Database : HANSEN Search on : ANTICORPOS/IMUNOL [Subject descriptor] References found : 6 [refine] Displaying: 1 .. 6   in format [Detailed]

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Id: 19745 Author: Ghaswala, Percy S; Mistry, Nerges F; Antia, Noschir H. Title: Serum antibodies for normals and leprosy patients show equal binding to peripheral nerve. Source: Int J Lep;57(3):690-692, sept. 1989. ^bgraf. Descriptors: Anticorpos/imunol Hanseníase/imunol Hanseníase/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n3/v57n3cor02.pdf / en Location: Br191.1

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Id: 19738 Author: Yandava, Chandri Naidu; Bhutani, Lalit K; Sharma, AK; Nath, Indira. Title: Lymphoproliferation and in vitro antibody synthesis in leprosy patients. Source: Int J Lep;57(3):633-640, sept. 1989. . Abstract: An in vitro system to assess B-cell function in leprosy patients is described. In vitro lymphoproliferation and antibody synthesis by peripheral blood mononuclear cells (PBMC) in response to pokeweed mitogen (PWM) and Formalin-treated Staphylococcus aureus Cowan I (FSA) from 31 leprosy patients and 13 healthy controls were studied. DNA synthesis was induced by both PWM and FSA in PBMC from all of the leprosy patients and control subjects. Lepromatous leprosy (LL) patients' cells showed higher responses to both PWM and FSA. However, these increases were not statistically significant. The levels of secreted IgM, IgG, or IgA were examined in the 7-day culture supernatants of PBMC cultured with or without PWM or FSA using an enzyme-linked immunosorbent assay. Wide individual variations were observed in in vitro antibody synthesis. IgM secretion in PBMC from normal subjects and various groups of leprosy patients in response to PWM and FSA was comparable. In vitro IgG secretion in response to PWM was the highest in cells from LL patients; it was significantly decreased in cells from tuberculoid leprosy (TT) patients (p less than 0.01). The levels in cells from borderline leprosy (BB) patients were intermediate in response to the same mitogen. Cells from leprosy patients as a group showed a higher spontaneous secretion of IgA in comparison with cells from normal subjects. Overall, the in vitro Ig secretion by PBMC in different patient groups appears to reproduce the spectrum of antibody levels observed in patients in vivo. Thus, the present in vitro culture system may help to delineate the mechanisms of B-cell dysregulation in leprosy^ien. Descriptors: Hanseníase/imunol Hanseníase/fisiopatol Anticorpos/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n3/v57n3a06.pdf / en Location: Br191.1

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Id: 19731 Author: Vilalva, Fernanda Castro Jobim Title: Determinação dos níveis séricos de MBL, dos anticorpos anti-PGL-I e dos alelos HLA de classe I e classe II em pacientes com hanseníase^ipt Determination of MBL and anti-PGL-I serum levels and HLA ClassI and II in patients with leprosy- Source: Bauru; s.n; 2010. 81 p. ilus, tab. Abstract: A hanseníase é uma doença infecto-contagiosa e endêmica, constitui grave problema de saúde pública por causar incapacidade física permanente. A doença caracteriza-se por apresentar um amplo espectro de manifestações clínicas que correspondem a distintos padrões de resposta imunológica diante do mesmo agente etiológico, o Mycobacterium leprae. Métodos sorológicos têm sido desenvolvidos com a finalidade de auxiliar no diagnóstico precoce e estados reacionais, no monitoramento da eficácia da quimioterapia e no estudo da epidemiologia da hanseníase. Este estudo teve como objetivos: avaliar os níveis séricos de Lectina Ligada a Manose (MBL) e dos anticorpos anti-PGL-I em poacientes com hanseníase, em atividades, atendidos no Instituto Lauro de Souza Lima, SP, com ou sem o tratamento de poliquimioterapia e nos estados reacionais tipo 1 e 2; correlacionar os resultados dos nívceis séricos de MBL, e dos anticorpos anti-PGL-I com o índice baciloscópico (IB); avaliar a freqüência dos alelos HLA de classe I e II (locus A, B, DR e DQ) neste grupo de pacientes. Para a avaliação do anticorpo anti-PGL-I e da MBL foram estudados 69 pacientes sendo 21 do gênero feminino e 48 do gênero masculino, com idade variando de 11 a 72 anos. Quanto a classificação clínica, 12 eram tuberculóides (HT), 23 vichovianos (HV) e 34 dimorfos [18 dimorfos-tuberculóides (HDT), 09 dimorfos-dimorfos (HDD) e 07 dimorfos-virchovianos (HDV)]. Entre os pacientes avaliados, 38 apresentaram reações, sendo 20 reação tipo 1 e 18 reação tipo 2. Quanto ao esquema de tratamento, 43 pacientes eram multibacilares (MB) e 26 paucibacilares (PB). Neste estudo foram avaliados marcadores labaratoriais séricos MBL e anti-PGL-I pelo método imunoenzimático (ELISA) e os antígenos de histocompatibilidade pelo método Reverse Line blot. Os resultados dos níveis de anti-PGL-I forma mais altos nos pacientes MB comparados aos PB e mostraram uma forte associação com a carga bacilar. Com relação à MBL, nossos achados sugerem... (AU)^ipt. Descriptors: Hanseníase/quimioter Anticorpos/imunol Antígenos HLA/imunol - Lectinas/imunol Location: BR191.1; WC335.504, V71a

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Id: 19694 Author: Saha, Kunal; Chattopadhya, Debasis; Kashyup, Arvind; Agarwal, Uma; Chakrabarty, Asit K. Title: Correspondence: Enhanced Response of Serum IgG Class of Anti-PGL-I Antibodies in Leprosy Patients During Onset and Following Clinical Remission of Type 1 and Type 2 Reactions. Source: Int. J. Lepr;63(1):105-109, 1995. ^btab, ^bgraf. Descriptors: Hanseníase/imunol Hanseníase/fisiopatol Anticorpos/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1995/pdf/v63n1/v63n1cor07.pdf / en Location: BR191.1

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Id: 13916 Author: Tarabini Castellani, Giovanni. Title: Serologia en lepra: anticuerpos antilipoideos y antitreponómicos. Source: Revista de Leprologia Fontilles;3(8):572-577, Jul. 1955. . Abstract: Se ha practicado la Pálida reacción (la desviación del complemento empleando antígeno treponémico, derivado del Treponema de Reiter) en 20 sueros de enfermos leprosos con R.W. (Antígeno Bordet), positivos, y con Mainicke, Khan y Citocol, también positivas en parte o todas. Dos sueros resultaron positivos a la Pálida reacción, uno fue dudoso, todos los demás negativos. Se concluye que en todos estos sueros hay presencia de anticuerpos antilipoideos; pero en dos solamente hay presencia también de anticuerpos antitreponémico, y un, de modo dudoso. (AU). Descriptors: HANSENIASE/imunol SEROLOGIA ANTICORPOS/imunol Location: BR191.1

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Id: 3624 Author: Malik, Uma; Khuller, Gopal K; Kumar, Bhushan Title: Suppression of the antibody response to sulfolipids in leprosy patients by 4, 4'-diaminodiphenyl sulfone (DDS) ..- Source: s.l; s.n; 1983. 5 p. ilus. Descriptors: HANSENIASE HANSENIASE ANTICORPOS FORMAÇAO DE ANTICORPOS DAPSONA DAPSONA LIPIDIOS MYCOBACTERIUM LEPRAE Location: BR191.1; 02463/s

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