|
|
| Id: | 13278
| | Author: | Waters, M. F. R; Isa, Bakri Bin HJ; Rees, R. J. W; McDougall, A. C
| | Title: | Experimental lepromatous leprosy in the white-handed gibbon (Hylobatus lar): successful inoculation with leprosy bacilli of human origin
..-
| | Source: | s.l; s.n; dec. 1978. 7 p. ilus, tab.
| | Abstract: | Leprosy bacilli of human origin were inoculated into a white-handed gibbon by the i.v. and i.p. routes, and also locally into ears, testis and around an ulnar nerve. The animal was observed closely during a period of nearly 15 years and did not exhibit any clinical evidence of cutaneous or neurological disease. At death, a wide range of tissues was taken for bacterial counts and histological examination, and a disseminated and progressive infection was demonstrated. Acid-fast bacilli were found in many sites; their morphological appearance, distribution in nerves, and pattern of multiplication in mouse foot-pads, and also the presence of anti-mycobacterial antibody in the serum and the absence of specific lymphocyte transformation were all in keeping with an infection by Mycobacterium leprae, at an early lepromatous infection in a primate. The findings are discussed in relation to the long incubation period of lepromatous leprosy and the difficulties of diagnosing the disease at an early stage in man.(AU).
| | Descriptors: | ANTICORPOS ANTIBACTERIAS/anal
MODELOS ANIMAIS DE DOENCAS
MEMBRO POSTERIOR/patol
HYLOBATES/anat
HANSENIASE/imunol
HANSENIASE/patol
MYCOBACTERIUM LEPRAEMURIUM/isol
MYCOBACTERIUM LEPRAEMURIUM/patogen
PONGIDAE/anat
NERVO ULNAR
| | Limits: | ANIMAL
MASCULINO
| | Electronic Medium: | http://www.ilsl.br
| | Location: | BR191.1; 00546/s |
|
