| Id: | 13354
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| Author: | Holmes, I. B; Banerjee, D. K; Hilson, G. R
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| Title: | Effect of rifampin, clofazimine, and B1912 on the viability of Mycobacterium leprae in established mouse footpad infection
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| Source: | s.l; s.n; apr. 1976. 5 p. graf.
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| Abstract: | Continuous dietary administration of rifampin to mice with an established Mycobacterium leprae footpad infection reduced the bacillary solid ratio, with an estimated survival half-life of 5-6 days. In rifampin-treated immunosuppressed animals the survival half-life of solid bacilli, in the absence of host immunity, was 12-13 days. Clofazimine and B1912 produced a significant effect on solid ratio only after a lag period of apparently 100 days. The rate of action was considerably slower than that of rifampin. Intermittent (once monthly) administration of both drugs produced effects similar to those of continuous administration.(AU).
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| Descriptors: | ANTICORPOS ANTIBACTERIAS
CLOFAZIMINA/analog
CLOFAZIMINA/farmacol
CLOFAZIMINA/uso terap
IMUNOSSUPRESSAO
HANSENIASE/quimioter
HANSENIASE/imunol
MYCOBACTERIUM LEPRAE/ef drogas
MYCOBACTERIUM LEPRAE/imunol
FATORES DE TEMPO
RIFAMPINA/farmacol
RIFAMPINA/uso terap
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| Limits: | ESTUDO COMPARATIVO
ANIMAL
CAMUNDONGOS
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| Electronic Medium: | http://www.ilsl.br
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| Location: | BR191.1; 01652/s |
