S; Portaels, F;; Elsen, A. van; Herzog, A; Bollen, A Título: Specific identification of Mycobacterium leprae by the polymerase chain reaction ..- Fonte: s.l; s.n; jun. 1990. 6 p. ilus, tab. Resumo: Oligonucleotide primers have been used to amplify DNA regions of the M. leprae genome by the polymerase chain reaction. A first set of primers, PLp1 and PLp2, identifies a specific 386 bp DNA fragment located in the gene coding for the 65 kDa antigen of M. leprae. A second pair of primers, targetted to the same gene, leads to the amplification of a 154 bp DNA piece conserved in mycobacteria. Primers PLp1 and PLp2 discriminate the pathogenic species from other mycobacteria, detect down to 40 bacilli, and constitute potentially useful tools for the identification of M. leprae in clinical specimens.(AU). Descritores: AMPLIFICACAO DE GENES HANSENIASE/diag HANSENIASE/microbiol DNA BACTERIANO/genet DNA BACTERIANO/isol MYCOBACTERIUM/genet MYCOBACTERIUM LEPRAE/genet MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/isol Limites: HUMANO ANIMAL SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 02123/s

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Id: 16381 Autor: Adams, Linda B; Scollard, David M; Ray, Nashome A; Cooper, Andrea M; Frank, Anthony A; Orme, Ian M; Krahenbuhl, James L Título: The study of mycobacterium leprae infection in interferon-gamma gene - disrupted mice as a model to explore the immunopathologic spectrum of leprosy ..- Fonte: s.l; s.n; 2002. 8 p. ilus, graf. Descritores: LINFOCITOS T CD4-POSITIVOS LINFOCITOS T CD8-POSITIVOS CITOCINAS MODELOS ANIMAIS DE DOENÇAS CITOMETRIA DE FLUXO PELE PELE DELEÇAO DE GENES IMUNOHISTOQUIMICA INTERFERON TIPO II HANSENIASE HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA MACROFAGOS PERITONEAIS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE Limites: ANIMAL Localização: BR191.1; 08655/s

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Id: 16337 Autor: Rambukkana, Anura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Título: Contact-dependent demyelination by mycobacterium leprae in the absence of immune cells ..- Fonte: s.l; s.n; May 2002. 5 p. ilus, graf. Descritores: APOPTOSE AXONIOS AXONIOS LINFOCITOS B ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL CAMUNDONGOS KNOCKOUT MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL FIBRAS NERVOSAS MIELINIZADAS NEURONIOS CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN NERVO CIATICO NERVO CIATICO LINFOCITOS T CULTURA DE TECIDO Limites: ANIMAL Localização: BR191.1; 08647/s

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Id: 16331 Autor: Maeda, Shinji; Matsuoka, Masanori; Nakata, Noboru; Kai, Masanori; Maeda, Yumi; Hashimoto, Ken; Kimura, Hiroaki; Kobayashi, Kazuo; Kashiwabara, Yoshiko Título: Multidrug resistant mycobacterium leprae from patients with leprosy ..- Fonte: s.l; s.n; Dec. 2001. 5 p. tab, graf. Descritores: AGENTES ANTIINFECCIOSOS DE FLUOROQUINOLONA AGENTES ANTIINFECCIOSOS DE FLUOROQUINOLONA ANTIBIOTICOS ANTITUBERCULOSE ANTIBIOTICOS ANTITUBERCULOSE SEQUENCIA DE BASES PRIMERS DO DNA DNA BACTERIANO DNA BACTERIANO RESISTENCIA MICROBIANA A DROGAS RESISTENCIA A MULTIPLAS DROGAS GENES BACTERIANOS GENES BACTERIANOS LEPROSTATICOS LEPROSTATICOS HANSENIASE HANSENIASE CAMUNDONGOS DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE OFLOXACINA OFLOXACINA RIFAMPINA RIFAMPINA REACAO EM CADEIA POR POLIMERASE VIA TRANSCRIPTASE REVERSA Limites: ANIMAL Localização: BR191.1; 08640/s

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Id: 16214 Autor: Cole, S. T; Eigimeier, K; Parkhill, J; James, K. D; Thomson, N. R; Wheeler, P. R; Honore, N; Garnier, T; Churcher, C; Harris, D; Mungall, K; Basham, D; Brown, D; Chillingworth, T; Connor, R; Davies, R. M; Devlin, K; Duthoy, S; Feltwell, T; Fraser, A; Hamlin, N; Holroyd, S; Hornsby, T; Jagels, K; Lacroix, C; Maclean, J; Moule, S; Murphy, L; Oliver, K; Quail, M. A; Rajandream, M.-A; Rutherford, K. M; Rutter, S; Seeger, K; Simon, S; Simmonds, M; Skelton, J; Squares, S; Stevens, K; Taylor, K; Whitehead, S; Woodward, J. R; Barrell, B. G Título: Massive gene decay in the leprosy bacillus ..- Fonte: s.l; s.n; feb. 2001. 5 p. ilus, tab, graf. Descritores: TATUS DNA BACTERIANO METABOLISMO ENERGÉTICO EVOLUÇAO MOLECULAR GENOMA BACTERIANO HANSENIASE DADOS DE SEQUENCIA MOLECULAR GENES REITERADOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ANALISE DE SEQUENCIA DE DNA Transferência Genética Horizontal Limites: ANIMAL Localização: BR191.1; 08699/s

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Id: 16017 Autor: Meada, Yumi; Makino, Masahiko; Crick, Dean C; Mahapatra, Sebabrata; Srisungnam, Sopa; Takii, Takemasa; Kashiwabara, Yoshiko; Brennan, Partrick J Título: Novel 33-kilodalton lipoprotein from Mycobacterium leprae ..- Fonte: s.l; s.n; 2002. 6 p. ilus, graf. Descritores: MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MONOCITOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS CLONAGEM MOLECULAR ESCHERICHIA COLI EXPRESSAO GENICA GENES BACTERIANOS INTERLEUCINA-12 PESO MOLECULAR ANALISE SEQUENCIAL PRECURSORES DE PROTEINAS PRECURSORES DE PROTEINAS PRECURSORES DE PROTEINAS Localização: BR191.1; 08605/s

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Id: 15813 Autor: Adams, Linda B; Scollard, David M; Ray, Nashone A; Cooper, Andrea M; Frank, Anthony A; Orne, Ian M; Krahenbuhl, James L Título: The study of Mycobacterium leprae infection in interferon-y gene-disrupted mice as a model to explore the immunopathologic spectrum of leprosy ..- Fonte: s.l; s.n; 2002. 8 p. ilus, graf. Descritores: LINFOCITOS T CD4-POSITIVOS LINFOCITOS T CD8-POSITIVOS CITOCINAS MODELOS ANIMAIS DE DOENÇAS CITOMETRIA DE FLUXO PÉ PÉ DELEÇAO DE GENES IMUNOHISTOQUIMICA INTERFERON TIPO II HANSENIASE HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA MACROFAGOS PERITONEAIS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ANIMAL LINFONODOS/IM Limites: ANIMAL Localização: BR191.1; 08511/s

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Id: 15807 Autor: Rambukkana, Amura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Título: Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells ..- Fonte: s.l; s.n; 2002. 5 p. ilus. Descritores: HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE AXONIOS AXONIOS ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS MACROFAGOS MUTAÇAO BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL - FIBRAS NERVOSAS MIELINIZADAS  NEURONIOS  CÉLULAS DE SCHWANN  CÉLULAS DE SCHWANN  NERVO CIATICO  NERVO CIATICO  LINFOCITOS T  CULTURA DE TECIDO Localização: BR191.1; 08525/s

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Id: 15786 Autor: Chua Intra, Boosbun; Peerapakorn, Somchai; Davey, Nick; Jurcevic, Stipo; Busson, Marc; Vordermeier, H. Martin; Pirayavaraporn, Charoon; Ivanyl, Juraj Título: T-cell recognition of mycobacterial groES peptides in Thai leprosy patients and contacts ..- Fonte: s.l; s.n; 1998. 7 p. ilus, tab, graf. Descritores: HANSENIASE HANSENIASE HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MYCOBACTERIUM MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS SEQUENCIA DE AMINOACIDOS EPITOPOS GENES CLASSE II DO COMPLEXO DE HISTOCOMPATIBILIDADE (MHC) PROTEINA GROES ANTIGENOS HLA-D ANTIGENOS HLA-DQ ANTIGENOS HLA-DR EXPOSIÇAO OCUPACIONAL FRAGMENTOS DE PEPTIDIOS LINFOCITOS T Localização: BR191.1; 07323/s

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Id: 15465 Autor: Cole, S. T; Eigimeier, K; Parkhill, J; James, K. D; Thomson, N. R; Wheeler, P. R; Honoré, N; Garnier, T; Churcher, C; Harris, D; Mungall, K; Basham, D; Brown, D; Chillingworth, T; Connor, R; Davies, R. M; Devlin, K; Duthoy, S; Feltwell, T; Fraser, A; Hamlin, N; Holroyd, S; Hornsby, T; Jagels, K; Lacroix, C; Maclean, J; Moule, S; Murphy, L; Oliver, K; Quail, M. A; Rajandream, M.-A; Rutherford, K. M; Rutter, S; Seeger, K; Simon, S; Simmonds, M; Skelton, J; Squares, R; Stevens, K; Taylor, K; Whitehead, S; Woodward, J. R; Barrell, B. G Título: Masssive gene decay in the leprosy bacillus ..- Fonte: s.l; s.n; 2001. 5 p. ilus, tab, graf. Descritores: TATUS METABOLISMO ENERGÉTICO DNA BACTERIANO EVOLUÇAO MOLECULAR GENOMA BACTERIANO HANSENIASE DADOS DE SEQUENCIA MOLECULAR GENES REITERADOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ANALISE DE SEQUENCIA DE DNA Transferência Genética Horizontal Localização: BR191.1; 08320/s

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Id: 15336 Autor: Rastogi, Nalin; Goh, Khye Seng; Berchel, Mylene Título: Species-specific identification of mycobacterium leprae by PCR-restriction fragment length polymorphism analysis of the hsp65 gene ..- Fonte: s.l; s.n; 1999. 4 p. ilus, tab, graf. Descritores: ALGORITMOS ANTIGENOS DE BACTÉRIAS TATUS CHAPERONINAS GENES ESTRUTURAIS BACTERIANOS HANSENIASE FIGADO GANGLIOS LINFATICOS CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS REAÇAO EM CADEIA POR POLIMERASE POLIMORFISMO DE FRAGMENTO DE RESTRIÇAO SENSIBILIDADE E ESPECIFICIDADE ESPECIFICIDADE DE ESPÉCIES BAÇO Localização: BR191.1; 07257/s

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Id: 15096 Autor: Shaw, Marie-Anne; Donaldson, I. J; Collins, A; Peacock, C. S; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Título: Association and linkage of leprosy phenotypes with HLA class II and tumor necrosis factor genes ..- Fonte: s.l; s.n; 2001. 9 p. tab. Descritores: HANSENIASE HANSENIASE GENES CLASSE II DO COMPLEXO DE HISTOCOMPATIBILIDADE (MHC) LIGAÇAO (GENÉTICA) FENOTIPO FATOR DE NECROSE DE TUMOR Localização: BR191.1; 07374/s

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HANSEN

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Id: 15034 Autor: Triccas, James A; Winter, Nathalie; Roche, Paul W; Gilpin, Andrea; Kendrick, Kathleen E; Britton, Warwick J Título: Molecular and immunological analyses of the mycobacterium avium homolog of the immunodominant mycobacterium leprae 35-kilodalton protein ..- Fonte: s.l; s.n; 1998. 7 p. ilus, tab, graf. Descritores: HANSENIASE MYCOBACTERIUM AVIUM MYCOBACTERIUM AVIUM MYCOBACTERIUM LEPRAE SEQUENCIA DE AMINOACIDOS SEQUENCIA DE BASES CLONAGEM MOLECULAR GENES BACTERIANOS COBAIAS PROTEINAS DO CHOQUE TÉRMICO PROTEINAS DO CHOQUE TÉRMICO HIPERSENSIBILIDADE TARDIA EPITOPOS IMUNODOMINANTES EPITOPOS IMUNODOMINANTES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PROTEINAS RECOMBINANTES HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS TUBERCULOSE PULMONAR Localização: BR191.1; 07286/s

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