Database : HANSEN
Search on : EPIDERME [Subject descriptor]
References found : 8 [refine]
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Texto Completo-en
Id:19691
Author:Seo, Young- Hoon; Cho, Wook; Choi, Hae-Young; Hah, Yong-Ma; Cho, Sang-Nae.
Title:Correspondence: Mycobacterium leprae in the Epidermis: Ultrastructural Study I.
Source:Int. J. Lepr;63(1):101-103, 1995. ^bilus.
Descriptors:Mycobacterium leprae/fisiol
Epiderme/fisiopatol
Electronic Medium:http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1995/pdf/v63n1/v63n1cor04.pdf / en
Location:BR191.1


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Id:19493
Author:Rea, Thomas H.
Title:Frequency and extent of thickening of the nucleated epidermis in leprosy lesions.
Source:Int. J. Lepr;68(4):410-416, Dec., 2000. graf, ilus.
Abstract:Using 28 specimens of clinically normal skin from lepromatous leprosy subjects as a standard for comparison, the mean thickness of the nucleated epidermis was found to be significantly increased in untreated lesions from 16 borderline tuberculoid, 21 erythema nodosum leprosum (ENL), and 14 reversal reaction patients, but was unchanged in borderline lepromatous and lepromatous patients. Using specimens from 36 untreated lepromatous and borderline lepromatous lesions as the standard for comparison with the lesions of reversal reactions or ENL which these patients eventually developed, there was a significant thickening of the nucleated epidermis in both reactional states. In both comparison groups, there was a greater mean increase and a larger frequency of thickening in the ENL lesions than in those with reversal reactions. In the borderline tuberculoid and reversal reaction lesions the increase can be understood as secondary to the presence of gamma interferon or interleukin-2. The increase in thickness in the ENL lesions is more difficult to explain, but it is not inconsistent with a role for these same two cytokines. (AU)^ien.
Descriptors:Epiderme/anorm
Epiderme/les
Hanseníase/fisiopatol
Hanseníase/cirurg
Limits:Humanos
Electronic Medium:http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n4/v68n4a02.pdf / en
Location:BR191.1


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Texto Completo-pt
Id:18818
Author:Silva, J. Ramos e.
Title:Sôbre a "hypodermite nodular lepromatosa recidivante" ("Erythema nodosum leproticum").
Source:Rev. bras. Leprol;26(3/4):155-158, jul.-dez. 1958. .
Descriptors:Epiderme/anorm
Epiderme/les
Hanseníase Virchowiana/compl
Hanseníase Virchowiana/diag
Hanseníase Virchowiana/fisiopatol
Limits:Humanos
Masculino
Feminino
Electronic Medium:http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1958/PDF/v26n3-4/v26n3-4a03.pdf / pt
Location:BR191.1


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Id:13937
Author:Teles, Rosane M. B; Moraes, Milton O; Geraldo, Natasha T. R; Salles, Ana M; Sarno, Euzenir N; Sampaio, Elizabeth P
Title:Differential TNFalpha mRNA regulation detected in the epidermis of leprosy patients ..-
Source:s.l; s.n; 2002. 8 p. ilus, tab, graf.
Abstract:The epidermis is an important site of the immunoinflammatory response in the skin. In the present study, the expression of cytokine and ICAM-1 (intercellular adhesion molecule-1) genes was evaluated by RT-PCR in the epidermis isolated from biopsies from 25 reactional leprosy patients. TNFalpha and IL-6 mRNAs were detected in all individuals during the reactional state (reversal reaction or erythema nodosum leprosum), IL-8 message was detected in 66.6 per cent and 62.5 per cent of the patients, IL-12 mRNA was present in 91.6 per cent and 62.5 per cent and ICAM-1 in 100 per cent and 71.4 per cent, respectively. In addition, when skin biopsies were obtained from the same patients before and during the reactional episode, an enhancement in cytokine mRNA, but not in ICAM-1 mRNA, was observed. Seven patients were also evaluated at the onset of reaction and during antiinflammatory treatment. In contrast to a preferential decrease in the TNFalpha gene detected in the dermis, during the treatment phase, persistent/enhanced TNFalpha mRNA expression was detected in the epidermis in six out of the seven patients assessed. This peculiar pattern of expression might reflect a differential impact that in vivo antiinflammatory therapy has on the epidermis. The present findings indicate that the epidermis plays an important role in the local inflammatory response in leprosy and that the profile of response detected in the epidermis during the reactions may be regulated differently from that in the dermis. (AU).
Descriptors:CITOCINAS/genet
CITOCINAS/metab
ANTIINFLAMATORIOS ESTERÓIDES/uso terap
DERME/metab
HANSENOSTATICOS/uso terap
EPIDERME/metab
MOLECULA 1 DE ADESAO INTERCELULAR/genet
MOLECULA 1 DE ADESAO INTERCELULAR/metab
HANSENIASE/quimioter
HANSENIASE/metab
PENTOXIFILINA/uso terap
ANTIINFLAMATORIOS/uso terap
RNA MENSAGEIRO/metab
TALIDOMIDA/uso terap
PREDNISONA/uso terap
FATOR DE NECROSE TUMORAL/genet
FATOR DE NECROSE TUMORAL/metab
Limits:HUMANO
MASCULINO
FEMININO
ADULTO
MEIA-IDADE
IDOSO
SUPPORT, NON-U.S. GOV'T
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 09157/s


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Id:13517
Author:Kapur, T. R; Verma, R. D
Title:Study of dermatoglyphics in tuberculoid leprosy ..-
Source:s.l; s.n; jan. 1982. 6 p. ilus, tab.
Abstract:Dermatoglyphics patterns and total ridge count have been atudied in 25 cases of Tuberculoid leprosy and were compared with 25 controls. There was no statiscally significant variations in loops, whrols and total average ridge count. There were 4 (1.6%) arches in Tuberculoid leprosy as compared to 11 (4.4%) of controls and was not statiscally significant. There was more decrease of arches on the left hand of the patients as compared to the left hand of the controls.(AU).
Descriptors:EPIDERME/patol
DEDOS
HANSENIASE/genet
DERMATOGLIFOS
Limits:HUMANO
MASCULINO
Electronic Medium:http://www.ilsl.br
Location:BR191.1; 01602/s


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Id:10368
Author:Hosokawa, Atsushi
Title:A clinical and bacteriological examination of Mycobacterium leprae in the epidermis and cutaneous appendages of patients with multibacillary leprosy ..-
Source:s.l; s.n; 1999. 10 p. ilus, tab.
Descriptors:CAPILARES
DIAGNOSTICO DIFERENCIAL
ENDOTÉLIO VASCULAR
EPIDERME
EXTREMIDADES
FOLICULO PILOSO
HANSENIASE
HANSENIASE
HANSENIASE
MYCOBACTERIUM LEPRAE
PELE
PELE
PELE
GLANDULAS SUDORIPARAS
Location:BR191.1; 07500/s


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Id:9308
Author:Sullivan, Laura; Sano, Shigetoshi; Pirmez, Claude; Salgame, Padmini; Mueller, Christoph; Hofaman, Florence; Uyemura, Koichi; Rea, Thomas H; Bloom, Barry R; Modlin, Robert L
Title:Expression of adhesion molecules in leprosy lesions ..-
Source:s.l; s.n; 1991. 7 p. ilus, tab, graf.
Descriptors:ANTIGENOS CD2
ANTIGENOS CD58
ANTIGENOS DE DIFERENCIAÇAO DE LINFOCITOS T
ANTIGENOS DE SUPERFICIE
MOLÉCULAS DE ADESAO CELULAR
EPIDERME
EPIDERME
EXPRESSAO GENICA
MOLÉCULA 1 DE ADESAO INTERCELULAR
INTERFERON TIPO II
HANSENIASE
HANSENIASE
HANSENIASE
ANTIGENO-1 LINFOCITARIO ASSOCIADO A FUNÇAO
HIBRIDIZAÇAO DE ACIDO NUCLÉICO
RECEPTORES IMUNOLOGICOS
LINFOCITOS T
LINFOTOXINA
Location:BR191.1; 06211/s


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Id:3604
Author:Rea, T. H; Shen, J. Y; Modlin, R. L
Title:Epidermal keratinocyte Ia expression, Langerhans cell hyperplasia and lymphocytic infiltration in skin lesions of leprosy ..-
Source:s.l; s.n; 1986. 7 p. ilus, tab.
Descriptors:MOVIMENTO CELULAR
EPIDERME
HIPERPLASIA
QUERATINA
CÉLULAS DE LANGERHANS
HANSENIASE
HANSENIASE
LINFOCITOS
PELE
Location:BR191.1; 02442/s



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