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Id:18389
Author:Rambukkana, Anura
Title:Mycobacterium leprae-induced demyelination: a model for early nerve degeneration ..-
Source:s.l; s.n; 2004. 7 p. ilus.
Abstract:The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstratation of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration (AU).
Descriptors:DOENCAS DESMIELINIZANTES/etiol
DOENCAS DESMIELINIZANTES/imunol
DOENCAS DESMIELINIZANTES/microbiol
DOENCAS DESMIELINIZANTES/patol
MYCOBACTERIUM LEPRAE/quim
MYCOBACTERIUM LEPRAE/cresc
MYCOBACTERIUM LEPRAE/patogen
- DEGENERACAO NEURAL/etiol
 DEGENERACAO NEURAL/patol
 HANSENIASE/compl
 HANSENIASE/imunol
 HANSENIASE/microbiol
 HANSENIASE/patol
Limits:HUMANO
Location:BR191.1; 09300/s


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