Database : HANSEN Search on : HANSENIASE VIRCHOWIANA/METAB [Subject descriptor] References found : 3 [refine] Displaying: 1 .. 3   in format [Detailed]

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Id: 19759 Author: Marolia, Jolly; Mahadevan, PR. Title: Reactive oxygen intermediates inactive Mycobacterium leprae in the phagocytes from human peripheral blood. Source: Int J Lepr;57(2):483-491, June 1989. ^btab. Abstract: Reactive oxygen intermediates such as hydrogen peroxide, superoxide, and hydroxyl radicals are important microbicidal components, and they could also play a role in an infection with Mycobacterium leprae. A comparative study of the level of hydrogen peroxide and superoxide produced by peripheral blood phagocytes from normal healthy individuals and lepromatous leprosy patients showed a deficiency in superoxide production in the patients. In the phagocytes from normal healthy individuals, there was good release of superoxide ions, and this mediated the killing of M. leprae. The lack of superoxide production allowed the viability of M. leprae inside the macrophages from leprosy patients. This deficiency could be rectified by the use of an immunomodulator, the delipidified cell wall of M. leprae. This modulation resulted in the ability of the patients' phagocytes to respond to M. leprae, to produce reactive oxygen intermediates such as superoxide, and also to kill the bacteria. These observations indicate that delipidified cell wall could have significant potential to positively modulate the immune-deficient cells of leprosy patients.^ien. Descriptors: Hanseníase Virchowiana/metab Hanseníase Virchowiana/microbiol Hanseníase Virchowiana/reabil Mycobacterium leprae/imunol Mycobacterium leprae/patogen Superóxido Dismutase/bios Superóxido Dismutase/metab Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2a06.pdf / en Location: Br191.1

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Id: 13951 Author: Kiszewski, C. A; Becerril, E; Baquera, J; Aguilar, L. D; Hernández-Pando, R Title: Expression of transforming growth factor-beta isoforms and their receptors in lepromatous and tuberculoid leprosy ..- Source: s.l; s.n; 2003. 7 p. ilus, tab, graf. Abstract: Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TT) and lepromatous leprosy (LL), that are characterized by strong cell-mediated immunity (CMI) and CMI anergy, respectively. Transforming growth factor-beta (TGF-beta) belongs to a family of pleiotropic cytokines (TGF-beta1, TGF-beta2 and TGF-beta3) that participate in the control of cell differentiation and proliferation, as well as tissue repair. This cytokine family is unique because it suppresses CMI. In this study, we compared the expression of the three TGF-beta isoforms and their receptors in skin biopsies from LL and TT patients (LL = 20; TT = 20) using immunohistochemistry and automated morphometry. The percentage of cells immunostained for the three TGF-beta isoforms and cells positive for the three TGF-beta receptors in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexal tissue were significantly higher in LL than that in TT, with macrophages being the most common and strongest immunoreactive cells. Some lymphocytes, fibroblasts, keratinocytes and epithelial cells from sweat glands and hair roots were also positive. In situ reverse-transcription polymerase chain reaction corroborated the capacity of these cells to synthesize TGF-beta1 and TGF-beta receptor 2. This high expression of TGF-beta isoforms and their receptors could contribute to CMI anergy and other clinical characteristic features of leprosy, like skin atrophy. (AU). Descriptors: HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/metab HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/metab MYCOBACTERIUM LEPRAE ISOFORMAS DE PROTEINAS HIBRIDIZACAO IN SITU RNA MENSAGEIRO/quim RNA MENSAGEIRO/genet RECEPTORES DO FATOR DE CRESCIMENTO TRANSFORMADOR BETA/bios RECEPTORES DO FATOR DE CRESCIMENTO TRANSFORMADOR BETA/imunol PELE/citol PELE/imunol REACAO EM CADEIA POR POLIMERASE VIA TRANSCRIPTASE REVERSA IMUNOHISTOQUIMICA BIOPSIA FATOR DE CRESCIMENTO TRANSFORMADOR BETA/bios FATOR DE CRESCIMENTO TRANSFORMADOR BETA/genet FATOR DE CRESCIMENTO TRANSFORMADOR BETA/imunol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09092/s

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Id: 13859 Author: Castaño Hernández, Santos T; Carrazana Hernández, Gonzalo B. Title: Alteraciones del metabolismo de los carbohidratos en lepra lepromatosa. Source: Fontilles - Revista de Leprología;17(6):565-573, Sep.-Dic. 1990. tab. Abstract: Se estudió el metabolismo de los carbohidratos (MC) en 84 casos de lepra lepromatosa de las áreas de salud de la ciudad de Camagüey, Cuba, a principios de 1989. Para evitar interferir en los resultados de la prueba de tolerancia a la glucosa oral (PTG), se excluyeron en este estudio los pacientes con enfermedades agudas, eritema nudoso leproso y los que ingirieron medicamentos orales. Todos los casos fueron sometidos a la PTG oral de acuerdo con las Normas Nacionales de Endocrinología. Para el diagnóstico de obesidad se utilizó el indicador de masa corporal. Los resultados obtenidos mostraron alteraciones del MC en el 7'1 por ciento de los pacientes con lepra lepromatosa; predominio de los casos con PTG alterada en relación con los diabéticos clínicos; así como el sexo masculino (83'3 por ciento) y del grupo de edades entre 56 y 75 años; la mayor parte de los pacientes con alteraciones del MC no resultaron obesos; el 66'7 por ciento de los enfermos negaron antecedentes familiares de diabetes mellitus y el 100'0 por ciento de los casos sólo presentaron dermotopatías. (AU). Descriptors: HANSENIASE VIRCHOWIANA/compl HANSENIASE VIRCHOWIANA/metab Location: BR191.1

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