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| Id: | 26266
| | Autor: | Hadler, W. A; Mauri, A. C. | | Título: | Lepra murina: estudo patogênico - evolutivo no rato inoculado por via peritoneal / Murine leprosy: a pathogenic - rolling the mouse inoculated by peritoneal
| | Fonte: | Rev. bras. Leprol;16(3):139-163, set. 1948. ^bilus.
| | Resumo: | The pathology of the murine leprosy was studied detailedly in the more advanced stages of the infection; the same having occured initially, or in the consecutive phases. excepting the works of Fite and Henderson who, using subcutaneous innoculation, made a detailled and systematic studies in the lesions of the innoculation point; they give attention also to the pathological process in the internal organs, but without intermission for the knowledge about the complete evolution of the infection. Conscious of the absence of minute characteristics as to the different evolutive stages of the disease when intraperitoneal experimental innoculations is made in rats, it was decided to carry on the progressive study of the lesions in the various organs of the animal. We made use of 265 young rats, ages varying between 30 and 50 days, belonging to the Mc Clollum and Wistar breeds, and some others crossbreedings with Rattus nervergicus. The material used to inoculations proceeds from experimentally injected rats, with several passages; the subcutaneous nodules were removed, and the internal organs rich in bacilli were triturated and diluted in physiological solution-glycerin at 40 per cente in the proportion of 1:20; being kept in ice-box at 4.øC. The turbidity of bacilli suspension corresponding approximated to that of test-tube n.ø 5 of Mac Farland scale. The work was done under sterility conditions. Before innoculation was carried forth richness of gacilli suspension was checked. Innoculation was effected through intraperitoneal route and single dosed at 0,5 cc. per animal. This dose was varied with some groups. Animals were sacrificed daily, from the first to the twetieth day, every five days to the hundred and eightieth day after innoculation and in continuation, every fifteen days. We shall emumate briefly here the...(AU)^ien.
| | Descritores: | Hanseníase/compl
Hanseníase/diag
Hanseníase/imunol
Hanseníase/fisiopatol
Ratos/imunol
Ratos/virol
| | Limites: | Ratos
| | Meio Eletrônico: | http://hansen.bvs.ilsl.br/textoc/revistas/1948/PDF/v16n3/v16n3a01.pdf - pt.
| | Localização: | BR191.1 |
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