Database : HANSEN Search on : INFECCOES POR HIV/QUIMIOTER [Subject descriptor] References found : 6 [refine] Displaying: 1 .. 6   in format [Detailed]

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Id: 13938 Author: Dredge, Keith; Marriott, J. Blake; Dalgleish, Angus G Title: Immunological effects of thalidomide and its chemical and functional analogs ..- Source: s.l; s.n; 2002. 13 p. ilus, tab. Abstract: Thalidomide has recently shown considerable promise in the treatment of a number of conditions, such as leprosy and cancer. Its effectiveness in the clinic has been ascribed to wide-ranging properties, including anti-TNF-alpha, T-cell costimulatory and antiangiogenic activity. Novel compounds with improved immunomodulatory activity and side effect profiles are also being evaluated. These include selective cytokine inhibitory drugs (SelCIDs), with greatly improved TNF-alpha inhibitory activity, and immunomodulatory drugs (IMiDs) that are structural analogs of thalidomide, with improved properties. A third group recently identified within the SelCID group, with phosphodiesterase type 4-independent activity, is in the process of being characterized in laboratory studies. This review describes the emerging immunological properties of thalidomide, from a historical context to present-day clinical applications, most notably in multiple myeloma but also in other cancers, inflammatory disease, and HIV. We also describe the laboratory studies that have led to the characterization and development of SelCIDs and IMiDs into potentially clinically relevant drugs. Early trial data suggest that these novel immunomodulatory compounds may supercede thalidomide to become established therapies, particularly in certain cancers. Further evidence is required, however, to correlate the clinical efficacy of these compounds with their known immunomodulatory, antiangiogenic, and antitumor properties. (AU). Descriptors: TALIDOMIDA/analog TALIDOMIDA/imunol TALIDOMIDA/farmacol SISTEMA IMUNE/ef drogas NEOPLASIAS/quimioter NEOPLASIAS/imunol INFECCOES POR HIV/quimioter INFECCOES POR HIV/imunol ADJUVANTES IMUNOLOGICOS/farmacol INIBIDORES DE ANGIOGÊNESE/imunol INIBIDORES DE ANGIOGÊNESE/farmacol ANTIVIRAIS/imunol ANTIVIRAIS/farmacol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 04731/s

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Id: 13734 Author: Lawn, S. D; Wood, C; Lockwood, D. N Title: Borderline tuberculoid leprosy: an immune reconstitution phenomenon in a human immunodeficiency virus-infected person ..- Source: s.l; s.n; 2003. 2 p. ilus. Abstract: Two months after starting highly active antiretroviral treatment (HAART), an individual with human immunodeficiency virus type 1 (HIV-1) infection and profound CD4+ T lymphocytopenia developed several erythematous plaques on his face, which were due to borderline tuberculoid leprosy with reversal reaction. The temporal association between the development of these lesions and changes in blood CD4+ lymphocyte count and plasma HIV-1 load observed during HAART strongly suggests that the presentation of leprosy resulted from immune reconstitution. (AU). Descriptors: INFECCOES OPORTUNISTAS RELACIONADAS COM A AIDS/imunol AGENTES ANTI-HIV/uso terap TERAPIA ANTI-RETROVIRAL DE ALTA ATIVIDADE/ef adv CONTAGEM DE LINFOCITO CD4 INFECCOES POR HIV/compl INFECCOES POR HIV/quimioter INFECCOES POR HIV/imunol HANSENIASE TUBERCULOIDE/etiol HANSENIASE TUBERCULOIDE/imunol IMUNIDADE/ef drogas Limits: RELATO DE CASO HUMANO MASCULINO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09026/s

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Id: 13540 Author: Lawn, S. D; Wood, C; Lockwood, D. N Title: Borderline tuberculoid leprosy: an immune reconstitution phenomenon in a human immunodeficiency virus-infected person ..- Source: s.l; s.n; Jan. 2003. 3 p. ilus. Abstract: Two months after starting highly active antiretroviral treatment (HAART), an individual with human immunodeficiency virus type 1 (HIV-1) infection and profound CD4+ T lymphocytopenia developed several erythematous plaques on his face, which were due to borderline tuberculoid leprosy with reversal reaction. The temporal association between the development of these lesions and changes in blood CD4+ lymphocyte count and plasma HIV-1 load observed during HAART strongly suggests that the presentation of leprosy resulted from immune reconstitution. (AU). Descriptors: HANSENIASE TUBERCULOIDE/etiol HANSENIASE TUBERCULOIDE/imunol INFECCOES POR HIV/compl INFECCOES POR HIV/quimioter INFECCOES POR HIV/imunol CONTAGEM DE LINFOCITO CD4 INFECCOES OPORTUNISTAS RELACIONADAS COM A AIDS/imunol AGENTES ANTI-HIV/uso terap TERAPIA ANTI-RETROVIRAL DE ALTA ATIVIDADE/ef adv IMUNIDADE/ef drogas Limits: RELATO DE CASO HUMANO MASCULINO ADULTO Location: BR191.1; 09166/s

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Id: 11306 Author: Miller, Marilyn T; Stromland, Kerstin Title: Teratogen update: thalidomide: a review, with a focus on ocular findings and new potential uses ..- Source: s.l; s.n; 1999. 16 p. ilus, tab. Descriptors: ANORMALIDADES DO OLHO ANORMALIDADES DO OLHO INFECÇOES POR HIV HISTORIA DA MEDICINA DO SÉCULO 15 HISTORIA DA MEDICINA DO SÉCULO 20 RECÉM-NASCIDO HANSENIASE TROCA MATERNO-FETAL NEOVASCULARIZAÇAO PATOLOGICA GRAVIDEZ SUÉCIA TERATOGENIOS TERATOGENIOS TALIDOMIDA TALIDOMIDA Deformidades Congênitas dos Membros/CI/EP/HI Location: BR191.1; 07245/s

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Id: 10963 Author: Calabrese, Leonard; Fleischer, Alan B Title: Thalidomide: current and potential clinical applications ..- Source: s.l; s.n; 2000. 9 p. tab. Descriptors: HANSENIASE LEPROMATOSA LEPROSTATICOS LEPROSTATICOS LEPROSTATICOS ARTRITE REUMATOIDE SINDROME DE BEHCET AGENTES DERMATOLOGICOS AGENTES DERMATOLOGICOS AGENTES DERMATOLOGICOS ECTROMELIA ERITEMA NODOSO DOENÇA ENXERTO-HOSPEDEIRO INFECÇOES POR HIV IMUNOSSUPRESSORES IMUNOSSUPRESSORES IMUNOSSUPRESSORES LUPUS ERITEMATOSO CUTANEO NEOPLASIAS DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO ESTOMATITE AFTOSA TERATOGENIOS TALIDOMIDA TALIDOMIDA TALIDOMIDA Location: BR191.1; 07430/s

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Id: 9636 Author: Giedlin, Martin A; Zimmerman, Robert J Title: The use of recombinant human interleukin-2 in treating infectious diseases ..- Source: s.l; s.n; 1993. 5 p. . Descriptors: INFECÇOES POR HIV INTERLEUCINA-2 HANSENIASE PROTEINAS RECOMBINANTES TUBERCULOSE Limits: ANIMAL Location: BR191.1; 06556/s

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